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S E S S I O N 11
To Open the Eyes of Modern Man
We have been allowing the thought of Pope John
Paul II to lead us into an understanding of the
beauty of the human person “created male and
female” and into an understanding of our current
culture. True leaders are willing to face the brutal
truth about their current situation without losing
hope.
The Ultimate Temptation
• Ricoeur has called Freud, Marx, and Nietzsche
„masters of suspicion‟” (John Paul II, October
29, 1980).
• Jean Paul Sartre and Simone du Beauvoir were
successful in integrating the three “masters of
suspicion” in a way that attacked the union of man
and woman.
• Love is impossible. It restricts our freedom, which
makes us less human. “Hell is other people.”
• Woman are the “sex second” because their ability to
bare life. To become more human, they must become
more free by rejecting their maternity and becoming
more like a man.
The Devil as an Imposter
• “I will ascend above the heights of the clouds, I will make myself like the
Most High” (Isaiah 14:14).
• “In the beginning was the Word … And God said” (John 1:1 and
Genesis 1:3).
• “When the devil lies, he speaks according to his own nature, for he is a
liar and the father of lies” (John 8:44).
• God uses the union of man and woman as a “primordial sacrament” by
which he works in the world. The “one flesh union” of man and woman
is simultaneously a sign and an actuation of the mystery.
• The devil uses the Pill as a type of “anti-sacrament.” It is a sign of man
and woman hiding from the Father, but it also actuates the mystery.
The Consequences of the Fall
1. Adam and Eve experience a changed
personal reality that directly impacts their
union.
2. Adam and Eve hide from God precisely
because of their changed personal reality.
3. Adam and Eve‟s changed reality flows upon
their children.
4. Adam and Eve‟s changed reality flows upon
greater creation.
A Changed Reality for Man and Woman
• “Then the eyes of both were opened,
and they knew that they were naked;
and they sewed fig leaves together”
(Genesis 3:7).
• Man and woman first perceive a
change within themselves and then
this change directly impacts their
union.
80
100
140
BreastCancerIncidenceRate
(Cases/100,000Women)
1950 1970 200
0
2010
60
120
1940 1960 1980 1990
A Changed Reality for Woman
Source: Cutler, S., et al, “Trends in Cancer Incidence and Mortality in the USA.” Host Environment Interactions in the
Etiology of Cancer in Man, Doll, E., et al, International Agency for Research on Cancer, 1973.
Cutler, S., et al, “National Cancer Institute Monograph. Bethesda: DHEW Publications, 1975. Third National Cancer
Survey: Incidence Data, v. 41.
Howlander, N., et al, SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. See
http://seer.cancer.gov/csr/1975_2010/,based on November 2012 SEER data submission, posted to SEER web
site, April 2013.
Region Incidence
Western Europe 89.7
Australia/New Zealand 85.5
Northern Europe 85.0
North America 76.7
Central America 26.0
Eastern Asia 25.3
Middle Africa 21.3
Eastern Africa 19.3
Source: Ferlay, J., et al, GLOBOCAN 2008
v1.2, Cancer Incidence and Mortality
Worldwide: IARC CancerBase No. 10.
The Reality of Breast Cancer
• BMI over 25: increased risk over 50%.
• Smoking: increased risk approximately 14%.
• Stress (Divorce or separation): increased risk more than doubled.
• Number/Timing of Children: Increased risk up to ⅓.
• Breast Feeding: Decreased risk of approximately¼ per 6 months.
• Oral Contraceptive Use: Increased risk up to 50%.
Sources:
Cecchini, R., et al., “Body Mass Index and the Risk for Developing Invasive Breast Cancer Among High-Risk Women in NSABP P-1 and STAR Breast Cancer
Prevention Trials,” Cancer Prevention Research, 2012.
Xue, F., et al, “Cigarette Smoking and the Incidence of Breast Cancer,” Archives of Internal Medicine, Vol. 171, No. 2, January 24, 2011.
Lillberg, K., “Stressful Life Events and Risk of Breast Cancer in 10,808 Women: A Cohort Study,” American Journal of Epidemiology, 2003.
Ewertz, M., et al, “Age at First Birth, Parity and Risk of Breast Cancer: A Meta-Analysis of 8 Studies from the Nordic Countries,” International Journal of
Cancer, 1990.
Tryggvadottir, L., “Breastfeeding and Reduced Risk of Breast Cancer in an Icelandic Cohort Study,” American Journal of Epidemiology, 2001.
Kahlenborn, C., et al, “Oral Contraceptive Use as a Risk Factor for Premenopausal Breast Cancer: A Meta-analysis,” Mayo Clinic Proceedings, October, 2006.
Glass, A., et al, “Breast Cancer Incidence, 1980-2006: Combined Roles of Menopausal Hormone Therapy, Screening Mammography, and Estrogen Receptor
Status,” Journal of the National Cancer Institute, August 1, 2007.
