Liver diseases - Part I
•
11 gefällt mir•3,037 views
Worldwide extensive research on liver disorders in herbal medicine is done till date. There are numerous plants that show hepato-protective activity and thus safeguard as well as repair against liver damages.
Empfohlen
Weitere ähnliche Inhalte
Was ist angesagt?
Was ist angesagt? (20)
Andere mochten auch
Andere mochten auch (12)
Ähnlich wie Liver diseases - Part I
Ähnlich wie Liver diseases - Part I (20)
Mehr von PPRC AYUR
Kürzlich hochgeladen
Kürzlich hochgeladen (20)
Liver diseases - Part I
- 1. Development of Novel Phyto-drugs in Curing LIVER Diseases Presented by Dr. Sudhakar Kokate Director PPRC, India
- 2. Liver ‽ Largest organ in the human body ‽ Pivotal role in maintenance of health and homeostasis ‽ Involved in vital functions – - Metabolism - Secretion - Storage - Detoxification of drugs & xenobiotics PPRC/INDIA 01
- 3. Origin of Liver diseases (Acute & Chronic) ‽ Viruses ‽ Toxins ‽ Drugs ‽ Metabolic disorders ‽ Exposure to solvents ‽ Genetic disorders ‽ Hydrocarbons ‽ Alcohol consumption PPRC/INDIA 02
- 4. Stat of Diseases ‽ Hepatitis A….In children 85 – 95 % in SE Asia ‽ Hepatitis B….5 – 7 % ‽ Hepatitis C….2 % ‽ Cirrhosis & Cancer….20 – 30 % ‽ Alcoholic hepatitis….60 % ‽ Hepato-toxicity….1 in 10,000 – 1 in 100,000 PPRC/INDIA 03
- 5. Phyto-Stat for Cure ‽ Hepato-protective plants….101 plants of Globe….150 phyto-constituents ‽ India….87 plants….33 patented herbal formulations ‽ A number of poly-herbal mixtures ‽ In U.S. >13 % patients on herbal remedy ‽ Other countries range 18 – 65 % PPRC/INDIA 04
- 6. Classification of Liver disorders ‽ Hepatitis ‽ Hepatosis ‽ Liver cirrhosis ‽ Liver injury ‽ Acute hepatitis PPRC/INDIA 05
- 7. Classification of Liver disorders ‽ Chronic active Hepatitis B ‽ Primary Sclerosing Cholangitis (PSC) ‽ Primary Biliary Cirrhosis (PBC) ‽ Alcoholic fibrosis ‽ Alcoholic hepatitis PPRC/INDIA 06
- 8. Well characterised phyto-drugs ‽ Silybum marinum ‽ Picrorhiza kurroa ‽ Liv. 52: - Capparis spinosa - Cassia occidentalis - Achillea millefolium - Tamarix gallica - Cichorium intybus - Solanum nigrum - Terminalia arjuna PPRC/INDIA 07
- 9. Well characterised phyto-drugs ‽ T J 9: Prescribed in China, Japan as “Sho-saiko-to” – an aqueous extract from the roots of Scutellaria, Glycyrrhiza, Bupleurum, Ginseng, Pinella tuber, Jujube fruit & ginger ‽ Compound 861: Chinese medicine with 10 defined herbs, main plants – Salvia miltiorrhiza, Astragalus membranaceous, Spatholobus suferectus PPRC/INDIA 08
- 12. Andrographis paniculata ‽ Habitat: Plains of India ‽ Extensively used in Unani and Ayurveda ‽ Aqueous extract of leaves …. Effective ‽ The extract inhibited BHC induced Liver toxicity in Swiss male mice …. Trivedi & Rawal, 2000 PPRC/INDIA 10
- 14. Boerhavia diffusa ‽ Commonly known as “Punarnava” ‽ Perennial creeping herb found in waste lands of India ‽ Roots effective in Liver Diseases …. Kirtikar & Basu 1933, Chopra 1956 PPRC/INDIA 12
- 15. Boerhavia diffusa ‽ Whole plant extract potent in cure …. Chakraborti & Handa 1989 ‽ Compounds Punarnavin, Beta-sitosterol from roots Beta-D-glucoside, tetracosanoic, hexacosanoic, stearic, palmitic, arachidic acid, hentriacontane, ursolic acid punarnavoside PPRC/INDIA 13
- 17. Peumus boldus ‽ Indigenous to Chile ‽ Small tree: 8 cm long, coriaceous texture, strong odour ‽ Family: Monimiaceae ‽ Chemicals: Boldine, Ascaridole, Linalool, P-cymene cineole PPRC/INDIA 15
- 19. Fumaria indica ‽ The whole plant: Constituent of Unani, Ayurvedic and Medicinal preparations ‽ Family: Fumariaceae ‽ Anti-hepatotoxic against thioacetamide in vitro & carbon tetrachloride, paracetamol, rifampicin ‽ Active principle: similar to Silymarin PPRC/INDIA 17
- 20. Fumaria indica ‽ The plant is useful in: - Blood purification - Cutaneous diseases - Obstructions of Liver PPRC/INDIA 18
- 22. Curcuma longa ‽ Hepato-protective against carbon tetra chloride, paracetamol and Aspergillus aflatoxin ‽ Effective due to anti-oxidant property ‽ Major metabolite of Curcumin – tetrahydrocurcumin (THC) ‽ THC prevents erythromycin estolate induced Liver disease PPRC/INDIA 20
- 24. Picrorhiza kurroa ‽ Family: Scrophulariaceae ‽ Small perennial herb ‽ Grows in northwest India ‽ Active principle: irioid glycoside, Picrosides I, II, III, Kutkoside ‽ Hepato-protective effect superior to that of Silymarin in many cases PPRC/INDIA 22
