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Current trends & Perspectives
in
Cancer Control
(Part – I)
Presented by
Dr. Sudhakar Kokate
Director PPRC, India
Dedication
This presentation is dedicated to all
Cancer patients across the globe and
may our efforts, towards research in
this area benefit those who are
fighting the dangerous disease
PPRC/INDIA01
Cancer
₪Second leading cause of death worldwide
₪Multifactorial process:
₪ Cellular transformation
₪ Hyper proliferation
₪ Metastatic lesions
PPRC/INDIA02
Cancer
₪The word “Kaensar” known medically as a
malignant neoplasm is a broad group of diseases
involving unregulated cell growth
₪Cancer: a deadly disease
₪A very lethal life threatening terrible disease
PPRC/INDIA03
Cancer
₪It is rapidly affecting the people all over the
world without any discrimination of age, race,
wealth or status in society
₪Pathetic disease with miserable side effects
₪There are more than 200 different known
cancers that affect humans
PPRC/INDIA04
Cancer
₪Cancer cells divide and grow uncontrollably
forming malignant tumours and invading nearby
parts of the body
₪Not all tumours are cancerous
₪Causes are diverse and complex
₪Cancer spread to more distant parts of the body
through the lymphatic system / bloodstream
PPRC/INDIA05
Common sites of cancer
PPRC/INDIA06
History of Cancer
₪Cancer has existed for all human history
₪Earliest written record of cancer is in circa 1600
B.C. in Egyptian Edwin Smith Papyrus ….
described “Breast cancer”
₪Hippocrates ca 460 B.C. – ca 370 B.C. described
several kinds of cancer
PPRC/INDIA07
History of Cancer
₪Cancer Greek word “Karkinos” means Crab or
Cray fish
₪Celsus ca 25 B.C. – 50 A.D. translated Karkinos
to Latin word “Cancer”. He recommended
surgery treatment for cancer
₪Galen (2nd century A.D.) disagreed with surgery
and recommended purgatives for respondent
PPRC/INDIA08
History of Cancer
₪15 th – 17 th centuries study of causes of cancer
were experimented after dissection of the body
PPRC/INDIA09
PPRC/INDIA10
Types of Cancer
TYPE ORIGIN NAMES
CARCINOMA Epithelial cells
In aged people, Common –
breast, prostate, colon…..
SARCOMA Connective tissue
Bone, cartilage, fat nerve
cancers
LYMPHOMA
Hematopoietic
(blood forming)
Leukaemia most common in
children
GERM CELL TUMOUR Pluripotent cells Testicle, ovarian cancer
BLASTOMA Embryonic tissue Common in most children
PPRC/INDIA11
PPRC/INDIA12
Diagnosis
₪Screening
₪Medical tests:
₪ Blood tests
₪ X – Rays
₪ CT Scans
₪ Endoscopy
PPRC/INDIA13
Symptoms: Cancer Metastasis
CANCER BODY PART SYMPTOMS
Brain Headache, seizures, vertigo
Respiratory Cough, Hemoptysis, Dyspanoea
Lymph nodes Lymphaclenopathy
Liver Hepatomegaly, Jaundice
Skeletal system
Pain, fractures, spinal and
compression
PPRC/INDIA14
Systematic symptoms
Weight loss
Fever
Fatigue
Persistent fever
Paraneoplastic
pneumonia
Distant parts affected:
PPRC/INDIA15
Cancerous cell
PPRC/INDIA16
Stat of cancer
₪The incidence of Lung cancer is highly co-
related with tobacco smoking…. 9% lung cancer
₪In western Europe 10% cancers in males and
3% in females are attributed to alcohol
₪Tobacco smoke contains > 50 carcinogens
₪200,000 people die worldwide every year
PPRC/INDIA17
Stat of cancer
₪High processed food, red meat are also said to
be major cause of cancer growth
₪A high salt diet linked to gastric cancer, aflatoxin
B, with Liver cancer, Betel nut chewing with oral
cancer
₪Gastric cancer more in Japan due to high salt
diet
PPRC/INDIA18
Stat of cancer
₪U.S. estimates 20,000 cancer deaths 40,000 new
cases each year are attributed to “occupation”
₪Obesity cause in 14 – 20% of all cancer deaths
₪Diet, physical inactivity and obesity 30 – 35% of
cancer deaths
₪Diets that are low in vegetables, fruits, whole
