If screening applications resemble a scientific or economic bottleneck in your company, a very unique approach can help: Autodisplay Biotech GmbH's proprietary technologies pMATE and Autodisplay enable the development of cost-efficient screening tools, which can be used for the identification of binding partners such as inhibitors, activators, biomarkers or autoantigens. We use fluorescence marked libraries in order to identify targets. Any binding activity can then be selected through fluorescence activated cell sorting (FACS). Find out how our custom-tailored products and services can assist in bringing your research forward.

1. are
you
ENGAGED IN
SCREENING ACTIVITIES?

2. SCREENING CAN BE SO MUCH
EASIER WITH …
bacterial
surface
display

3. OUR TECHNOLOGY…
OM
PP
IM
CP
SP
PASSENGER
LINKER
β-BARREL

4. … IS A SELF-SUFFICIENT SYSTEM
OM
PP
IM
CP
SP
PASSENGER
LINKER
β-BARREL

5. SURFACE DISPLAY ENABLES A
SIMPLE APPROACH TO SCREENING
create
diversity
use a
library
display the
library
display the
library
display the
target
analyse
analyse
ACTIVITY SCREENING
BINDING INTERACTIONS

6. WHAT ARE THE BENEFITS

7. SPEED UP YOUR SCREENING FOR
BINDING INTERACTION WITH FACS
1
2
PEPTIDE OR PROTEIN
CREATE DIVERSITY
PREPARE SAMPLE

8. LIBRARY DISPLAY AND USE OF A
FLUORESCING TARGET STRUCTURE
STREPTAVIDIN
FITC
FLUORESCENT
MARKER
INHIBITOR
PRODUCT
WASTE
CATCHER TUBE
LASER
BIOTIN MARKED
TARGET MOLECULE
3
SCREEN WITH FACS
(OPTION A)
PROBE INJECTION

9. LIBRARY DISPLAY AND USE OF A
DISPLAYED TARGET
FLUORESCENT CELL
DISPLAYING TARGET
INHIBITOR
PRODUCT
WASTE
CATCHER TUBE
LASER
TARGET MOLECULE
PROBE INJECTION
3
SCREEN WITH FACS
(OPTION B)

10. SIMPLIFY YOUR ENZYME
OPTIMIZATION PROCESSES
NO MORE
PURIFICATION
OF TARGET
&
NO MORE
USE OF CELL
LYSATES
PEPTIDE OR PROTEIN
DETERMINE ACTIVITY
STRAIGHT AWAY

11. HELP
WE CAN
, WHEN
OTHER SYSTEMS FAIL
ESPECIALLY IN THE CASE OF
CHALLENGING ENZYMES

12. you
may
ask
WHAT ARE
CHALLENGING
ENZYMES?

13. ALL ENZYMES WHICH ARE
DIFFICULT TO HANDLE, DUE TO…
inclusion
bodies
incorrect
folding
multimerisation
lack of
stability
co-factors

14. TALK TO US, IF YOU
WANT TO KNOW MORE