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Medical Imaging – Opportunities
          for Business
                24.01.12
         Henry Wellcome Building
          University of Leicester

         A Space IDEAS Hub Event
            In association with:
About Space IDEAS Hub
• A knowledge exchange project from the
  Space Research Centre of the University of
  Leicester
• Feed expertise developed from space
  missions into commercial benefit for UK
  industry.
• Delivering Innovative Design, Engineering,
  Analysis and Support (IDEAS) to your
  business.
• Part financed by the European Regional
  Development Fund
• UK companies can access and benefit from
  our technology and experience.

If your organisation would like to benefit from
our knowledge and expertise, please contact us
at enquiries@spaceideashub.com
Session 3b – Developing you Product
            and Market
  14:45 Two-Minute Company Presentations
         Various
  15:30 Are you Social?
         The place of social media in you marketing and communication
         strategy
         Paul Dixey
  15:50 Benchmarking Countries, Selecting Markets
        or Which Countries Should I Export To?
         Richard Gilbert
  16:20 Closing Remarks
         Prof George Fraser
Company Presentations

Two Minute Presentations by
       Companies
Company Presentations
1.   CapnaDSP
2.   Defect Detection Technologies
3.   Diagnostic Imaging Ltd
4.   Frazer-Nash Consultancy
5.   Medibord Ltd
Hardware Acceleration of Algorithms
    and Applications >>
           •      Ultra-high performance Image Processing
           •      World leader in high performance systems
           •      Massively parallel compute technology (FPGA, some GPU)
           •      Rapid prototyping and development
    >> CapnaDSP.com




Ultra-high Performance Image Processing
1
SmartVent from Diagnostic Imaging Ltd
About Frazer-Nash Consultancy

       Ian Webb, Engineer
       i.webb@fnc.co.uk
       Tel: 01306 885050
       Web: www.fnc.co.uk



               Who are we?
                         Engineers who enjoy tackling difficult problems!
               What do we do?
                    Innovative solutions
                    Experience across several market sectors

               What can we offer?
                    Design
                    Analysis
                    Project Support
                    Systems Engineering


© Frazer-Nash Consultancy Ltd 2012. All rights reserved.                     SYSTEMS AND ENGINEERING TECHNOLOGY
Composites with Clarity™




Medibord® is a ground-breaking MRI, CT and LINACS compatible couch top and
overlay material developed as a direct response to issues with CT and MR image
      fusion; resulting in improved radiotherapy planning and treatment.

                                      Medibord® was developed in response to
                                      an existing need to fuse CT and MR scans in
                                      order to improve the treatment of diseases such
                                      as prostate cancer.
                                       Medibord® allows oncologists to position
                                       Patients with repeated precision to facilitate
                                       CT and MR image fusion.
                                       This has enabled NUH oncologists to achieve
                                       their long-term goal of precisely outlining
                                       prostate cancer patient scans.
Company Presentations
5. Medical Technologies IKC
6. Midven Ltd
7. Montague Healthcare
9. Panchromos Ltd
10.Plastic Antibodies Ltd
Advanced Imaging for Musculoskeletal & Cardiovascular Applications



                                           Diagnostics:                                   Outcomes:
                                              Imaging,
                                    Biosensors, Optical Sensors,                      Medical Devices &
                                   Bio-Functionalised Microarrays,                  Regenerative Therapies,
                                                                                     Commercial Adoption,
 Devices & Therapies:                                                                 Clinical Translation
 Implantable Materials,        Innovation •       Accelerated Innovation
       Stem Cells,            & Knowledge •       Reducing Late Failure & Total Costs
                                          •       Developing Partnerships &
  Biological Scaffolds,          Centre           Integration of Technologies
Self-Assembling Peptides                                                           Increased: Safety, Efficacy
                                                                                       Process Efficiency,
                                Computer and Experimental Simulation,               Regulatory Compliance,
                                           Patient Targeting,
                                                                                        Supporting Trials,
                             Short Term Prediction of Long Term Outcomes
                                                                                     Viable Reimbursement



