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Human Heart
                HEART

                   is a squared
              shape, muscular
              organ responsible
              for pumping blood
              through the blood
              vessels by
              repeated, rhythmic
              contractions, or a
              similar structure in
              annelids,
              mollusks, and
              arthropods
The Heart is divided into two




         Right heart



          Left heart
Right heart
               is a term used to refer collectively to the right atrium and
  right ventricle of the heart; occasionally, this term is intended to
  reference the right atrium, right ventricle, and the pulmonary trunk
  collectively.
       The right atrium receives deoxygenated systemic blood from the
  superior and inferior vena cavae. The blood is then pumped through
  the tricuspid valve into the right ventricle, which in turn pumps the
  blood through the pulmonary valve into the pulmonary artery.
Vena cavae, Coronary sinus
→ Right atrium (auricle, fossa ovalis, limbus of fossa
  ovalis, crista terminalis, valve of the inferior vena cava,
  valve of the coronary sinus)
Tricuspid valve
→ Right ventricle (conus arteriosus, moderator
  band/septomarginal trabecula)
Pulmonary valve
→ Pulmonary Artery
→ Pulmonary Circulation
The superior and inferior vena
Venae cavae     cava are collectively called the
                venae cavae. They are the veins
                that return de-oxygenated blood
                from the body into the heart.
                They both empty into the right
                atrium.

              The superior vena cava (or
                anterior)
                 is above the heart, and
                forms from a convergence of the
                left and right brachiocephalic
                veins that contain blood from
                the head and the arms. The vena
                cavae carry deoxygenated blood
                from the body to the right atrium
                of the heart.
                The venae cavae is the largest
                blood vessel in the heart.

              The inferior vena cava (or
                posterior vena cava)
                     travels up alongside the
                abdominal aorta with blood from
                the lower part of the body.
Coronary Sinus
Coronary Sinus     is a collection of veins
                  joined together to form a large
                  vessel that collects blood from
                  the myocardium of the heart. It
                  is present in humans and other
                  animals.
                          Location
                        It is located between the left
                  atrium and ventricle on the
                  posterior surface of the heart.
                        It runs transversely in the
                  groove between the left atrium
                  and ventricle on the posterior
                  surface of the heart.
                        The coronary sinus orifice
                  (opening) is just superior to the
                  septal leaflet of the tricuspid
                  valve. The coronary sinus orifice
                  is also known as the ostium of
                  the coronary sinus
Right Atrium
Right Atrium (in older texts
  termed the "right auricle")
   is one of four chambers (two
  atria and two ventricles) in the
  human heart. It receives de-
  oxygenated blood from the superior
  and inferior vena cavae and the
  coronary sinus, and pumps it into
  the right ventricle through the
  tricuspid valve.

Sinoatrial node (SAN)
   is located within this chamber
  next to the vena cava. This is a
  group of pacemaker cells which
  spontaneously depolarise to create
  an Action Potential. The cardiac
  action potential then spreads across
  both atria causing them to contract
  forcing the blood they hold into their
  corresponding ventricles.
Right Ventricle
   Right Auricular Appendix

         Fossa Ovalis

    Limbus of Fossa Ovalis

      Crista Terminalis

Valve of the Inferior Vena Cava

 Valve of the Coronary Sinus
Right Auricular Appendix
            Right auricular appendix
              (right auricula, right
              auricle) is a small conical
              muscular pouch attached
              to the right atrium of the
              heart. Its margins present
              a dentated edge. It projects
              from the upper and front
              part of the sinus forward
              and toward the left side,
              overlapping the root of the
              aorta.
Fossa Ovalis (heart)

               Found in the right
           atrium of the heart, the
           Fossa Ovalis is an
           embryonic remnant of
           the foramen ovale,
           which normally closes
           shortly after birth.
           Failure of the foramen
           ovale to close results
           in a disorder known as
           patent foramen ovale.
Limbus of Fossa Ovalis
           Limbus of fossa ovalis
             (annulus ovalis)

              is the prominent oval
             margin of the fossa ovalis.
                 It is most distinct above
             and at the sides of the fossa;
             below, it is deficient.

                  A small slit-like valvular
             opening is occasionally found,
             at the upper margin of the fossa,
             leading upward beneath the
             limbus, into the left atrium; it is
             the remains of the fetal aperture
             between the two atria.
Crista Terminalis
              In the development of
          the human heart, the right
          horn and transverse
          portion of the sinus
          venosus ultimately
          become incorporated with
          and form a part of the adult
          right atrium, the line of
          union between it and the
          right auricle being
          indicated in the interior of
          the atrium by a vertical
          crest, the crista terminalis
          of His (Wilhelm His, Jr.).
Valve of the Inferior Vena Cava
                     The valve of the
                 inferior vena cava
                 (eustachian valve) serves
                 to direct the blood from
                 that vessel through the
                 foramen ovale into the left
                 atrium.

                      The eustachian valve
                 is the valve at the distal
                 end of the inferior vena
                 cava the passes blood
                 from the lower extremities
                 into the Right Atrium of the
                 heart
Valve of the Coronary Sinus
                    The valve of the
               coronary sinus (Thebesian
               valve) is a semicircular
               fold of the lining
               membrane of the atrium, at
               the orifice of the coronary
               sinus. The valve may vary
               in size, or be completely
               absent.
                    It may prevent the
               regurgitation of blood into
               the sinus during the
               contraction of the atrium.
                    This valve may be
               double or it may be
               cribriform.
Tricuspid Valve
        Tricuspid valve

          is on the right side of
         the heart, between the
         right atrium and the right
         ventricle. The normal
         tricuspid valve usually has
         three leaflets and three
         papillary muscles.
Tricuspid Valve
      The largest cusp is interposed between the
 atrioventricular orifice and the conus arteriosus and is
 termed the anterior or infundibular cusp.
      A second, the posterior or marginal cusp, is in relation
 to the right margin of the ventricle.
      A third, the medial or septal cusp, to the ventricular
 septum.
      The tricuspid valve prevents the blood from returning
 to the right atrium when the right ventricle contracts


***** The tricuspid valve also opens and
  closes at periods of time making the blood
  flow through from the right atrium to the
  right ventricle*****
Right Ventricle


      Conus Arteriosus



Moderator Band/Septomarginal
          Trabecula
Right Ventricle
Right ventricle
  is one of four chambers
 (two atria and two
 ventricles) in the human
 heart. It receives de-
 oxygenated blood from the
 right atrium via the
 tricuspid valve, and pumps
 it into the pulmonary artery
 via the pulmonary valve.
      It is triangular in form,
 and extends from the right
 atrium to near the apex of
 the heart.
Conus Arteriosus
        Conus Arteriosus
          is a conical pouch formed
         from the upper and left angle of
         the right ventricle, from which
         the pulmonary artery arises.
              A tendinous band, which
         may be named the tendon of the
         conus arteriosus, extends
         upward from the right
         atrioventricular fibrous ring and
         connects the posterior surface
         of the conus arteriosus to the
         aorta. This is also called the
         infundibulum, and it is the
         entrance from the right ventricle
         into the pulmonary artery and
         pulmonary trunk. The wall of the
         infundibulum is smooth.
Septomarginal trabecula
Septomarginal     (or moderator band)
  Trabecula          is a muscular band of heart
                 tissue found in the right ventricle. It
                 is well-marked in sheep and some
                 other animals, and frequently
                 extends from the base of the
                 anterior papillary muscle to the
                 ventricular septum.

                       From its attachments it was
                 thought to prevent overdistension
                 of the ventricle, and was named the
                 "moderator band". However, more
                 recent research has indicated that it
                 is more properly considered part of
                 the electrical conduction system of
                 the heart, and in that capacity it is
                 called the "septomarginal
                 trabecula". The TA name is
                 "trabecula septomarginalis".

