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JALA & JBS Authors Workshop
How to Get Your Work Published

     Dr.
     Dr Edward Kai Hua Chow
                 Kai-Hua
       Dept. of Pharmacology
      Cancer Science Institute
  National University of Singapore
Official SLAS Peer‐Reviewed Scientific Journals




     Journal of Laboratory Automation (JALA)
      Journal of Biomolecular Screening (JBS)
      Journal of Biomolecular Screening (JBS)
                                              2
Journal of Laboratory Automation (JALA)
                     Editor‐in‐Chief:
                     Dean Ho, Ph.D.
                     Professor
                     UCLA (2012 AY)

                     Impact Factor:  1.420 (Ranked 14 out of 32 in 
                     Medical Laboratory Technology category

                     Scope: The Journal of Laboratory Automation
                     (JALA) is a multi‐disciplinary, bimonthly 
                     international peer‐reviewed journal devoted to 
                     international peer‐reviewed journal devoted to
                     the advancement of technology in the 
                     laboratory. 

                     JALA highlights innovation at the intersection of 
                     academia, industry, and government research 
                     and is backed by an internationally‐renowned 
                     Scientific Advisory Board and Editorial Board.
                     Scientific Advisory Board and Editorial Board.


                                                          3
JALA Audience
 JALA authors, readers, and reviewers are academic, commercial, and government
 researchers, scientists, and engineers who conduct research and develop new
 technologies to increase productivity, elevate data quality, reduce lab process
 cycle times or enable experimentation that otherwise would be impossible
       times,                                                   impossible.




                                                                   4
JALA Indexing
Analytical Abstracts                        ProQuest
Biological Abstracts                        CSA Technology Research Database
BIOSIS Previews                             Science Citation Index Expanded (Web of 
Ceramic Abstracts
Ceramic Abstracts                           Science)
Chemical Abstracts                          SciFinder
CINAHL                                      SCIRUS
Compendex                                   Scopus
Computer and Information Systems 
Abstracts Journal
Corrosion Abstracts
EMBASE/Excerpta Medica
Engineering Index Monthly
Google Scholar
INSPEC
Journal Citation Report – Science edition
MEDLINE




                                                                      5
JALA Scientific Advisors
World Leaders in Academic and Economic Innovation




       Dr. Jing Cheng        Dr. Nicolas Di Rooij   Dr. Raymond Dessy       Dr. Lee Hood
       Capital Biochip              EPFL                Virginia Tech   Institute for Systems 
       Tsinghua Univ.          Inst Microtech            Chemistry             Biology




     Dr. Edward McCabe        Dr. Chad Mirkin     Dr. Eiji Osawa    Dr. Michael Phelps
        Univ Colorado
        U i C l d            Northwestern Univ NanoCarbon Research  M l/M d Ph
                                 h            i    C b           h Mol/Med Pharm
     Linda Crnic Institute       Chemistry           Institute             UCLA

                                                                                    6
JALA Editorial Board
Internationally‐Recognized Researchers and Business Leaders from 7 Countries

AuraSense                              Northwestern University
Automated Laboratory Processing        Peking University
Biotic Laboratories                    Pennsylvania State University
Bristol-Myers
Bristol Myers Squibb                   PerkinElmer
BSSN Software                          Procter & Gamble
Chinese University of Hong Kong        Syngenta Seeds
Genefluidics                           Technical University of Denmark
Harvard Medical School                 U.S. Dept. of Agriculture
Hospira Shanghai                       University of Arizona
Johns Hopkins University               University of California, Irvine
Merck Research Laboratories            University of California Los Angeles
                                                     California,
Nanyang Technological University       University of Texas at Dallas
National University of Singapore       University of Toronto
North Carolina State University        University of Washington
                                       Ziath
                                       Zi th




                                                                     7
JALA Editorial Highlights At‐A‐Glance
Editor s
Editor’s Choice Collections
•Diagnostics and Detection
•Emerging Technologies in Medicine
•Laboratory Automation and Robotics
•Microfluidics
 Mi fl idi
•Nanomedicine

Special Issues
  p
•Advancements in Biomedical Micro/Nano Tools & Technology (Jan. 25)
•New Developments in Global Health Technologies (Mar. 15)
•Novel Drug Development and Delivery
•Robotics for Laboratory Automation
•Next Generation Microarrays
•Nanomaterials and Microfluidics for Automation
•Nanomedicine
•Biosecurity and Biosafety
•Food and Agriculture
•Bionanotechnology



                                                             8
JALA Market




              9
Journal of Biomolecular Screening (JBS)

                        Editor‐in‐Chief:
                        Robert Campbell, Ph.D.
                        Senior Research Advisor
                        Eli Lilly & Company

                        Impact Factor: 2.049

                        Ranked:
                        32 out of 73 in Chemistry, Analytical
                        79 out of 157 in Biotechnology & Applied 
                        Microbiology
                        45 out of 72 in Biochemical Research Methods 