- 25. Picrorhiza kurroa ‽ Protects Liver cells from a wide variety of injuries including: - Carbon tetrachloride (Santra et. al 1998) - - Galactosamine (Dwivedi 1992) - Ethanol (Rastogi et. al 1996) - Acetaminophen (Singh et. al 1992) - Thioacetamide (Dwivedi et. al 1991) PPRC/INDIA 23
- 27. Phyllanthus amarus ‽ Family: Euphorbiaceae ‽ Widespread throughout tropic and subtropics in sandy regions or cultivated & wastelands ‽ The plant is bitter, astringent, cooling, diuretic, stomachic, febrifuge & antiseptic ‽ Butanol fraction of the whole plant exhibited potent activity (Tripathi et. al 1992) PPRC/INDIA 25
- 28. Phyllanthus amarus ‽ Whole plant powder 0.66 gm/kg in rat showed hepatoprotective action against carbon tetrachloride (Sane et. al 1955) ‽ Albino rats treated with ethanol were orally given whole plant powder 200 mg/rat per day for 45 days showed significant activity PPRC/INDIA 26
- 30. Glycyrrhiza glabra ‽ Glycyrrhizin, main component of Licorice root ‽ Found to be effective for chronic hepatitis and liver cirrhosis ‽ It showed hepato-protective effect against toxicity by carbon tetrachloride and Gal N ‽ Antioxidant properties of glycyrrhizin & glycyrrhetinic acid responsible for anti-hepatotoxic activity PPRC/INDIA 28
- 32. Silybum marianum ‽ Most characterised useful important plant ‽ Mixture of Silvbin, Silvdianin & Silychristin ‽ Significant action against induction by carbon tetrachloride of Liver damage in rats ‽ It reduces the prolongation of hexa-harbital sleeping time produced by carbon tetrachloride PPRC/INDIA 30
- 34. Cichorium intybus ‽ Family: Compositae ‽ Aqueous extract showed hepato-protective toxicity induced by carbon tetrachloride & paracetamol (Gadgoli & Mishra 1995) ‽ Scientists conducted several experiments on this plant PPRC/INDIA 32
- 36. Tinospora cordifolia ‽ Commonly known as Guduchi or Amrita ‽ Most valuable medicinal herb in Ayurveda ‽ Plant has ability to impart youthfulness vitality & longevity ‽ Also quite effective in Liver injury PPRC/INDIA 34
- 37. Tinospora cordifolia ‽ In modern times it is well known as hepatoprotective, adaptogenic & immuno-modulatory activities ‽ Clinical studies in patients of hepatitis showed that Guduchi plays an important role in relieving the symptoms of Liver disease PPRC/INDIA 35
- 39. Wedelia calendulacea ‽ Family: Compositae ‽ Perennial herb with light camphor-like odour ‽ Traditionally used as tonic, spleen enlargement and skin diseases ‽ Showed protective action in Paracetamol induced Liver damage PPRC/INDIA 37
- 40. Wedelia calendulacea ‽ The alcoholic extract of whole plant exhibited protection against carbon tetrachloride ‽ The extract increased bile flow in rats. ‽ Min. lethal dose was greater than 200 mg/kg P.O. in mice PPRC/INDIA 38
- 42. Tephrosia purpurea ‽ Locally known as “Sarapunkha” ‽ Most important ingredient of formulations available in Indian market for liver ailments ‽ Good results in Cirrhosis & vital Hepatitis in clinical trials ‽ It prevents cellular leakage & loss of functional integrity of Liver cell membranes, release in hepatic regeneration PPRC/INDIA 40
- 44. Protium heptaphyllum ‽ Family: Burseraceae ‽ Active principle: alpha & beta amyrin, a triterpene mixture ‽ Folk medicinal plant ‽ It protects acetaminophen induced Liver injury PPRC/INDIA 42
- 46. Buddleja officinalis ‽ Family: Loganiaceae ‽ Flowers, buds effective ‽ Active principle: Acteoside, a phenylethanoid glycoside ‽ Possesses antioxidant property ‽ Protects against carbon tetrachloride PPRC/INDIA 44
- 48. Anastatica hierochuntica ‽ Egyptian medicinal herb ‽ Chemicals: Anastatins A & B from Methanolic extract ‽ Protective against d-galactosamine induced cytotoxicity in primary cultured mouse ‽ Activity is stronger than that of commercial Silybin PPRC/INDIA 46
- 50. Tilia argentea ‽ Methanolic ext. showed protection against dgalactosamine, Lipopolysaccharide induced Liver injury in mice ‽ Flowers are effective hepato-protectors PPRC/INDIA 48
- 52. Garcinia kola ‽ Extract of seeds of this plant showed protection against carbon tetrachloride induced Liver injury ‽ Extensively studied plant PPRC/INDIA 50
- 54. Hymenaea martiana ‽ Active principle: Astibin ‽ Protects against carbon tetrachloride induced Liver injury ‽ One of the important useful herb PPRC/INDIA 52
- 55. Thank You !! “BE WITH US”