                      The moderator band is often
                 used by radiologists to more easily
                 identify the right ventricle in
                 prenatal ultrasound.
Pulmonary Valve
Pulmonary Valve
  is the semilunar valve of the
 heart that lies between the right
 ventricle and the pulmonary artery
 and has three cusps. Similar to the
 aortic valve, the pulmonic valve
 opens in ventricular systole, when
 the pressure in the right ventricle
 rises above the pressure in the
 pulmonary artery. At the end of
 ventricular systole, when the
 pressure in the right ventricle falls
 rapidly, the pressure in the
 pulmonary artery will close the
 pulmonic valve.
Pulmonary Valve



  Pulmonary Artery



Pulmonary Circulation
Pulmonary Artery
    Pulmonary arteries carry
blood from the heart to the lungs.
They are the only arteries (other
than umbilical arteries in the
fetus) that carry deoxygenated
blood.
    In the human heart, the
pulmonary trunk (pulmonary
artery or main pulmonary artery)
begins at the base of the right
ventricle. It is short and wide -
approximately 5 cm (2 inches) in
length and 3 cm (1.2 inches) in
diameter. It then branches into
two pulmonary arteries (left and
right), which deliver deoxygenated
blood to the corresponding lung.
Pulmonary Circulation




Pulmonary Circulation
  is the portion of the cardiovascular system which carries oxygen-
 depleted blood away from the heart, to the lungs, and returns oxygenated
 blood back to the heart. The term is contrasted with systemic circulation.
      Oxygen-depleted blood from the body leaves the right heart through the
 pulmonary arteries, which carry it to the lungs, where red blood cells release
 carbon dioxide and pick up oxygen during respiration. The oxygenated blood
 then leaves the lungs through the pulmonary veins, which return it to the left
 heart, completing the pulmonary cycle. The blood is then distributed to the
 body through the systemic circulation before returning again to the
 pulmonary circulation.
Left heart
  is a term used to refer collectively to the left atrium and lef
 ventricle of the heart; occasionally, this term is intended to reference
 the left atrium, left ventricle, and the aorta collectively.
      The left atrium receives oxygenated pulmonic blood from the
 pulmonary veins. The blood is then pumped through the mitral valve
 into the left ventricle, which in turn pumps the blood through the aortic
 valve into the aorta.
      The left side of the heart is thicker than the right because of the
 requirement to pump blood from the left throughout the body, as
 opposed to the right side pumping only through the lungs.
Pulmonary veins
 Left atrium
    Left Auricular Appendix
 Mitral valve
 Left ventricle
 Aortic valve
    Aortic sinus
             Aorta
             Systemic circulation
Pulmonary Veins

               The pulmonary veins carry
          oxygen-rich blood from the
          lungs to the left atrium of the
          heart. They are the only veins in
          the post-fetal human body that
          carry oxygenated (red) blood.
        • The pulmonary veins return the
          oxygenated blood from the
          lungs to the left atrium of the
          heart. They are four in number,
          two from each lung, and are
          destitute of valves. They are

        •   Right Inferior
        •   Right Superior
        •   Left Inferior
        •   Left Superior
Left Atrium
      Left atrium

        is one of the four chambers
       in the human heart. It receives
       oxygenated blood from the
       pulmonary veins, and pumps it
       into the left ventricle.


            Blood is pumped through
       the left atrioventricular orifice,
       which contains the mitral valve.
       A normal left atrium may be up
       to 5.5cm in maximum diameter;
       any larger than this is a sign of
       cardiac failure. This may occur
       in cases of mitral regurgitation.
Left Auricular Appendix
            Left Auricular Appendix
              (left auricula, left
              auricle)

               is a conical muscular
              pouch connected to the left
              atrium of the heart. It is
              somewhat constricted at its
              junction with the principal
              cavity; it is longer, narrower,
              and more curved than the right
              auricular appendix, and its
              margins are more deeply
              indented.
                   It is directed forward and
              toward the right and overlaps
              the root of the pulmonary artery.
Mitral Valve
      Mitral valve (also known
        as the bicuspid valve or
        left atrioventricular
        valve)

         is a dual flap (bi = 2) valve
        in the heart that lies between the
        left atrium (LA) and the left
        ventricle (LV). In Latin, the term
        mitral means shaped like a
        miter, or bishop's cap. The
        mitral valve and the tricuspid
        valve are known collectively as
        the atrioventricular valves
        because they lie between the
        atria and the ventricles of the
        heart and control flow.
Left ventricle
                  The left ventricle is
            one of four chambers
            (two atria and two
            ventricles) in the human
            heart. It receives
            oxygenated blood from
            the left atrium via the
            mitral valve, and pumps
            it into the aorta via the
            aortic valve.
                  The left ventricle is
            longer and more conical
            in shape than the right,
            and on transverse
            section its concavity
            presents an oval or
            nearly circular outline. It
            forms a small part of the
            sternocostal surface and
            a considerable part of
            the diaphragmatic
            surface of the heart; it
            also forms the apex of
            the heart.
Aortic Valve
      Aortic valve
         is one of the valves of the
        heart. It lies between the left
        ventricle and the aorta.


               Morphology
             The aortic valve has three
        cusps. These cusps are half
        moon shaped hence also called
        aortic semilunar valve. Each
        cusp has a small swelling in the
        center called the nodule.
        Dilatation of the wall of the aorta
        behind these cusps is called
        aortic sinus. When the aortic
        valve is open, the normal size of
        the orifice is 3-4 cm² in adults.
Aortic Sinus




      An aortic sinus is one of the anatomic dilations of the
  ascending aorta, which occurs just above the aortic valve.

There are generally three aortic sinuses, the left, the right and the
  posterior.
• The left aortic sinus gives rise to the left coronary artery.
• The right aortic sinus gives rise to the right coronary artery.
• Usually, no vessels arise from the posterior aortic sinus, which
  is therefore known as the non-coronary sinus.
Aorta
      The aorta (generally
  pronounced [eɪˈɔːtə] or
  "ay-orta") is the largest
  artery in the human body,
  originating from the left
  ventricle of the heart and
  bringing oxygenated blood
  to all parts of the body in
  the systemic circulation.
 The course of the Aorta
The aorta is usually divided
  into five
  segments/sections:
• Ascending aorta
• Arch of aorta
• Descending aorta
• Thoracic aorta
• Abdominal aorta
Ascending aorta, Arch of aorta, Descending aorta

                        • Ascending Aorta —
                          the section between the
                          heart and the arch of aorta


                        • Arch of Aorta — the
                          peak part that looks
                          somewhat like an inverted
                          "U"


                        • Descending Aorta —
                          the section from the arch
                          of aorta to the point where
                          it divides into the common
                          iliac arteries
Thoracic aorta
       Thoracic aorta
         is contained in the
        posterior mediastinal cavity.
              It begins at the lower
        border of the fourth thoracic
        vertebra where it is
        continuous with the aortic
        arch, and ends in front of the
        lower border of the twelfth at
        the aortic hiatus in the
        diaphragm.
              At its commencement, it
        is situated on the left of the
        vertebral column; it
        approaches the median line
        as it descends; and, at its
        termination, lies directly in
        front of the column.
Abdominal Aorta
          Abdominal Aorta

            is a large artery in
           the abdominal cavity.
           As part of the aorta, it
           is a direct continuation
           of descending aorta
           (of the thorax).
Systemic Circulation
       Systemic Circulation
         is the portion of the cardiovascular
        system which carries oxygenated
        blood away from the heart, to the body,
        and returns deoxygenated blood back
        to the heart. The term is contrasted
        with pulmonary circulation.
              Oxygenated blood from the lungs
        leaves the left heart through the aorta,
        from where it is distributed to the
        body's organs and tissues, which
        absorb the oxygen, through a complex
        network of arteries, arterioles, and
        capillaries. The deoxygenated blood is
        then collected by venules, from where
        it flows first into veins, and then into
        the inferior and superior venae cavae,
        which return it to the right heart,
        completing the systemic cycle. The
        blood is then re-oxygenated through
        the pulmonary circulation before
        returning again to the systemic
        circulation.
Layers of the Heart
1.)   Pericardium
      1.1.)Sinus
            a.) Oblique Sinus
            b.) Transverse Sinus
2.)   Epicardium
3.)   Myocardium
4.)   Endocardium
5.)   Cardiac skeleton
      5.1.) Fibrous trigone
      5.2.) Fibrous rings
Pericardium
    is a double-walled sac that contains the heart and the roots of the great
vessels.