                                                      10
Journal of Biomolecular Screening (JBS)

                     Scope:  Readers are encouraged to submit material in any 
                     relevant topic area, including: target 
                     identification/validation, assay design and development, 
                     assay technologies (novel applications, comparisons), 
                          y           g (          pp         ,     p       ),
                     automation/robotics, lead generation and/or lead 
                     optimization, high‐content screening/imaging platforms, 
                     virtual screening and chemoinformatics, data/image 
                     analysis, statistics and information technologies/ methods, 
                     sample management (e.g., library design, compound 
                     logistics, chemical diversity), biological reagent production, 
                     characterization and management for drug discovery (cell 
                     lines, stem cells, surrogate tissues/species [e.g., xenopus, 
                     zebrafish, yeast]), genomic and proteomic screening 
                     zebrafish yeast]) genomic and proteomic screening
                     biomarkers, high‐throughput approaches to ADME/PK and 
                     predictive toxicology, and legal/ licensing issues insofar as 
                     they impact the field of screening and/or drug discovery. 
                     The Journal will also publish reviews, mini reviews, and 
                     The Journal will also publish reviews, mini‐reviews, and
                     perspectives in these topic areas. Other features include: 
                     upcoming conferences and training seminars, product 
                     applications, employment opportunities, society and 
                     member news, and book reviews. 


                                                                   11
JBS Indexing

Biomolecular Interaction Network Database (BIND)
BIOSIS database
BIOSIS Previews
Biotechnology Citation Index
Bi t h l         Cit ti I d
Chemical Abstracts
Current Contents: Life Sciences
Elsevier BIOBASE/Current Awareness in Biological Sciences
EMBASE/Excerpta Medica
EMBiology
Index Medicus
InfoTrac (full text)
InfoTrac (full text)
MEDLINE
Prous Science Integrity®
Science Citation Index Expanded (Web of Science)
Scopus




                                                            12
JBS Editorial Board
Internationally-Recognized Researchers and Business Leaders from 6 Countries

Albert-Ludwigs-Universitat            Noscira
    Freiburg                          Novartis Pharma
AstraZeneca                           Pfizer
Boehringer Ingelheim                  Promega
Pharmaceuticals                       Sanofi Aventis
Cellzome                              Tecan Italia
Eli Lilly & C
            Company                   Threshold Pharmaceuticals
Exelixis                              U.S. Environmental Protection Agency
GlaxoSmithKline                       Venenum Biodesign
Johnson & Johnson                     Vertex Pharmaceuticals
Lankenau Institute for Medical
    Research
Memorial Sloan-Kettering
    Cancer C t
    C        Center
U.S. National Institutes of Health




                                                                    13
JBS Editorial Highlights At‐A‐Glance
Editor’s Choice Collections
•ADME/Tox
•Assay Data Analysis, Statistics
      y         y
•Compound Management
•Epigenetics
•Flow Cytometry (FACS)-Based Screening Methods
•HCS, Imaging, Data Analysis
          g g            y
•High-Throughput Screening Methods
•High-Throughput Screening Reviews
•NMR, Mass Spectrometry-Based Screening Methods

Special Issues
•Data Mining and Analysis (TBD Soon)
•Phenotypic Drug Discovery (Jan. 25)
•Stem Cells in Drug Discovery
•Epigenetic-Targeted Drug Discovery
•High Content Screening, Imaging and Data Analysis
•Compound Management



                                                     14
JBS Market




             15
How to Get Published
Central Message
Central Message
    •What are the key take‐away points of your paper?
    •Summarize the messages of your paper in 3‐5 sentences
Choosing the Right Journal
Choosing the Right Journal
    •Choose the right audience
    •Be realistic about the impact/significance of your paper
    •IF versus the best audience/category
Manuscript Composition – Enhance the Readability
    •Title
    •Abstract
    •Introduction
    •Results
    •Discussion
     R f        /Ci i
    •References/Citing




                                                                16
Manuscript Composition
Title
    •What is the most important message of your paper? 
    •The message is more than just the data
       p                       g
    •Capture the audience’s imagination
         • Cellular‐Level Surgery Using Nano Robots (JALA, Dec 2012)
    •Be Clear:
         • Bad Example: Treatment of Pediatric Melanoma Patients with Lasers 
         • Better Example: Laser Treatment of Pediatric Melanoma Patients

    •Follow journal rules for title length and format




                                                                         17
Manuscript Composition
Abstract
    •Establish the narrative of your paper
    •Convince the editors, reviewers and audience to want to read your paper
                                                        g     p p
    •Should be able to stand on its own without reading the paper
    •State the hypothesis, question or objective of the study
    •Complete the story by answering the hypothesis, question or objective
    •How does this work impact your field of research and the larger 
    scientific/medical/commercial industry?
      i ifi / di l/              i li d    ?

    •Stay consistent with title and introduction in the use of keywords and concepts
    •Follow the correct style and format
     Follow the correct style and format
    •Follow order of the manuscript (Intro‐Methods‐Results‐Discussion)
    •Stay within the allowed word count
    •Do not include data that isn’t in the paper
    •Do not suggest conclusions that can’t be supported by the data in the paper
    •Limit abbreviations to a minimum
    •No references and no figure or table citations



                                                                             18
Manuscript Composition
Introduction
    •Why was this study conducted?
    •Sufficiently introduce the current state of research without becoming a review paper
          g         y                        y
    •Recognize key works that came before yours
    •Be clear how your work differentiates from previous publications.
          • What did you do differently?
          • What is novel?
          • Concisely reiterate/summarize the key talking points/data/ideas that you will 
             demonstrate in the paper and emphasized in abstract
Methods
     Eff ti l d        ib h      t di            f
    •Effectively describe how studies were performed.  d
    •Explain techniques in sufficient detail that an expert in your field could effectively 
    replicate your work.
    •Be clear about the source of materials
    •Describe statistics techniques employed
    •If your studies involved living subjects, describe ethical and regulatory considerations of 
    the study



                                                                                19
Manuscript Composition
Results
    •Order your Results and Figures in a clear and sensible manner that fits your narrative
    •Provide enough data in Results to convince the audience of your conclusions
           y
    •Title your Results subsections in a concise and clear manner
    •In each subsection, start by clearly stating why these experiments are important.
    •State your results clearly and with no embellishments or overreaching conclusions
    •Always begin and end with a bang (what are the most important experiments of the 
    paper?)?)


