Detox For Physical Spiritual Health Rev 0111

Detoxification forDetoxification for
Physical and SpiritualPhysical and Spiritual
HealthHealth

www.designsforhealth.comwww.designsforhealth.com
Why is there a need toWhy is there a need to
Detox?Detox?
All of us live in an
ever-increasing
toxic environment

ENVIROMENTAL TOXINSENVIROMENTAL TOXINS
Many of the toxins
abundant in our
environment
today did not
even exist 30
years ago!

Toxic OverloadToxic Overload
• Body burden from
environmental toxins,
including pesticides,
herbicides, chemical
solvents, xenobiotics, and
industrial chemicals of all
types come through our
food, water, and air supply.

From The WaterFrom The Water
• Neurotoxins were found in
33% of a random
sampling of drinking
water (diazinon: from
insecticide)

From The AirFrom The Air
• Since WWII 80,000
new synthetic
chemicals have been
released into the
environment and less
than half have been
tested for potential
toxicity to adult
humans

Xenobiotic ExposureXenobiotic Exposure
• Over 4 billion pounds of pesticides are used annually in the U.S.
This amounts to 8 pounds for every man, woman, and child.
• Current law allows for 350 different pesticides to be used on the
food we eat.
• The average home contains 3-10 gallons of hazardous materials
• 400 Synthetic chemicals can be found in the average human body
• There is no single regulatory agency that oversees industrial
chemicals to ensure their safety: industrial chemicals are
presumed safe until proven hazardous even through they may
have physiological effects that are almost identical to a drug and
are often manufactured by pharmaceutical companies.
• Any toxicity testing that is done typically involves individual
compounds in highly controlled settings and almost never
investigates effects of complex mixtures.

EXPOSUREEXPOSURE
• In addition, we are
eating more sugar
and processed foods
than ever before in
human history and
regularly abuse our
bodies with various
stimulants and
sedatives.

Synergistic Effects of ToxinsSynergistic Effects of Toxins
• Cigarette Smoking increases the
risk of lung cancer by 10 times
• Asbestos exposure increases the
risk of lung cancer by 5 times
• Smoking and asbestos exposure
increase the risk of lung cancer
by 55 times
• Total Effect: More than additive
or even multiplicative!

Categories of ToxicantsCategories of Toxicants
• Pesticides
– Insecticides
– Herbicides
• Industrial Compounds and Chemical Byproducts
– Volatile organics such as solvents and detergents
– Toxic metals
– Plasticizers
– Insulators (asbestos)
• Combustion / Incineration Pollutants
• Synthetic Medications
• Food Additives and preparation by-products
• Cosmetic Additives

Toxic MetalsToxic Metals
Arsenic
Mercury
Lead
Cadmium
Aluminum
(see protocols for removal, DFH
website, Library – protocol section)

Heavy metalsHeavy metals
• Heavy metals such as mercury deposit in fat
cells.
• Is the body not eager to draw on this fat
because the mercury will get released into the
system??
• Could inability to lose weight be a protective
mechanism?
1-800-847-8302

• Whey Protein Raises Glutathione levels
up to 64%
- Glutathione is a sulfur-containing tripeptide made up of
glutamic acid, cysteine, and glycine
- present in high concentrations in almost every cell
- protects cells against free radical and hydrogen peroxide
damage
- respiratory carrier of oxygen
- regenerates Vitamin E and Vitamin C
- for every atom of mercury that is removed the body loses 3
glutathione tripeptides.

