This newsletter provides information on recent advances in senology and oncology. It includes summaries of recent literature on topics such as using digital mammography plus tomosynthesis versus digital mammography alone in breast cancer screening. It also provides information on upcoming conferences and workshops, and highlights recent publications on various cancer types from journals. Readers are encouraged to join online groups and forums to discuss issues and share opinions.

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Senology.org - Newsletter
International Senologic and Oncologic Scientific Community (ISOSC)
"Connecting specialists worldwide"
Editor-in-Chief: Gian Paolo Andreoletti, MD
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Literature Selection
Skaane P et al.: "Comparison of Digital Mammography Alone and Digital Mammography Plus
Tomosynthesis in a Population-based Screening Program", Radiology. 2013 Jan 7. [Epub ahead of
print]
Marinovich ML et al.: "Meta-analysis of Magnetic Resonance Imaging in Detecting Residual Breast
Cancer After Neoadjuvant Therapy", J Natl Cancer Inst. 2013 Jan 7. [Epub ahead of print]
Magbanua MJ et al.: "Genomic profiling of isolated circulating tumor cells from metastatic breast
cancer patients", Cancer Res. 2013 Jan 1;73(1):30-40
Wallwiener M et al.: "The prognostic impact of circulating tumor cells in subtypes of metastatic breast
cancer", Breast Cancer Res Treat. 2013 Jan;137(2):503-10
Zhu Q et al.: "Breast Cancer: Assessing Response to Neoadjuvant Chemotherapy by Using US-guided
Near-Infrared Tomography", Radiology. 2012 Dec 21. [Epub ahead of print]
Goss PE et al.: "Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a
randomised, controlled, phase 3 trial", Lancet Oncol. 2012 Dec 7 [Epub ahead of print]
Prat A et al.: "Prognostic Significance of Progesterone Receptor-Positive Tumor Cells Within
Immunohistochemically Defined Luminal A Breast Cancer", J Clin Oncol. 2012 Dec 17. [Epub ahead of
print]
Zhang X et al.: "Postmenopausal plasma sex hormone levels and breast cancer risk over 20 years of
follow-up", Breast Cancer Res Treat. 2013 Jan 3. [Epub ahead of print]
Eliassen AH et al.: "Circulating Carotenoids and Risk of Breast Cancer: Pooled Analysis of Eight
Prospective Studies", J Natl Cancer Inst. 2012 Dec 6. [Epub ahead of print]
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Comment
"Antiviral therapy should be used in patients with HBV-related hepatocellular carcinoma after curative
resection" - Chun-Ying Wu, School of Medicine, National Yang-Ming University, Taipei, Taiwan
"Tumor recurrence is a major issue for patients with hepatocellular carcinoma (HCC) following curative liver
resection. In the present study, we found antiviral agents can reduce one-third HBV-related HCC tumor
recurrence after curative liver resection for hepatitis B virus (HBV)-related HCC patients,. Based on 100,983
HCC patients in the Taiwan's nationwide database, we identified 518 HBV-related HCC patients receiving
nucleoside analogues and 4051 untreated HBV-related HCC patients. After adjusting competing mortality,
we found the treated group had significantly reduced 6-year HCC recurrence rate and overall mortality rate.
We recommend antiviral therapy should be used in HBV-related HCC patients after curative resection".
(Commentary on: Wu CY et al.: "Association between nucleoside analogues and risk of hepatitis B
virus–related hepatocellular carcinoma recurrence following liver resection", JAMA. 2012 Nov
14;308(18):1906-14)
Discussion
"Breast cancer screening: significant increase in cancer detection rates and decrease in false-positive
rates with mammography plus tomosynthesis compared with mammography alone " - Share your opinion on
LinkedIn
Questions and Answers
Breast Cancer Workshop Summary - with Gabriel Hortobagyi, The University of Texas MD Anderson
Cancer Center, Houston, Texas, USA
Calendar of Events
Breast-Gynecological International Cancer Congress, January 17-18, 2013, Cairo, Egypt
13th St. Gallen International Breast Cancer Conference, March 13-16, 2013, St. Gallen, Switzerland
5th IMPAKT Breast Cancer Conference, May 2-4, 2013, Brussels, Belgium
Literature Selection
Wand HM et al.: "Improved survival outcomes with the incidental use of beta-blockers among patients
with non-small-cell lung cancer treated with definitive radiation therapy", Ann Oncol. 2013 Jan 8.
[Epub ahead of print]
Lindgren ME et al.: "Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer
patients", Psychooncology. 2012 Dec 17 [Epub ahead of print]
Francica G et al.: "Long-term effectiveness of Radiofrequency Ablation for solitary small
Hepatocellular Carcinoma: A retrospective analysis of 363 patients", Dig Liver Dis. 2012 Dec 12 [Epub
ahead of print]
Hosaka T et al.: "Long-term entecavir treatment reduces hepatocellular carcinoma incidence in
patients with hepatitis B virus infection", Hepatology. 2012 Dec 5 [Epub ahead of print]
Bao Y et al.: "A Prospective Study of Plasma Adiponectin and Pancreatic Cancer Risk in Five US
Cohorts", J Natl Cancer Inst. 2012 Dec 14. [Epub ahead of print]
Pence BC et al.: "Combination aspirin and/or calcium chemoprevention with colonoscopy in
colorectal cancer prevention: cost-effectiveness analysis", Cancer Epidemiol Biomarkers Prev. 2012
Dec 18. [Epub ahead of print]
Thosani N et al.: "Reduced Risk of Colorectal Cancer With Use of Oral Bisphosphonates: A
Systematic Review and Meta-Analysis", J Clin Oncol. 2012 Dec 26. [Epub ahead of print]
Isham CR et al.: "Pazopanib enhances Paclitaxel-induced mitotic catastrophe in anaplastic thyroid
cancer", Sci Transl Med. 2013 Jan 2;5(166):166ra3
Kinde I et al.: "Evaluation of DNA from the papanicolaou test to detect ovarian and endometrial
cancers", Sci Transl Med. 2013 Jan 9;5(167):167ra4
Questions and Answers
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Leukemia Workshop Summary - with Jorge Cortes, The University of Texas MD Anderson Cancer Center,
Houston, TX, USA
Bladder Cancer Workshop Summary - with Steven Wong, UCLA School of Medicine, Los Angeles, CA,
USA
Pediatric Neuro-Oncology Workshop Summary - with Adam Levy, Children's Hospital at Montefiore, New
York, NY, USA
Palliative Care Workshop Summary - with Thomas Smith, Johns Hopkins Sidney Kimmel Comprehensive
Cancer Center, Baltimore, MD, USA
Melanoma Workshop Summary - with David Fisher, Massachusetts General Hospital, Boston, MA, USA
Fragments of History
Sidney Farber (1903–1973) showed for the first time in 1948 that folic acid antagonists could induce
temporary remission in childhood leukemia (Farber S et al.: “Temporary remissions in acute leukemia in
children produced by folic acid antagonist, 4-amino-pteroyl-glutamic acid (aminopterin)”, N Engl J
Med 1948;238:787-793)
Literature Selection
Gupta J et al.: "Levonorgestrel intrauterine system versus medical therapy for menorrhagia, N Engl J
Med. 2013 Jan 10;368(2):128-37
Stay informed....
Recent Advances in Clinical Medicine
Gane EJ et al.: "Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C ", N Engl J
Med. 2013 Jan 3;368(1):34-44
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