8. Definition 4 “Use of molecular or genetic characteristics to customize therapy for individuals” But how well does individual resemble various sub-populations? Patient Sub-Populations A Patient’s resemblance to a sub-population is probabilistic vs. deterministic. This is not a perfect science, but benefits can be achieved. Kohane, 2009, p. 1
9. Categories and Benefits Ginsburg, 2009, p. 1 Aspinall, 2007, p. 1 5
65. Patient responses may be inaccurate (i.e. what is your race?)1/3 of disease risk predictions differ between genetic testing companies 23andMe and Navigenics1 Ng, 2009, p. 1-3
72. References 24 Aspinall, M. & Hamermesh, R. (2007) Realizing the Promise of Personalized Medicine. Harvard Business Review. October, 2007. David, J., Ma, P. & Sufaria, S. (2010) The Microeconomics of Personalized Medicine. McKinsey Quarterly. Retrieved from http://www.mckinseyquarterly.com/The_microeconomics_of_personalized_medicine_2527. February, 2010. Downing, G., Boyle, S., Brinner, K. & Osheroff, J. (2009) Information Management to Enable Personalized Medicine: Stakeholder Roles in Building Clinical Decision Support. BMC Medical Informatics and Decision Making. Retrieved from http://www.biomedcentral.com/content/pdf/1472-6947-9-44.pdf. October 8, 2009. Ginsburg, G. & McCarthy, J. (2009) Transforming the Practice of Medicine Using Genomics. Clinical Cases in Bone Metabolism. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781216/pdf/ClinicalCases-6-0025.pdf, April 28, 2010. Kohane, I. (2009) The Twin Questions of Personalized Medicine: Who Are You and Whom Do You Resemble? Genome Medicine. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651581/pdf/gm4.pdf. January 20, 2009. Ng., P., Murray, S., Levy, S. & Venter, J. (2009) An Agenda for Personalized Medicine. Nature. Vol. 461. October 8, 2009. Ratain, M. (2007) Personalized Medicine: Building the GPS to Take Us There. Clinical and Pharmacology Therapeutics. Volume 81, Number 3. March, 2007. Woodcock, J. (2007) Molecular Medicine: How, What, and When? Nature. Volume 82, Number 4. October, 2007.
Hinweis der Redaktion
The presentation focused on the scientific and clinical challenges posed by personalized medicine