Discussion
    •Explain why your work is important. This is your narrative. What conclusions do you 
    take from your Results that advance what is known in your field of research?
    •Do not just summarize your results. Answer bigger questions.
    •Do not be afraid to talk about the limitations of your work
     Do not be afraid to talk about the limitations of your work
    •How does your current work indicate where future research should go?




                                                                              20
Originality
Importance of Citations
Importance of Citations
    •Ideas are the currency of Academia
    •Failure to cite violates the rights of the person who originated the idea
                                     g        gy
    •Academics need to trace the genealogy of ideas
Originality of Research
    •How does your work differentiate from work that came before it?
    •What novel insights or conclusions can you make from your work?
Evaluation of Originality by Peer Reviewers
    •How does your work compare to the work cited in your paper?
    •How does your work compare to work that you failed to cite (This can kill your paper)
Description of Originality in Manuscript
    •Create and maintain a narrative that easily explains why and how your work is novel.
    •Differentiate your work from properly cited work that came before yours. Show how 
    your work extends beyond what is known.




                                                                                 21
The Importance of Citations
Ideas are the Currency of Academia
Ideas are the Currency of Academia
• Ideas enable the originator of the idea to receive credit for their work

• Citations are a key indicator of impact

• Giving credit to one who makes new discoveries is important for the field


Failing to Cite Violates the Rights of the Person who Originated the Idea
• It is important to keep track of sources

• During the course of describing new findings, it is important to formally describe 
  how prior discoveries have served as a foundation for new ideas




          From: The Importance of Citation, Judy Hunter, Grinnell College



                                                                       22
The Importance of Citations
Academics Need to Trace Genealogy of Ideas
Academics Need to Trace Genealogy of Ideas
• Inspiration for new ideas should be acknowledged

• Mapping out the course of innovation is important for those within the field as 
  those who are new to the field
   h     h              h f ld

• Mapping out the course of innovation makes how your work is novel easier to 
  follow




         From: The Importance of Citation, Judy Hunter, Grinnell College




                                                                     23
The Importance of Citations – During Review Process
How are Citations Evaluated?
How are Citations Evaluated?
•Did the authors sufficiently acknowledge previous work?
•Do the citations sufficiently explain the genealogy of ideas leading up to this 
paper?

Reviewer Response to Citations
•Thorough referencing will make the review process easier
•Failure to cite key papers that your work clearly builds on will greatly harm your
•Failure to cite key papers that your work clearly builds on will greatly harm your 
paper and the reviewer’s perception of your work

Citations in Reviewers
Citations in Reviewers’ Critiques
•If citations are not sufficient in paper, Reviewers will point it out
•If Reviewers are not specific about requests for greater citation – Don’t just add 1 
or 2 token cites.




                                                                         24
Authorship Issues
Authorship Order
Authorship Order
•   Which graduate student/postdoc/tech did the most work/led the project?
•   Co‐first author is fine
•   Lead PI should go last
•   Gamesmanship: Do you have collaborators that helped with your project that 
                 h          h      ll b      h h l d       h               h
    can add legitimacy to your work?

Corresponding Authorship
Corresponding Authorship
• The lead PI should generally be Corresponding Author. In cases of multi‐
  disciplinary studies, can have two Corresponding Authors.
• Situation‐specific cases for making postdoctoral fellow Corresponding Author

Authorship Permissions
•   Does everyone on the authorship list know they are associated with your 
    paper?




                                                                     25
Peer Review Process
•   The review process is confidential, and reviewers are obliged not to discuss papers or 
               p                      ,                       g                  p p
    authors with anyone outside of the SLAS editorial staff. 

•   Manuscripts are typically evaluated in response to stated Peer Review Guidelines 
    and initial feedback is usually provided to authors within four weeks after 
    and initial feedback is usually provided to authors within four weeks after
    submission. 

•   Manuscripts can be accepted as written by reviewers, declined as inappropriate, or 
    as is more often the case, reviewers will suggest revisions in the SLAS Spirit of 
       i        ft th             i       ill       t    ii     i th SLAS S i it f
    Mentorship. 

•   Authors are then offered the opportunity to revise and re‐submit their manuscripts, 
    or provide explanations in response to reviewer questions or suggestions. 

•   Revisions and responses are re‐reviewed by the editor‐in‐chief and/or peer 
    reviewers before final publishing decisions are made. 

•   Invited reviewers are asked to decline their invitation if they have any perceived 
    conflict of interest with the author, the author's affiliation and/or the topic of the 
    paper.


