Latest Advances in Clinical Senology and Oncology

1. Senology Newsletter Page 1 of 3
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community (ISOSC)
"Connecting specialists worldwide"
Editor-in-Chief: Gian Paolo Andreoletti, MD
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de Koning H: "A tribute to Stefano Ciatto (2 June 1949-4 May 2012)", J Med Screen. 2012 Sep 8. [Epub
ahead of print]
Literature Selection
The Cancer Genome Atlas Network : "Comprehensive molecular portraits of human breast tumours",
Nature. 2012 Sep 23. [Epub ahead of print]
Pijpe A et al.: "Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2
mutations: retrospective cohort study (GENE-RAD-RISK)", BMJ. 2012 Sep 6;345:e5660. doi:
10.1136/bmj.e5660
Falck AK et al.: "Analysis of and prognostic information from disseminated tumour cells in bone
marrow in primary breast cancer: a prospective observational study", BMC Cancer. 2012 Sep 11;12
(1):403. [Epub ahead of print]
Maaskant-Braat AJ et al.: "Sentinel Node and Recurrent Breast Cancer (SNARB): Results of a
Nationwide Registration Study", Ann Surg Oncol. 2012 Sep 1. [Epub ahead of print]
Solà M et al.: "Complete Axillary Lymph Node Dissection Versus Clinical Follow-up in Breast Cancer
Patients with Sentinel Node Micrometastasis: Final Results from the Multicenter Clinical Trial AATRM
048/13/2000", Ann Surg Oncol. 2012 Sep 7. [Epub ahead of print]
Iwata H et al.: "Analysis of Ki-67 expression with neoadjuvant anastrozole or tamoxifen in patients
receiving goserelin for premenopausal breast cancer", Cancer. 2012 Sep 12. doi: 10.1002/cncr.27818.
[Epub ahead of print]
Karasawa K et al.: "Comparison of hypofractionated and conventionally fractionated whole-breast
irradiation for early breast cancer patients: a single-institute study of 1,098 patients", Breast Cancer.
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2. Senology Newsletter Page 2 of 3
2012 Sep 12. [Epub ahead of print]
Cramer H et al.: "Yoga for breast cancer patients and survivors: a systematic review and meta-
analysis", BMC Cancer. 2012 Sep 18;12(1):412. [Epub ahead of print]
Comment
"The European breast screening programmes are preventing large numbers of breast cancer deaths" ,
Mireille Broeders, Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical
Centre, Nijmegen, The Netherlands
"After considering all published data from European studies, the reduction in breast cancer mortality
associated with mammographic population-based service screening programmes is in the range of 25–31%
for women invited for screening and 38–48% for women actually screened with sufficient follow-up time. It
appears that much of the current controversy surrounding the value of mammography screening is due to the
use of inappropriate methodological approaches that are unable to capture the true effect of mammographic
screening. Overall, the results of this first comprehensive review of European breast screening services show
that for every 1,000 women screened every two years from the age of 50 to the age of about 68-69, between
seven and nine lives would be saved, and four cases would be over-diagnosed. The European breast
screening programmes are preventing large numbers of breast cancer deaths, and the benefits outweigh the
harms of screening. The programmes should continue to provide high quality screening services and should
work towards achieving targets on coverage, uptake and assessment rates. In addition, communication
methods should be improved in order to raise women’s awareness, and to make information on the pros and
cons of breast cancer screening more accessible, relevant and comprehensible"
(Commentary on: Broeders M et al.: "The impact of mammographic screening on breast cancer
mortality in Europe: a review of observational studies ", J Med Screen 2012 Sep: 19(1): 14-25)
"Review of breast cancer screening programs in Europe: lives saved by screening outweigh over-