                  Layers of Pericardium
A.) Fibrous Pericardium
     is the most superficial layer. It is a dense connective tissue,
protecting the heart, anchoring it to the surrounding walls, and
preventing it from overfilling with blood. It is continuous with the outer
adventitial layer of the neighboring great blood vessels.

B.) Serous Pericardium
    is deep to the fibrous pericardium. It contains two layers, both of
which function in lubricating the heart to prevent friction from
occurring during heart activity.
Pericardial Sinuses

     The cul-de-sac enclosed between the limbs of the
inverted U of the venous mesocardium lies behind the left
atrium and is known as the Oblique Sinus.

     The passage between the venous and arterial
mesocardia—i.e., between the aorta and pulmonary artery
in front and the atria behind—is termed the Transverse
Sinus.
Epicardium

    describes the outer layer of heart tissue (from Greek; epi-
outer, cardium heart). When considered as a part of the
pericardium, it is the inner layer, or visceral pericardium.


     Its largest constituent is connective tissue and functions as
a protective layer. The visceral pericardium apparently
produces the pericardial fluid, which lubricates motion between
the inner and outer layers of the pericardium.


   During ventricular contraction, the wave of depolarization
moves from endocardial to epicardial surface.
Myocardium
     is the muscular tissue of the heart.

               Relationship to other layers
The other tissues of the heart are:

The Endocardium (inner lining, effectively a specialised endothelium)
The Epicardium (a connective tissue layer around the heart with a
serous surface. It may be considered as the inner (visceral) layer of the
pericardium).
                          Composition
     The myocardium is composed of specialized cardiac muscle cells
with an ability not possessed by muscle tissue elsewhere in the body.
Cardiac muscle, like other muscles, can contract, but it can also
conduct electricity, like nerves.

    The blood supply of the myocardium is by the coronary arteries.
Endocardiumlayer of tissue that lines
     In the heart, the endocardium is the innermost
the chambers of the heart. Its cells, embryologically and biologically, are
similar to the endothelial cells that line blood vessels.
      The endocardium overlies the much more voluminous myocardium, the
muscular tissue responsible for the contraction of the heart. The outer layer
of the heart is termed epicardium and the heart is surrounded by a small
amount of fluid enclosed by a fibrous sac called the pericardium.
                               Function
      Recently, it has become evident that the endocardium, which is
primarily made up of endothelial cells, controls myocardial function. This
modulating role is separate from the homeometric and heterometric
regulatory mechanisms that control myocardial contractility. Moreover, the
endothelium of the myocardial (heart muscle) capillaries, which is also
closely appositioned to the cardiomyocytes (heart muscle cells) are involved
in this modulatory role. Thus, the cardiac endothelium (both the endocardial
endothelium and the endothelium of the myocardial capillaries) controls the
development of the heart in the embryo as well as in the adult, for example
during hypertrophy. Additionally, the contractility and electrophysiological
environment of the cardiomyocyte are regulated by the cardiac endothelium.
      The endocardial endothelium may also act as a kind of blood-heart
barrier (analogous to the blood-brain barrier), thus controlling the ionic
composition of the extracellular fluid in which the cardiomyocytes bathe.
Cardiac skeleton
Cardiac skeleton (sometimes called "fibrous skeleton of the heart") refers to
  the structure of dense connective tissue in the heart that separates the atria
  from the ventricles.
       It is not a "true" skeleton, but it does provide structure and support for
  the heart, as well as isolating the electric charges that go through the heart.

         The left atrioventricular ring is closely connected, by its right margin,
   with the aortic arterial ring; between these and the right atrioventricular ring
   is a triangular mass of fibrous tissue, the fibrous trigone, which represents
   the os cordis seen in the heart of some of the larger animals, as the ox and
   elephant.

          The right and left fibrous rings of heart (anulus fibrosus cordis)
   surround the atrioventricular and arterial orifices, and are stronger upon the
   left than on the right side of the heart. The right fibrous ring is known as the
   anulus fibrosus dexter cordis, and the left is known as the anulus fibrosus
   sinister cordis
Heart Structures
  A.) Atria                           B.) Ventricle

                                    *Interventricular Septum
*Interatrial septum
                                      *Trabeculae Carneae
*Musculi pectinati
                                      *Chordae Tendinae
                                        *Papillary Muscle

                      C.) Valve

             1.) Atrioventricular valves
                  1.1.) Mitral valve
                  1.2.) Tricuspid valve

             2.) Semilunar valves
                  2.1.) Aortic valve
                  2.2.) Pulmonic valve
Interatrial septum
Interatrial Septum is the wall of tissue that separates the

                    right and left atria of the heart.
Musculi Pectinati

                   In the right atrium,
             behind the crest the
             internal surface of the
             atrium is smooth, while in
             front of it the muscular
             fibers of the wall are
             raised into parallel ridges
             resembling the teeth of a
             comb, and hence named
             the musculi pectinati
             (pectinate muscles).
Interventricular Septum
Interventricular Septum
                                                  Portions
     Interventricular septum (or
ventricular septum, or during
development septum inferius) is               The greater portion of it is
the stout wall separating the lower     thick and muscular and constitutes
chambers (the ventricles) of the        the muscular ventricular septum.
heart from one another.
                                              Its upper and posterior part,
      The ventricular septum is         which separates the aortic
directed obliquely backward and to      vestibule from the lower part of the
the right, and is curved with the       right atrium and upper part of the
convexity toward the right ventricle:   right ventricle, is thin and fibrous,
its margins correspond with the         and is termed the membranous
anterior and posterior longitudinal     ventricular septum (septum
sulci.                                  membranaceum).
Trabeculae Carneae
          The trabeculae carneae (columnae carneae) are
      rounded or irregular muscular columns which project from the
      whole of the inner surface of the ventricle, with the exception of
      the conus arteriosus.


They are of three kinds:
1.)        Some are attached along their entire length on one side and merely
      form prominent ridges,

2.)        Others are fixed at their extremities but free in the middle,

3.)        While a third set (musculi papillares) are continuous by their bases with
      the wall of the ventricle, while their apices give origin to the chordæ
      tendineæ which pass to be attached to the segments of the tricuspid valve.
Chordae Tendinae
                  The chordae
            tendineae, or heart
            strings, are cord-like
            tendons that connect the
            papillary muscles to the
            tricuspid valve and the
            mitral valve in the heart.

                  When the right
            ventricle of the heart
            contracts, the blood
            pressure pushes the
            tricuspid valve which closes
            and prevents a backflow of
            blood into the right atrium.
            The chordae tendineae
            prevents the flaps from
            being everted into the right
            atrium. Similarly, these
            cord-like tendons hold in
            position other flaps like the
            bicuspid or mitral valve.
Papillary Muscle

            Papillary muscles of
              the heart serve to limit
              the movements of the
              mitral and tricuspid
              valves. These muscles
              contract to tighten the
              chordae tendineae,
              which in turn prevent
              inversion. This occurs
              in response to
              pressure gradients.
              Instead they brace the
              valves against the high
              pressure, preventing
              regurgitation of
              ventricular blood back
              into the atrial cavities.
Heart Valves

                Heart valves are
           valves in the heart that
           maintain the
           unidirectional flow of
           blood by opening and
           closing depending on
           the difference in
           pressure on each side.
           The mechanical
           equivalent of the heart
           valves would be the
           reed valves.
Mitral Valve
                 The mitral valve
           (also known as the
           bicuspid valve or left
           atrioventricular valve), is
           a dual flap (bi = 2) valve in
           the heart that lies between
           the left atrium (LA) and the
           left ventricle (LV). In Latin,
           the term mitral means
           shaped like a miter, or
           bishop's cap. The mitral
           valve and the tricuspid
           valve are known
           collectively as the
           atrioventricular valves
           because they lie between
           the atria and the ventricles
           of the heart and control
           flow.
Tricuspid Valve