                                                                              26
Peer Review Guidelines (available at www.slas.org)

Four Primary Areas of Evaluation

•Content

•Presentation

•Ethics

•General




                                            27
Content
1. Is the manuscript within the defined scope of the j
                  p                        p         journal?

2. Is the subject of the paper of sufficient interest to the journal's readership?

3. Does the paper report a specific, identifiable, advance in knowledge?
            p p     p       p      ,             ,                   g

4. Has the work reported in this paper been published before? (Suggestion: search
   MEDLINE and/or Google Scholar by author and keywords.)

5. Are the title and abstract truly descriptive of the content?

6. Are the procedures and methods complete and sufficiently clear that the work
   could be repeated by anyone knowledgeable in the field?
              p       y y             g

7. Are the conclusions justified, sound and logically consistent?

8. Are the references to prior work p
                         p          pertinent and complete?
                                                     p




                                                                            28
Presentation
1. Is the paper as concise as it could be; consistent with clarity?

2. Are all figures and tables relevant and properly prepared?

3. Reviewers are not required t comment on grammar and punctuation.
3 R i               t     i d to         t              d      t ti
   Instead, reviewers are encouraged to suggest changes that would
   remove ambiguity or clarify meaning.




                                                                  29
Ethics
1. Papers under review are confidential and should not be discussed or shown to
      p
   others without the express permission of the editor-in-chief.

2. The identity of reviewers is kept anonymous. A reviewer should reveal his or her
   identify to an author only with p
          y                 y      permission from the editor-in-chief.




                                                                       30
General
1. Ensure the appropriate manuscript category is selected by the author. If y do not
                 pp p               p      g y                  y             you
   think the category selected by the author is the best fit for the manuscript,
   recommend a more appropriate category.

2. Ensure the author is following the j
                                g     journal's Instruction for Authors and American
   Chemistry Society (ACS) Style Guidelines.

3. Assessments should be returned on or before the specified deadline. Reviewers
   who may not be able to meet a deadline are urged to say so as soon as p
         y                                      g        y               possible.

4. Please keep in mind that reviewer manuscript evaluations and comments will be
   relayed to authors as guides for revision. Be honest, but courteous. Offer
   constructive criticism to the authors so they can benefit from your expertise.
                                               y                  y      p
   Critique the manuscript, not the author.

5. Any comments for the editor's eyes only should be shared in a separate note.




                                                                        31
Permission Guidelines
• Any text, tables, or figures reproduced from previously published work can only
  Any text, tables, or figures reproduced from previously published work can only 
  be reprinted with written permission from the copyright holder. 

• Permissions must be submitted with the manuscript, and must include print and 
  online publication. 
    li     bli ti

• Acquiring permission is the sole responsibility of the author. 

• The publication from which the material is taken must be listed in the 
  references. 




                                                                     32
Copyright and Simultaneous Submissions
• Manuscripts are considered for publication with the understanding that if a
  Manuscripts are considered for publication with the understanding that if a 
  paper is accepted, copyright is transferred to the Society for Laboratory 
  Automation and Screening, and that no paper presenting the same information 
  has been or will be published elsewhere. 

• If part of a contribution has appeared or will appear elsewhere, the author 
  must specify the details in the comments portion of his or her submission. 
  Simultaneous submissions of manuscripts to multiple journals at the same 
                                         p           p j
  time is not acceptable — please do not submit manuscripts that may be under 
  consideration by another publication or electronic medium.

• Published manuscripts may be published elsewhere only with the written
  Published manuscripts may be published elsewhere only with the written 
  permission of SLAS. 

• Authors whose research was funded by an NIH grant may submit the final, 
  accepted version of the manuscript for deposit in PubMedCentral. JALA requires 
  such authors to specify a release date of 11 months following the date of print 
  publication of the manuscript.



                                                                    33
Ethics of Publishing
Definition of Plagiarism
Definition of Plagiarism
•From Merriam-Webster Dictionary: to steal and pass off (the ideas or
words of another) as one's own : use (another's production) without crediting
the source

Typical Responses to Plagiarism
•Author will be given an opportunity to explain themselves
•During review process – failure to be accepted
•During review process failure to be accepted
•After publication – Retraction

Conflict of Interests
Conflict of Interests
•All prospective authors must recognize and disclose any conflict of interest, or 
potential conflict of interest, that may bias their work, or could be perceived to bias 
their work, and acknowledge all financial support and any other personal 
connections. 
        ti
•JALA follows the Uniform Requirements for Manuscripts of the International 
Committee of Medical Journal Editors, especially as they relate to conflicts of 
interest.