U.S. Department of Health and Human Services, Report on Carcinogens (RoC), “Known to be Human Carcinogen” (1 of 58 substances).
International Agency for Research on Cancer (IARC) of the World Health Organization: “IARC Monographs on the Evaluation of Carcinogen Risks to Humans,”
v. 91, “Group 1 Carcinogen: Known to cause cancer in humans.”
3
4
6
TesticularCancerIncidenceRate
(Cases/100,000Men)
1950 1970 200
0
2010
2
5
1940 1960 1980 1990
A Changed Reality for Men
Source: National Cancer Institute, SEER Cancer
Statistics Review 1793-1996, Table I-3.
SEER Database, SEER Cancer Statistics Review
1975-2010.
Region Incidence
Western Europe 7.8
Australia/New Zealand 6.7
Northern Europe 6.7
North America 5.1
Central America 3.7
Eastern Asia 0.5
Middle Africa 0.2
Eastern Africa 0.5
Source: World Health
Organization, International Agency for
Research on Cancer, GLOBOCAN 2008
Database
Control Fertile
8.0
8.5
9.
0
9.5
10.0
TestosteroneLevel(ng/dl)
Non-
Fertile
Source: Sharpe, R., “Male Reproductive Health Disorders and the Potential Role
of Exposure to Environmental Chemicals, ChemTrust, May, 2009.
Travison, T., et al, “A Population-Level Decline in Serum Testosterone Levels
in American Men,” The Journal of Clinical Endocrinology & Metabolism, 2007.
Miller, S., et al, “Scent of a Woman: Men’s Testosterone Responses to Olfactory
Ovulation Cues,” Psychological Science, 2009.
Brizendine, L., “The Male Brain,” Broadway Books, 2010, pp. 80-81.
The Reality of the Change for Men
• Significant increase in reproductive
tract disorders for men throughout the
“developed world.”
• Research points to hormonal disruption
during fetal development.
• Between 1988 and 2003 testosterone
levels have dropped by 17%.
• Testosterone levels in men respond to
the fertility of a woman. They increase
when she is fertile, decrease after
ovulation and decrease during
pregnancy.
• Women on oral contraception are
placed in a chemical pregnancy state.
9.01
9.86
8.36
1940’s 1960’s
0
10
20
30
40
PercentageEverDivorced
Source: General Social Survey.
Year Married
The Changed Reality of their Union
20.4
43.7
20
40
50
Age
MilitaryNo Job
PillIncome
(10)
CauseofDivorceRateIncrease
Unaccount
Source: Michael, R., “Why Did the U.S. Divorce Rate
Double Within A Decade?” Research in Population
Economics, 1988.
30
0
10
24.9 23.1
49.6
(0.8) (2.6)
5.8
Reason Divorce Rate IncreasedDivorce Rate
ImportanceinMateSelection
Source: Havlicek, J., et al, “He sees, she smells? Male and female reports of
sensory reliance in mate choice and non-mate choice contexts,” Personality
and Individual Differences, 2008.
Wedekind, C., et al, “MHC-dependent mate preferences in humans,”
Proceedings of the Royal Society B, 1995.
Garver-Apgar, “Major Histocompatibility Complex Alleles, Sexual
Responsivity, and Unfaithfulness in Romantic Couples, Psychological
Science, 2006.
Sight Smell
0
0.
2
0.
4
0.
6
0.8
Sight Smell
WomenMen
Chemically Changed Attraction
• In mate selection, women are
particularly sensitive to olfactory clues.
• Through pheromones, women seek
men with dissimilar but compatible
immune systems (MHC), which
provides their offspring with the
greatest immune system protection.
• Women on the oral contraception are
more likely to select men with similar
MHC profiles.
• In couples with more MHC
similarities, women are less sexually
responsive to their partners, are more
attracted to other men and have more
extra partner couplings.
0.47 .045
.015
.075
A Changed Relationship with God
• “And they heard the sound of the Lord
God walking in the garden in the cool of
the day, and the man and his wife hid
themselves from the presence of the
Lord God among the trees of the garden
… I was afraid, because I was naked;
and I hid myself” (Genesis 3:8-10).
• Man and woman from God precisely
because of their changed reality.
2.0
2.5
3.5
TotalFertilityRate
(ChildrenperWoman)
1950 1970 200
0
2010
1.5
3.0
1940 1960 1980 1990
Hiding from God the Father
Source: CDC, National Center for Health
Statistics, Total Fertility Rate, 1940-2010.
Region TFR
Western Europe 1.6
Australia/New Zealand 1.9
Northern Europe 1.8
North America 2.0
Central America 2.5
Eastern Asia 1.7
Middle Africa 5.7
Eastern Africa 5.3
Source: United Nations Population
Division, World Fertility Patterns 2009.
