This newsletter from Senology.org provides information on recent developments in breast cancer research and treatment. It includes summaries of several new studies on topics such as obesity and breast cancer outcomes, metformin treatment for early breast cancer, and breast cancer treatment during pregnancy. It also lists upcoming conferences and provides a commentary and Q&A on the potential link between night shift work and breast cancer risk. The newsletter aims to connect specialists around the world and keep them informed of the latest advances in clinical oncology.

1. Senology Newsletter Page 1 of 3
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community (ISOSC)
"Connecting specialists worldwide"
Editor-in-Chief: Gian Paolo Andreoletti, MD
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real-time updates
Literature Selection
Sparano JA et al.: "Obesity at diagnosis is associated with inferior outcomes in hormone receptor-
positive operable breast cancer", Cancer. 2012 Aug 27 [Epub ahead of print]
Niraula S et al.: "Metformin in early breast cancer: a prospective window of opportunity neoadjuvant
study", Breast Cancer Res Treat. 2012 Aug 30. [Epub ahead of print]
Loibl S et al.: "Treatment of breast cancer during pregnancy: an observational study", Lancet Oncol.
2012 Sep;13(9):887-96
Cuk K et al.: "Circulating microRNAs in plasma as early detection markers for breast cancer", Int J
Cancer. 2012 Aug 28 [Epub ahead of print]
Autier P et al.: "Mammography screening and breast cancer mortality in Sweden", J Natl Cancer Inst.
2012 Jul 18;104(14):1080-93
Karlsson P et al.: "Patterns and risk factors for locoregional failures after mastectomy for breast
cancer: an International Breast Cancer Study Group report", Ann Oncol. 2012 Jul 9. [Epub ahead of
print]
Jeevan R et al.: "Reoperation rates after breast conserving surgery for breast cancer among women in
England: retrospective study of hospital episode statistics", BMJ. 2012 Jul 12;345 e4505
Shah C et al.: "Clinical outcomes using accelerated partial breast irradiation in patients with ductal
carcinoma in situ", Clin Breast Cancer. 2012 Aug;12(4):259-63
Comment
"Association between night-work and breast cancer risk", Johnni Hansen, Institute of Cancer
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2. Senology Newsletter Page 2 of 3
Epidemiology, Danish Cancer Society, Copenhagen, Denmark
"Our study has the following clinical implications: 1) Overall, this study further strengths the evidence for an
association between night-work and breast cancer risk. Now, 10 out of 13 epidemiological studies have
supported this link, which was evaluated by the International Agency for Research on Cancer in 2007 as
“possibly carcinogenic”. 2) The breast cancer risk seems minimal, if any, for less than 3 consecutive night
shifts per week. 3) Diurnal preference seems to be an indicator of breast cancer risk. 4) Especially women
with morning preference should avoid or limit night shift work. 5) Further studies are needed and ongoing,
also in other potential target organs such as the prostate and colo-rectal. "
(Commentary on: Hansen J et al.: "Nested case-control study of night shift work and breast cancer
risk among women in the Danish military", Occup Environ Med. 2012 [Epub ahead of print])
Calendar of Events
IBUS Update in Breast Imaging, 19 - 22 September 2012, Ferrara, Italy
12th Michelangelo Foundation Seminar: “Moving from adjuvant to neoadjuvant trials for development
of new therapies in breast cancer: a hopeless heresy or a feasible paradigm shift?”, October 12, 2012
Milan, Italy
17th World Congress on Breast Diseases of the Senologic International Society, -SIS, October 10-13,
2012, Salvador, Bahia, Brazil
Breast Cancer in Young Women Conference, 8-10 November 8-10, 2012, Dublin, Ireland
IBUS - International Breast Ultrasound Course, 13 - 15 November 2012, Tel Aviv, Israel
8th Meet the Professor. Advanced International Breast Cancer Conference (AIBCC), November 15-17,
2012, Padova , Italy - under the Patronage of Senology.org
2012 CTRC-AACR San Antonio Breast Cancer Symposium , December 4-8, 2012, San Antonio, TX,
USA
Literature Selection
Tavani A et al.: "Dietary folates and cancer risk in a network of case-control studies", Ann Oncol. 2012
Aug 16. [Epub ahead of print]
Nam JH et al.: "Association of the interval between endoscopies with gastric cancer stage at
diagnosis in a region of high prevalence,", Cancer. 2012 Jul 16. doi: 10.1002/cncr.27495. [Epub ahead
of print]
de Vathaire F et al.: "Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer
survivors: a retrospective cohort study", Lancet Oncol. 2012 Aug 22. [Epub ahead of print]
Levenback CF et al.: "Lymphatic Mapping and Sentinel Lymph Node Biopsy in Women With
Squamous Cell Carcinoma of the Vulva: A Gynecologic Oncology Group Study, J Clin Oncol. 2012 Jul
2. [Epub ahead of print]
Wilt TJ et al.: "Radical prostatectomy versus observation for localized prostate cancer", N Engl J Med.
