Heme iron tablet supplements have been in use in Scandinavia for more than 30 years. There has been no cases of serious side-effects or poisonings reported after use by literally millions.
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Questions and answers about heme iron as supplementation
1. Heme iron tablet supplements
have been in use in Scandinavia for
more than 30 years. There has
been no cases of serious side-
effects or poisonings reported a>er
use by literally millions.
The raw material is pharma-grade
and comes with all necessary
cerAficaAon
Is it safe?
It’s an organic product based on
bovine hemoglobin.
2. Natural hemoglobin contains a relatively low
content of iron, how does this work in tablets?
TradiAonally an iron salt such as Ferrous
Fumarate has been added in the tablets at
manufacture to raise the total content of
iron.
Today there is a technology available that
will transfer iron ions from added Ferrous
Sulphate directly to the protein part of
hemoglobin, which means the total
content will be absorbed by the heme iron
pathway.
3. The OptiFer® tablets contain only 18 mgs of iron.
Is this enough?
This has to do with the basic dose
regulated for food supplements, but since
hemoglobin iron is so well absorbed, the
efficacy means that the dose can
compete with non-heme products with
50 mg or more per dose.
(see “Iron supplementaAon in pregnancy: is less
enough”, Eskeland et al Acta Obstet Gyn Scand 76 1997)
It is advantageous with a steady and slow
absorpAon. Also, doses over 50 mg per
day will inhibit zinc absorpAon. Heme iron
in itself aids absorpAon of non-heme iron.
OpAFer® tablets contain both heme- and
non-heme iron.
4. Is there an upper limit to raw
material availability?
In pracAce, the food industry
is equipped to produce much
more raw material than
needed for supplement
tablets.
5. Is the raw material, being organic,
very sensitive?
The dried raw material powder when
used as a in tablets is totally inert over
Ame and not suscepAble to any
disturbance. The product withstands
Ame and heat and since the tablets are
packed in airAght blister charts also
moisture to a degree. Supplement/Food
legislaAon however implies a best-before
date, usually two or three years from
date of manufacture.
6. What about religious concerns,
such as halal or kosher?
The product contains material derived
from bovine hemoglobin, which can be a
sensiAve issue.
However, when used purely as a medical
supplement for a situaAon which can be
fatal, it is therefore of no religious
concern. (religious authority imam
Mohammed Saieed Waezi)
7. Are there other forms of heme iron and
why is natural bovine important?
The heme iron in OpAFer® products comes exclusively from bovine sources, unlike the other
major form Heme Iron PolypepAde, which is fabricated out of porcine raw material by
denaturing natural proteins or by using proteolyAc enzymes.
It is listed to have as common side-effects gastro-intesAnal problems such as upset stomach,
gas, diarrhea or consApaAon. Also, “Heme iron polypepAde may cause your urine or stools to
turn a reddish-brown or dark color”
In clinical studies natural heme iron preparaAons such as OpAFer® are reported to have the
side-effects levels of placebo products.
A total of 134 drugs (706 brand and generic names) are known to interact with
heme iron polypepAde.
Natural heme iron has no known interacAons or side-effects.