Current and Future Treatments for Azoospermia

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The 2nd Gulf Andrology Conference Riyadh Military Hospital, Ministry of Defense Riyadh, Saudi Arabia, March 3-4, 2012 Lectures: Current and Future Treatments for Azoospermia

Gesundheit & Medizin Technologie

Sperm!
Detection!
Rate!

FNA Sites/Testicle!

Finding Sperm in Nonobstructive Azoospermia
Microdissection FNA Mapping

“Directed”
TESE
Sperm Present

<2 sites >2 FNA All FNA
sperm/map sites/map sites/map

TESE TESA
(n=29) (n=38)

In the testis, somatic cells
are metabolically
“quiet” compared to
rapidly dividing germ
cells!

Analogy: A pile of bricks
along a desert road-
indicates something is
being built.!

The Metabolomic Signature of a Testicle
Phosphocholine (PC)!
Glycerophosphocholine (GPC)! Total Choline!
Choline!
Normal/Fertile !
Aaronson et al. !
Creatine! Hum Reprod. 2010!
Alanine! Lactate!

Azoospermic Men
with Sertoli Cell
Only !

Leydig cells!

Stromal cells!

Sertoli cells!

Fibronectin!

Current and Future Treatments for Azoospermia

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