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Pathophysiology of Chronic HPN with Superimposed Pre- eclampsia

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RoxanneMae Birador
RoxanneMae Birador

PATHOPHYSIOLOGY *NCM 102

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PATHOPHYSIOLOGY Chronic Hypertension with Superimposed Preeclampsia PREDISPOSING FACTORS -Age (42y/o) -Family History HTN -Medical History PRECIPITATING FACTORS -High-salt,high-fatdiet Activation of Sympathetic Nervous System Endothelial damage - heart rate - cardiac contractility - produces widespread vasoconstriction in the peripheral arterioles uterine placental blood flow -severe headache -dizziness - vomiting -loss of normal balance -Muscle Strength Grading 2/5, left side of the body -unable to sit without support VASOPASMS Peripheral resistance Abnormal clottingoccurs N.O., Prostacyclin, Endothelin renal perfusion Angiotensin IAngiotensinogen renin Juxtaglomerular cells ELEVATED BP compression of brain A-C-E Acute Cerebellar Hemmorhage Increased IOP Premature delivery Adrenal cortex Angiotensin II aldosterone Na reabsorption H2O reabsorption Arteriolar vasoconstriction -blurringof vision

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Pathophysiology of Chronic HPN with Superimposed Pre- eclampsia

  • 1. PATHOPHYSIOLOGY Chronic Hypertension with Superimposed Preeclampsia PREDISPOSING FACTORS -Age (42y/o) -Family History HTN -Medical History PRECIPITATING FACTORS -High-salt,high-fatdiet Activation of Sympathetic Nervous System Endothelial damage - heart rate - cardiac contractility - produces widespread vasoconstriction in the peripheral arterioles uterine placental blood flow -severe headache -dizziness - vomiting -loss of normal balance -Muscle Strength Grading 2/5, left side of the body -unable to sit without support VASOPASMS Peripheral resistance Abnormal clottingoccurs N.O., Prostacyclin, Endothelin renal perfusion Angiotensin IAngiotensinogen renin Juxtaglomerular cells ELEVATED BP compression of brain A-C-E Acute Cerebellar Hemmorhage Increased IOP Premature delivery Adrenal cortex Angiotensin II aldosterone Na reabsorption H2O reabsorption Arteriolar vasoconstriction -blurringof vision