The document provides an overview of approach to evaluating abnormal liver function tests (LFTs). It defines relevant liver enzymes and tests. Epidemiology studies show most abnormal LFT cases can be diagnosed noninvasively, and the most common findings are non-alcoholic fatty liver disease and steatohepatitis. A thorough history and physical exam is important to identify potential causes like medications, viruses, autoimmune conditions, or metabolic disorders. Common patterns on lab testing can help indicate hepatocellular injury, cholestasis or other chronic processes. A methodical evaluation and testing approach is outlined.
Z Score,T Score, Percential Rank and Box Plot Graph
Approach to the patient with abnormal LFTs
1. Approach to The Patient with Abnormal Liver Function Tests Bushra MI Sulieman, MD MS Consultant, Gastroenterology & Hepatology Department of Medicine King Faisal Specialist Hospital & Research Center - Jeddah
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8. Laboratory Testing Patterns Pattern Cause AST/ALT > ALP Bilirubin Hepatocellular Injury ALP > AST/ALT Bilirubin Cholestasis Albumin Chronic process (cirrhosis / cancer) Albumin Acute process (viral hepatitis / choledocholithiasis. PT/INR Prolonged jaundice / Vit K malabsorption Hepatocellular dysfunction.
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