2012 Jul 19;367(3):203-13
Heijnsdijk EA et al. : "Quality-of-life effects of prostate-specific antigen screening", N Engl J Med.
2012 Aug 16;367(7):595-605
Choe KS et al.: "Aspirin Use and the Risk of Prostate Cancer Mortality in Men Treated With
Prostatectomy or Radiotherapy", J Clin Oncol. 2012 Aug 27. [Epub ahead of print]
Kunath F et al.: "Tamoxifen for the management of breast events induced by non-steroidal
antiandrogens in patients with prostate cancer: A systematic review", BMC Med. 2012 Aug 28;10
(1):96. [Epub ahead of print]
Petrelli F et al.: "Risk of venous and arterial thromboembolic events associated with anti-EGFR
agents: a meta-analysis of randomized clinical trials", Ann Oncol. 2012 Jul;23(7):1672-9
Fragments of History
1910 - Discovery of a viral cause of avian cancer by Francis Peyton Rous (Baltimora, October 5, 1879 - New
York, February 16, 1970). Rous P. : "A transmissible avian neoplasm (Sarcoma of the common fowl)", J
Exp Med. 1910 Sep 1;12(5).696-705
Literature Selection
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Le Ray I et al.: "Local estrogen therapy and risk of breast cancer recurrence among hormone-treated
patients: a nested case-control study", Breast Cancer Res Treat. 2012 Sep;135(2):603-9
Nichols HB et al.: "Postoophorectomy Estrogen Use and Breast Cancer Risk", Obstet Gynecol. 2012
Jul;120(1):27-36
Senology.org collaborates with TalkAboutHealth.com - "Cancer questions, answers, and support". Follow the
Expert Q&A Workshops and join the conversation.
Q&A of the month
"What are tumorgrafts and how can they help me personalize my cancer treatment? "
"Every patient’s cancer is unique. Two patients with the same type of cancer will often respond
differently to the same treatment. Tumorgrafts are pieces of living tumor tissue from a specific patient
that are implanted (or grafted) into a mouse. Once the patients tumor (graft) begins to grow in the
mice, it can be expanded in additional mice and tested against different cancer drugs. The graft can
be used to personalize cancer therapy by finding the drug or combination of drugs that works best to
shrink the tumor in the mouse. This information can then be used by the treating physician to
personalize the patient’s cancer care ."
(Answer by David Sidransky, Johns Hopkins Hospital, Baltimore, MD USA)
Next Q&A Workshops
"Neuro- Oncology", with Lawrence Recht, Stanford Cancer Institute, September 10, 2012
"Uveal melanoma", with William Harbour, University of Miami, September 11, 2012
Stay informed....
Recent Advances in Clinical Medicine
Olmes MJ et al.: "Eltrombopag and improved hematopoiesis in refractory aplastic anemia", N Engl J
Med. 2012 Jul 5;367(1):11-9
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