                  The tricuspid valve
            is on the right side of the
            heart, between the right
            atrium and the right
            ventricle. The normal
            tricuspid valve usually has
            three leaflets and three
            papillary muscles.
            Tricuspid valves may also
            occur with two or four
            leaflets, and the number
            may change during life.
Aortic Valve
Aortic Valve
      The aortic valve is one of the valves of the heart. It lies between the
left ventricle and the aorta.
                             Morphology
     The aortic valve has three cusps. These cusps are half moon shaped
hence also called aortic semilunar valve. Each cusp has a small swelling in
the center called the nodule. Dilatation of the wall of the aorta behind these
cusps is called aortic sinus. When the aortic valve is open, the normal size of
the orifice is 3-4 cm² in adults.
                    Function & Physiology
      During ventricular systole, pressure rises in the left ventricle. When the
pressure in the left ventricle rises above the pressure in the aorta, the aortic
valve opens, allowing blood to exit the left ventricle into the aorta. When
ventricular systole ends, pressure in the left ventricle rapidly drops. When
the pressure in the left ventricle decreases, the aortic pressure forces the
aortic valve to close. The closure of the aortic valve contributes the A2
component of the second heart sound (S2).
Pumonary Valve
Pumonary Valve
    is the semilunar valve of the heart that lies between the
right ventricle and the pulmonary artery and has three
cusps. Similar to the aortic valve, the pulmonic valve
opens in ventricular systole, when the pressure in the right
ventricle rises above the pressure in the pulmonary artery.
At the end of ventricular systole, when the pressure in the
right ventricle falls rapidly, the pressure in the pulmonary
artery will close the pulmonic valve.

     The closure of the pulmonic valve contributes the P2
component of the second heart sound (S2). The right heart
is a low-pressure system, so the P2 component of the
second heart sound is usually softer than the A2
component of the second heart sound. However, it is
physiologically normal in some young people to hear both
components separated during inhalation.
Regions of The Heart
1.)   Base
2.)   Apex
3.)   Grooves
           a.)   Coronary/atrioventricular
           b.)   Interatrial
           c.)   Anterior interventricula
           d.)   Posterior interventricular
4.)   Surfaces
           a.)   Sternocostal
           b.)   Diaphragmatic
5.)   Borders
           a.)   Right
           b.)   Left
Base of the Heart
    Base of the heart, directed upward, backward,
      and to the right, is separated from the fifth,
      sixth, seventh, and eighth thoracic vertebræ by
      the esophagus, aorta, and thoracic duct.
            It is formed mainly by the left atrium, and,
      to a small extent, by the back part of the right
      atrium.
            Somewhat quadrilateral in form, it is in
      relation above with the bifurcation of the
      pulmonary artery, and is bounded below by
      the posterior part of the coronary sulcus,
      containing the coronary sinus.
            On the right it is limited by the sulcus
      terminalis of the right atrium, and on the left by
      the ligament of the left vena cava and the
      oblique vein of the left atrium.
            The four pulmonary veins, two on either
      side, open into the left atrium, while the
      superior vena cava opens into the upper, and
      the anterior vena cava into the lower, part of
      the right atrium.
Apex of the Heart
Apex of the heart
  is the lowest superficial part of
 the heart.
      It is directed downward, forward,
 and to the left, and is overlapped by
 the left lung and pleura.


      External Anatomy
       It lies behind the fifth left
 intercostal space, 8 to 9 cm. from the
 mid-sternal line, slightly medial to the
 midclavicular line.
       Alternately, it can be found about
 4 cm. below and 2 mm. to the medial
 side of the left mammary papilla.
       It's function is to pump blood to
 left atruim
Grooves

Coronary/atrioventricular

       Interatrial

Anterior interventricula

Posterior interventricular
Coronary Sulcus

    The atria of the heart are separated from
the ventricles by the coronary sulcus
(coronary groove, auriculoventricular
groove, atrioventricular groove); this
contains the trunks of the nutrient vessels
of the heart, and is deficient in front, where
it is crossed by the root of the pulmonary
artery.
Interatrial Groove


   Interatrial groove, separating the two
atria, is scarcely marked on the
posterior surface, while anteriorly it is
hidden by the pulmonary artery and
aorta.
Anterior Interventricular Sulcus


      The ventricles of the heart are separated
  by two grooves, one of which, the anterior
  longitudinal sulcus (or anterior
  interventricular sulcus), is situated on the
  sternocostal surface of the heart, close to its
  left margin. The other groove separating the
  ventricles is the posterior interventricular
  sulcus.
Posterior Interventricular Sulcus

    The ventricles are separated by two grooves,
one of which, the anterior longitudinal sulcus, is
situated on the sternocostal surface of the heart,
close to its left margin, the other posterior
longitudinal sulcus (posterior interventricular
sulcus, inferior interventricular groove), on the
diaphragmatic surface near the right margin.
    In it run the posterior interventricular artery
and middle cardiac vein.
Surfaces



Sternocostal



Diaphragmatic
Sternocostal Surface of Heart
    The sternocostal surface of the heart (anterior
surface of the heart) is directed forward, upward,
and to the left.
    Its lower part is convex, formed chiefly by the
right ventricle, and traversed near its left margin
by the anterior longitudinal sulcus.
    Its upper part is separated from the lower by
the coronary sulcus, and is formed by the atria; it
presents a deep concavity, occupied by the
ascending aorta and the pulmonary artery.
Diaphragmatic Surface of Heart
   The diaphragmatic surface of the heart,
directed downward and slightly backward, is
formed by the ventricles, and rests upon the
central tendon and a small part of the left
muscular portion of the diaphragm.
   It is separated from the base by the
posterior part of the coronary sulcus, and is
traversed obliquely by the posterior
longitudinal sulcus.
Borders


Right Border of Heart



Left Margin of Heart
Right Border of Heart
Right margin of the heart (right border of
  heart)
  is long, and is formed by the right atrium above and the
 right ventricle below.

      The atrial portion is rounded and almost vertical; it is
 situated behind the third, fourth, and fifth right costal
 cartilages about 1.25 cm. from the margin of the sternum.
      The ventricular portion, thin and sharp, is named the
 acute margin; it is nearly horizontal, and extends from the
 sternal end of the sixth right coastal cartilage to the apex
 of the heart.
Left Margin of Heart
The left margin of heart (or obtuse margin) is shorter
  than the right border of heart, full, and rounded: it
  is formed mainly by the left ventricle, but to a
  slight extent, above, by the left atrium.

      It extends from a point in the second left
  intercostal space, about 2.5 mm. from the sternal
  margin, obliquely downward, with a convexity to
  the left, to the apex of the heart.
Electrical conduction system of
            the heart
The normal electrical conduction in the heart allows the
  impulse that is generated by the sinoatrial node (SA node)
  of the heart to be propagated to (and stimulate) the
  myocardium (Cardiac muscle). After myocardium is
  stimulated, it contracts. It is the ordered stimulation of the
  myocardium that allows efficient contraction of the heart,
  thereby allowing blood to be pumped throughout the body.


