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2010 Conference - Toward a Treatment Standard for Pathological Gambling (Grant)
- 13. 12
Placebo
20mg
40mg
PG-YBOCS Urges
10
8
p=.027
6
4
2
4 6 8 10
Visit
- 14. 1.0
.9
.8
Naltrexone /
Proportion Nonrelapsed
Asp40 Allele (A/G, G/G)
.7
Naltrexone
.6
Asn40 Allele (A/A)
.5
Placebo /
Asp40 Allele (A/G, G/G)
.4
Placebo /
Asn40 Allele (A/Al)
.3
.2
.1
0.0
0
14
28
42
56
70
84
Days
- 15. Analysis of Maximum Likelihood Estimates
(N=282)
Variable Parameter Standard Chi- Pr>ChiSq Hazard
Estimate Error Square Ratio
FH-AUD 0.55 0.24 7.53 0.006 1.74
Baseline urges were significantly associated with response to
higher doses of opiate antagonists (i.e. nalmefene 50mg or
100mg or naltrexone 100mg or 150mg) (parameter estimate =
1.77; SE= 0.84; Wald 2 =4.41; p= .036; HR= 5.86; HR 95%
CI=1.12-30.6
- 22. Visit 1 Visit 6 p-value
PG-YBOCS total
score 21.8 8.9 <.001
Responder, n (%) n/a 18 <.001
(62.1)
Dollars lost per week 743 309 <.001
Hours gambled per
week 10.4 4.0 <.001
- 23. PG B v E PG B v C PG E v C
T P t p t p
IDED total
2.20 0.037 2.09 0.041 1.06 0.294
errors
- 25. *
*
*
* p<.05
Hollander et al, 2002