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Vitamin K: Tool to control the osteophrosis

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Muhammad Yasin
Muhammad Yasin
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Vitamin K: Tool to control osteoporosis Muhammad Yasin, Masood Sadiq Butt and Faqir Muhammad Anjum National Institute of Food Science and Technology University of Agriculture Faisalabad 12/28/10
Road map ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Vitamin K: Introduction ,[object Object],[object Object],[object Object],[object Object],12/28/10
Types and sources Phylloquinone (K 1 ) Menaquinone (K 2 ) Menadione (K 3 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Functions of vitamin K ,[object Object],[object Object],[object Object],[object Object],12/28/10
Cont… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Cont… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Vitamin K dosage and toxicity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10 Age RDI Males and females, 0-6 months 2µg Males and females, 7-12 months 2.5µg Males and females, 1-3 years 30µg Males and females, 4-8 years 55µg Males and females, 9-13 years 60µg Males and females, 14-18 years 75µg Males, 19 years and older 120µg Females, 19 years and older 90µg
Osteoporosis and vitamin K ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Cont… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Cont… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Cont… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
The vitamin K-dependent carboxylation reaction 12/28/10 The enzyme is located at the luminal surface of the endoplasmic reticulum, and post-translationally carboxylates specific Glu residues of a limited number of proteins to Ď’ -carboxyglutamyl (Gla) residues during protein processing glutamyl (Glu) 7-carboxyglutamyl (Gla) residues The vitamin K-dependent carboxylation reaction
Osteocalcin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Relationship between vitamin K status and bone health ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Under- Ď’ -carboxylated osteocalcin ( ucOC ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Vitamin K supplementation and bone health ,[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Cont… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
Observations relating to osteoporosis ,[object Object],[object Object],[object Object],[object Object],12/28/10
Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10
References ,[object Object],[object Object],[object Object],[object Object],[object Object],12/28/10

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Vitamin K: Tool to control the osteophrosis

  • 1. Vitamin K: Tool to control osteoporosis Muhammad Yasin, Masood Sadiq Butt and Faqir Muhammad Anjum National Institute of Food Science and Technology University of Agriculture Faisalabad 12/28/10
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  • 13. The vitamin K-dependent carboxylation reaction 12/28/10 The enzyme is located at the luminal surface of the endoplasmic reticulum, and post-translationally carboxylates specific Glu residues of a limited number of proteins to Ď’ -carboxyglutamyl (Gla) residues during protein processing glutamyl (Glu) 7-carboxyglutamyl (Gla) residues The vitamin K-dependent carboxylation reaction
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