U.S. France
0
5
10
15
25
PercentNoPregnancyin12mo.
Germany
20
Source: Thoma, M., et al, “Prevalence of infertility in the United States as
estimated by the current duration approach and a traditional construct
approach,” Fertility and Sterility, April 2013.
Slama, R., et al, “Estimation of the frequency of involuntary infertility on a
nation-wide basis,” Human Reproduction, 2012.
Karmaus, W., et al, “Infertility and subfecundity in population-based samples
from Denmark, Germany, Italy, Poland and Spain,” European Journal of Public
Health, 19999.
Fertility Change in the Life of the Couple
• Approximately 1/6 to ¼ of couples
desiring a child are unable to achieve
pregnancy within 12 months.
• Delayed child bearing: women‟s fertility
begins to decline by her mid 20‟s,
falling almost ½ by her mid 30‟s.
• Many STDs have impaired fertility or
infertility as a consequence.
• MHC similarity leads to more
spontaneous miscarriages/abortions.
• MHC similarity leads to higher levels of
infertility.
15.5
24
26.2
Source: Dunson, D., et al, “Changes with age in the level and duration of fertility in the
menstrual cycle,” Human Reproduction, 2002.
Coulam, C., et al, “Association between Major Histocompatibility Antigen and Reproductive
Performance,” American Journal of Reproductive Immunology and Microbiology, 1987.
Ober, C., “Human leukocyte antigen matching and fetal loss: results of a 10 year prospective
study, Human Reproduction, 1998.
1996 2000
1
2
3
4
6
UsingART/SeekingPregnancy
(Percentage)
2010
5
Source: Vital and Health Statistics, Series 23, Number 19, “Fertility, Family
Planning, and Reproductive Health of U.S. Women: Data from the 1995
National Survey of Family Growth, May 1997, Table 41.
Vital and Health Statistics, Series 23, Number 25, “Fertility, Family
Planning, and Reproductive Health of U.S. Women: Data from the
2002National Survey of Family Growth, December 2005, Table 56.
National Health Reports, Number 60, “Current Contraceptive Use in the United
States, 2006-2010, and Changes in Patterns of Use Since 1995,” Table 1.
Statistical Abstract of the United States, 2012, Table 100.
Fertility Change in the Life of the Woman
• Women using Assisted Reproductive
Technology to attempt pregnancy have
increased substantially.
• BMI > 25 increases the probability of
infertility by approximately ÂĽ.
• Smoking increases probability of
infertility by approximately 70%.
• STDs can lead to infertility.
• Animal studies suggest exposure to
endocrine disruptors, including ethinyl
estradiol, during fetal development
decreases fertility as an adult.
2.71
3.92
5.90
Source: Killick, S., et al, “Factors associated with subfertility among women attending an
antenatal clinic in Hull,” Human Fertility, December 2009.
Bolumar, F., et al, “Smoking Reduces Fecundity: A European Multicenter Study on Infertility
and Subfecundity,” American Journal of Epidemiology, 1996.
Ryan, B., et al, In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl
Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of
Female LE Rats, Toxicological Sciences, 2010.
Source: Carlsen, E., et al., “Evidence for Decreasing Quality of Semen During
Past 50 Years,” British Medical Journal, September 12, 1992.
Rolland, M., et al, “Decline in semen concentration and morphology in a sample
of 26,609 men close to general population between 1989 and 2005 in France,”
Reproductive Epidemiology, 2012.
Bonde, J., et al, “Relation between semen quality and fertility: a population-
based study of 430 first pregnancy planners,” The Lancet, October 10, 1998.
Fertility Change in the Life of the Man
• Sperm rates have decreased in men,
especially in the “developed world.”
• Sperm counts below 40 million per ml
lead to reduced fertility.
• Maternal alcohol consumption reduces
sperm counts by approximately 1/3.
• Maternal smoking reduces sperm
counts of up to ½.
• Animal studies suggest exposure to
endocrine disruptors, including ethinyl
estradiol, during fetal development
decreases sperm counts as an adult.
Source: Ramlau-Hansen, C., et al, “Maternal alcohol consumption during pregnancy and semen
quality in the male offspring: tow decades of follow-up,” Human Reproduction, 2010.
Storgaard, L., et al, “Does Smoking During Pregnancy Affect Sons’ Sperm Counts?”
Epidemiology, May 2003.
Howdeshell, K., et al, “Gestational and Lactational Exposure to Ethinyl Estradiol, but not
Bisphenol A, Decreases Androgen-Dependent Reproductive Organ Weights and Epididymal
Sperm Abundance in the Male Long Evans Hooded Rate,” Toxicological Sciences, 2008.