                  Cardiac Pacemaker
                       SA node
                       AV node
                     Bundle of His
                    Purkinje Fibers
Cardiac Pacemaker

    The contractions of the heart are controlled by
chemical impulses, which fire at a rate which controls the
beat of the heart.
    The cells that create these rhythmical impulses are
called pacemaker cells, and they directly control the heart
rate. Artificial devices also called pacemakers can be
used after damage to the body's intrinsic conduction
system to produce these impulses synthetically.
Sinoatrial node


Sinoatrial node (abbreviated SA node or
  SAN, also called the sinus node)
  is the impulse generating (pacemaker) tissue
 located in the right atrium of the heart. It is a group
 of cells positioned on the wall of the right atrium,
 near the entrance of the superior vena cava. These
 cells are modified cardiac myocytes. They possess
 some contractile filaments, though they do not
 contract.
Atrioventricular node
Atrioventricular node (abbreviated AV
 node)
  is an area of specialized tissue between the atria
 and the ventricles of the heart, which conducts the
 normal electrical impulse from the atria to the
 ventricles. The AV node is also known as the
 Aschoff-Tawara node.
      The AV node receives two inputs from the atria:
 posteriorly via the crista terminalis, and anteriorly
 via the interatrial septum.
      An important property that is unique to the AV
 node is decremental conduction. This is the property
 of the AV node that prevents rapid conduction to the
 ventricle in cases of rapid atrial rhythms, such as
 atrial fibrillation or atrial flutter.
Bundle of His

      Bundle of His
         is a collection of heart
        muscle cells specialized for
        electrical conduction that
        transmits the electrical impulses
        from the AV node (located
        between the atria and the
        ventricles) to the point of the
        apex of the fascicular branches.
        The fascicular branches then
        lead to the Purkinje fibers which
        innervate the ventricles, causing
        the cardiac muscle of the
        ventricles to contract at a paced
        interval. These specialized
        muscle fibres in the heart were
        named after the Swiss
        cardiologist Wilhelm His, Jr.,
        who discovered them in 1893.
Purkinje Fibers
    Purkinje fibers (or Purkyne tissue) are located in the
inner ventricular walls of the heart, just beneath the
endocardium. These fibers are specialized myocardial
fibers that conduct an electrical stimulus or impulse that
enables the heart to contract in a coordinated fashion.

                      Function
    Purkinje fibers work with the sinoatrial node (SA node)
and the atrioventricular node (AV node) to control the heart
rate.
    During the ventricular contraction portion of the
cardiac cycle, the Purkinje fibers carry the contraction
impulse from the left and right bundle branches to the
myocardium of the ventricles. This causes the muscle
tissue of the ventricles to contract and force blood out of
the heart — either to the pulmonary circulation (from the
right ventricle) or to the systemic circulation (from the left
ventricle).
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Human heart

