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The Health Concerns Related to
Air Quality in Washington County
       David Blodgett MD, MPH
     SouthWest Utah Public Health
             Department
SW Utah Public Health Department
•   5 counties
•   225,000 population
•   128 programs
•   Environmental Health
•   Not the regulating agency for Air quality
Air Quality and Health
• Diseases
• Pollutants
Introduction to Coccidioides immitis
C. immitis is a pathogenic fungus that can be found in
  two different forms during the life cycle.

   1. As a mold 4 to 12 inches below the surface of
      the soil.

   2. As a yeast after inhaled into the lungs of
      certain mammals.
Unique to a Small Area
           • In areas where there is a
             lot of C. immitis in the
             environment the area is
             considered endemic.

           • Endemic areas in the
             United States include
             southern Arizona,
             central California,
             southern New Mexico,
             west Texas and southern
             Utah.
Environmental Risk Factors
• Living in or traveling through an endemic area
  can lead to exposure and illness.

• People retiring and moving into endemic areas
  can be at risk of infection due to decreased
  immune system functions associated with age.

• C immitis outbreaks can occur following dust
  storms, earthquakes and soil excavation.
Cocci growth requirements
•   Alkaline Soil
•   Lower Elevation
•   Rainfall 5-15 inches
•   Mild Winters, Hot Summers
Coccidioidomycosis illness and
              complications
• Sixty percent of cases do not have symptoms,
  and most acquire life-long immunity.
• Thirty percent of cases involve mild to
  moderate complications.
• Five to ten percent of cases result in lung
  disease, and significant complications.
• A smaller percentage of cases result in chronic
  illness, and fatal complications.
Washington County Population Growth

                                         Washington County Population Growth 1997 -Year
                                          Washington County Population Increase by 2020
                       270000
                       260000
                    270000
                       250000
                    260000
                       240000
                    250000
                       230000
                    240000
                    230000
                       220000
                    220000
                       210000
Population Growth




                    210000
                       200000
                    200000
                       190000
                    190000
                       180000
                    180000
                       170000
                    170000
                       160000
                    160000
                       150000
                    150000
                       140000
                    140000
                       130000
                    130000
                       120000
                    120000
                       110000
                    110000
                       100000
                    100000
                        90000
                     90000
                        80000
                     80000
                        70000
                     70000
                        60000
                     60000
                        50000
                     50000
                                1977
                                  1977        1999
                                                 1999      2000
                                                              2000     2005
                                                                          2005      2010
                                                                                       2010   20202020
Cocci in Animals
•   Known to cause disease and even death in
•   Cats
•   Dogs
•   Cattle
•   Horses
•   Pigs and ruminants


                 Center for Food Security and Public Health
                        Iowa State University - 2004
Coccidioidomycosis Prevention
• Avoid endemic areas and dust in an endemic area
• Decrease the amount of dust in environment:
     • Install air conditioning
     • Pour concrete
     • Plant grass
     • Water down construction sites
  Educate people on risk factors
  Seek medical attention early
Air Quality and Health
• Diseases
• Pollutants
Daytime in London, 1952




Particulate levels – 3,000 µg/m^3


                                       Source: National Archives
Designer Smog Masks - London 1950’s




            Source: DL Davis. When Smoke Ran Like Water (2002)
50+ Years of Air Pollution Research
1950
        London Fog