Chemical AdditivesChemical Additives
• Over 10,000 food and chemical additives are allowed
into the U.S. food supply including colorings,
sweeteners, stimulants, preservatives, flavorings,
emulsifiers, humectants and antimicrobials
• In 1984, 3,200 tons of coal tar dyes added to foods
• Average American eats approximately 14 pounds of
additives per year

Additional EnvironmentalAdditional Environmental
ToxicantsToxicants
• Microbial toxins
– Aflatoxin (peanuts)
– Mycotoxins from molds
• Medications and “lifestyle chemicals”
– Alcohol
– Acetaminophen
• By-products of food preparation
– Acrylamide from French Fries
– Nitrosamine from cold cuts and sausages
– Polycyclic aromatic hydrocarbons from charbroiled
meats

Endogenous Toxins:Endogenous Toxins:
Intestinal SourcesIntestinal Sources
• Products of dysbiosis
– Bacteria: putrescine, cadaverine,
ammonia
– Yeasts: arabinose, tartarate,
citramalate, beat ketoglutarate
– Secondary bile acids (deconjugated)
– Beta glucuronidase (causing
enterohepatic recirculation of
hormones and other toxins)

Chronic ToxicantChronic Toxicant
Exposure: A “Meta-Exposure: A “Meta-
process” Whichprocess” Which
• Amplifies Other Pathological
Processes
• Negatively Impacts General Health
• Creates or Contributes to a Wide
Variety of Chronic Diseases
• Accelerates Senescence

Chronic Exposure toChronic Exposure to
Environmental ToxicantsEnvironmental Toxicants::
Systemic Health EffectsSystemic Health Effects
• Carcinogenesis
• Endocrine & metabolic disruption
• Immunologic dysfunction
– Immunosuppression (direct effects on bone marrow)
– Autoimmunity & allergy
– Chronic inflammation (cardiovascular disease)
• Neurotoxicity
– Cognitive & behavioral dysfunction
– Neurodegenerative disorders
– Neuropathy

DetoxificationDetoxification
begins in the gutbegins in the gut

Detoxification: theDetoxification: the
ProcessProcess
• Detoxification refers to the metabolic
pathways via which cells transform
toxic substances into relatively inert
metabolites that can be readily
excreted via the urine or bile.
• Since the majority of toxic
substances are fat soluble, they have
an affinity for and are stored in high
fat tissues and organs when not
detoxified and excreted promptly.

Detoxification – theDetoxification – the
processprocess
• Most toxic substances are fat-soluble
and must be converted to a water-
soluble form before they can be
excreted.
• This is done in a two-step process
referred to as phase 1 and phase 2.
• Although most of this activity takes
place in the liver, about 25% occurs
in the small intestine, and all tissues
have some detoxification capacity.

The Liver is the MajorThe Liver is the Major
Detoxifying OrganDetoxifying Organ
The liver utilizes a two-phase system in
detoxifying the body of harmful substances:
• 11stst
:: Transforms toxins into more water-
soluble compounds that are then carried
through the blood to the liver for further
processing, or to the kidney for elimination.
• 22nd:nd:
Completing the detoxification in the
liver and sending the toxins back to the
kidney for elimination, or into the bile for
elimination via the GI tract.

Phase I & Phase IIPhase I & Phase II
• The congested or sluggish liver is
characterized by a diminished bile flow,
while impaired liver (hepatic)
detoxification refers to decreased phase I
and/or phase II enzyme activity.
• Phase I detoxification rates that are in
excess of phase II activity will also cause
toxicity problems due to excessive
accumulation of activated intermediates.

Imbalanced DetoxificationImbalanced Detoxification
Phase I
CYP P450
Phase II
Conjugation
Damage to DNA,
RNA, Proteins
Reactive IntermediateNon-Polar
Xenobiotic
Inert
Water-Soluble
Metabolite

Detox enzyme capacity isDetox enzyme capacity is
highly variablehighly variable
• Many phase 1 enzymes are induced by
their substrates.
• These are often xenobiotics.
• This leads to more rapid production of
reactive intermediates.
• Many substances including xenobiotics,
drugs and even nutrients (grapefruit) can
inhibit some phase 1 enzymes.
• This inhibition leads to an accumulation of
their substrates in the bloodstream and
increased storage in fatty tissues.

