The document discusses the growing threat of antibiotic-resistant infections. It states that antibiotic-resistant infections affect over 2 million Americans annually and cause around 23,000 deaths. These infections cost $20 billion in direct healthcare costs and $35 billion in lost productivity in the United States each year. Nearly 50% of antibiotics prescribed in the U.S. are unnecessary or inappropriate, contributing to the rise of resistance. Since the 1970s, 40 new infectious diseases have emerged, including influenza strains like swine flu, SARS, and MERS. There are currently 394 medicines and vaccines in development against infectious diseases. Vaccination has allowed diseases like hepatitis A/B and several cancers caused by viruses to now be preventable or targeted for elimination and

1. ANTIBIOTIC
I
N
F
E
C
RESISTANT
T
I
O N
AFFECT
2 MILLION+
AMERICANS
ANNUALLY
Source: Centers for Disease Control and Prevention (CDC)
S

2. ANTIBIOTIC
I
N
F
E
C
RESISTANT
T
I
O N
CAUSE
~23,000
DEATHS
ANNUALLY
Source: Centers for Disease Control and Prevention (CDC)
S

3. ANTIBIOTIC
I
F
N
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ACCOUNT FOR
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$20 BILLION
IN DIRECT HEALTH CARE COSTS
ANNUALLY
Source: Centers for Disease Control and Prevention (CDC)

4. ANTIBIOTIC
I
N
F
E
C
RESISTANT
T
I
O N
ACCOUNT FOR
$35 BILLION
IN LOST PRODUCTIVITY
ANNUALLY
Source: Centers for Disease Control and Prevention (CDC)
S

5. INFECTIOUS
R
E
S
I
S
DISEASES
T
A N C
NEARLY
50%
OF ANTIBIOTICS
UNNECESSARILY or
INAPPROPRIATELY
PRESCRIBED
Source: Centers for Disease Control and Prevention (CDC)
E

6. INFECTIOUS
DISEASES
E M E R G I N G T H R E A T S
SINCE 1970s
40
INFECTIOUS
DISEASES
DISCOVERED
—INCLUDING—
SWINE and AVIAN FLU
MERS and SARS
Source: World Health Organization (WHO)

7. INFECTIOUS
DISEASES
RESEARCH & DEVELOPMENT
394
MEDICINES
AND VACCINES
IN DEVELOPMENT AGAINST
INFECTIOUS DISEASES
Source: PhRMA 2013 Medicines in Development for
Infectious Diseases

8. INFECTIOUS
DISEASES
VACCINATION FOR PREVENTION
hepatitis A NOW PREVENTABLE
hepatitis B NOW PREVENTABLE
cancer caused by viruses NOW PREVENTABLE
pneumonia NOW PREVENTABLE
TARGETED FOR ELIMINATION rubella
TARGETED FOR ELIMINATION
measles
TARGETED FOR ELIMINATION
ERADICATED
Source: PhRMA 2013 Vaccine Fact Book
polio
smallpox