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 Prevention  Of Dengue
    An overview…
   M. Afzal Naeem (Lecturer in Botany)
   Govt. Post Graduate College of Science,
   Samanabad, Faisalabad.
   Dengue fever is a virus infection caused by
    the dengue virus. There are 4 kinds of
    dengue viruses.




                        Close up of Aedes aegypti Mosquito
   50-100 million dengue fever infections per
    year globally
   500,000 cases of severe dengue, dengue
    hemorrhagic fever or dengue shock syndrome
   100-200 cases annually in U.S.
   Average case fatality 5%
   Endemic in more than 100 tropical and
    subtropical countries.
   Pandemic began in Southeast Asia after WW
    II with subsequent global spread.
   Several epidemics since 1980s.
   Distribution is comparable to malaria.
• New infections annually: 50 million
• Deaths: 24,000 annually
• People at risk: 2.5-3 billion
• Hospitalized cases: 500 000/year
     (90% of those affected are children)
• Disease burden: 465,000 Disability
Adjusted Life Years (DALY)
Dengue Fever In 2006
                         Cases    Deaths


        3500
        3000
        2500
        2000
Cases
        1500
        1000
        500
          0
               India   Pakistan            Karachi   Lahore
    Cases      3331     3230                1836      400
    Deaths      49       50                  30        4
2005 Dengue Outbreak
                                 Cases       Deaths


        100,000

         80,000

         60,000
Cases
         40,000

         20,000

             0
                  India, (West
                                   Sri Lanka     Thailand   Pakistan
                    Bengal)

        Cases        90,000          3,000        31,000     4,800
        Deaths       15,000            0              58       50
Aedes aegypti   Aedes albopictus
   Dengue fever and dengue hemorrhagic
    fever are the most common mosquito-
    borne viral disease in the world.

   Only the female mosquito feeds on blood.
    This is because they need the protein found
    in blood to produce eggs. Male mosquitoes
    feed only on plant nectar.
   The mosquito is attracted by the body
    odors, carbon dioxide and heat emitted
    from the animal or humans.

   •The female Aedes mosquito searches for
    suitable places to lay their eggs.
    •Aedes are day-biters, most active during
    dawn and dusk.
1-2 Days




 Pupae     4-5 Days   Larvae   2 – 3 Days   Eggs =300
Flavivirus family
Small enveloped viruses
containing single
stranded RNA
Four distinct viral
serotypes (Den-1, Den-
2, Den-3, Den-4)
Transmitted by the bite
of Aedes mosquito
(Aedes aegypti)
Incubation 3-14 days
Acute illness and
viremia 3-7 days
Recovery or progression
to leakage phase
ASYMPTOMATIC
               Undifferentiated
               Fever
                                  Without haemorrhage

SYMPTOMATIC    Dengue Fever
                                  With unusual haemorrhage



               Dengue             No shock
               Haemorrhagic
               Fever              DSS
   May be the most common manifestation of
    dengue
   Prospective study found that 87% of students
    infected were either asymptomatic or only
    mildly symptomatic
   Other prospective studies including all age-
    groups also demonstrate silent transmission
   DS Burke, et al. A prospective study of dengue infections
   in Bangkok. Am J Trop Med Hyg 1988; 38:172-80.
 Skin hemorrhages:
petechiae, purpura, ecchymoses
 Gingival bleeding
 Nasal bleeding
 Gastro-intestinal bleeding:
  hematemesis, melena, hematochezia
 Hematuria
 Increased menstrual flow
hematemesis
purpura
                                       petechiae




  Gingival bleeding   Nasal bleeding
1.       Fever, or recent history of acute fever
2.       Hemorrhagic manifestations
3.       Low platelet count (100,000/mm3 or less)
4.       Objective evidence of “leaky capillaries:”
     ◦     elevated hematocrit (20% or more over
           baseline)
     ◦     low albumin
     ◦     pleural or other effusions
   Abdominal pain - intense and sustained
   Persistent vomiting
   Abrupt change from fever to hypothermia,
    with sweating and prostration
   Restlessness or somnolence

   Martínez Torres E. Salud Pública Mex 37 (supl):29-44, 1995.
   Fluids
   Rest
   Antipyretics (avoid aspirin and non-steroidal
    anti-inflammatory drugs)
   Monitor blood pressure, hematocrit, platelet
    count, level of consciousness
   All above treatment +
   – In case of severe bleeding, give fresh whole blood
    20 ml/kg as a bolus
   – Give platelet rich plasma transfusion
    exceptionally when platelet counts are below
    5,000–10,000/ mm3 .
   – After blood transfusion, continue fluid therapy at
    10 ml/kg/h and reduce it stepwise to bring it down
    to 3 ml/kg/h and maintain it for 24-48 hrs
Papaya Juice vs. Dengue ?
                       