1940 1989
40
60
80
100
120
SpermCountinFrenchMen
(million/ml)
2005
113
73.6
49.9
A Changed Reality for Children
• “Now Adam knew Eve his wife, and she
conceived and bore Cain … and again,
she bore his brother Abel … And when
they were in the field, Cain rose up
against his brother Abel, and killed him”
(Genesis 4:1-8).
• The children of Adam and Eve participate
in Adam and Eve‟s changed reality.
The Sex Programming Window
• Sexual differentiation begins about the 8th week
after fertilization.
• The SRY gene on the Y chromosome directs the
development of testes, which begin producing
large amounts of testosterone.
• The developing male fetus will receive
approximately 10 times the exposure to
testosterone as the developing female fetus.
• The surge of testosterone simultaneously forms
the male sexual organs and wires the brain for
male typical behavior.
• “If you set it up wrongly to begin with, there‟s no
going back” (Professor Richard Sharpe).
Source: Sobel, V., “Fetal Hormones and Sexual
Differentiation,” Obstetrics and Gynecology Clinics
of North America, 2004.
Professor Richard Sharpe, MRC Human
Reproductive Sciences Unit, Centre for
Reproductive Biology, The Queen’s Medical
Research Institute, University of Edinburg, Hope
Undimmed Series, Session 6.
A Changing Reality for Children
• Approximately 8% of women taking oral
contraception get pregnant in a given year.
• Hormone levels remain altered for several months.
• Animal studies on female mice indicate reduced
fertility, reduced weight gain during pregnancy,
decreased age of puberty, malformations of
external genitalia, and defeminization of typical
female behaviors. (Study used “dosage levels
within the dose range…for therapeutic purposes.”)
• Animal studies on male mice indicate reduced
overall body weight, decreased size of testes and
seminal vesicles and reduction in sperm count.
(Study used dosage “approximately fivefold higher
than is used for oral contraceptives.”
Source: Ryan, B., et al, In Utero and Lactational
Exposure to Bisphenol A, In Contrast to Ethinyl
Estradiol, Does Not Alter Sexually Dimorphic Behavior,
Puberty, Fertility, and Anatomy of Female LE Rats,
Toxicological Sciences, 2010.
Howdeshell, K., et al, “Gestational and Lactational
Exposure to Ethinyl Estradiol, but not Bisphenol A,
Decreases Androgen-Dependent Reproductive Organ
Weights and Epididymal Sperm Abundance in the Male
Long Evans Hooded Rate,” Toxicological Sciences,
2008.
A Changed Reality for Nature
• “Cursed is the ground because of
you … thorns and thistles it shall
bring forth to you” (Genesis 3:17-
18).
• The bareness of Adam and Eve‟s
union flows out upon all of
creation.
A Changing Reality for Nature
• Approximately 27% of ethinyl estradiol consumed
in the pill is excreted in urine.
• Wild life around the world is being altered: reduced
male/female ratios, low fertility and poor mating
habits, male fish producing female hormones,
intersex fish, genetic males with female organs.
• Test lake in Northwestern Ontario Canada.
• Ethinyl estradiol added in 5-6 ng/L for 3 summers.
• Test Year 1: Within seven weeks, male fish began
producing female proteins: delayed
spermatogenesis/malformations of the tubules.
• Test Year 2: Fish with ova-testes and primary-
stage oocytes; fish population begins to collapse.
Source: Johnson, A., et al, “A Model to Estimate Influent
and Effluent Concentrations of Estradiol, Estrone, and
Ethinylestradiol at Sewage Treatment Works,”
Environmental Science and Technology, 2004.
Lyons, G., “Effects of Pollutants on the Reproductive
Health of Male Vertebrate Wildlife – Males Under
Threat,” ChemTrust, December, 2008.
Kidd, K., et al, “Collapse of a fish population after
exposure to a synthetic estrogen,” Proceedings of the
National Academy of Sciences, May 22, 2007.
Modern man has once more been tempted and he
has fallen. We have now awaken to a different
world. It is a type of anti-creation that impacts all
of creation. Fortunately, the Father is “rich in
mercy” (Ephesians 2:4).
Next Week
A Culture of Death
Small Group Discussion
Starter Questions
1. How can you better see the spiritual realities
behind modern culture?
2. How can you help “open the eyes” of others to
the changed reality of modern man?
The Reality of “Impossible” Love
• Michael, R., “Why did the U.S. Divorce Rate
Double within a Decade?” Research in
Population Economics, 1988, v. 6, pp. 367-399.
• The rapid diffusion of modern contraception was
the greatest reason for the substantially
increased divorce rate in the 1970s.
• Roberts, S., “MHC-correlated odour preferences
in humans and the use of oral contraceptives,”
Proceedings of the Royal Society B, 2008.
• Women taking the Pill alter their mate selection
so that the choose MHC similar men.