  • 1. www.Examville.com Online practice tests, live classes, tutoring, study guides Q&A, premium content and more.
  • 2. Human Heart HEART is a squared shape, muscular organ responsible for pumping blood through the blood vessels by repeated, rhythmic contractions, or a similar structure in annelids, mollusks, and arthropods
  • 3. The Heart is divided into two Right heart Left heart
  • 4. Right heart  is a term used to refer collectively to the right atrium and right ventricle of the heart; occasionally, this term is intended to reference the right atrium, right ventricle, and the pulmonary trunk collectively. The right atrium receives deoxygenated systemic blood from the superior and inferior vena cavae. The blood is then pumped through the tricuspid valve into the right ventricle, which in turn pumps the blood through the pulmonary valve into the pulmonary artery. Vena cavae, Coronary sinus → Right atrium (auricle, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve of the inferior vena cava, valve of the coronary sinus) Tricuspid valve → Right ventricle (conus arteriosus, moderator band/septomarginal trabecula) Pulmonary valve → Pulmonary Artery → Pulmonary Circulation
  • 5. The superior and inferior vena Venae cavae cava are collectively called the venae cavae. They are the veins that return de-oxygenated blood from the body into the heart. They both empty into the right atrium. The superior vena cava (or anterior)  is above the heart, and forms from a convergence of the left and right brachiocephalic veins that contain blood from the head and the arms. The vena cavae carry deoxygenated blood from the body to the right atrium of the heart. The venae cavae is the largest blood vessel in the heart. The inferior vena cava (or posterior vena cava)  travels up alongside the abdominal aorta with blood from the lower part of the body.
  • 6. Coronary Sinus Coronary Sinus  is a collection of veins joined together to form a large vessel that collects blood from the myocardium of the heart. It is present in humans and other animals. Location It is located between the left atrium and ventricle on the posterior surface of the heart. It runs transversely in the groove between the left atrium and ventricle on the posterior surface of the heart. The coronary sinus orifice (opening) is just superior to the septal leaflet of the tricuspid valve. The coronary sinus orifice is also known as the ostium of the coronary sinus
  • 7. Right Atrium Right Atrium (in older texts termed the "right auricle")  is one of four chambers (two atria and two ventricles) in the human heart. It receives de- oxygenated blood from the superior and inferior vena cavae and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. Sinoatrial node (SAN)  is located within this chamber next to the vena cava. This is a group of pacemaker cells which spontaneously depolarise to create an Action Potential. The cardiac action potential then spreads across both atria causing them to contract forcing the blood they hold into their corresponding ventricles.
  • 8. Right Ventricle Right Auricular Appendix Fossa Ovalis Limbus of Fossa Ovalis Crista Terminalis Valve of the Inferior Vena Cava Valve of the Coronary Sinus
  • 9. Right Auricular Appendix Right auricular appendix (right auricula, right auricle) is a small conical muscular pouch attached to the right atrium of the heart. Its margins present a dentated edge. It projects from the upper and front part of the sinus forward and toward the left side, overlapping the root of the aorta.
  • 10. Fossa Ovalis (heart) Found in the right atrium of the heart, the Fossa Ovalis is an embryonic remnant of the foramen ovale, which normally closes shortly after birth. Failure of the foramen ovale to close results in a disorder known as patent foramen ovale.
  • 11. Limbus of Fossa Ovalis Limbus of fossa ovalis (annulus ovalis)  is the prominent oval margin of the fossa ovalis. It is most distinct above and at the sides of the fossa; below, it is deficient. A small slit-like valvular opening is occasionally found, at the upper margin of the fossa, leading upward beneath the limbus, into the left atrium; it is the remains of the fetal aperture between the two atria.
  • 12. Crista Terminalis In the development of the human heart, the right horn and transverse portion of the sinus venosus ultimately become incorporated with and form a part of the adult right atrium, the line of union between it and the right auricle being indicated in the interior of the atrium by a vertical crest, the crista terminalis of His (Wilhelm His, Jr.).
  • 13. Valve of the Inferior Vena Cava The valve of the inferior vena cava (eustachian valve) serves to direct the blood from that vessel through the foramen ovale into the left atrium. The eustachian valve is the valve at the distal end of the inferior vena cava the passes blood from the lower extremities into the Right Atrium of the heart
  • 14. Valve of the Coronary Sinus The valve of the coronary sinus (Thebesian valve) is a semicircular fold of the lining membrane of the atrium, at the orifice of the coronary sinus. The valve may vary in size, or be completely absent. It may prevent the regurgitation of blood into the sinus during the contraction of the atrium. This valve may be double or it may be cribriform.
  • 15. Tricuspid Valve Tricuspid valve  is on the right side of the heart, between the right atrium and the right ventricle. The normal tricuspid valve usually has three leaflets and three papillary muscles.
  • 16. Tricuspid Valve The largest cusp is interposed between the atrioventricular orifice and the conus arteriosus and is termed the anterior or infundibular cusp. A second, the posterior or marginal cusp, is in relation to the right margin of the ventricle. A third, the medial or septal cusp, to the ventricular septum. The tricuspid valve prevents the blood from returning to the right atrium when the right ventricle contracts ***** The tricuspid valve also opens and closes at periods of time making the blood flow through from the right atrium to the right ventricle*****
  • 17. Right Ventricle Conus Arteriosus Moderator Band/Septomarginal Trabecula
  • 18. Right Ventricle Right ventricle  is one of four chambers (two atria and two ventricles) in the human heart. It receives de- oxygenated blood from the right atrium via the tricuspid valve, and pumps it into the pulmonary artery via the pulmonary valve. It is triangular in form, and extends from the right atrium to near the apex of the heart.
  • 19. Conus Arteriosus Conus Arteriosus  is a conical pouch formed from the upper and left angle of the right ventricle, from which the pulmonary artery arises. A tendinous band, which may be named the tendon of the conus arteriosus, extends upward from the right atrioventricular fibrous ring and connects the posterior surface of the conus arteriosus to the aorta. This is also called the infundibulum, and it is the entrance from the right ventricle into the pulmonary artery and pulmonary trunk. The wall of the infundibulum is smooth.
  • 20. Septomarginal trabecula Septomarginal (or moderator band) Trabecula  is a muscular band of heart tissue found in the right ventricle. It is well-marked in sheep and some other animals, and frequently extends from the base of the anterior papillary muscle to the ventricular septum. From its attachments it was thought to prevent overdistension of the ventricle, and was named the "moderator band". However, more recent research has indicated that it is more properly considered part of the electrical conduction system of the heart, and in that capacity it is called the "septomarginal trabecula". The TA name is "trabecula septomarginalis". The moderator band is often used by radiologists to more easily identify the right ventricle in prenatal ultrasound.
  • 21. Pulmonary Valve Pulmonary Valve  is the semilunar valve of the heart that lies between the right ventricle and the pulmonary artery and has three cusps. Similar to the aortic valve, the pulmonic valve opens in ventricular systole, when the pressure in the right ventricle rises above the pressure in the pulmonary artery. At the end of ventricular systole, when the pressure in the right ventricle falls rapidly, the pressure in the pulmonary artery will close the pulmonic valve.
  • 22. Pulmonary Valve Pulmonary Artery Pulmonary Circulation
  • 23. Pulmonary Artery Pulmonary arteries carry blood from the heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood. In the human heart, the pulmonary trunk (pulmonary artery or main pulmonary artery) begins at the base of the right ventricle. It is short and wide - approximately 5 cm (2 inches) in length and 3 cm (1.2 inches) in diameter. It then branches into two pulmonary arteries (left and right), which deliver deoxygenated blood to the corresponding lung.
  • 24. Pulmonary Circulation Pulmonary Circulation  is the portion of the cardiovascular system which carries oxygen- depleted blood away from the heart, to the lungs, and returns oxygenated blood back to the heart. The term is contrasted with systemic circulation. Oxygen-depleted blood from the body leaves the right heart through the pulmonary arteries, which carry it to the lungs, where red blood cells release carbon dioxide and pick up oxygen during respiration. The oxygenated blood then leaves the lungs through the pulmonary veins, which return it to the left heart, completing the pulmonary cycle. The blood is then distributed to the body through the systemic circulation before returning again to the pulmonary circulation.
  • 25. Left heart  is a term used to refer collectively to the left atrium and lef ventricle of the heart; occasionally, this term is intended to reference the left atrium, left ventricle, and the aorta collectively. The left atrium receives oxygenated pulmonic blood from the pulmonary veins. The blood is then pumped through the mitral valve into the left ventricle, which in turn pumps the blood through the aortic valve into the aorta. The left side of the heart is thicker than the right because of the requirement to pump blood from the left throughout the body, as opposed to the right side pumping only through the lungs. Pulmonary veins Left atrium Left Auricular Appendix Mitral valve Left ventricle Aortic valve Aortic sinus Aorta Systemic circulation
  • 26. Pulmonary Veins The pulmonary veins carry oxygen-rich blood from the lungs to the left atrium of the heart. They are the only veins in the post-fetal human body that carry oxygenated (red) blood. • The pulmonary veins return the oxygenated blood from the lungs to the left atrium of the heart. They are four in number, two from each lung, and are destitute of valves. They are • Right Inferior • Right Superior • Left Inferior • Left Superior
  • 27. Left Atrium Left atrium  is one of the four chambers in the human heart. It receives oxygenated blood from the pulmonary veins, and pumps it into the left ventricle. Blood is pumped through the left atrioventricular orifice, which contains the mitral valve. A normal left atrium may be up to 5.5cm in maximum diameter; any larger than this is a sign of cardiac failure. This may occur in cases of mitral regurgitation.
  • 28. Left Auricular Appendix Left Auricular Appendix (left auricula, left auricle)  is a conical muscular pouch connected to the left atrium of the heart. It is somewhat constricted at its junction with the principal cavity; it is longer, narrower, and more curved than the right auricular appendix, and its margins are more deeply indented. It is directed forward and toward the right and overlaps the root of the pulmonary artery.
