This document discusses key concepts in pharmacology. It begins by defining pharmacology as the science of drugs and their interactions within living systems. It then discusses what drugs are and what they can and cannot do. The rest of the document outlines general pharmacological principles like pharmacokinetics, pharmacodynamics, and adverse drug reactions. It emphasizes the importance of studying pharmacology and provides guidance on how to study topics like classifications, mechanisms of action, and indications of drugs. The document stresses continuous lifelong learning in pharmacology.

2. CONGRATULATIONS……..
YOU ALL HAVE FAILED

3. YOU ALL HAVE FAILED
TO MISS SUCCESS….!

17. PHARMACOLOGY-
KNOW-WHAT, KNOW-WHY, KNOW
Dr. V.SATHYA NARAYANAN M.B.B.S., M.D.,
PROFESSOR OF PHARMACOLOGY

26. PHARMACOLOGY TEXT BOOKS

27. PHARMACOLOGY TEXT BOOKS

29. WHAT IS PHARMACOLOGY ?
∗ SCIENCE OF DRUGS
AND THEIR
∗ INTERACTIONS ON LIVING SYSTEM

34. WHAT IS A DRUG ?
∗ ANY SUBSTANCE
USEFUL FOR
∗ CURING THE DISEASE
∗ PREVENTING THE DISEASE

37. WHAT A DRUG ALSO CAN DO ?
∗ HARM- From minor to serious
∗ Sometimes even FATAL

42. WHAT A DRUG CANNOT DO?
∗ Magical cure for every disease…

47. WHY PHARMACOLOGY ?

48. Increased intake of a prescribed
and unPrescribed medicine

49. Prescribing drugs is the deciding
factor in patient cure

51. To choose drugs wisely

52. WHEN TO STUDY PHARMACOLOGY ?

53. KNOW-WHEN?
∗ NOW AND…
∗ EVERYDAY
∗ WITH BOOKS AND PATIENTS
∗ GUIDED BY EXPERTS

57. CONTINUOUS AND EVEN
LIFELONG….
∗ Should be continuous, life long

59. WHAT TO STUDY IN
PHARMACOLOGY?

61. WHAT TO STUDY IN PHARMACOLOGY ?
∗ General pharmacology
- Definitions
- Routes of drug administration
- Pharmacokinetics
- Pharmacodynamics
- Adverse drug reactions
∗ Systemic pharmacology
- ANS, CVS, blood, autacoids related drugs, RS, CNS,
GIT, Hormones, Chemotherapy

62. General pharmacological principles
∗

63. Definitions

64. Routes of drug administration

65. PHARMACOKINETICS
∗ What the body does to the drug.

66. Pharmacokinetics
Is what the body does to the drug.
∗ Absorption
∗ Distribution
∗ Metabolism
∗ Elimination

68. PHARMACODYNAMICS
∗ What the drug does to the body.
∗

69. Pharmacodynamics
Is what the drug does to the body.
Interaction of drugs with cellular proteins, such as
receptors or enzymes, to control changes in
physiological function of particular organs.
∗ Drug-Receptor Interactions
∗ Binding
∗ Dose-Response
∗ Effect
∗ Signal Transduction
∗ Mechanism of action, Pathways

70. Endogenous compounds act on their
Receptors
Neurotransmitter
Neuropeptides
Hormones
Ions
http://www.morphonix.com/software/education/science/brain/game/specimens/neurotrans

71. Drug-Receptor Interactions
∗Drug-receptor interactions  signals to trigger a cascade of
events. collection of many cellular responses serve to amplify
the signal produce a final effect.
∗Effectors are thus the molecules that translate the drug-
receptor interaction into changes in cellular activity.
•  •+         EFFECT
DRUG UG + RECEPTOR DRUG + RECEPTOR EFFECTOR EFFECTOR
INTERACTION COMPLEX SYSTEM
STIMULUS BINDING ACTIVATION TRANSDUCTION
AMPLIFICATION RESPONSE
SIGNALLING PATHWAY

74. Adverse drug reactions

80. Prevention is better than cure

81. Clinical pharmacology & drug
development

84. SYSTEMIC PHARMACOLOGY

85. Systemic pharmacology
∗ ANS
∗ CVS
∗ BLOOD
∗ Autacoids
∗ RS
∗ CNS
∗ GIT
∗ Hormones
∗ Chemotherapy

86. KNOW-HOW

88. HOW TO STUDY PHARMACOLOGY ?
∗ Classification
∗ Pharmacological actions
∗ Mechanism of action
∗ Pharmacokinetics
∗ Adverse drug reactions
∗ Drug interactions
∗ Precautions
∗ Contraindications
∗ Indications (Therapeutic uses)

89. Classification

90. Pharmacological actions

91. Mechanism of action

92. Pharmacokinetics

93. Adverse drug reactions

94. Drug interactions

95. Precautions

96. Contraindications

97. Indications (Therapeutic uses)

118. DO”S
∗ Keep correct time
∗ Be attentive
∗ Hear and listen
∗ Take notes
∗ Be relaxed
∗ Maintain silence

120. DON”Ts
∗ Talk with others during lecture
∗ Use cellphones
∗ Call the names of your friends

123. Even thousands of miles of journey
starts with a single step……..
lao tzu a chinese mystic

124. A JOKE TO END
∗ A chief doctor was on a practical
demonstration of the two top most qualities
of a skilful doctor to newly arrived young
medical students with a patient
∗ He said, “listen my dear students…
∗ you must have keen observation and
tolerance for becoming skilful and efficient”

125. ∗ Then He did a PerRectal examination in the
patient and sucked his middle finger
∗ The students were amazed and stunned..!
∗ He asked “Now can any of you demonstrate
this..?”
∗ There was a murmuring among the
youngsters and slowly One student came
forward with bravery

126. ∗ He did the P.R examination through his
middle finger and sucked his middle
finger with a disgusting face
∗ The senior doctor smiled to the student
and said , good.. You have tolerance, but
no observation and added I did P.R with
my index finger and I sucked my middle
finger……..