 1960        Surveys
             Ecological studies
 1970
             Early time-series
             studies

 1980        Six           Exposure
             Cities        Assessment
 1990        Study
                                  Modern        Toxicology,
 2000
                                  time-series   cohort,
                                  studies       multi-city
2005
                                                studies;
• NAAQS have been established for:
  Photochemical Oxidants, currently indexed by ozone (O3) for 8 hr
  daily max.
•       Nitrogen Oxides (NOx), indexed by nitrogen dioxide (NO2) for
  annNAAQS have been established for:
  Photochemical Oxidants, currently indexed by ozone (O3) for 8 hr
  daily max.
  Nitrogen Oxides (NOx), indexed by nitrogen dioxide (NO2) for
  annual av.
  Sulfur Oxides (SOx), indexed by sulfur dioxide (SO2) for 24 hr daily
  max. and annual av.
  Lead (Pb, all forms) - for 3 month av.
  Particulate Matter (PM), for 24 hr daily max. and annual av.
  currently indexed by:
        PM2.5
        PM10
• NAAQS have been established for:
•    Health Effects Basis for NAAQS (Major Influence):
      Premature Mortality (PM, and possibly for SOx)
      Hospital Admissions (O3, PM)
      Angina (CO)
      Immune System Dysfunction (NO2)
      Neurobehavioral Deficits (Pb)
      Increased Blood Pressure (Pb)

• Widespread NAAQS Exceedances for:
      O3
      PM2.5
Why is Ozone Bad to Breathe?
• Ozone can irritate lungs and airways, and cause inflammation
  much like a sunburn on your lungs.

• Ozone can aggravate respiratory illnesses like asthma.

• 10 to 20% of summertime respiratory-related hospital visits in
  the Northeast are associated with ozone pollution.

• Children and people with chronic lung diseases are particularly
  at risk.
Ozone from other parts
• At night the earth cools
  and a “nocturnal
  inversion” is created
  several hundred meters
  above the surface
• Ozone, created earlier in
  the day is trapped above
  the inversion and moved
  to the north by night-
  time jets.
• Ozone below the
  inversion drops to very
  low levels.
Hourly Ground Level Ozone Graph for
           a Summer Day


  120


  100


  80


  60


  40


  20


    0
        0   1   2   3   4   5   6   7   8   9   10    11   12     13   14   15   16   17   18   19   20   21   22   23
                                                     Time (EDT)
How Much Ozone May be in the Low
            Level Jet?
• The low level jet can
  routinely carry 80 to 90
  ppb ozone.
Asthma in SW Utah
• Adults with Asthma: 7.89 %
  – In the State: 8.45%
Children With Asthma
ED Visits for Asthma
Hospitalizations due to Asthma
Emergency Department Visits due to Asthma
       by Month, Utah, 1998-2007
What is Particulate Matter?
• particles of different substances suspended in
  the air
• in the form of solid particles and liquid droplets
• particles vary widely in size
Where does Pm come from?
Fine particles come from a variety of sources:
•    diesel trucks and buses
•   construction equipment
•   power plants
•   woodstoves
•   Wildfires
•   Dust




Also, Chemical reactions in the atmosphere
can transform gases into fine particles.
How Fine is Fine?
 • Fine particles are only a fraction
   of the size of a human hair.
                   Cross section of a human hair (magnified to 60 µm)




Coarse Particles                                       Fine Particles
(10 µm)                                                (2.5 µm)
Why are Fine Particles
    Bad to Breathe?

•   Fine particles easily reach the deepest parts of the lungs.

•   Particulate matter causes 10,000 premature deaths every year in the US.

•   Fine particles from Diesel exhaust can cause lung cancer.
Health Effects of Exposure
             to Fine Particles
• Premature death
• Aggravated asthma
• Respiratory-related emergency room visits and
     hospital admissions
• Acute respiratory symptoms
• Chronic bronchitis
• Decreased lung function (shortness of breath)
• People with existing heart and lung disease, as well
  as the elderly and children, are particularly at risk
PM: Key Data on Short-Term Effects
      The National Morbidity, Mortality and Air Pollution Study
                      90 Largest Cities in the US

• Daily changes in PM, mortality,
  weather
• Relatively consistent increase in
  Mortality:
   – 2% per 100 ug/m3 of PM 10
• Smaller results than previous
  U.S. analyses
• Remain significant
• Not sensitive to inclusion of
  other pollutants
• Results different in different
  regions require additional
  analysis
LITTLE VALLEY PM2.5 CONCENTRATIONS