                                  Clinical Need / Market Intelligence

                 Marcus Orton: Technology Innovation Manager – Imaging and Medical Devices
                 •  Contact us: Tel: 0113 3430921   m.a.orton@leeds.ac.uk
                 •  Follow us on Twitter:           http://twitter.com/#!/medtechleeds
                 •  Website:                        www.medical-technologies.co.uk
Venture capital funding

Tel: 0121 710 1990

Email: Giovanni.Finocchio@midven.co.uk

Website: www.midven.com
Virtual Scanning
1. The light which is absorbed and emitted by proteins is a measure of
 the levels of proteins expressed from DNA (genotype) and the rate at
    which proteins react with their reactive substrates (phenotype)

                        [reaction conditions]
                      A        >           Proteins

                          [reaction conditions]
 light + Proteins + substrates > Proteins* + metabolites + light


 2. The reaction conditions which govern the rate at which a proteins
 react (pH, temperature, levels of minerals, levels of cofactors, etc) are
                  physiologically regulated systems.
Product Design & Engineering
Plastic Antibodies have advantages over biologic counterparts




                                       Biological Antibodies                          Plastic Antibodies



        Target type             Epitopes                                  Small molecules, peptides and proteins


        Lead time               26 - 52 weeks                             2-4 weeks


        Stability               Poor                                      High physicochemical stability


        Storage                 Refrigerated or frozen                    Ambient temperature


        Conjugation             Established                               Diverse potential




Copyright © Alacrita LLP 2011                                  Page | 0                                            alacrita
Company Presentations
9. Q Scientific Consulting
10.Tactiq Ltd
13.Tutela Monitoring Systems
14.Warwick Design
Regulatory development of an imaging medicinal
        product to Clinical Trial Application
 N Shepherd from Q Scientific Consulting Ltd
    an experienced drug development consultancy: www.qscl.co.uk
 Example: New Chemical Entity (NCE) for local injection
    Development path to the clinical trial, microdose (dose<100µg/subject)
        http://www.mhra.gov.uk/home/groups/l-unit1/documents/websiteresources/con009394.pdf
    Less extensive regulatory requirements
    Need regulatory dossiers: Clinical Trial Application (CTA) ; Investigational
     Medicinal Product Dossier (IMPD); Investigator Brochure (IB)
    Need defined quality: for synthesis; pharmacodynamics; product (GMP);
     analytical methods (GMP); toxicology package (GLP)
    External costs total ~£105K:
       Drug substance manufacture, product formulation & analysis (£45K)
       Toxicity and mutagenicity package (£30-40K)
       QSCL Project management & Regulatory dossier (£28K)
Product Development Consultancy
               Applied Intelligence           ISO13485 Certified

•Broad medical imaging development experience

Nuclear Medicine           PET/CT      X-Ray            Endoscopy   Ophthalmology    OCT      MRI




  Gamma Rays                  X-Rays                  Ultraviolet         Infrared    microwave
10-14              10-12                       10-8   10-6             10-4            10-2



• Software, Electronics, User Interfaces and turnkey development

• Regulatory Expertise (ISO 60601, 62304, 62366, 14971, 61508)

• Clients ranging from start-ups to Global corporations like GE Healthcare

• Partnership approach
   Wireless Monitoring
   Web Based
   24/7 Alarm Bureau
   Eliminate Compliance Risk
   Release Valuable Resources
   Protect Invaluable Assets
   Deliver Return on Investment


                                    APPLICATIONS
                                    • HOSPITALS AND HEALTHCARE
                                    • BLOOD PLASMA & TISSUE
                                    • BIOTECH & LIFE SCIENCES
                                    • PHARMACY
     Refrigerators                 • MEDICAL LABORATORIES
      Freezers
      Cold Rooms                    • MEDICAL RESEARCH
      Stability Chambers
      LN2 Chambers                 Contact
      Clean Rooms                  zadams@tutelamedical.com
      Incubators
      Ambient Storage              Mobile: 07823 322762
      The Environment              Tel: 01252 406398
                                   www.tutelamedical.com
Thank you for your interest
 If your organisation would like to benefit from
our knowledge and expertise, please contact us.