                                                                         34
Ethics of Publishing
Scientific Misconduct
Scientific Misconduct
In accordance with the Council of Science Editors, SLAS recognizes that as a general 
guide, the term "research misconduct" applies to any action that involves 
purposeful manipulation of the scientific record such that it no longer reflects 
observed truth, or mistreatment of research subjects. The concepts of negligence 
  b     d      h     i             f         h bj       Th               f     li
and deceit are central to the definition of research misconduct. Research 
misconduct generally falls into one of four areas: fabrication of data, falsification of 
data, plagiarism, and unethical treatment of research subjects. 
     ,p g        ,                                          j

If SLAS suspects misconduct by authors, reviewers, editorial staff, or other editors, it 
will take action. This duty extends to both published and unpublished papers. SLAS 
will first seek a response from those accused. If SLAS is not satisfied with the 
will first seek a response from those accused If SLAS is not satisfied with the
response, SLAS will ask the employers of the authors, reviewers, or editors, or some 
other appropriate body (perhaps a regulatory body) to investigate. In the case of its 
own editorial staff, SLAS will conduct the investigation itself. SLAS will make all 
reasonable efforts to ensure that a proper investigation is conducted. If this is not 
possible, or does not happen for whatever reason, SLAS will make all reasonable 
attempts to persist in obtaining a resolution to the problem and a correction of the 
record if it is needed.
record if it is needed

                                                                          35
Tips and Resources
Go to www.SLAS.org

Click on  “Scientific Journals” button (on right side of page) or go directly to
www.slas.org/publications/journals.cfm

Scroll down to “Tips for Authors” box for links to:
•This presentation
•Clinical Chemistry Guide to Scientific Writing
•Advice for Published Journal Authors
 H l R d Fi d Y           A ti l
•Help Readers Find Your Article
•Promote Your Article
•Increase Use and Citations of Your Article

Other Recommended Reading:
•How to Write and Publish a Scientific Paper (by Day and Gastel)
       y
•ACS Style Guide

                                                                   36

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How to Get Published in a Scientific Journal