                        140.0

                        120.0
CONCENTRATION (UG/M3)




                        100.0

                         80.0
                                                                     CONCENTRATION
                                                                     ACTION LEVEL
                         60.0

                         40.0

                         20.0

                          0.0



                                   DAILY AVERAGE READINGS
PM 2.5, 10 measurements

• Few controls to reduce exposure:
  – Reduce dust
  – Reduce exposure time during dust storms
• Personal protective equipment impractical
• Administrative controls: Move !
Unresolved Problems in Characterizing Health
      Effects of Ambient Air Pollution
• lack of demonstrated biological mechanisms for PM-
  related effects,
• potential influence of measurement error and exposure
  error,
• potential confounding by copollutants,
• evaluation of the effects of components, surface coatings
  or other characteristics of PM,
• the shape of concentration-response relationships,
• methodological uncertainties in epidemiological analyses,
• the extent of life span shortening,
• characterization of annual and daily background
  concentrations,
• understanding of the effects of coarse fraction PM, and
• effects, if any, of air toxics.
Public Health Significance


In US, EPA estimates on order of 10,000 particle-
attributable deaths per year if cohort relative risks
represent a causal effect


Smoking – 400,000 smoking attributable deaths per
     year
2. Co-pollutants


Recent Testimony on the EPA Proposed Decision on Particulate Matter
                 Suresh H. Moolgavkar, M.D., Ph.D.
   Member, Fred Hutchinson Cancer Research Center; Professor of
  Epidemiology and Biostatistics, University of Washington - Leading
                        Industry Consultant


“the potential for uncontrolled confounding by co-
pollutants currently preclude the conclusion that
the particulate component of air pollution is
causally associated with adverse effects on human
health.”
Testimony on the EPA Proposed Decision on
            Particulate Matter

                 Suresh H. Moolgavkar, M.D., Ph.D.
Professor of Epidemiology and Biostatistics, University of Washington
                        Industry Consultant

“The proposed new regulations for particulate matter are based on the
 assumption that the magnitude of the associations between these pollutants
 and adverse human health effects reported in some epidemiologic studies is
 predictive of the gains in human health that would accrue by lowering
 ambient concentrations. The evidence simply does not support this
 assumption. Briefly, the dearth of toxicological information, the absence of
 biological understanding of underlying mechanism, and the potential for
 uncontrolled confounding by co-pollutants currently preclude the conclusion
 that the particulate component of air pollution is causally associated with
 adverse effects on human health.”

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Air Quality and Health Concerns in Washington County