20
40
50
1920s 1960s1950s1940s1930s
10
PercentageEverDivorced
1970s
Source: General Social Survey, 1972-2010
30
Year Enter into Marriage
A Changed Reality for their Union
25.0
18.8
20.4
28.4
43.7
39.3
20
40
50
Age
MilitaryJob
PillIncome
(10)
CauseofDivorceRateIncrease
Unaccount
Source: Michael, R., “Why Did the U.S. Divorce Rate
Double Within A Decade?” Research in Population
Economics, 1988.
30
0
10
A Changed Reality for their Union
24.9 23.1
49.6
(0.8) (2.6)
5.8

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Light to the Nations - Week 11

  • 1.
  • 2. S E S S I O N 11 To Open the Eyes of Modern Man
  • 3. We have been allowing the thought of Pope John Paul II to lead us into an understanding of the beauty of the human person “created male and female” and into an understanding of our current culture. True leaders are willing to face the brutal truth about their current situation without losing hope.
  • 4. The Ultimate Temptation • Ricoeur has called Freud, Marx, and Nietzsche „masters of suspicion‟” (John Paul II, October 29, 1980). • Jean Paul Sartre and Simone du Beauvoir were successful in integrating the three “masters of suspicion” in a way that attacked the union of man and woman. • Love is impossible. It restricts our freedom, which makes us less human. “Hell is other people.” • Woman are the “sex second” because their ability to bare life. To become more human, they must become more free by rejecting their maternity and becoming more like a man.
  • 5. The Devil as an Imposter • “I will ascend above the heights of the clouds, I will make myself like the Most High” (Isaiah 14:14). • “In the beginning was the Word … And God said” (John 1:1 and Genesis 1:3). • “When the devil lies, he speaks according to his own nature, for he is a liar and the father of lies” (John 8:44). • God uses the union of man and woman as a “primordial sacrament” by which he works in the world. The “one flesh union” of man and woman is simultaneously a sign and an actuation of the mystery. • The devil uses the Pill as a type of “anti-sacrament.” It is a sign of man and woman hiding from the Father, but it also actuates the mystery.
  • 6. The Consequences of the Fall 1. Adam and Eve experience a changed personal reality that directly impacts their union. 2. Adam and Eve hide from God precisely because of their changed personal reality. 3. Adam and Eve‟s changed reality flows upon their children. 4. Adam and Eve‟s changed reality flows upon greater creation.
  • 7. A Changed Reality for Man and Woman • “Then the eyes of both were opened, and they knew that they were naked; and they sewed fig leaves together” (Genesis 3:7). • Man and woman first perceive a change within themselves and then this change directly impacts their union.
  • 8. 80 100 140 BreastCancerIncidenceRate (Cases/100,000Women) 1950 1970 200 0 2010 60 120 1940 1960 1980 1990 A Changed Reality for Woman Source: Cutler, S., et al, “Trends in Cancer Incidence and Mortality in the USA.” Host Environment Interactions in the Etiology of Cancer in Man, Doll, E., et al, International Agency for Research on Cancer, 1973. Cutler, S., et al, “National Cancer Institute Monograph. Bethesda: DHEW Publications, 1975. Third National Cancer Survey: Incidence Data, v. 41. Howlander, N., et al, SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. See http://seer.cancer.gov/csr/1975_2010/,based on November 2012 SEER data submission, posted to SEER web site, April 2013. Region Incidence Western Europe 89.7 Australia/New Zealand 85.5 Northern Europe 85.0 North America 76.7 Central America 26.0 Eastern Asia 25.3 Middle Africa 21.3 Eastern Africa 19.3 Source: Ferlay, J., et al, GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10.
  • 9. The Reality of Breast Cancer • BMI over 25: increased risk over 50%. • Smoking: increased risk approximately 14%. • Stress (Divorce or separation): increased risk more than doubled. • Number/Timing of Children: Increased risk up to â…“. • Breast Feeding: Decreased risk of approximatelyÂĽ per 6 months. • Oral Contraceptive Use: Increased risk up to 50%. Sources: Cecchini, R., et al., “Body Mass Index and the Risk for Developing Invasive Breast Cancer Among High-Risk Women in NSABP P-1 and STAR Breast Cancer Prevention Trials,” Cancer Prevention Research, 2012. Xue, F., et al, “Cigarette Smoking and the Incidence of Breast Cancer,” Archives of Internal Medicine, Vol. 171, No. 2, January 24, 2011. Lillberg, K., “Stressful Life Events and Risk of Breast Cancer in 10,808 Women: A Cohort Study,” American Journal of Epidemiology, 2003. Ewertz, M., et al, “Age at First Birth, Parity and Risk of Breast Cancer: A Meta-Analysis of 8 Studies from the Nordic Countries,” International Journal of Cancer, 1990. Tryggvadottir, L., “Breastfeeding and Reduced Risk of Breast Cancer in an Icelandic Cohort Study,” American Journal of Epidemiology, 2001. Kahlenborn, C., et al, “Oral Contraceptive Use as a Risk Factor for Premenopausal Breast Cancer: A Meta-analysis,” Mayo Clinic Proceedings, October, 2006. Glass, A., et al, “Breast Cancer Incidence, 1980-2006: Combined Roles of Menopausal Hormone Therapy, Screening Mammography, and Estrogen Receptor Status,” Journal of the National Cancer Institute, August 1, 2007. U.S. Department of Health and Human Services, Report on Carcinogens (RoC), “Known to be Human Carcinogen” (1 of 58 substances). International Agency for Research on Cancer (IARC) of the World Health Organization: “IARC Monographs on the Evaluation of Carcinogen Risks to Humans,” v. 91, “Group 1 Carcinogen: Known to cause cancer in humans.”