  • 29. Mitral Valve Mitral valve (also known as the bicuspid valve or left atrioventricular valve)  is a dual flap (bi = 2) valve in the heart that lies between the left atrium (LA) and the left ventricle (LV). In Latin, the term mitral means shaped like a miter, or bishop's cap. The mitral valve and the tricuspid valve are known collectively as the atrioventricular valves because they lie between the atria and the ventricles of the heart and control flow.
  • 30. Left ventricle The left ventricle is one of four chambers (two atria and two ventricles) in the human heart. It receives oxygenated blood from the left atrium via the mitral valve, and pumps it into the aorta via the aortic valve. The left ventricle is longer and more conical in shape than the right, and on transverse section its concavity presents an oval or nearly circular outline. It forms a small part of the sternocostal surface and a considerable part of the diaphragmatic surface of the heart; it also forms the apex of the heart.
  • 31. Aortic Valve Aortic valve  is one of the valves of the heart. It lies between the left ventricle and the aorta. Morphology The aortic valve has three cusps. These cusps are half moon shaped hence also called aortic semilunar valve. Each cusp has a small swelling in the center called the nodule. Dilatation of the wall of the aorta behind these cusps is called aortic sinus. When the aortic valve is open, the normal size of the orifice is 3-4 cm² in adults.
  • 32. Aortic Sinus An aortic sinus is one of the anatomic dilations of the ascending aorta, which occurs just above the aortic valve. There are generally three aortic sinuses, the left, the right and the posterior. • The left aortic sinus gives rise to the left coronary artery. • The right aortic sinus gives rise to the right coronary artery. • Usually, no vessels arise from the posterior aortic sinus, which is therefore known as the non-coronary sinus.
  • 33. Aorta The aorta (generally pronounced [eɪˈɔːtə] or "ay-orta") is the largest artery in the human body, originating from the left ventricle of the heart and bringing oxygenated blood to all parts of the body in the systemic circulation. The course of the Aorta The aorta is usually divided into five segments/sections: • Ascending aorta • Arch of aorta • Descending aorta • Thoracic aorta • Abdominal aorta
  • 34. Ascending aorta, Arch of aorta, Descending aorta • Ascending Aorta — the section between the heart and the arch of aorta • Arch of Aorta — the peak part that looks somewhat like an inverted "U" • Descending Aorta — the section from the arch of aorta to the point where it divides into the common iliac arteries
  • 35. Thoracic aorta Thoracic aorta  is contained in the posterior mediastinal cavity. It begins at the lower border of the fourth thoracic vertebra where it is continuous with the aortic arch, and ends in front of the lower border of the twelfth at the aortic hiatus in the diaphragm. At its commencement, it is situated on the left of the vertebral column; it approaches the median line as it descends; and, at its termination, lies directly in front of the column.
  • 36. Abdominal Aorta Abdominal Aorta  is a large artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta (of the thorax).
  • 37. Systemic Circulation Systemic Circulation  is the portion of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. The term is contrasted with pulmonary circulation. Oxygenated blood from the lungs leaves the left heart through the aorta, from where it is distributed to the body's organs and tissues, which absorb the oxygen, through a complex network of arteries, arterioles, and capillaries. The deoxygenated blood is then collected by venules, from where it flows first into veins, and then into the inferior and superior venae cavae, which return it to the right heart, completing the systemic cycle. The blood is then re-oxygenated through the pulmonary circulation before returning again to the systemic circulation.
  • 38. Layers of the Heart 1.) Pericardium 1.1.)Sinus a.) Oblique Sinus b.) Transverse Sinus 2.) Epicardium 3.) Myocardium 4.) Endocardium 5.) Cardiac skeleton 5.1.) Fibrous trigone 5.2.) Fibrous rings
  • 39. Pericardium is a double-walled sac that contains the heart and the roots of the great vessels. Layers of Pericardium A.) Fibrous Pericardium is the most superficial layer. It is a dense connective tissue, protecting the heart, anchoring it to the surrounding walls, and preventing it from overfilling with blood. It is continuous with the outer adventitial layer of the neighboring great blood vessels. B.) Serous Pericardium is deep to the fibrous pericardium. It contains two layers, both of which function in lubricating the heart to prevent friction from occurring during heart activity.
  • 40. Pericardial Sinuses The cul-de-sac enclosed between the limbs of the inverted U of the venous mesocardium lies behind the left atrium and is known as the Oblique Sinus. The passage between the venous and arterial mesocardia—i.e., between the aorta and pulmonary artery in front and the atria behind—is termed the Transverse Sinus.
  • 41. Epicardium describes the outer layer of heart tissue (from Greek; epi- outer, cardium heart). When considered as a part of the pericardium, it is the inner layer, or visceral pericardium. Its largest constituent is connective tissue and functions as a protective layer. The visceral pericardium apparently produces the pericardial fluid, which lubricates motion between the inner and outer layers of the pericardium. During ventricular contraction, the wave of depolarization moves from endocardial to epicardial surface.
  • 42. Myocardium  is the muscular tissue of the heart. Relationship to other layers The other tissues of the heart are: The Endocardium (inner lining, effectively a specialised endothelium) The Epicardium (a connective tissue layer around the heart with a serous surface. It may be considered as the inner (visceral) layer of the pericardium). Composition The myocardium is composed of specialized cardiac muscle cells with an ability not possessed by muscle tissue elsewhere in the body. Cardiac muscle, like other muscles, can contract, but it can also conduct electricity, like nerves. The blood supply of the myocardium is by the coronary arteries.
  • 43. Endocardiumlayer of tissue that lines In the heart, the endocardium is the innermost the chambers of the heart. Its cells, embryologically and biologically, are similar to the endothelial cells that line blood vessels. The endocardium overlies the much more voluminous myocardium, the muscular tissue responsible for the contraction of the heart. The outer layer of the heart is termed epicardium and the heart is surrounded by a small amount of fluid enclosed by a fibrous sac called the pericardium. Function Recently, it has become evident that the endocardium, which is primarily made up of endothelial cells, controls myocardial function. This modulating role is separate from the homeometric and heterometric regulatory mechanisms that control myocardial contractility. Moreover, the endothelium of the myocardial (heart muscle) capillaries, which is also closely appositioned to the cardiomyocytes (heart muscle cells) are involved in this modulatory role. Thus, the cardiac endothelium (both the endocardial endothelium and the endothelium of the myocardial capillaries) controls the development of the heart in the embryo as well as in the adult, for example during hypertrophy. Additionally, the contractility and electrophysiological environment of the cardiomyocyte are regulated by the cardiac endothelium. The endocardial endothelium may also act as a kind of blood-heart barrier (analogous to the blood-brain barrier), thus controlling the ionic composition of the extracellular fluid in which the cardiomyocytes bathe.
  • 44. Cardiac skeleton Cardiac skeleton (sometimes called "fibrous skeleton of the heart") refers to the structure of dense connective tissue in the heart that separates the atria from the ventricles. It is not a "true" skeleton, but it does provide structure and support for the heart, as well as isolating the electric charges that go through the heart. The left atrioventricular ring is closely connected, by its right margin, with the aortic arterial ring; between these and the right atrioventricular ring is a triangular mass of fibrous tissue, the fibrous trigone, which represents the os cordis seen in the heart of some of the larger animals, as the ox and elephant. The right and left fibrous rings of heart (anulus fibrosus cordis) surround the atrioventricular and arterial orifices, and are stronger upon the left than on the right side of the heart. The right fibrous ring is known as the anulus fibrosus dexter cordis, and the left is known as the anulus fibrosus sinister cordis
  • 45. Heart Structures A.) Atria B.) Ventricle *Interventricular Septum *Interatrial septum *Trabeculae Carneae *Musculi pectinati *Chordae Tendinae *Papillary Muscle C.) Valve 1.) Atrioventricular valves 1.1.) Mitral valve 1.2.) Tricuspid valve 2.) Semilunar valves 2.1.) Aortic valve 2.2.) Pulmonic valve
  • 46. Interatrial septum Interatrial Septum is the wall of tissue that separates the right and left atria of the heart.
  • 47. Musculi Pectinati In the right atrium, behind the crest the internal surface of the atrium is smooth, while in front of it the muscular fibers of the wall are raised into parallel ridges resembling the teeth of a comb, and hence named the musculi pectinati (pectinate muscles).
  • 49. Interventricular Septum Portions Interventricular septum (or ventricular septum, or during development septum inferius) is The greater portion of it is the stout wall separating the lower thick and muscular and constitutes chambers (the ventricles) of the the muscular ventricular septum. heart from one another. Its upper and posterior part, The ventricular septum is which separates the aortic directed obliquely backward and to vestibule from the lower part of the the right, and is curved with the right atrium and upper part of the convexity toward the right ventricle: right ventricle, is thin and fibrous, its margins correspond with the and is termed the membranous anterior and posterior longitudinal ventricular septum (septum sulci. membranaceum).
  • 50. Trabeculae Carneae The trabeculae carneae (columnae carneae) are rounded or irregular muscular columns which project from the whole of the inner surface of the ventricle, with the exception of the conus arteriosus. They are of three kinds: 1.) Some are attached along their entire length on one side and merely form prominent ridges, 2.) Others are fixed at their extremities but free in the middle, 3.) While a third set (musculi papillares) are continuous by their bases with the wall of the ventricle, while their apices give origin to the chordæ tendineæ which pass to be attached to the segments of the tricuspid valve.
  • 51. Chordae Tendinae The chordae tendineae, or heart strings, are cord-like tendons that connect the papillary muscles to the tricuspid valve and the mitral valve in the heart. When the right ventricle of the heart contracts, the blood pressure pushes the tricuspid valve which closes and prevents a backflow of blood into the right atrium. The chordae tendineae prevents the flaps from being everted into the right atrium. Similarly, these cord-like tendons hold in position other flaps like the bicuspid or mitral valve.