  • 1. JALA & JBS Authors Workshop How to Get Your Work Published Dr. Dr Edward Kai Hua Chow Kai-Hua Dept. of Pharmacology Cancer Science Institute National University of Singapore
  • 2. Official SLAS Peer‐Reviewed Scientific Journals Journal of Laboratory Automation (JALA) Journal of Biomolecular Screening (JBS) Journal of Biomolecular Screening (JBS) 2
  • 3. Journal of Laboratory Automation (JALA) Editor‐in‐Chief: Dean Ho, Ph.D. Professor UCLA (2012 AY) Impact Factor:  1.420 (Ranked 14 out of 32 in  Medical Laboratory Technology category Scope: The Journal of Laboratory Automation (JALA) is a multi‐disciplinary, bimonthly  international peer‐reviewed journal devoted to  international peer‐reviewed journal devoted to the advancement of technology in the  laboratory.  JALA highlights innovation at the intersection of  academia, industry, and government research  and is backed by an internationally‐renowned  Scientific Advisory Board and Editorial Board. Scientific Advisory Board and Editorial Board. 3
  • 4. JALA Audience JALA authors, readers, and reviewers are academic, commercial, and government researchers, scientists, and engineers who conduct research and develop new technologies to increase productivity, elevate data quality, reduce lab process cycle times or enable experimentation that otherwise would be impossible times, impossible. 4
  • 5. JALA Indexing Analytical Abstracts ProQuest Biological Abstracts CSA Technology Research Database BIOSIS Previews Science Citation Index Expanded (Web of  Ceramic Abstracts Ceramic Abstracts Science) Chemical Abstracts SciFinder CINAHL SCIRUS Compendex Scopus Computer and Information Systems  Abstracts Journal Corrosion Abstracts EMBASE/Excerpta Medica Engineering Index Monthly Google Scholar INSPEC Journal Citation Report – Science edition MEDLINE 5
  • 6. JALA Scientific Advisors World Leaders in Academic and Economic Innovation Dr. Jing Cheng Dr. Nicolas Di Rooij Dr. Raymond Dessy Dr. Lee Hood Capital Biochip EPFL Virginia Tech Institute for Systems  Tsinghua Univ. Inst Microtech Chemistry Biology Dr. Edward McCabe Dr. Chad Mirkin Dr. Eiji Osawa Dr. Michael Phelps Univ Colorado U i C l d Northwestern Univ NanoCarbon Research  M l/M d Ph h i C b h Mol/Med Pharm Linda Crnic Institute Chemistry Institute UCLA 6
  • 7. JALA Editorial Board Internationally‐Recognized Researchers and Business Leaders from 7 Countries AuraSense Northwestern University Automated Laboratory Processing Peking University Biotic Laboratories Pennsylvania State University Bristol-Myers Bristol Myers Squibb PerkinElmer BSSN Software Procter & Gamble Chinese University of Hong Kong Syngenta Seeds Genefluidics Technical University of Denmark Harvard Medical School U.S. Dept. of Agriculture Hospira Shanghai University of Arizona Johns Hopkins University University of California, Irvine Merck Research Laboratories University of California Los Angeles California, Nanyang Technological University University of Texas at Dallas National University of Singapore University of Toronto North Carolina State University University of Washington Ziath Zi th 7
  • 8. JALA Editorial Highlights At‐A‐Glance Editor s Editor’s Choice Collections •Diagnostics and Detection •Emerging Technologies in Medicine •Laboratory Automation and Robotics •Microfluidics Mi fl idi •Nanomedicine Special Issues p •Advancements in Biomedical Micro/Nano Tools & Technology (Jan. 25) •New Developments in Global Health Technologies (Mar. 15) •Novel Drug Development and Delivery •Robotics for Laboratory Automation •Next Generation Microarrays •Nanomaterials and Microfluidics for Automation •Nanomedicine •Biosecurity and Biosafety •Food and Agriculture •Bionanotechnology 8
  • 10. Journal of Biomolecular Screening (JBS) Editor‐in‐Chief: Robert Campbell, Ph.D. Senior Research Advisor Eli Lilly & Company Impact Factor: 2.049 Ranked: 32 out of 73 in Chemistry, Analytical 79 out of 157 in Biotechnology & Applied  Microbiology 45 out of 72 in Biochemical Research Methods  10
  • 11. Journal of Biomolecular Screening (JBS) Scope:  Readers are encouraged to submit material in any  relevant topic area, including: target  identification/validation, assay design and development,  assay technologies (novel applications, comparisons),  y g ( pp , p ), automation/robotics, lead generation and/or lead  optimization, high‐content screening/imaging platforms,  virtual screening and chemoinformatics, data/image  analysis, statistics and information technologies/ methods,  sample management (e.g., library design, compound  logistics, chemical diversity), biological reagent production,  characterization and management for drug discovery (cell  lines, stem cells, surrogate tissues/species [e.g., xenopus,  zebrafish, yeast]), genomic and proteomic screening  zebrafish yeast]) genomic and proteomic screening biomarkers, high‐throughput approaches to ADME/PK and  predictive toxicology, and legal/ licensing issues insofar as  they impact the field of screening and/or drug discovery.  The Journal will also publish reviews, mini reviews, and  The Journal will also publish reviews, mini‐reviews, and perspectives in these topic areas. Other features include:  upcoming conferences and training seminars, product  applications, employment opportunities, society and  member news, and book reviews.  11
  • 12. JBS Indexing Biomolecular Interaction Network Database (BIND) BIOSIS database BIOSIS Previews Biotechnology Citation Index Bi t h l Cit ti I d Chemical Abstracts Current Contents: Life Sciences Elsevier BIOBASE/Current Awareness in Biological Sciences EMBASE/Excerpta Medica EMBiology Index Medicus InfoTrac (full text) InfoTrac (full text) MEDLINE Prous Science Integrity® Science Citation Index Expanded (Web of Science) Scopus 12
  • 13. JBS Editorial Board Internationally-Recognized Researchers and Business Leaders from 6 Countries Albert-Ludwigs-Universitat Noscira Freiburg Novartis Pharma AstraZeneca Pfizer Boehringer Ingelheim Promega Pharmaceuticals Sanofi Aventis Cellzome Tecan Italia Eli Lilly & C Company Threshold Pharmaceuticals Exelixis U.S. Environmental Protection Agency GlaxoSmithKline Venenum Biodesign Johnson & Johnson Vertex Pharmaceuticals Lankenau Institute for Medical Research Memorial Sloan-Kettering Cancer C t C Center U.S. National Institutes of Health 13
  • 14. JBS Editorial Highlights At‐A‐Glance Editor’s Choice Collections •ADME/Tox •Assay Data Analysis, Statistics y y •Compound Management •Epigenetics •Flow Cytometry (FACS)-Based Screening Methods •HCS, Imaging, Data Analysis g g y •High-Throughput Screening Methods •High-Throughput Screening Reviews •NMR, Mass Spectrometry-Based Screening Methods Special Issues •Data Mining and Analysis (TBD Soon) •Phenotypic Drug Discovery (Jan. 25) •Stem Cells in Drug Discovery •Epigenetic-Targeted Drug Discovery •High Content Screening, Imaging and Data Analysis •Compound Management 14
  • 16. How to Get Published Central Message Central Message •What are the key take‐away points of your paper? •Summarize the messages of your paper in 3‐5 sentences Choosing the Right Journal Choosing the Right Journal •Choose the right audience •Be realistic about the impact/significance of your paper •IF versus the best audience/category Manuscript Composition – Enhance the Readability •Title •Abstract •Introduction •Results •Discussion R f /Ci i •References/Citing 16