  • 10. 3 4 6 TesticularCancerIncidenceRate (Cases/100,000Men) 1950 1970 200 0 2010 2 5 1940 1960 1980 1990 A Changed Reality for Men Source: National Cancer Institute, SEER Cancer Statistics Review 1793-1996, Table I-3. SEER Database, SEER Cancer Statistics Review 1975-2010. Region Incidence Western Europe 7.8 Australia/New Zealand 6.7 Northern Europe 6.7 North America 5.1 Central America 3.7 Eastern Asia 0.5 Middle Africa 0.2 Eastern Africa 0.5 Source: World Health Organization, International Agency for Research on Cancer, GLOBOCAN 2008 Database
  • 11. Control Fertile 8.0 8.5 9. 0 9.5 10.0 TestosteroneLevel(ng/dl) Non- Fertile Source: Sharpe, R., “Male Reproductive Health Disorders and the Potential Role of Exposure to Environmental Chemicals, ChemTrust, May, 2009. Travison, T., et al, “A Population-Level Decline in Serum Testosterone Levels in American Men,” The Journal of Clinical Endocrinology & Metabolism, 2007. Miller, S., et al, “Scent of a Woman: Men’s Testosterone Responses to Olfactory Ovulation Cues,” Psychological Science, 2009. Brizendine, L., “The Male Brain,” Broadway Books, 2010, pp. 80-81. The Reality of the Change for Men • Significant increase in reproductive tract disorders for men throughout the “developed world.” • Research points to hormonal disruption during fetal development. • Between 1988 and 2003 testosterone levels have dropped by 17%. • Testosterone levels in men respond to the fertility of a woman. They increase when she is fertile, decrease after ovulation and decrease during pregnancy. • Women on oral contraception are placed in a chemical pregnancy state. 9.01 9.86 8.36
  • 12. 1940’s 1960’s 0 10 20 30 40 PercentageEverDivorced Source: General Social Survey. Year Married The Changed Reality of their Union 20.4 43.7 20 40 50 Age MilitaryNo Job PillIncome (10) CauseofDivorceRateIncrease Unaccount Source: Michael, R., “Why Did the U.S. Divorce Rate Double Within A Decade?” Research in Population Economics, 1988. 30 0 10 24.9 23.1 49.6 (0.8) (2.6) 5.8 Reason Divorce Rate IncreasedDivorce Rate
  • 13. ImportanceinMateSelection Source: Havlicek, J., et al, “He sees, she smells? Male and female reports of sensory reliance in mate choice and non-mate choice contexts,” Personality and Individual Differences, 2008. Wedekind, C., et al, “MHC-dependent mate preferences in humans,” Proceedings of the Royal Society B, 1995. Garver-Apgar, “Major Histocompatibility Complex Alleles, Sexual Responsivity, and Unfaithfulness in Romantic Couples, Psychological Science, 2006. Sight Smell 0 0. 2 0. 4 0. 6 0.8 Sight Smell WomenMen Chemically Changed Attraction • In mate selection, women are particularly sensitive to olfactory clues. • Through pheromones, women seek men with dissimilar but compatible immune systems (MHC), which provides their offspring with the greatest immune system protection. • Women on the oral contraception are more likely to select men with similar MHC profiles. • In couples with more MHC similarities, women are less sexually responsive to their partners, are more attracted to other men and have more extra partner couplings. 0.47 .045 .015 .075
  • 14. A Changed Relationship with God • “And they heard the sound of the Lord God walking in the garden in the cool of the day, and the man and his wife hid themselves from the presence of the Lord God among the trees of the garden … I was afraid, because I was naked; and I hid myself” (Genesis 3:8-10). • Man and woman from God precisely because of their changed reality.
  • 15. 2.0 2.5 3.5 TotalFertilityRate (ChildrenperWoman) 1950 1970 200 0 2010 1.5 3.0 1940 1960 1980 1990 Hiding from God the Father Source: CDC, National Center for Health Statistics, Total Fertility Rate, 1940-2010. Region TFR Western Europe 1.6 Australia/New Zealand 1.9 Northern Europe 1.8 North America 2.0 Central America 2.5 Eastern Asia 1.7 Middle Africa 5.7 Eastern Africa 5.3 Source: United Nations Population Division, World Fertility Patterns 2009.
