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Anthrax MIlad khoury Spring 2011
ARTICLE ,[object Object]
Bouzianas et al. Current and Future Medical Approaches To Combat the Anthrax Threat. Journal of Medicinal Chemistry, 2010; 53 (11): 4305 DOI: 10.1021/jm901024b
Outline I  Introduction II  History of the disease III  Its use as a biological weapons IV  Bacillus anthracis  V  the 3 routs of inection VI  Pathogenesis VII  The fight against anthrax VIII  Conclusion
Anthrax: basics ,[object Object]
caused by the bacteria B.anthracis
Zoonotic disease in herbivores (e.g., sheep, goats, cattle)
Human infection typically acquired through contact with anthrax-infected animals or animal products .
Three forms -Cutaneous -Inhalational -Gastrointestinal
history ,[object Object]
Moses threatened the Egyptian pharaoh that the hand of the lord will fall on the livestock ,horses and birds and kill everything.
5 th  century B.C
the Greek Doctor Hippocrates named the disease that caused black skin lesions as anthracis.
history ,[object Object]
The disease was  also called Wool Sorter’s disease and Rag Picker’s disease .
1876 - German bacteriologist Robert Koch confirmed bacterial origin of anthrax.
1881: Louis Pasteur developed the first vaccine
Anthrax a biological weapon ,[object Object]
1979 - In  Soviet Union , aerosolized anthrax spores were released accidentally at a military facility, affecting 94 and killing 64 people.
1995 - Iraq produced 8,500 liters of concentrated anthrax as part of the biological weapon program under  Saddam Hussein’s  administration.
Anthrax cases 2001 ,[object Object]
-11 cutaneous
-11 inhalational
5 deaths ( all inhalational )
-case in Florida
-2 postal workers in Maryland
-hospital worker in NY city
Farm woman in Connecticut
Bacillus anthracis ,[object Object]
has a diameter of 1-1.5 µm and a length of 3-10 µm.
Facilitative anaerobe
Belogns to the B.cereus family
- Nonmotile
-glutamyl-polypeptide capsule

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