  • 17. Manuscript Composition Title •What is the most important message of your paper?  •The message is more than just the data p g •Capture the audience’s imagination • Cellular‐Level Surgery Using Nano Robots (JALA, Dec 2012) •Be Clear: • Bad Example: Treatment of Pediatric Melanoma Patients with Lasers  • Better Example: Laser Treatment of Pediatric Melanoma Patients •Follow journal rules for title length and format 17
  • 18. Manuscript Composition Abstract •Establish the narrative of your paper •Convince the editors, reviewers and audience to want to read your paper g p p •Should be able to stand on its own without reading the paper •State the hypothesis, question or objective of the study •Complete the story by answering the hypothesis, question or objective •How does this work impact your field of research and the larger  scientific/medical/commercial industry? i ifi / di l/ i li d ? •Stay consistent with title and introduction in the use of keywords and concepts •Follow the correct style and format Follow the correct style and format •Follow order of the manuscript (Intro‐Methods‐Results‐Discussion) •Stay within the allowed word count •Do not include data that isn’t in the paper •Do not suggest conclusions that can’t be supported by the data in the paper •Limit abbreviations to a minimum •No references and no figure or table citations 18
  • 19. Manuscript Composition Introduction •Why was this study conducted? •Sufficiently introduce the current state of research without becoming a review paper g y y •Recognize key works that came before yours •Be clear how your work differentiates from previous publications. • What did you do differently? • What is novel? • Concisely reiterate/summarize the key talking points/data/ideas that you will  demonstrate in the paper and emphasized in abstract Methods Eff ti l d ib h t di f •Effectively describe how studies were performed. d •Explain techniques in sufficient detail that an expert in your field could effectively  replicate your work. •Be clear about the source of materials •Describe statistics techniques employed •If your studies involved living subjects, describe ethical and regulatory considerations of  the study 19
  • 20. Manuscript Composition Results •Order your Results and Figures in a clear and sensible manner that fits your narrative •Provide enough data in Results to convince the audience of your conclusions y •Title your Results subsections in a concise and clear manner •In each subsection, start by clearly stating why these experiments are important. •State your results clearly and with no embellishments or overreaching conclusions •Always begin and end with a bang (what are the most important experiments of the  paper?)?) Discussion •Explain why your work is important. This is your narrative. What conclusions do you  take from your Results that advance what is known in your field of research? •Do not just summarize your results. Answer bigger questions. •Do not be afraid to talk about the limitations of your work Do not be afraid to talk about the limitations of your work •How does your current work indicate where future research should go? 20
  • 21. Originality Importance of Citations Importance of Citations •Ideas are the currency of Academia •Failure to cite violates the rights of the person who originated the idea g gy •Academics need to trace the genealogy of ideas Originality of Research •How does your work differentiate from work that came before it? •What novel insights or conclusions can you make from your work? Evaluation of Originality by Peer Reviewers •How does your work compare to the work cited in your paper? •How does your work compare to work that you failed to cite (This can kill your paper) Description of Originality in Manuscript •Create and maintain a narrative that easily explains why and how your work is novel. •Differentiate your work from properly cited work that came before yours. Show how  your work extends beyond what is known. 21
  • 22. The Importance of Citations Ideas are the Currency of Academia Ideas are the Currency of Academia • Ideas enable the originator of the idea to receive credit for their work • Citations are a key indicator of impact • Giving credit to one who makes new discoveries is important for the field Failing to Cite Violates the Rights of the Person who Originated the Idea • It is important to keep track of sources • During the course of describing new findings, it is important to formally describe  how prior discoveries have served as a foundation for new ideas From: The Importance of Citation, Judy Hunter, Grinnell College 22
  • 23. The Importance of Citations Academics Need to Trace Genealogy of Ideas Academics Need to Trace Genealogy of Ideas • Inspiration for new ideas should be acknowledged • Mapping out the course of innovation is important for those within the field as  those who are new to the field h h h f ld • Mapping out the course of innovation makes how your work is novel easier to  follow From: The Importance of Citation, Judy Hunter, Grinnell College 23
  • 24. The Importance of Citations – During Review Process How are Citations Evaluated? How are Citations Evaluated? •Did the authors sufficiently acknowledge previous work? •Do the citations sufficiently explain the genealogy of ideas leading up to this  paper? Reviewer Response to Citations •Thorough referencing will make the review process easier •Failure to cite key papers that your work clearly builds on will greatly harm your •Failure to cite key papers that your work clearly builds on will greatly harm your  paper and the reviewer’s perception of your work Citations in Reviewers Citations in Reviewers’ Critiques •If citations are not sufficient in paper, Reviewers will point it out •If Reviewers are not specific about requests for greater citation – Don’t just add 1  or 2 token cites. 24
  • 25. Authorship Issues Authorship Order Authorship Order • Which graduate student/postdoc/tech did the most work/led the project? • Co‐first author is fine • Lead PI should go last • Gamesmanship: Do you have collaborators that helped with your project that  h h ll b h h l d h h can add legitimacy to your work? Corresponding Authorship Corresponding Authorship • The lead PI should generally be Corresponding Author. In cases of multi‐ disciplinary studies, can have two Corresponding Authors. • Situation‐specific cases for making postdoctoral fellow Corresponding Author Authorship Permissions • Does everyone on the authorship list know they are associated with your  paper? 25
  • 26. Peer Review Process • The review process is confidential, and reviewers are obliged not to discuss papers or  p , g p p authors with anyone outside of the SLAS editorial staff.  • Manuscripts are typically evaluated in response to stated Peer Review Guidelines  and initial feedback is usually provided to authors within four weeks after  and initial feedback is usually provided to authors within four weeks after submission.  • Manuscripts can be accepted as written by reviewers, declined as inappropriate, or  as is more often the case, reviewers will suggest revisions in the SLAS Spirit of  i ft th i ill t ii i th SLAS S i it f Mentorship.  • Authors are then offered the opportunity to revise and re‐submit their manuscripts,  or provide explanations in response to reviewer questions or suggestions.  • Revisions and responses are re‐reviewed by the editor‐in‐chief and/or peer  reviewers before final publishing decisions are made.  • Invited reviewers are asked to decline their invitation if they have any perceived  conflict of interest with the author, the author's affiliation and/or the topic of the  paper. 26
