1. TRANSPARENCIES AND SLIDES
IDENTIFICATION POINTS
 HISTOPATHOLOGY
 FOR
 MIDTERM
 MBBS 4th Year
 2012
 By
 SIDRA NAWAZ
 SIRSYED COLLEGE OF MEDICAL
SCIENCES FOR GIRLS

2. TRANSPARENCIES

3. CVS: ANEURYSM
 The muscle fibre of the
medial core has disappeared
and replaced by collagenous
fibrous tissue.
 In the lumen of the
aneurysm there is a layer of
deeply red stained thrombosis
b/w the thrombus and fibrous
tissue there is lipid rich
zone, platelates, fibrins, red
cells behind the thrombus
where is thin track of fresh
blood in the media.

4. CVS: MYOCARDIAL INFARCTION
 One day old ifarct
shows coagulative
necrosis and wavy
fibers.widend spaces
b/w the dead fibers
contain edema fluid
and scattered
neutrophills.
 Dense
polymorphonuclear
leukocyte infiltirate in
area of acute
myocardialinfarction of
3 to 4 days duration.

5. CVS: THROMBOSIS
 Thrombus consist of
pale staining finely
granules sheet of
fused platelates and
eosinophilic strands
of fibrins.
 There is also a
moderate population
of monocytes
lymphocytes and
polymorphs in
thrombus.

6. GIT: Adenocarcinoma of colon
 Pleomorphic cells
are present.
 There are several
acini filled with
mucous
 There is necrotic
debris surrounded
by macrophages.
 C.T is filled with
plasma cells.

7. GIT: Carcinoid tumor
 A goblet cell carcinoid
type which shows
abundant mucous
producing signet ring
type of cells.
 The nodule is composed
of tumor cells embedded
in dense fibrous tissue.
 Composed of
island,trabeculae, strand
s, glands, or sheets of
uniform cells with
scant, pink granular
cytoplasm and a round
to oval stipped nucleus.

8. GIT: Chronic peptic ulcer
 The classic peptic ulcer
is a round to oval,
sharply punched out
defect.
 During the active phase,
the base of the ulcer
shows 4 zones:
inflammatory exudate,
fibrinoid necrosis,
granulation tissue and
fibrous tissue.
 The fibrous base of the
ulcer may contain
vessels with thickened
wall or with thrombosis.

9. GIT: Crohn's disease
 Cluster of
neutrophils within a
crypts are reffered to
as Crypt abscesses.
 Noncaseating
granulomas are
present.
 It include abundant
neutrophils that
infiltrate and damage
crypt epithelium.

10. GIT: Tubovillous adenoma
 Shows mixed pattern
of both villous and
tubular type.
 Consist of
hyperchromatic single
layer of cell lining the
glands secreting pale
mass.
 Head of stalk consist
of large closely paked
gland & tubular
irregular in sized lined
by deeply basophilic
epithelial cells.

11. GIT: Typhoid Ileum
 Peyer’s patches in
the terminal ileum to
enlarge into sharply
delineated plateau-
like elevations up to
8cm in diameter.
 Draining mesenteric
lymph nodes are
also enlarged.
 Mucosal shedding
creates oval ulcers,
oriented along the
axis of the ileum.

12. GIT: Ulcerative colitis
 Crypt abscesses
are present.
 Diffuse
inflammatory
process limited to
mucosa and
superficial
submucosa.
 Architectural crypt
distortion is also
present.

13. GIT: Villous adenoma
 Many finger like villi
arises directly from
muscularis mucosa.
 Each papillae are lined
by dysplastic epithelium
with fibrovascular
stromal cone.
 The cone of the villous
infiltrated with
lymphocytes & plasma
cells.
 C.S. shows 2 glands
with columnar epithelium
with proper basement
membrane.

15. SLIDES

16. Acute tubular necrosis

17. Adenocarcinoma of colon

18. Chronic pyelonephritis

19. Cirrhosis with nodules

20. Cirrhosis

21. Folicular carcinoma of thyroid

22. Hashimotos thyroiditis

23. Tubovillous adenoma of colon

24. Ulcerative colitis