Phase 2Phase 2
• Phase 2 enzymes are highly
dependent on energy and on
adequate dietary protein.
• Phase 2 enzymes can be induced by
numerous substances found in fruits,
vegetables, spices and herbs.
• Both phase 1 and 2 are highly
dependent on adequate nutritional
status for their activity

excretory
derivatives
Supportive Nutrients for
Detoxification Pathways
Lipid-soluble
molecule
polar
water-soluble( )
Bile
Feces/stools
Serum
Kidneys
Urine
ATP
glutathione
glycine
taurine
glutamine
ornithine
arginine
methyl donors
N-acetylcysteine
cysteine
methionine
riboflavin (vit. B2)
niacin (vit. B3)
pyridoxine (vit. B6)
folic acid
vitamin B12
glutathione
branched-chain amino acids
flavonoids
phospholipids
Phase II
[conjugation
pathways]
Phase I
[cytochrome P450
enzymes]
Activated
Intermediates

Genetic VariationsGenetic Variations
• There are numerous genetic
variations in the activity of both
phase 1 and phase 2 enzymes.
• This, along with nutritional status
and total toxic load may help explain
why detoxification abilities for a
particular substance may vary as
much as 100-fold or more between
different individuals.

Causes of ImpairedCauses of Impaired
Detoxication: SummaryDetoxication: Summary
• Overwhelming toxic load
(exogenous + endogenous)
• Impaired excretion (constipation or
increased transit time; renal dysfunction)
• Inefficient fuels (macronutrient imbalance)
• Deficiency of detoxifying substances
(antioxidants, cofactors, conjugating
agents)
• Genetic Variation

Is Detox right for you?Is Detox right for you?
Detoxification can be beneficial for
those with one or more of the
following conditions:
Parasite infestation
Recurring headaches
Bad breath
Hemorrhoids
Irritability
Frequent colds
Protruding belly
Chronic constipation
Frequent gas & bloating
Excess weight
Frequent fatigue
Impaired digestion
Irritable Bowel Syndrome (IBS)
Candida infection

How Toxic Are You?How Toxic Are You?
TESTTEST
To find out
exactly where
you are at…

Common Signs & SymptomsCommon Signs & Symptoms
Linked toLinked to
Chronic Toxicant ExposureChronic Toxicant Exposure
• Marked sensitivity to environmental chemicals,
odors, medications, &/or nutritional supplements
• Chronic, debilitating fatigue & lethargy
• Depression, anxiety &/or mood swings
• Cognitive dysfunction (poor memory and
concentration; learning disorders)

Common Signs & SymptomsCommon Signs & Symptoms
Linked toLinked to
Chronic Toxicant ExposureChronic Toxicant Exposure
• Recurrent headaches
• Muscle aching & weakness
• Paresthesias and neuropathic
pain
• Recurrent infections
• Infertility

Disorders Linked ToDisorders Linked To
Toxicant ExposureToxicant Exposure
• Chronic Fatigue
Syndrome
• Fibromyalgia
• Multiple Chemical
Sensitivity
• Allergies, Asthma
• Atherosclerosis
• Cancer

Why Test…Why Test…
• TO:
– Point to metabolic dysfunctions that
lead to disease
– Show essential nutrient deficiencies
and digestive system abnormalities
that reveal root causes of symptoms
– Target use of vitamins, minerals, and
other essential nutrients
– Avoid costly, time-consuming, trial and
error processes

Assessing ToxicityAssessing Toxicity
• Identify pathological disruption
– Symptom questionnaire( MSQ, HAQ)
– Abnormal liver function tests
• Identify antecedents
– Genetic polymorphisms of phase I & II
enzymes
• Identify triggers
– Toxic metals
– Organic toxicants (fat biopsy; blood, urine)
• Identify mediators
– Oxidative stress markers
– Essential fatty acid profile

Provides a roadmap that recognizes multiple
interactions & deficiencies and translates that
information into specific corrections that can
lead to improved health.
Designs for HealthDesigns for Health
Comprehensive Metabolic ProfileComprehensive Metabolic Profile™