  • 52. Papillary Muscle Papillary muscles of the heart serve to limit the movements of the mitral and tricuspid valves. These muscles contract to tighten the chordae tendineae, which in turn prevent inversion. This occurs in response to pressure gradients. Instead they brace the valves against the high pressure, preventing regurgitation of ventricular blood back into the atrial cavities.
  • 53. Heart Valves Heart valves are valves in the heart that maintain the unidirectional flow of blood by opening and closing depending on the difference in pressure on each side. The mechanical equivalent of the heart valves would be the reed valves.
  • 54. Mitral Valve The mitral valve (also known as the bicuspid valve or left atrioventricular valve), is a dual flap (bi = 2) valve in the heart that lies between the left atrium (LA) and the left ventricle (LV). In Latin, the term mitral means shaped like a miter, or bishop's cap. The mitral valve and the tricuspid valve are known collectively as the atrioventricular valves because they lie between the atria and the ventricles of the heart and control flow.
  • 55. Tricuspid Valve The tricuspid valve is on the right side of the heart, between the right atrium and the right ventricle. The normal tricuspid valve usually has three leaflets and three papillary muscles. Tricuspid valves may also occur with two or four leaflets, and the number may change during life.
  • 57. Aortic Valve The aortic valve is one of the valves of the heart. It lies between the left ventricle and the aorta. Morphology The aortic valve has three cusps. These cusps are half moon shaped hence also called aortic semilunar valve. Each cusp has a small swelling in the center called the nodule. Dilatation of the wall of the aorta behind these cusps is called aortic sinus. When the aortic valve is open, the normal size of the orifice is 3-4 cm² in adults. Function & Physiology During ventricular systole, pressure rises in the left ventricle. When the pressure in the left ventricle rises above the pressure in the aorta, the aortic valve opens, allowing blood to exit the left ventricle into the aorta. When ventricular systole ends, pressure in the left ventricle rapidly drops. When the pressure in the left ventricle decreases, the aortic pressure forces the aortic valve to close. The closure of the aortic valve contributes the A2 component of the second heart sound (S2).
  • 59. Pumonary Valve is the semilunar valve of the heart that lies between the right ventricle and the pulmonary artery and has three cusps. Similar to the aortic valve, the pulmonic valve opens in ventricular systole, when the pressure in the right ventricle rises above the pressure in the pulmonary artery. At the end of ventricular systole, when the pressure in the right ventricle falls rapidly, the pressure in the pulmonary artery will close the pulmonic valve. The closure of the pulmonic valve contributes the P2 component of the second heart sound (S2). The right heart is a low-pressure system, so the P2 component of the second heart sound is usually softer than the A2 component of the second heart sound. However, it is physiologically normal in some young people to hear both components separated during inhalation.
  • 60. Regions of The Heart 1.) Base 2.) Apex 3.) Grooves a.) Coronary/atrioventricular b.) Interatrial c.) Anterior interventricula d.) Posterior interventricular 4.) Surfaces a.) Sternocostal b.) Diaphragmatic 5.) Borders a.) Right b.) Left
  • 61. Base of the Heart Base of the heart, directed upward, backward, and to the right, is separated from the fifth, sixth, seventh, and eighth thoracic vertebræ by the esophagus, aorta, and thoracic duct. It is formed mainly by the left atrium, and, to a small extent, by the back part of the right atrium. Somewhat quadrilateral in form, it is in relation above with the bifurcation of the pulmonary artery, and is bounded below by the posterior part of the coronary sulcus, containing the coronary sinus. On the right it is limited by the sulcus terminalis of the right atrium, and on the left by the ligament of the left vena cava and the oblique vein of the left atrium. The four pulmonary veins, two on either side, open into the left atrium, while the superior vena cava opens into the upper, and the anterior vena cava into the lower, part of the right atrium.
  • 62. Apex of the Heart Apex of the heart  is the lowest superficial part of the heart. It is directed downward, forward, and to the left, and is overlapped by the left lung and pleura. External Anatomy It lies behind the fifth left intercostal space, 8 to 9 cm. from the mid-sternal line, slightly medial to the midclavicular line. Alternately, it can be found about 4 cm. below and 2 mm. to the medial side of the left mammary papilla. It's function is to pump blood to left atruim
  • 63. Grooves Coronary/atrioventricular Interatrial Anterior interventricula Posterior interventricular
  • 64. Coronary Sulcus The atria of the heart are separated from the ventricles by the coronary sulcus (coronary groove, auriculoventricular groove, atrioventricular groove); this contains the trunks of the nutrient vessels of the heart, and is deficient in front, where it is crossed by the root of the pulmonary artery.
  • 65. Interatrial Groove Interatrial groove, separating the two atria, is scarcely marked on the posterior surface, while anteriorly it is hidden by the pulmonary artery and aorta.
  • 66. Anterior Interventricular Sulcus The ventricles of the heart are separated by two grooves, one of which, the anterior longitudinal sulcus (or anterior interventricular sulcus), is situated on the sternocostal surface of the heart, close to its left margin. The other groove separating the ventricles is the posterior interventricular sulcus.
  • 67. Posterior Interventricular Sulcus The ventricles are separated by two grooves, one of which, the anterior longitudinal sulcus, is situated on the sternocostal surface of the heart, close to its left margin, the other posterior longitudinal sulcus (posterior interventricular sulcus, inferior interventricular groove), on the diaphragmatic surface near the right margin. In it run the posterior interventricular artery and middle cardiac vein.
  • 69. Sternocostal Surface of Heart The sternocostal surface of the heart (anterior surface of the heart) is directed forward, upward, and to the left. Its lower part is convex, formed chiefly by the right ventricle, and traversed near its left margin by the anterior longitudinal sulcus. Its upper part is separated from the lower by the coronary sulcus, and is formed by the atria; it presents a deep concavity, occupied by the ascending aorta and the pulmonary artery.
  • 70. Diaphragmatic Surface of Heart The diaphragmatic surface of the heart, directed downward and slightly backward, is formed by the ventricles, and rests upon the central tendon and a small part of the left muscular portion of the diaphragm. It is separated from the base by the posterior part of the coronary sulcus, and is traversed obliquely by the posterior longitudinal sulcus.
  • 71. Borders Right Border of Heart Left Margin of Heart
  • 72. Right Border of Heart Right margin of the heart (right border of heart)  is long, and is formed by the right atrium above and the right ventricle below. The atrial portion is rounded and almost vertical; it is situated behind the third, fourth, and fifth right costal cartilages about 1.25 cm. from the margin of the sternum. The ventricular portion, thin and sharp, is named the acute margin; it is nearly horizontal, and extends from the sternal end of the sixth right coastal cartilage to the apex of the heart.
  • 73. Left Margin of Heart The left margin of heart (or obtuse margin) is shorter than the right border of heart, full, and rounded: it is formed mainly by the left ventricle, but to a slight extent, above, by the left atrium. It extends from a point in the second left intercostal space, about 2.5 mm. from the sternal margin, obliquely downward, with a convexity to the left, to the apex of the heart.
  • 74. Electrical conduction system of the heart The normal electrical conduction in the heart allows the impulse that is generated by the sinoatrial node (SA node) of the heart to be propagated to (and stimulate) the myocardium (Cardiac muscle). After myocardium is stimulated, it contracts. It is the ordered stimulation of the myocardium that allows efficient contraction of the heart, thereby allowing blood to be pumped throughout the body. Cardiac Pacemaker SA node AV node Bundle of His Purkinje Fibers
  • 75. Cardiac Pacemaker The contractions of the heart are controlled by chemical impulses, which fire at a rate which controls the beat of the heart. The cells that create these rhythmical impulses are called pacemaker cells, and they directly control the heart rate. Artificial devices also called pacemakers can be used after damage to the body's intrinsic conduction system to produce these impulses synthetically.
  • 76. Sinoatrial node Sinoatrial node (abbreviated SA node or SAN, also called the sinus node)  is the impulse generating (pacemaker) tissue located in the right atrium of the heart. It is a group of cells positioned on the wall of the right atrium, near the entrance of the superior vena cava. These cells are modified cardiac myocytes. They possess some contractile filaments, though they do not contract.
  • 77. Atrioventricular node Atrioventricular node (abbreviated AV node)  is an area of specialized tissue between the atria and the ventricles of the heart, which conducts the normal electrical impulse from the atria to the ventricles. The AV node is also known as the Aschoff-Tawara node. The AV node receives two inputs from the atria: posteriorly via the crista terminalis, and anteriorly via the interatrial septum. An important property that is unique to the AV node is decremental conduction. This is the property of the AV node that prevents rapid conduction to the ventricle in cases of rapid atrial rhythms, such as atrial fibrillation or atrial flutter.
  • 78. Bundle of His Bundle of His  is a collection of heart muscle cells specialized for electrical conduction that transmits the electrical impulses from the AV node (located between the atria and the ventricles) to the point of the apex of the fascicular branches. The fascicular branches then lead to the Purkinje fibers which innervate the ventricles, causing the cardiac muscle of the ventricles to contract at a paced interval. These specialized muscle fibres in the heart were named after the Swiss cardiologist Wilhelm His, Jr., who discovered them in 1893.
  • 79. Purkinje Fibers Purkinje fibers (or Purkyne tissue) are located in the inner ventricular walls of the heart, just beneath the endocardium. These fibers are specialized myocardial fibers that conduct an electrical stimulus or impulse that enables the heart to contract in a coordinated fashion. Function Purkinje fibers work with the sinoatrial node (SA node) and the atrioventricular node (AV node) to control the heart rate. During the ventricular contraction portion of the cardiac cycle, the Purkinje fibers carry the contraction impulse from the left and right bundle branches to the myocardium of the ventricles. This causes the muscle tissue of the ventricles to contract and force blood out of the heart — either to the pulmonary circulation (from the right ventricle) or to the systemic circulation (from the left ventricle).
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