diagnosed cases by a factor of two to one" - Share your opinion on LinkedIn®
Calendar of Events
12th Michelangelo Foundation Seminar: “Moving from adjuvant to neoadjuvant trials for development
of new therapies in breast cancer: a hopeless heresy or a feasible paradigm shift?”, October 12, 2012
Milan, Italy
17th World Congress on Breast Diseases of the Senologic International Society, -SIS, October 10-13,
2012, Salvador, Bahia, Brazil
Breast Cancer in Young Women Conference, 8-10 November 8-10, 2012, Dublin, Ireland
IBUS - International Breast Ultrasound Course, 13 - 15 November 2012, Tel Aviv, Israel
8th Meet the Professor. Advanced International Breast Cancer Conference (AIBCC), November 15-17,
2012, Padova , Italy - with the Patronage of Senology.org
2012 CTRC-AACR San Antonio Breast Cancer Symposium , December 4-8, 2012, San Antonio, TX,
USA
Literature Selection
Stoffels I et al.: "Association between sentinel lymph node excision with or without preoperative
SPECT/CT and metastatic node detection and disease-free survival in melanoma", JAMA. 2012 Sep
12;308(10):1007-14
The Cancer Genome Atlas Research Network: "Comprehensive genomic characterization of
squamous cell lung cancers", Nature. 2012 Sep 9. doi: 10.1038/nature11404. [Epub ahead of print]
Moyer VA et al.: "Screening for Ovarian Cancer: U.S. Preventive Services Task Force Reaffirmation
Recommendation Statement", Ann Intern Med. 2012 Sep 11 [Epub ahead of print]
Huang ZM et al.: "Minimally invasive therapies have good survival rate for patients with unresectable
pancreatic cancer", Chin J Cancer. 2012 Sep 10. doi: 10.5732/cjc.012.10093. [Epub ahead of print]
Uehara T et al.: "H. pylori Infection Is Associated with DNA Damage of Lgr5-Positive Epithelial Stem
Cells in the Stomach of Patients with Gastric Cancer", Dig Dis Sci. 2012 Sep 4. [Epub ahead of print]
Kennedy TJ et al.: "Laparoscopic radiofrequency ablation for the management of colorectal liver
metastases: 10-year experience", J Surg Oncol. 2012 Sep 20 [Epub ahead of print]
Lacson JC et al.: "Population-based case-control study of recreational drug use and testis cancer risk
confirms an association between marijuana use and nonseminoma risk", Cancer. 2012 Sep 10. doi:
10.1002/cncr.27554. [Epub ahead of print]
Fragments of History
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3. Senology Newsletter Page 3 of 3
1914 - Proposal by Theodor Boveri (Bamberg, 1862 - Wurzburg, 1915) that cancer can be triggered by
chromosomal mutations
Literature Selection
Pavone ME et al.: "Aromatase inhibitors for the treatment of endometriosis", Fertil Steril. 2012 Sep 19
[Epub ahead of print]
Zeng XT et al.: "Passive Smoking and Cervical Cancer Risk: A Meta-analysis Based on 3,230 Cases
and 2,982 Controls", Asian Pac J Cancer Prev. 2012;13(6):2687-93
Senology.org collaborates with TalkAboutHealth.com - "Cancer questions, answers, and support". Follow the
Expert Q&A Workshops and join the conversation.
Q&A of the month
"What is the current status of targeted therapies for ovarian cancer?"
"Currently the only targeted therapy routinely employed in ovarian cancer is directed at the cancer-
associated blood vessels. The term, “anti-angiogenesis”, is employed to describe this therapeutic
concept. The drug, bevacizumab, has been shown to be helpful in some patients when used alone
(single agent therapy) or employed in combination with certain chemotherapeutic agents. Other
targeted therapies remain under active clinical investigation (for example, PARP inhibitors), but have
not at this point in time been approved for routine use by the FDA outside the confines of clinical
trials"
(Answer by Maurie Markman, Cancer Treatment Centers of America, USA)
Stay informed....
Recent Advances in Clinical Medicine
Gold R et al.: "Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis ",N
Engl J Med. 2012 Sep 20;367(12):1098-107
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