What the ComprehensiveWhat the Comprehensive
Metabolic Profile uncovers:Metabolic Profile uncovers:
• B Vitamin Status
• Cellular Energy
• Neural Function
• Detoxification Function
• Intestinal Microbial Balance Markers
• Fatty Acid Status
• IgG Food Antibodies

Detoxification TestingDetoxification Testing

Potential Benefits ofPotential Benefits of
the Detoxification Programthe Detoxification Program
• Increased Energy & Vitality
• Weight Loss
• Breaking Weight Loss Plateaus
• Better gut function
• Clearer thinking
• Improved Skin
• Better Sleep
• Improved Mood
What are you waiting for?

Why Can’t I just eat aWhy Can’t I just eat a
healthy diet?healthy diet?
• Individuals who are candidates for a
detoxification program have been typically
experiencing symptoms for long periods of
time.
• They have built up an excessive toxic
burden over time and have typically
depleted antioxidant reserves.
• They may have specific genetic
polymorphisms that require higher than
normal levels of particular nutrients

• Diet alone may not provide enough
concentrated nutrients to satisfy the
requirements of these individuals
• They may find it difficult to prepare fresh
whole organically grown meals because of
their health, travel or work schedules
• Medical foods like PaleoMeal provide a
concentrated source of appropriate
micronutrients within a hypoallergenic
matrix that cannot be duplicated by food
alone.

Why not just fast?Why not just fast?
• Breakdown of adipose tissue (lipolysis) results in
surge of toxins into the circulation further
overloading already impaired liver function
• Lack of fiber impedes fecal excretion and increases
enterohepatic recirculation
• Insufficient calories impairs biotransformation
(detoxification is highly energy dependent)

The Problem withThe Problem with
FastingFasting
• Fasting induces phase I enzymes--leading
to overproduction of toxic intermediates
• Lack of exogenous antioxidants
+ depletion of
endogenous glutathione
= inadequate quenching of free radicals
• Lack of cofactors impairs phase II
conjugation
• End result: oxidative stress, inflammation,
aggravation of symptoms

What about chronic GIWhat about chronic GI
problemsproblems
• These patients may have leaky gut, IgG-
mediated food allergies and inflammation.
• Their liver is constantly burdened by
toxins and allergens arriving from the gut.
• These patients need to go on a 4R
program to restore normal gut function
and relieve the burden on the liver before
they can become well.

[ The Road to
Immunity
By Stephen
Bock]

28 Day Detox Program28 Day Detox Program
• There are three evening (or weekend) meetings
between the DFH nutrition consultant and the
Detoxification participants.
• Meetings are held on day 1, day 8 and day 28 of
the program.
• The health care practitioner is encouraged to
attend, and it is suggested that they detox with
their patients.
• Meetings should be held at the practitioner’s
office if possible, with a minimum enrollment of 8
patients and a maximum of 20.

• Expect the meetings to last one hour =/-
depending on the number of participants and the
extent of their questions.
• The program’s suggested enrollment fee to the
patient is $450, which includes ALL fees and
supplements.
• Remember that you will be providing 45 meal
replacements during the course of the 21 day
detox.
• The patient will be SAVING $360 in meal costs
during the detox (using a value of only $8.00 per
meal)

• All Participants will be supplied with 2
PaleoCleanse, 1 each or 540gram and 900 gram
PaleoMeal their choice of flavor, PaleoGreens,
PaleoFiber, and a 30 day supply of Detoxification
Support Packets.
• Detoxification Support Packets contains 3 Amino
D-Tox, 1 Detox-Antiox and 1 LV-GB
• Patients have the option of getting Dairy Free
PaleoMeal and their choice of flavor of Lemon-
lime, Mint or unflavored PaleoGreens

