1) The document summarizes research on how stakeholder engagement can help national eHealth programs lead to improved patient care and sustainable organizational change. 2) Case studies in England and Wales found that top-down, technocratic approaches in England led to failures, while bottom-up collaboration in Wales engaged stakeholders and led to success. 3) Effective stakeholder engagement requires viewing them as a resource, involving clinicians and end-users early, and facilitating empowerment and learning while retaining overall control of implementation.