 Raw papaya leaves, 2 pcs just cleaned and pound
  and squeeze with filter cloth. You will only get one
  tablespoon per leaf. So two tablespoon per serving
  once a day.
 Do not boil or cook or rinse with hot water, it will
  loose its strength. Only the leafy part and no stem
  or sap.
 It is very bitter and you have to swallow it like Won
  Low Kat. But it works.
   Source: from Indonesia March 2005
Biological:
 Target larval stage of Aedes in large water
  storage containers
 Larvivorous fish (Gambusia), endotoxin
  producing bacteria (Bacillus), copepod
  crustaceans (mesocyclops)
Chemical:
 Insecticide treatment of water containers
 Space spraying (thermal fogs)
Dawn   Dusk
A. STATE/ GOVERNMENT             B. COMMUNITY LEVEL             C. INDIVIDUAL MEASURES
LEVEL MEASURES                   MEASURES
1.   ERADICATION OF MOSQUITO     1. FORMULATE A HEALTH          1. SHEILDING THE HOME ,
     BREEDING SITES & MOSQUITO   RELATED REPRESENTAIVE BODY     OWNSELF & FAMILY FROM
     ERADICATION                                                MOSQUITOES



                                 2. STOP FORMATION OF           2. MOSQUITO ERADICATION
                                 MOSQUITO BREEDING SITES & DO
                                 MOSQUITO ERADICATION
2. HEALTH EDUCATION              3. PARTICPATION IN HEALTH      3. EDUCATING MEMBERS OF
                                 PROGRAMMES                     FAMILY
3. DIAGNOSIS & TREATMENT OF      4. COMMUNITY BASED             4. CONSULTING THE PHYSICIANS
DENGUE CASES                     MECHANISM OF REFERAL &         ON SEEING SYMPTOMS AND SIGNS
                                 TRANSPORTATION OF SUSPECTED    AS EARLY AS POSSIBLE.
                                 CASES
   It is the prime duty of the government to
    clean up all mosquito breeding sites e.g.
   Stagnant Water Ponds
   Garbage Heaps
   Choked Sewerage and drainage system
   Regular Anti Mosquito spray in all localities
   3.Lifting the living standard of people and
    bringing them out of slums
I.     Continuous liaison with Health Department
II.    To be aware of and spread the awareness about
       the Health Programmes offered by the
       Government and to efficiently participate in them.
III.   To raise funds for the betterment of community
       health
IV.    To keep a vigilant eye on proper execution of
       Health Related Programmes offered by
       Government.
   This is what you can do to help…




    Change water in vases on alternate days.
2.Ways to keep
the Mosquitoes
away
Use Of Anti Mosquito Sprays
Use of Coils   Mats   Electric Devices
Use of Mosquito Nets and Mosquito Repellent
                             Oils
   Spread the dengue prevention message to
     others…
Let your family,
 friends and
 neighbours know
about the dangers
 Itcan carry the dengue virus and
 infect a healthy person with dengue
 fever.
   Name the 5 steps in the 10-Minute
    Dengue Wipe-out Exercise
1.   Change water in vases on alternate.
2.   Remove water from flowerpot plates on alternate
     days.
3.   Turn over all pails and water storage containers.
4.   Cover bamboo pole holders when not in use.
5.   Clear blockages and put in Bti insecticide in roof
     gutters monthly.
•   Cover all toilet bowls in your home.
•   Seal off the overflow pipe of the flushing cistern.
•   Cover all gully/floor traps.
•    Add sand granular insecticide to places that mosquitoes could potentially breed, such
    as flower vases and places where stagnant water could not be removed.
•   Clear blockages and add Bti insecticide in roof gutters.
   • Turn over all pails and water storage containers.
•   Ask a relative or close friend to check your home regularly for stagnant water if you
    are going away for a long period of time.
•    Leave your contact with your neighbours or the neighbourhood police post/ centre so
    that you can be reached easily.
Dengue fever ppt(1)