Comprehensive Support for LiverComprehensive Support for Liver
Detoxification and CleansingDetoxification and Cleansing
• PaleoCleanse
– Quality hypoallergenic protein and macronutrients to
fuel detox pathways
– Full multivitamin / multimineral for detox enzyme
support
– Specific nutrients to support and balance phase I & II
metabolic pathways
– High levels of antioxidant support for safe detoxification
– Botanical hepatics, alternatives and cholagogues to
promote liver function and elimination
– The only detox powder that tastes great and does not
contain fructose

• PaleoMeal
– Optimizes intake of proteins, fats, carbohydrates and
micronutrients
– Exceptional quality whey protein which comes from
herds that graze on pesticide-free, chemical-free natural
grass pastures. No bovine growth or any other
hormones, nor genetically modified organisms or
injected pathogens.
– Cold processed protein rich in immunoglobulins and
lactoferrin free of artificial flavors
– Benefits of high quality protein
• raises HDL, lower triglycerides, benefits insulin resistance,
promotes lean muscle growth, promotes satiety and
gluconeogenesis
• source of amino acids, cysteine and leucine, which support
the production of detoxifying elements needed to eliminate
mercury from the body

• PaleoMeal
– 840 mg of phosphatidyl choline per serving which is the
most important nutrient for liver support
• liver cell membranes are made of phosphatidyl choline
– 2.5 grams of Flaxseed powder per serving
• Flaxseeds contain lignans which are anticancer,
antibacterial, antifungal and antiviral
– 900 mg L-Glutamine per serving
• Glutamine is an amino acid which is essential for the health
of the immune system and digestive tract
• promotes optimal muscle growth and strength
– NatureFolate (equal to more then 200mcg Folic Acid)
• Made from concentrated vegetable juice powder including
5-methyltetrahydrofolate, 5-formyltetrahydrofolate and
fortified 5-formyltetrahydrofolate as calcium folinate
• more bioavailable than synthetic folic acid
– Glutathione
• body’s master antioxidant

Additional Support for Detox ProgramAdditional Support for Detox Program
• PaleoGreens
– Great tasting greens food made with organic ingredients
– 90% active ingredients compared to other formulas with
up to 60% fillers
– No grains, legumes, low allergenic
– No alfalfa a common ingredient in other leading brands
which has been shown to aggravate autoimmune
disease
– Freeze-dried vs spray-dried resulting in ultra-low
maltodextrin carrier content
– Barley and wheat grass are 100% cold-processed juice
solids vs powders, resulting in 3 times the amount of
chlorophyll of other formulations
– Certified organic spirulina
– Kale, broccoli and cauliflower sprouts assessed to
contain high levels of glucosinolates and sulforaphanes

• PaleoFiber
– 12 Types of fiber includes:
• acacia gum, guar gum, cellulose gum, carrot fiber,
cranberry and flax seeds, psyllium husk, apple pectin,
orange and prune fiber, and two root fibers: inulin from
chicory root and Konjac Glucomannan
– Gluten, Lectin and Phytate free (low allergenicity)
– Significant antioxidant activity from Fibregum Tan and
Cranberry seed
• unique acacia gum high in polyphenols
• cranberry seed also high in anthocyanidins
– Good balance of soluble and insoluble fibers
– Guaranteed purity
• natural flavored and no artificial sweeteners or colors

• PaleoFiber
– Arabinogalactan from acacia tree
• Prebiotic which supports growth of friendly bacteria,
bifidobacteria, lactobacilli while inhibiting clostridium
• Certified antioxidant capacity of 39 ORAC units due to its
polyphenol content
– Cranberry seed extract with ORAC value of 197
– Probiotics
• room stable lactobicillus and bifidus strains
– Guar Gum which reduces Glycemic load of a meal
– Protects from environmental toxins
– Reduces appetite and prolonged sense of fullness
between meals

• Amino D-Tox
– Encapsulated formula for support of liver detoxification
– Perfect for those that may need added cleansing support
in addition to PaleoCleanse
– Supports Phase II (conjugation) without upregulating
Phase I (CP-450) for imbalanced or pathological
detoxifiers
– Formulated to minimize potential for allergenicity and
suited for the most sensitive patients with multiple
chemical sensitivity