  • 16. U.S. France 0 5 10 15 25 PercentNoPregnancyin12mo. Germany 20 Source: Thoma, M., et al, “Prevalence of infertility in the United States as estimated by the current duration approach and a traditional construct approach,” Fertility and Sterility, April 2013. Slama, R., et al, “Estimation of the frequency of involuntary infertility on a nation-wide basis,” Human Reproduction, 2012. Karmaus, W., et al, “Infertility and subfecundity in population-based samples from Denmark, Germany, Italy, Poland and Spain,” European Journal of Public Health, 19999. Fertility Change in the Life of the Couple • Approximately 1/6 to ÂĽ of couples desiring a child are unable to achieve pregnancy within 12 months. • Delayed child bearing: women‟s fertility begins to decline by her mid 20‟s, falling almost ½ by her mid 30‟s. • Many STDs have impaired fertility or infertility as a consequence. • MHC similarity leads to more spontaneous miscarriages/abortions. • MHC similarity leads to higher levels of infertility. 15.5 24 26.2 Source: Dunson, D., et al, “Changes with age in the level and duration of fertility in the menstrual cycle,” Human Reproduction, 2002. Coulam, C., et al, “Association between Major Histocompatibility Antigen and Reproductive Performance,” American Journal of Reproductive Immunology and Microbiology, 1987. Ober, C., “Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study, Human Reproduction, 1998.
  • 17. 1996 2000 1 2 3 4 6 UsingART/SeekingPregnancy (Percentage) 2010 5 Source: Vital and Health Statistics, Series 23, Number 19, “Fertility, Family Planning, and Reproductive Health of U.S. Women: Data from the 1995 National Survey of Family Growth, May 1997, Table 41. Vital and Health Statistics, Series 23, Number 25, “Fertility, Family Planning, and Reproductive Health of U.S. Women: Data from the 2002National Survey of Family Growth, December 2005, Table 56. National Health Reports, Number 60, “Current Contraceptive Use in the United States, 2006-2010, and Changes in Patterns of Use Since 1995,” Table 1. Statistical Abstract of the United States, 2012, Table 100. Fertility Change in the Life of the Woman • Women using Assisted Reproductive Technology to attempt pregnancy have increased substantially. • BMI > 25 increases the probability of infertility by approximately ÂĽ. • Smoking increases probability of infertility by approximately 70%. • STDs can lead to infertility. • Animal studies suggest exposure to endocrine disruptors, including ethinyl estradiol, during fetal development decreases fertility as an adult. 2.71 3.92 5.90 Source: Killick, S., et al, “Factors associated with subfertility among women attending an antenatal clinic in Hull,” Human Fertility, December 2009. Bolumar, F., et al, “Smoking Reduces Fecundity: A European Multicenter Study on Infertility and Subfecundity,” American Journal of Epidemiology, 1996. Ryan, B., et al, In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats, Toxicological Sciences, 2010.
  • 18. Source: Carlsen, E., et al., “Evidence for Decreasing Quality of Semen During Past 50 Years,” British Medical Journal, September 12, 1992. Rolland, M., et al, “Decline in semen concentration and morphology in a sample of 26,609 men close to general population between 1989 and 2005 in France,” Reproductive Epidemiology, 2012. Bonde, J., et al, “Relation between semen quality and fertility: a population- based study of 430 first pregnancy planners,” The Lancet, October 10, 1998. Fertility Change in the Life of the Man • Sperm rates have decreased in men, especially in the “developed world.” • Sperm counts below 40 million per ml lead to reduced fertility. • Maternal alcohol consumption reduces sperm counts by approximately 1/3. • Maternal smoking reduces sperm counts of up to ½. • Animal studies suggest exposure to endocrine disruptors, including ethinyl estradiol, during fetal development decreases sperm counts as an adult. Source: Ramlau-Hansen, C., et al, “Maternal alcohol consumption during pregnancy and semen quality in the male offspring: tow decades of follow-up,” Human Reproduction, 2010. Storgaard, L., et al, “Does Smoking During Pregnancy Affect Sons’ Sperm Counts?” Epidemiology, May 2003. Howdeshell, K., et al, “Gestational and Lactational Exposure to Ethinyl Estradiol, but not Bisphenol A, Decreases Androgen-Dependent Reproductive Organ Weights and Epididymal Sperm Abundance in the Male Long Evans Hooded Rate,” Toxicological Sciences, 2008. 1940 1989 40 60 80 100 120 SpermCountinFrenchMen (million/ml) 2005 113 73.6 49.9
  • 19. A Changed Reality for Children • “Now Adam knew Eve his wife, and she conceived and bore Cain … and again, she bore his brother Abel … And when they were in the field, Cain rose up against his brother Abel, and killed him” (Genesis 4:1-8). • The children of Adam and Eve participate in Adam and Eve‟s changed reality.