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Dengue fever ppt(1)

  • 1.  Prevention Of Dengue An overview…  M. Afzal Naeem (Lecturer in Botany)  Govt. Post Graduate College of Science,  Samanabad, Faisalabad.
  • 2. Dengue fever is a virus infection caused by the dengue virus. There are 4 kinds of dengue viruses. Close up of Aedes aegypti Mosquito
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  • 4. 50-100 million dengue fever infections per year globally  500,000 cases of severe dengue, dengue hemorrhagic fever or dengue shock syndrome  100-200 cases annually in U.S.  Average case fatality 5%
  • 5. Endemic in more than 100 tropical and subtropical countries.  Pandemic began in Southeast Asia after WW II with subsequent global spread.  Several epidemics since 1980s.  Distribution is comparable to malaria.
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  • 7. • New infections annually: 50 million • Deaths: 24,000 annually • People at risk: 2.5-3 billion • Hospitalized cases: 500 000/year (90% of those affected are children) • Disease burden: 465,000 Disability Adjusted Life Years (DALY)
  • 8. Dengue Fever In 2006 Cases Deaths 3500 3000 2500 2000 Cases 1500 1000 500 0 India Pakistan Karachi Lahore Cases 3331 3230 1836 400 Deaths 49 50 30 4
  • 9. 2005 Dengue Outbreak Cases Deaths 100,000 80,000 60,000 Cases 40,000 20,000 0 India, (West Sri Lanka Thailand Pakistan Bengal) Cases 90,000 3,000 31,000 4,800 Deaths 15,000 0 58 50
  • 10. Aedes aegypti Aedes albopictus
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  • 12. Dengue fever and dengue hemorrhagic fever are the most common mosquito- borne viral disease in the world.  Only the female mosquito feeds on blood. This is because they need the protein found in blood to produce eggs. Male mosquitoes feed only on plant nectar.
  • 13. The mosquito is attracted by the body odors, carbon dioxide and heat emitted from the animal or humans.  •The female Aedes mosquito searches for suitable places to lay their eggs.  •Aedes are day-biters, most active during dawn and dusk.
  • 14. 1-2 Days Pupae 4-5 Days Larvae 2 – 3 Days Eggs =300
  • 15. Flavivirus family Small enveloped viruses containing single stranded RNA Four distinct viral serotypes (Den-1, Den- 2, Den-3, Den-4)
  • 16. Transmitted by the bite of Aedes mosquito (Aedes aegypti) Incubation 3-14 days Acute illness and viremia 3-7 days Recovery or progression to leakage phase
  • 17. ASYMPTOMATIC Undifferentiated Fever Without haemorrhage SYMPTOMATIC Dengue Fever With unusual haemorrhage Dengue No shock Haemorrhagic Fever DSS
  • 18. May be the most common manifestation of dengue  Prospective study found that 87% of students infected were either asymptomatic or only mildly symptomatic  Other prospective studies including all age- groups also demonstrate silent transmission  DS Burke, et al. A prospective study of dengue infections  in Bangkok. Am J Trop Med Hyg 1988; 38:172-80.
  • 19.  Skin hemorrhages: petechiae, purpura, ecchymoses  Gingival bleeding  Nasal bleeding  Gastro-intestinal bleeding: hematemesis, melena, hematochezia  Hematuria  Increased menstrual flow
  • 20. hematemesis purpura petechiae Gingival bleeding Nasal bleeding
  • 21. 1. Fever, or recent history of acute fever 2. Hemorrhagic manifestations 3. Low platelet count (100,000/mm3 or less) 4. Objective evidence of “leaky capillaries:” ◦ elevated hematocrit (20% or more over baseline) ◦ low albumin ◦ pleural or other effusions
  • 22. Abdominal pain - intense and sustained  Persistent vomiting  Abrupt change from fever to hypothermia, with sweating and prostration  Restlessness or somnolence  Martínez Torres E. Salud Pública Mex 37 (supl):29-44, 1995.
  • 23. Fluids  Rest  Antipyretics (avoid aspirin and non-steroidal anti-inflammatory drugs)  Monitor blood pressure, hematocrit, platelet count, level of consciousness
  • 24. All above treatment +  – In case of severe bleeding, give fresh whole blood 20 ml/kg as a bolus  – Give platelet rich plasma transfusion exceptionally when platelet counts are below 5,000–10,000/ mm3 .  – After blood transfusion, continue fluid therapy at 10 ml/kg/h and reduce it stepwise to bring it down to 3 ml/kg/h and maintain it for 24-48 hrs