grains are linked with number of cancers
PPRC/INDIA19
Stat of cancer
₪Worldwide 18% of cancer deaths due to
infectious diseases, high in Africa (25%) and low
in developed world (10%)
₪Upto 10% of cancers are caused due to
radiation
₪Hereditary cancers contribute to 3 – 10%
PPRC/INDIA20
Stat of cancer
₪Some hormones play a major role in division of
cells by promoting cell proliferation
₪Sex linked cancers:
₪ Breast
₪ Endometrium
₪ Prostate
₪ Ovary
₪ Testis
₪ Thyroid
₪ Bone
PPRC/INDIA21
Cancerous cell
PPRC/INDIA22
Stat of cancer in India
₪500,000 people succumb to cancer / year
₪300 cancer hospitals / centres in India
₪40% of India: No appropriate facility for
fighting with cancer
₪Ratio of doctor: patient – 1 : 2000
₪By 2015 …….. Cancer patients 700,000
PPRC/INDIA23
Stat of cancer in India
₪Most specific cancers in India:
₪ Lung cancer
₪ Ovarian cancer
₪ Cervical cancer
₪ Breast cancer
₪According to “Indian Republic” Press – Cancer
incidence likely to rise five fold in India by 2025
PPRC/INDIA24
Cancerous cell
PPRC/INDIA25
10 most deadly types on cancer
 Non-Hodgkin Lymphoma
 Ovarian cancer
 Leukaemia
 Prostate cancer
 Liver cancer
 Pancreatic cancer
 Breast cancer
 Colorectal cancer
 Stomach cancer
 Lung cancer
PPRC/INDIA26
Top celebrities who survived cancer
Sharon
Osbourne
T.V. host, businesswoman,
author, music promoter
Colon cancer
Robert de Niro
American actor, Producer,
Director
Prostate gland
cancer
Christina
Applegate
American actress Breast cancer
Kylie Minogue
Australian singer, actress,
record artist, songwriter
Breast cancer
Tom Green
Canadian actor, comedian,
writer
Testicular
cancer
PPRC/INDIA27
Top celebrities who survived cancer
Lance
Armstrong
Racing cyclist
Testicular
cancer
Michael Douglas
American producer,
director
Throat cancer
Yuvraj Singh Famous Indian Cricketer
Mediastinal
seminoma
Manisha Koirala
Indian actress, social
activist
Ovarian cancer
Lisa Ray
Canadian actress, Model,
Philanthropist
Multiple
myelana
PPRC/INDIA28
Cancer development
PPRC/INDIA29
Significant cancers in Science
₪Acute myeloid leukemia (AML)
₪Acute lymphoblastic leukemia (ALL)
₪AIDS related cancers…. Kaposi sarcoma
Lymphoma
₪Anal cancer
₪Appendix cancer
₪Basal cell cancer
PPRC/INDIA30
Brain tumour
PPRC/INDIA31
Significant cancers in Science
₪Bile duct cancer
₪Bladder cancer
₪Bone cancer
₪Brain tumour
₪Breast cancer
₪Bronchial tumours
₪Cardiac tumours
PPRC/INDIA32
Bone cancer
PPRC/INDIA33
Significant cancers in Science
₪Cervical cancer
₪Colon cancer
₪Colo-rectal cancer
₪Embryonal tumours
₪Esophageal cancer
₪E wing sarcoma
₪Eye cancer
PPRC/INDIA34
Colon cancer
PPRC/INDIA35
Significant cancers in Science
₪Gall bladder cancer
₪Gastric cancer
₪Gastrointestinal cancer
₪Germ cell tumour
₪Head and neck cancer
₪Heart cancer
₪Liver cancer
PPRC/INDIA36
Lung cancer
PPRC/INDIA37
Significant cancers in Science
₪Kidney cancer
₪Laryngeal cancer
₪Lung cancer
₪Mouth cancer
₪Nasal cavity and paranasal sinus cancer
₪Neuroblastoma
₪Oral cancer
PPRC/INDIA38
Bladder cancer
PPRC/INDIA39
Significant cancers in Science
₪Ovarian cancer
₪Salivary gland cancer
₪Skin cancer
₪Stomach cancer
₪Testicular cancer
₪Throat cancer
₪Thyroid cancer
PPRC/INDIA40
Kidney cancer
PPRC/INDIA41
Significant cancers in Science
₪Uterine cancer
₪Vaginal cancer
₪Wilms tumour
PPRC/INDIA42
Liver cancer
PPRC/INDIA43
PPRC/INDIA44
Top cancer fighting foods
Cabbage
Cauliflower
Mushrooms
Broccoli
Carrots
Blueberry
Grapes
Tomatoes
Raspberry
Papaya
PPRC/INDIA45
Top cancer fighting foods
PPRC/INDIA46
Top cancer fighting foods
PPRC/INDIA47
Top cancer fighting foods
Sweet potatoes
Flax seeds
Garlic
Turmeric
Lime
Oranges
Green tea
Soya powder
Water melon
Ginger
PPRC/INDIA48
Top cancer fighting foods
PPRC/INDIA49
Top cancer fighting foods
PPRC/INDIA50
Thank You!!