               Space IDEAS Hub
          W: www.spaceideashub.com
       E: enquiries@spaceideashub.com
               T: 0116 229 7700
                  Follow us on:

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Medical Imaging Seminar Company Presentations

  • 1. Medical Imaging – Opportunities for Business 24.01.12 Henry Wellcome Building University of Leicester A Space IDEAS Hub Event In association with:
  • 2. About Space IDEAS Hub • A knowledge exchange project from the Space Research Centre of the University of Leicester • Feed expertise developed from space missions into commercial benefit for UK industry. • Delivering Innovative Design, Engineering, Analysis and Support (IDEAS) to your business. • Part financed by the European Regional Development Fund • UK companies can access and benefit from our technology and experience. If your organisation would like to benefit from our knowledge and expertise, please contact us at enquiries@spaceideashub.com
  • 3. Session 3b – Developing you Product and Market 14:45 Two-Minute Company Presentations Various 15:30 Are you Social? The place of social media in you marketing and communication strategy Paul Dixey 15:50 Benchmarking Countries, Selecting Markets or Which Countries Should I Export To? Richard Gilbert 16:20 Closing Remarks Prof George Fraser
  • 4. Company Presentations Two Minute Presentations by Companies
  • 5. Company Presentations 1. CapnaDSP 2. Defect Detection Technologies 3. Diagnostic Imaging Ltd 4. Frazer-Nash Consultancy 5. Medibord Ltd
  • 6. Hardware Acceleration of Algorithms and Applications >> • Ultra-high performance Image Processing • World leader in high performance systems • Massively parallel compute technology (FPGA, some GPU) • Rapid prototyping and development >> CapnaDSP.com Ultra-high Performance Image Processing
  • 7. 1
  • 9. About Frazer-Nash Consultancy Ian Webb, Engineer i.webb@fnc.co.uk Tel: 01306 885050 Web: www.fnc.co.uk  Who are we?  Engineers who enjoy tackling difficult problems!  What do we do?  Innovative solutions  Experience across several market sectors  What can we offer?  Design  Analysis  Project Support  Systems Engineering © Frazer-Nash Consultancy Ltd 2012. All rights reserved. SYSTEMS AND ENGINEERING TECHNOLOGY
  • 10. Composites with Clarity™ Medibord® is a ground-breaking MRI, CT and LINACS compatible couch top and overlay material developed as a direct response to issues with CT and MR image fusion; resulting in improved radiotherapy planning and treatment. Medibord® was developed in response to an existing need to fuse CT and MR scans in order to improve the treatment of diseases such as prostate cancer. Medibord® allows oncologists to position Patients with repeated precision to facilitate CT and MR image fusion. This has enabled NUH oncologists to achieve their long-term goal of precisely outlining prostate cancer patient scans.
  • 11. Company Presentations 5. Medical Technologies IKC 6. Midven Ltd 7. Montague Healthcare 9. Panchromos Ltd 10.Plastic Antibodies Ltd
  • 12. Advanced Imaging for Musculoskeletal & Cardiovascular Applications Diagnostics: Outcomes: Imaging, Biosensors, Optical Sensors, Medical Devices & Bio-Functionalised Microarrays, Regenerative Therapies, Commercial Adoption, Devices & Therapies: Clinical Translation Implantable Materials, Innovation • Accelerated Innovation Stem Cells, & Knowledge • Reducing Late Failure & Total Costs • Developing Partnerships & Biological Scaffolds, Centre Integration of Technologies Self-Assembling Peptides Increased: Safety, Efficacy Process Efficiency, Computer and Experimental Simulation, Regulatory Compliance, Patient Targeting, Supporting Trials, Short Term Prediction of Long Term Outcomes Viable Reimbursement Clinical Need / Market Intelligence Marcus Orton: Technology Innovation Manager – Imaging and Medical Devices • Contact us: Tel: 0113 3430921 m.a.orton@leeds.ac.uk • Follow us on Twitter: http://twitter.com/#!/medtechleeds • Website: www.medical-technologies.co.uk