  • 1. The Health Concerns Related to Air Quality in Washington County David Blodgett MD, MPH SouthWest Utah Public Health Department
  • 2. SW Utah Public Health Department • 5 counties • 225,000 population • 128 programs • Environmental Health • Not the regulating agency for Air quality
  • 3.
  • 4.
  • 5.
  • 6. Air Quality and Health • Diseases • Pollutants
  • 7. Introduction to Coccidioides immitis C. immitis is a pathogenic fungus that can be found in two different forms during the life cycle. 1. As a mold 4 to 12 inches below the surface of the soil. 2. As a yeast after inhaled into the lungs of certain mammals.
  • 8. Unique to a Small Area • In areas where there is a lot of C. immitis in the environment the area is considered endemic. • Endemic areas in the United States include southern Arizona, central California, southern New Mexico, west Texas and southern Utah.
  • 9. Environmental Risk Factors • Living in or traveling through an endemic area can lead to exposure and illness. • People retiring and moving into endemic areas can be at risk of infection due to decreased immune system functions associated with age. • C immitis outbreaks can occur following dust storms, earthquakes and soil excavation.
  • 10. Cocci growth requirements • Alkaline Soil • Lower Elevation • Rainfall 5-15 inches • Mild Winters, Hot Summers
  • 11. Coccidioidomycosis illness and complications • Sixty percent of cases do not have symptoms, and most acquire life-long immunity. • Thirty percent of cases involve mild to moderate complications. • Five to ten percent of cases result in lung disease, and significant complications. • A smaller percentage of cases result in chronic illness, and fatal complications.
  • 12. Washington County Population Growth Washington County Population Growth 1997 -Year Washington County Population Increase by 2020 270000 260000 270000 250000 260000 240000 250000 230000 240000 230000 220000 220000 210000 Population Growth 210000 200000 200000 190000 190000 180000 180000 170000 170000 160000 160000 150000 150000 140000 140000 130000 130000 120000 120000 110000 110000 100000 100000 90000 90000 80000 80000 70000 70000 60000 60000 50000 50000 1977 1977 1999 1999 2000 2000 2005 2005 2010 2010 20202020
  • 13. Cocci in Animals • Known to cause disease and even death in • Cats • Dogs • Cattle • Horses • Pigs and ruminants Center for Food Security and Public Health Iowa State University - 2004
  • 14. Coccidioidomycosis Prevention • Avoid endemic areas and dust in an endemic area • Decrease the amount of dust in environment: • Install air conditioning • Pour concrete • Plant grass • Water down construction sites Educate people on risk factors Seek medical attention early
  • 15.
  • 16. Air Quality and Health • Diseases • Pollutants
  • 17. Daytime in London, 1952 Particulate levels – 3,000 µg/m^3 Source: National Archives
  • 18. Designer Smog Masks - London 1950’s Source: DL Davis. When Smoke Ran Like Water (2002)
  • 19. 50+ Years of Air Pollution Research 1950 London Fog 1960 Surveys Ecological studies 1970 Early time-series studies 1980 Six Exposure Cities Assessment 1990 Study Modern Toxicology, 2000 time-series cohort, studies multi-city 2005 studies;
  • 20. • NAAQS have been established for: Photochemical Oxidants, currently indexed by ozone (O3) for 8 hr daily max. • Nitrogen Oxides (NOx), indexed by nitrogen dioxide (NO2) for annNAAQS have been established for: Photochemical Oxidants, currently indexed by ozone (O3) for 8 hr daily max. Nitrogen Oxides (NOx), indexed by nitrogen dioxide (NO2) for annual av. Sulfur Oxides (SOx), indexed by sulfur dioxide (SO2) for 24 hr daily max. and annual av. Lead (Pb, all forms) - for 3 month av. Particulate Matter (PM), for 24 hr daily max. and annual av. currently indexed by: PM2.5 PM10
  • 21. • NAAQS have been established for: • Health Effects Basis for NAAQS (Major Influence): Premature Mortality (PM, and possibly for SOx) Hospital Admissions (O3, PM) Angina (CO) Immune System Dysfunction (NO2) Neurobehavioral Deficits (Pb) Increased Blood Pressure (Pb) • Widespread NAAQS Exceedances for: O3 PM2.5
  • 22.
  • 23.
  • 24. Why is Ozone Bad to Breathe? • Ozone can irritate lungs and airways, and cause inflammation much like a sunburn on your lungs. • Ozone can aggravate respiratory illnesses like asthma. • 10 to 20% of summertime respiratory-related hospital visits in the Northeast are associated with ozone pollution. • Children and people with chronic lung diseases are particularly at risk.
  • 25. Ozone from other parts • At night the earth cools and a “nocturnal inversion” is created several hundred meters above the surface • Ozone, created earlier in the day is trapped above the inversion and moved to the north by night- time jets. • Ozone below the inversion drops to very low levels.