“BE WITH US”

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Cancer - I

  • 1. Current trends & Perspectives in Cancer Control (Part – I) Presented by Dr. Sudhakar Kokate Director PPRC, India
  • 2.
  • 3. Dedication This presentation is dedicated to all Cancer patients across the globe and may our efforts, towards research in this area benefit those who are fighting the dangerous disease
  • 5. Cancer ₪Second leading cause of death worldwide ₪Multifactorial process: ₪ Cellular transformation ₪ Hyper proliferation ₪ Metastatic lesions PPRC/INDIA02
  • 6. Cancer ₪The word “Kaensar” known medically as a malignant neoplasm is a broad group of diseases involving unregulated cell growth ₪Cancer: a deadly disease ₪A very lethal life threatening terrible disease PPRC/INDIA03
  • 7. Cancer ₪It is rapidly affecting the people all over the world without any discrimination of age, race, wealth or status in society ₪Pathetic disease with miserable side effects ₪There are more than 200 different known cancers that affect humans PPRC/INDIA04
  • 8. Cancer ₪Cancer cells divide and grow uncontrollably forming malignant tumours and invading nearby parts of the body ₪Not all tumours are cancerous ₪Causes are diverse and complex ₪Cancer spread to more distant parts of the body through the lymphatic system / bloodstream PPRC/INDIA05
  • 9. Common sites of cancer PPRC/INDIA06
  • 10. History of Cancer ₪Cancer has existed for all human history ₪Earliest written record of cancer is in circa 1600 B.C. in Egyptian Edwin Smith Papyrus …. described “Breast cancer” ₪Hippocrates ca 460 B.C. – ca 370 B.C. described several kinds of cancer PPRC/INDIA07
  • 11. History of Cancer ₪Cancer Greek word “Karkinos” means Crab or Cray fish ₪Celsus ca 25 B.C. – 50 A.D. translated Karkinos to Latin word “Cancer”. He recommended surgery treatment for cancer ₪Galen (2nd century A.D.) disagreed with surgery and recommended purgatives for respondent PPRC/INDIA08
  • 12. History of Cancer ₪15 th – 17 th centuries study of causes of cancer were experimented after dissection of the body PPRC/INDIA09
  • 14. Types of Cancer TYPE ORIGIN NAMES CARCINOMA Epithelial cells In aged people, Common – breast, prostate, colon….. SARCOMA Connective tissue Bone, cartilage, fat nerve cancers LYMPHOMA Hematopoietic (blood forming) Leukaemia most common in children GERM CELL TUMOUR Pluripotent cells Testicle, ovarian cancer BLASTOMA Embryonic tissue Common in most children PPRC/INDIA11
  • 16. Diagnosis ₪Screening ₪Medical tests: ₪ Blood tests ₪ X – Rays ₪ CT Scans ₪ Endoscopy PPRC/INDIA13
  • 17. Symptoms: Cancer Metastasis CANCER BODY PART SYMPTOMS Brain Headache, seizures, vertigo Respiratory Cough, Hemoptysis, Dyspanoea Lymph nodes Lymphaclenopathy Liver Hepatomegaly, Jaundice Skeletal system Pain, fractures, spinal and compression PPRC/INDIA14
  • 18. Systematic symptoms Weight loss Fever Fatigue Persistent fever Paraneoplastic pneumonia Distant parts affected: PPRC/INDIA15
  • 20. Stat of cancer ₪The incidence of Lung cancer is highly co- related with tobacco smoking…. 9% lung cancer ₪In western Europe 10% cancers in males and 3% in females are attributed to alcohol ₪Tobacco smoke contains > 50 carcinogens ₪200,000 people die worldwide every year PPRC/INDIA17
  • 21. Stat of cancer ₪High processed food, red meat are also said to be major cause of cancer growth ₪A high salt diet linked to gastric cancer, aflatoxin B, with Liver cancer, Betel nut chewing with oral cancer ₪Gastric cancer more in Japan due to high salt diet PPRC/INDIA18
  • 22. Stat of cancer ₪U.S. estimates 20,000 cancer deaths 40,000 new cases each year are attributed to “occupation” ₪Obesity cause in 14 – 20% of all cancer deaths ₪Diet, physical inactivity and obesity 30 – 35% of cancer deaths ₪Diets that are low in vegetables, fruits, whole grains are linked with number of cancers PPRC/INDIA19