  • 20. The Sex Programming Window • Sexual differentiation begins about the 8th week after fertilization. • The SRY gene on the Y chromosome directs the development of testes, which begin producing large amounts of testosterone. • The developing male fetus will receive approximately 10 times the exposure to testosterone as the developing female fetus. • The surge of testosterone simultaneously forms the male sexual organs and wires the brain for male typical behavior. • “If you set it up wrongly to begin with, there‟s no going back” (Professor Richard Sharpe). Source: Sobel, V., “Fetal Hormones and Sexual Differentiation,” Obstetrics and Gynecology Clinics of North America, 2004. Professor Richard Sharpe, MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen’s Medical Research Institute, University of Edinburg, Hope Undimmed Series, Session 6.
  • 21. A Changing Reality for Children • Approximately 8% of women taking oral contraception get pregnant in a given year. • Hormone levels remain altered for several months. • Animal studies on female mice indicate reduced fertility, reduced weight gain during pregnancy, decreased age of puberty, malformations of external genitalia, and defeminization of typical female behaviors. (Study used “dosage levels within the dose range…for therapeutic purposes.”) • Animal studies on male mice indicate reduced overall body weight, decreased size of testes and seminal vesicles and reduction in sperm count. (Study used dosage “approximately fivefold higher than is used for oral contraceptives.” Source: Ryan, B., et al, In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats, Toxicological Sciences, 2010. Howdeshell, K., et al, “Gestational and Lactational Exposure to Ethinyl Estradiol, but not Bisphenol A, Decreases Androgen-Dependent Reproductive Organ Weights and Epididymal Sperm Abundance in the Male Long Evans Hooded Rate,” Toxicological Sciences, 2008.
  • 22. A Changed Reality for Nature • “Cursed is the ground because of you … thorns and thistles it shall bring forth to you” (Genesis 3:17- 18). • The bareness of Adam and Eve‟s union flows out upon all of creation.
  • 23. A Changing Reality for Nature • Approximately 27% of ethinyl estradiol consumed in the pill is excreted in urine. • Wild life around the world is being altered: reduced male/female ratios, low fertility and poor mating habits, male fish producing female hormones, intersex fish, genetic males with female organs. • Test lake in Northwestern Ontario Canada. • Ethinyl estradiol added in 5-6 ng/L for 3 summers. • Test Year 1: Within seven weeks, male fish began producing female proteins: delayed spermatogenesis/malformations of the tubules. • Test Year 2: Fish with ova-testes and primary- stage oocytes; fish population begins to collapse. Source: Johnson, A., et al, “A Model to Estimate Influent and Effluent Concentrations of Estradiol, Estrone, and Ethinylestradiol at Sewage Treatment Works,” Environmental Science and Technology, 2004. Lyons, G., “Effects of Pollutants on the Reproductive Health of Male Vertebrate Wildlife – Males Under Threat,” ChemTrust, December, 2008. Kidd, K., et al, “Collapse of a fish population after exposure to a synthetic estrogen,” Proceedings of the National Academy of Sciences, May 22, 2007.
  • 24. Modern man has once more been tempted and he has fallen. We have now awaken to a different world. It is a type of anti-creation that impacts all of creation. Fortunately, the Father is “rich in mercy” (Ephesians 2:4).
  • 25. Next Week A Culture of Death Small Group Discussion Starter Questions 1. How can you better see the spiritual realities behind modern culture? 2. How can you help “open the eyes” of others to the changed reality of modern man?
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  • 27. The Reality of “Impossible” Love • Michael, R., “Why did the U.S. Divorce Rate Double within a Decade?” Research in Population Economics, 1988, v. 6, pp. 367-399. • The rapid diffusion of modern contraception was the greatest reason for the substantially increased divorce rate in the 1970s. • Roberts, S., “MHC-correlated odour preferences in humans and the use of oral contraceptives,” Proceedings of the Royal Society B, 2008. • Women taking the Pill alter their mate selection so that the choose MHC similar men.
  • 28. 20 40 50 1920s 1960s1950s1940s1930s 10 PercentageEverDivorced 1970s Source: General Social Survey, 1972-2010 30 Year Enter into Marriage A Changed Reality for their Union 25.0 18.8 20.4 28.4 43.7 39.3
  • 29. 20 40 50 Age MilitaryJob PillIncome (10) CauseofDivorceRateIncrease Unaccount Source: Michael, R., “Why Did the U.S. Divorce Rate Double Within A Decade?” Research in Population Economics, 1988. 30 0 10 A Changed Reality for their Union 24.9 23.1 49.6 (0.8) (2.6) 5.8