• LV-GB Complex
– Provides support for liver and gallbladder function by
providing lipotropic substances to aid in the elimination
of fatty substances from the liver, as well as promoting
proper bile flow.
• L-methionine, L-taurine, Inositol and Choline, Beta-
carotene, Ox bile
– Critical catalysts of hepatic detoxification enzymes
• pyridoxyl 5-phosphate form of B6, Folic Acid, B12
– Botanical hepatic and cholagogue aid for optimal
processing and elimination of toxins
• Milk Thistle, Greater Celandine, Dandelion, Fridge Tree,
Artichoke, Beet extract

• Detox Antiox
– Synergistic formula designed to combat free radicals and
help detoxify harmful chemicals including heavy metals
– Contains L-Leucine when taken with NAC prevents
mercury from being re-absorbed into the central
nervous system
– Improved Formula!!
• Alpha Tocopherol - all inclusive mixed tocopherols
• Lipoic Acid added to regenerate Vitamin E and C
• Proprietary Leucoselect Grape Seed Extract is phospholipid
bound for superior absorptioin and standardized for
polyphenol activity
• Standardized Curcumin 95% curcuminoids
• Standardized Green Tea 50% EGCG
• Albion Chelated Manganese and Molydbenum
• Methionine bound Zinc and Selenium

• What does that mean to you?
– Formula aids in the synthesis of metallothionine which is
an important zinc binding protein which helps in the
removal of heavy metals such as cadmium.
– Methionine is a sulfur containing amino acid involved in
Phase II detoxification
– The metabolism and excreation of heavy metals depend
on the presence of antioxidants
– Antioxidants reduce the damage from free radicals that
alter mitochondrial activity and genetic information

Justifying cost of the 28 DayJustifying cost of the 28 Day
Detoxification ProgramDetoxification Program
• Not only do we include all the supplements but
we also include enough products to provide
45 COMPLETE MEAL REPLACEMENTS!
• Most Americans spend around $8.00 per meal
• 45 meals at $8.00 is $360
• One DFH Detox Program meal replacement
including high quality protein, multivitamins,
multiminerals along with the macronutrients and
botanicals needed to fuel detox pathways, along
with our PaleoGreens and fiber to provide you
with 3 servings of fruits and veggies and prolong
your sense of fullness costs only $7.20 per meal

Justifying cost of the 28 DayJustifying cost of the 28 Day
Detoxification ProgramDetoxification Program
• Is $15 a day worth a program that is one of the
most exciting and simplest tools that natural
medicine has to offer?
• If you take the ENTIRE cost of the program,
including 3 coaching sessions, educational
materials, email support and a wrap up
conversation that gets the patients on a monthly
maintenance program for less than what your
patients would be paying for just the meals that
are being replaced…..
• Can you see how you can attract a bunch of
patients into essentially a FREE program like
this?

SummarySummary
• Detoxification is a continuous physiologic process
that your body depends on for survival.
• There are complex cellular detoxification
mechanisms that are constantly at work for you
all day, every day.
• Natural and synthetic chemicals are processes by
this complex system of cells, organs, and organ
systems to keep you healthy in the face of a
virtually constant barrage of toxic material
• Our program is an excellent tool to improve your
detoxification

Mental DetoxificationMental Detoxification
• Relax…Breathe…Go for walks…
• Enjoy the change of season
• This is a time for you to care for your
unique self…
• You are a priority, if only for this
short time
The cleansing of our mind of negative thought pattern, is
essential to health and physical detoxification and can aid in
this process. Emotionally, detoxification helps us uncover and
express hidden frustrations, anger, resentments and fear and
replace them with forgiveness, love, joy and hope.

Detox For Physical Spiritual Health Rev 0111

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Detox For Physical Spiritual Health Rev 0111