  • 23. Stat of cancer ₪Worldwide 18% of cancer deaths due to infectious diseases, high in Africa (25%) and low in developed world (10%) ₪Upto 10% of cancers are caused due to radiation ₪Hereditary cancers contribute to 3 – 10% PPRC/INDIA20
  • 24. Stat of cancer ₪Some hormones play a major role in division of cells by promoting cell proliferation ₪Sex linked cancers: ₪ Breast ₪ Endometrium ₪ Prostate ₪ Ovary ₪ Testis ₪ Thyroid ₪ Bone PPRC/INDIA21
  • 26. Stat of cancer in India ₪500,000 people succumb to cancer / year ₪300 cancer hospitals / centres in India ₪40% of India: No appropriate facility for fighting with cancer ₪Ratio of doctor: patient – 1 : 2000 ₪By 2015 …….. Cancer patients 700,000 PPRC/INDIA23
  • 27. Stat of cancer in India ₪Most specific cancers in India: ₪ Lung cancer ₪ Ovarian cancer ₪ Cervical cancer ₪ Breast cancer ₪According to “Indian Republic” Press – Cancer incidence likely to rise five fold in India by 2025 PPRC/INDIA24
  • 29. 10 most deadly types on cancer  Non-Hodgkin Lymphoma  Ovarian cancer  Leukaemia  Prostate cancer  Liver cancer  Pancreatic cancer  Breast cancer  Colorectal cancer  Stomach cancer  Lung cancer PPRC/INDIA26
  • 30. Top celebrities who survived cancer Sharon Osbourne T.V. host, businesswoman, author, music promoter Colon cancer Robert de Niro American actor, Producer, Director Prostate gland cancer Christina Applegate American actress Breast cancer Kylie Minogue Australian singer, actress, record artist, songwriter Breast cancer Tom Green Canadian actor, comedian, writer Testicular cancer PPRC/INDIA27
  • 31. Top celebrities who survived cancer Lance Armstrong Racing cyclist Testicular cancer Michael Douglas American producer, director Throat cancer Yuvraj Singh Famous Indian Cricketer Mediastinal seminoma Manisha Koirala Indian actress, social activist Ovarian cancer Lisa Ray Canadian actress, Model, Philanthropist Multiple myelana PPRC/INDIA28
  • 33. Significant cancers in Science ₪Acute myeloid leukemia (AML) ₪Acute lymphoblastic leukemia (ALL) ₪AIDS related cancers…. Kaposi sarcoma Lymphoma ₪Anal cancer ₪Appendix cancer ₪Basal cell cancer PPRC/INDIA30
  • 35. Significant cancers in Science ₪Bile duct cancer ₪Bladder cancer ₪Bone cancer ₪Brain tumour ₪Breast cancer ₪Bronchial tumours ₪Cardiac tumours PPRC/INDIA32
  • 37. Significant cancers in Science ₪Cervical cancer ₪Colon cancer ₪Colo-rectal cancer ₪Embryonal tumours ₪Esophageal cancer ₪E wing sarcoma ₪Eye cancer PPRC/INDIA34
  • 39. Significant cancers in Science ₪Gall bladder cancer ₪Gastric cancer ₪Gastrointestinal cancer ₪Germ cell tumour ₪Head and neck cancer ₪Heart cancer ₪Liver cancer PPRC/INDIA36
  • 41. Significant cancers in Science ₪Kidney cancer ₪Laryngeal cancer ₪Lung cancer ₪Mouth cancer ₪Nasal cavity and paranasal sinus cancer ₪Neuroblastoma ₪Oral cancer PPRC/INDIA38
  • 43. Significant cancers in Science ₪Ovarian cancer ₪Salivary gland cancer ₪Skin cancer ₪Stomach cancer ₪Testicular cancer ₪Throat cancer ₪Thyroid cancer PPRC/INDIA40
  • 45. Significant cancers in Science ₪Uterine cancer ₪Vaginal cancer ₪Wilms tumour PPRC/INDIA42
  • 48. Top cancer fighting foods Cabbage Cauliflower Mushrooms Broccoli Carrots Blueberry Grapes Tomatoes Raspberry Papaya PPRC/INDIA45
  • 49. Top cancer fighting foods PPRC/INDIA46
  • 50. Top cancer fighting foods PPRC/INDIA47
  • 51. Top cancer fighting foods Sweet potatoes Flax seeds Garlic Turmeric Lime Oranges Green tea Soya powder Water melon Ginger PPRC/INDIA48
  • 52. Top cancer fighting foods PPRC/INDIA49
  • 53. Top cancer fighting foods PPRC/INDIA50