  • 13. Venture capital funding Tel: 0121 710 1990 Email: Giovanni.Finocchio@midven.co.uk Website: www.midven.com
  • 14. Virtual Scanning 1. The light which is absorbed and emitted by proteins is a measure of the levels of proteins expressed from DNA (genotype) and the rate at which proteins react with their reactive substrates (phenotype) [reaction conditions] A > Proteins [reaction conditions] light + Proteins + substrates > Proteins* + metabolites + light 2. The reaction conditions which govern the rate at which a proteins react (pH, temperature, levels of minerals, levels of cofactors, etc) are physiologically regulated systems.
  • 15. Product Design & Engineering
  • 16. Plastic Antibodies have advantages over biologic counterparts Biological Antibodies Plastic Antibodies Target type Epitopes Small molecules, peptides and proteins Lead time 26 - 52 weeks 2-4 weeks Stability Poor High physicochemical stability Storage Refrigerated or frozen Ambient temperature Conjugation Established Diverse potential Copyright © Alacrita LLP 2011 Page | 0 alacrita
  • 17. Company Presentations 9. Q Scientific Consulting 10.Tactiq Ltd 13.Tutela Monitoring Systems 14.Warwick Design
  • 18. Regulatory development of an imaging medicinal product to Clinical Trial Application  N Shepherd from Q Scientific Consulting Ltd  an experienced drug development consultancy: www.qscl.co.uk  Example: New Chemical Entity (NCE) for local injection  Development path to the clinical trial, microdose (dose<100µg/subject)  http://www.mhra.gov.uk/home/groups/l-unit1/documents/websiteresources/con009394.pdf  Less extensive regulatory requirements  Need regulatory dossiers: Clinical Trial Application (CTA) ; Investigational Medicinal Product Dossier (IMPD); Investigator Brochure (IB)  Need defined quality: for synthesis; pharmacodynamics; product (GMP); analytical methods (GMP); toxicology package (GLP)  External costs total ~£105K:  Drug substance manufacture, product formulation & analysis (£45K)  Toxicity and mutagenicity package (£30-40K)  QSCL Project management & Regulatory dossier (£28K)
  • 19. Product Development Consultancy Applied Intelligence ISO13485 Certified •Broad medical imaging development experience Nuclear Medicine PET/CT X-Ray Endoscopy Ophthalmology OCT MRI Gamma Rays X-Rays Ultraviolet Infrared microwave 10-14 10-12 10-8 10-6 10-4 10-2 • Software, Electronics, User Interfaces and turnkey development • Regulatory Expertise (ISO 60601, 62304, 62366, 14971, 61508) • Clients ranging from start-ups to Global corporations like GE Healthcare • Partnership approach
  • 20. Wireless Monitoring  Web Based  24/7 Alarm Bureau  Eliminate Compliance Risk  Release Valuable Resources  Protect Invaluable Assets  Deliver Return on Investment APPLICATIONS • HOSPITALS AND HEALTHCARE • BLOOD PLASMA & TISSUE • BIOTECH & LIFE SCIENCES • PHARMACY  Refrigerators • MEDICAL LABORATORIES Freezers Cold Rooms • MEDICAL RESEARCH Stability Chambers LN2 Chambers Contact Clean Rooms zadams@tutelamedical.com Incubators Ambient Storage Mobile: 07823 322762 The Environment Tel: 01252 406398 www.tutelamedical.com
  • 21.
  • 22. Thank you for your interest If your organisation would like to benefit from our knowledge and expertise, please contact us. Space IDEAS Hub W: www.spaceideashub.com E: enquiries@spaceideashub.com T: 0116 229 7700 Follow us on: