Urethral injection of patient-derived adipose stem cells (ASCs) and collagen may represent a viable alternative to surgery in women with stress urinary incontinence (SUI), according to a pilot study published online July 1 in Stem Cells Translational Medicine.
Although insertion of a suburethral sling remains the curative "gold standard" for female SUI, the procedure is not always effective. The 5 women recruited for this study had significant independent multiple risk factors for sling failure, including being overweight, having mixed incontinence, having a history of failed continence surgery, or having intrinsic sphincter deficiency.
"Tissue engineering offers an attractive method to regenerate sphincter muscle," write Kirsi Kuismanen, MD, from the Department of Obstetrics and Gynaecology and the Science Center, Tampere University Hospital, Finland, and colleagues. Adipose stem cells are more readily available than those derived from skeletal muscle or bone marrow and have been used more extensively in different surgical applications, they note.