The role of the Transcription Factor Engrailed in Neuronal Identity

The role of the Transcription Factor Engrailed in Neuronal Identity Nelson Almodóvar Arbelo University of Puerto Rico at Cayey RISE Program student Bruno Marie-Bordes P.h.D. Institute of Neurobiology

What is a transcription factor? ,[object Object],[object Object]

Transcription Factors define the development of cells A B Transcription Factor x Transcription Factor y

Transcription Factors Regulate Aspects in the Neuronal Development ,[object Object],[object Object],[object Object],[object Object]

Engrailed during embryogenesis ,[object Object],[object Object]

Engrailed expression in the larva CNS ,[object Object],[object Object]

Hypothesis: Over-Expression of Engrailed will perturb neuronal development and/or maintenance.

Methods: Modifying gene expression in Drosophila using the Gal4/UAS system

Methods: Modifying gene expression in Drosophila using the Gal4/UAS system Early Neuroblasts UAS – Engrailed Post-Mitotic Motorneuron UAS – Engrailed

Objectives ,[object Object],[object Object]

References ,[object Object],[object Object]

The role of the Transcription Factor Engrailed in Neuronal Identity

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