  • 28. Content 1. Is the manuscript within the defined scope of the j p p journal? 2. Is the subject of the paper of sufficient interest to the journal's readership? 3. Does the paper report a specific, identifiable, advance in knowledge? p p p p , , g 4. Has the work reported in this paper been published before? (Suggestion: search MEDLINE and/or Google Scholar by author and keywords.) 5. Are the title and abstract truly descriptive of the content? 6. Are the procedures and methods complete and sufficiently clear that the work could be repeated by anyone knowledgeable in the field? p y y g 7. Are the conclusions justified, sound and logically consistent? 8. Are the references to prior work p p pertinent and complete? p 28
  • 29. Presentation 1. Is the paper as concise as it could be; consistent with clarity? 2. Are all figures and tables relevant and properly prepared? 3. Reviewers are not required t comment on grammar and punctuation. 3 R i t i d to t d t ti Instead, reviewers are encouraged to suggest changes that would remove ambiguity or clarify meaning. 29
  • 30. Ethics 1. Papers under review are confidential and should not be discussed or shown to p others without the express permission of the editor-in-chief. 2. The identity of reviewers is kept anonymous. A reviewer should reveal his or her identify to an author only with p y y permission from the editor-in-chief. 30
  • 31. General 1. Ensure the appropriate manuscript category is selected by the author. If y do not pp p p g y y you think the category selected by the author is the best fit for the manuscript, recommend a more appropriate category. 2. Ensure the author is following the j g journal's Instruction for Authors and American Chemistry Society (ACS) Style Guidelines. 3. Assessments should be returned on or before the specified deadline. Reviewers who may not be able to meet a deadline are urged to say so as soon as p y g y possible. 4. Please keep in mind that reviewer manuscript evaluations and comments will be relayed to authors as guides for revision. Be honest, but courteous. Offer constructive criticism to the authors so they can benefit from your expertise. y y p Critique the manuscript, not the author. 5. Any comments for the editor's eyes only should be shared in a separate note. 31
  • 32. Permission Guidelines • Any text, tables, or figures reproduced from previously published work can only Any text, tables, or figures reproduced from previously published work can only  be reprinted with written permission from the copyright holder.  • Permissions must be submitted with the manuscript, and must include print and  online publication.  li bli ti • Acquiring permission is the sole responsibility of the author.  • The publication from which the material is taken must be listed in the  references.  32
  • 33. Copyright and Simultaneous Submissions • Manuscripts are considered for publication with the understanding that if a Manuscripts are considered for publication with the understanding that if a  paper is accepted, copyright is transferred to the Society for Laboratory  Automation and Screening, and that no paper presenting the same information  has been or will be published elsewhere.  • If part of a contribution has appeared or will appear elsewhere, the author  must specify the details in the comments portion of his or her submission.  Simultaneous submissions of manuscripts to multiple journals at the same  p p j time is not acceptable — please do not submit manuscripts that may be under  consideration by another publication or electronic medium. • Published manuscripts may be published elsewhere only with the written Published manuscripts may be published elsewhere only with the written  permission of SLAS.  • Authors whose research was funded by an NIH grant may submit the final,  accepted version of the manuscript for deposit in PubMedCentral. JALA requires  such authors to specify a release date of 11 months following the date of print  publication of the manuscript. 33
  • 34. Ethics of Publishing Definition of Plagiarism Definition of Plagiarism •From Merriam-Webster Dictionary: to steal and pass off (the ideas or words of another) as one's own : use (another's production) without crediting the source Typical Responses to Plagiarism •Author will be given an opportunity to explain themselves •During review process – failure to be accepted •During review process failure to be accepted •After publication – Retraction Conflict of Interests Conflict of Interests •All prospective authors must recognize and disclose any conflict of interest, or  potential conflict of interest, that may bias their work, or could be perceived to bias  their work, and acknowledge all financial support and any other personal  connections.  ti •JALA follows the Uniform Requirements for Manuscripts of the International  Committee of Medical Journal Editors, especially as they relate to conflicts of  interest. 34
  • 35. Ethics of Publishing Scientific Misconduct Scientific Misconduct In accordance with the Council of Science Editors, SLAS recognizes that as a general  guide, the term "research misconduct" applies to any action that involves  purposeful manipulation of the scientific record such that it no longer reflects  observed truth, or mistreatment of research subjects. The concepts of negligence  b d h i f h bj Th f li and deceit are central to the definition of research misconduct. Research  misconduct generally falls into one of four areas: fabrication of data, falsification of  data, plagiarism, and unethical treatment of research subjects.  ,p g , j If SLAS suspects misconduct by authors, reviewers, editorial staff, or other editors, it  will take action. This duty extends to both published and unpublished papers. SLAS  will first seek a response from those accused. If SLAS is not satisfied with the  will first seek a response from those accused If SLAS is not satisfied with the response, SLAS will ask the employers of the authors, reviewers, or editors, or some  other appropriate body (perhaps a regulatory body) to investigate. In the case of its  own editorial staff, SLAS will conduct the investigation itself. SLAS will make all  reasonable efforts to ensure that a proper investigation is conducted. If this is not  possible, or does not happen for whatever reason, SLAS will make all reasonable  attempts to persist in obtaining a resolution to the problem and a correction of the  record if it is needed. record if it is needed 35
  • 36. Tips and Resources Go to www.SLAS.org Click on  “Scientific Journals” button (on right side of page) or go directly to www.slas.org/publications/journals.cfm Scroll down to “Tips for Authors” box for links to: •This presentation •Clinical Chemistry Guide to Scientific Writing •Advice for Published Journal Authors H l R d Fi d Y A ti l •Help Readers Find Your Article •Promote Your Article •Increase Use and Citations of Your Article Other Recommended Reading: •How to Write and Publish a Scientific Paper (by Day and Gastel) y •ACS Style Guide 36