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Curviform bacteria The spirochetes Campylobacter  Helicobacter
Curviform bacteria that are pathogenic for human ,[object Object],[object Object],[object Object],[object Object],[object Object]
“ Sodoku” disease Spirillum minor causes rat-bite fever (“sodoku”)
Campilobacter   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Scanning micrograph of Campylibacter jejuni
Helicobacter pylori ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Helicobacter morphology
Diagnosis, treatment Helicobacter pylori in the gastric mucosa ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Classification of spirochetes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Free-living saprobes Human pathogens
Properties of spirochetes   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dark-field photomicrograph of spirochetes
Structure of spirochete
Structure of spirochete cell
Bacterial flagella
Electron micrographs of spirochetes Treponema  Borrelia  Leptospira
Phase contrast photomicrograph of free-living spirochete
Spirochetes morphology Treponema  Leptospira  Borrelia
Members of genus Treponema ,[object Object],[object Object],[object Object],[object Object]
Treponema properties   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treponemes in the specimen from a patient with syphilis
Pathogenesis and forms of syphilis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogenesis  of syphilis. Primary syphilis Hard chancre on external male genitalia  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Electron micrograph of the Tr.pallidum attached to cells . Tip of spirochete  Host cell
Pathogenesis  of syphilis. Secondary  syphilis ,[object Object],[object Object],[object Object],[object Object],[object Object],The skin rash in  secondary syphilis
Pathogenesis  of syphilis. Tertiary  syphilis ,[object Object],[object Object],[object Object],[object Object],A ring-shaped erosive gumma on the arm in late  (tertiary syphilis)
Congenital syphilis A profuse nasal discharge that obstructs breathing Hutchinson's teeth Consequences: from mild to the extremes of spontaneous miscarriage or stillbirth Signs - nasal discharge ,  skin eruptions and loss, bone deformation, and nervous system abnormalities.  In the late form - formation of Hutchinson's teeth
Nonsyphilitic Trepanematoses Yaws  (frambesia tropica) Bejel  (endemic syphilis)
Diagnosis  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunofluorescence microscopy. Treponemes in the specimen from a patient with syphilis
Diagnosis  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment and prevention ,[object Object],[object Object]
Properties of Borrelia   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Scanning electron micrograph of Borrelia
Diseases caused by Borrelia ,[object Object],[object Object],[object Object],Tick  Lice
Pathogenesis of relapsing fever ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogenesis of relapsing fever ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],4. A second antibody response, producing a second remission 5, 6. This pattern can continue for up to four relapses
Diagnosis of relapsing fever ,[object Object],[object Object],[object Object]
Borrelia in blood smear Romanowsky-Giemsa staining
The main reservoir – small mammalians (mice), upon which the nymphs feed. Large mammalians (deer),  are an obligatory host in the tick’s life cycle but are not an important reservoir of the Borrelia. There is no human-to-human spread
Pathogenesis of Lime disease ,[object Object],[object Object],[object Object],[object Object]
Diagnosis, treatment, prevention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Leptospira  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Leptospira morphology
Pathogenesis of leptospirosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis, treatment, prevention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Bohomolets Microbiology Lecture #22