  • 26. Hourly Ground Level Ozone Graph for a Summer Day 120 100 80 60 40 20 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Time (EDT)
  • 27. How Much Ozone May be in the Low Level Jet? • The low level jet can routinely carry 80 to 90 ppb ozone.
  • 28. Asthma in SW Utah • Adults with Asthma: 7.89 % – In the State: 8.45%
  • 30. ED Visits for Asthma
  • 32. Emergency Department Visits due to Asthma by Month, Utah, 1998-2007
  • 33. What is Particulate Matter? • particles of different substances suspended in the air • in the form of solid particles and liquid droplets • particles vary widely in size
  • 34. Where does Pm come from? Fine particles come from a variety of sources: • diesel trucks and buses • construction equipment • power plants • woodstoves • Wildfires • Dust Also, Chemical reactions in the atmosphere can transform gases into fine particles.
  • 35. How Fine is Fine? • Fine particles are only a fraction of the size of a human hair. Cross section of a human hair (magnified to 60 µm) Coarse Particles Fine Particles (10 µm) (2.5 µm)
  • 36. Why are Fine Particles Bad to Breathe? • Fine particles easily reach the deepest parts of the lungs. • Particulate matter causes 10,000 premature deaths every year in the US. • Fine particles from Diesel exhaust can cause lung cancer.
  • 37. Health Effects of Exposure to Fine Particles • Premature death • Aggravated asthma • Respiratory-related emergency room visits and hospital admissions • Acute respiratory symptoms • Chronic bronchitis • Decreased lung function (shortness of breath) • People with existing heart and lung disease, as well as the elderly and children, are particularly at risk
  • 38. PM: Key Data on Short-Term Effects The National Morbidity, Mortality and Air Pollution Study 90 Largest Cities in the US • Daily changes in PM, mortality, weather • Relatively consistent increase in Mortality: – 2% per 100 ug/m3 of PM 10 • Smaller results than previous U.S. analyses • Remain significant • Not sensitive to inclusion of other pollutants • Results different in different regions require additional analysis
  • 39. LITTLE VALLEY PM2.5 CONCENTRATIONS 140.0 120.0 CONCENTRATION (UG/M3) 100.0 80.0 CONCENTRATION ACTION LEVEL 60.0 40.0 20.0 0.0 DAILY AVERAGE READINGS
  • 40. PM 2.5, 10 measurements • Few controls to reduce exposure: – Reduce dust – Reduce exposure time during dust storms • Personal protective equipment impractical • Administrative controls: Move !
  • 41. Unresolved Problems in Characterizing Health Effects of Ambient Air Pollution • lack of demonstrated biological mechanisms for PM- related effects, • potential influence of measurement error and exposure error, • potential confounding by copollutants, • evaluation of the effects of components, surface coatings or other characteristics of PM, • the shape of concentration-response relationships, • methodological uncertainties in epidemiological analyses, • the extent of life span shortening, • characterization of annual and daily background concentrations, • understanding of the effects of coarse fraction PM, and • effects, if any, of air toxics.
  • 42. Public Health Significance In US, EPA estimates on order of 10,000 particle- attributable deaths per year if cohort relative risks represent a causal effect Smoking – 400,000 smoking attributable deaths per year
  • 43. 2. Co-pollutants Recent Testimony on the EPA Proposed Decision on Particulate Matter Suresh H. Moolgavkar, M.D., Ph.D. Member, Fred Hutchinson Cancer Research Center; Professor of Epidemiology and Biostatistics, University of Washington - Leading Industry Consultant “the potential for uncontrolled confounding by co- pollutants currently preclude the conclusion that the particulate component of air pollution is causally associated with adverse effects on human health.”
  • 44. Testimony on the EPA Proposed Decision on Particulate Matter Suresh H. Moolgavkar, M.D., Ph.D. Professor of Epidemiology and Biostatistics, University of Washington Industry Consultant “The proposed new regulations for particulate matter are based on the assumption that the magnitude of the associations between these pollutants and adverse human health effects reported in some epidemiologic studies is predictive of the gains in human health that would accrue by lowering ambient concentrations. The evidence simply does not support this assumption. Briefly, the dearth of toxicological information, the absence of biological understanding of underlying mechanism, and the potential for uncontrolled confounding by co-pollutants currently preclude the conclusion that the particulate component of air pollution is causally associated with adverse effects on human health.”