  • 25. Papaya Juice vs. Dengue ?   Raw papaya leaves, 2 pcs just cleaned and pound and squeeze with filter cloth. You will only get one tablespoon per leaf. So two tablespoon per serving once a day.  Do not boil or cook or rinse with hot water, it will loose its strength. Only the leafy part and no stem or sap.  It is very bitter and you have to swallow it like Won Low Kat. But it works.  Source: from Indonesia March 2005
  • 26. Biological:  Target larval stage of Aedes in large water storage containers  Larvivorous fish (Gambusia), endotoxin producing bacteria (Bacillus), copepod crustaceans (mesocyclops) Chemical:  Insecticide treatment of water containers  Space spraying (thermal fogs)
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  • 28. Dawn Dusk
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  • 36. A. STATE/ GOVERNMENT B. COMMUNITY LEVEL C. INDIVIDUAL MEASURES LEVEL MEASURES MEASURES 1. ERADICATION OF MOSQUITO 1. FORMULATE A HEALTH 1. SHEILDING THE HOME , BREEDING SITES & MOSQUITO RELATED REPRESENTAIVE BODY OWNSELF & FAMILY FROM ERADICATION MOSQUITOES 2. STOP FORMATION OF 2. MOSQUITO ERADICATION MOSQUITO BREEDING SITES & DO MOSQUITO ERADICATION 2. HEALTH EDUCATION 3. PARTICPATION IN HEALTH 3. EDUCATING MEMBERS OF PROGRAMMES FAMILY 3. DIAGNOSIS & TREATMENT OF 4. COMMUNITY BASED 4. CONSULTING THE PHYSICIANS DENGUE CASES MECHANISM OF REFERAL & ON SEEING SYMPTOMS AND SIGNS TRANSPORTATION OF SUSPECTED AS EARLY AS POSSIBLE. CASES
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  • 38. It is the prime duty of the government to clean up all mosquito breeding sites e.g.  Stagnant Water Ponds  Garbage Heaps  Choked Sewerage and drainage system  Regular Anti Mosquito spray in all localities  3.Lifting the living standard of people and bringing them out of slums
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  • 49. I. Continuous liaison with Health Department II. To be aware of and spread the awareness about the Health Programmes offered by the Government and to efficiently participate in them. III. To raise funds for the betterment of community health IV. To keep a vigilant eye on proper execution of Health Related Programmes offered by Government.
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  • 53. This is what you can do to help… Change water in vases on alternate days.
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  • 61. 2.Ways to keep the Mosquitoes away
  • 62. Use Of Anti Mosquito Sprays
  • 63. Use of Coils Mats Electric Devices
  • 64. Use of Mosquito Nets and Mosquito Repellent Oils
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  • 66. Spread the dengue prevention message to others… Let your family, friends and neighbours know about the dangers
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  • 69.  Itcan carry the dengue virus and infect a healthy person with dengue fever.
  • 70. Name the 5 steps in the 10-Minute Dengue Wipe-out Exercise
  • 71. 1. Change water in vases on alternate. 2. Remove water from flowerpot plates on alternate days. 3. Turn over all pails and water storage containers. 4. Cover bamboo pole holders when not in use. 5. Clear blockages and put in Bti insecticide in roof gutters monthly.
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  • 73. Cover all toilet bowls in your home. • Seal off the overflow pipe of the flushing cistern. • Cover all gully/floor traps. • Add sand granular insecticide to places that mosquitoes could potentially breed, such as flower vases and places where stagnant water could not be removed. • Clear blockages and add Bti insecticide in roof gutters.  • Turn over all pails and water storage containers. • Ask a relative or close friend to check your home regularly for stagnant water if you are going away for a long period of time. • Leave your contact with your neighbours or the neighbourhood police post/ centre so that you can be reached easily.