1. ANTIMICOTICI
!
" ! #
$
1

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%
!
!&
%
'(
#
!
) " #
$
*
"+ , ,
, -
#
* . #
#
#
2

3. ! % &
!
# # # # '
## % ( '
&
) ) / '% ( ! &
" * " '
) ) '
) ) '
)
)* $
)# )*
* '
# # ''
0
+, #
# /
#
*. +. .
1 2
# !
-
" ,
0 3,,
%4
) ( 5 !5 !
&
3

4. .
Cl (H3C)2N N(CH3)2
O NH
I N #
OH OH
Cl
N
H3C CH3
, #
NH2 OH
[CH2=CH-(CH2)8-COO]2Zn
/ 01, #
N OH
CH2(CH2)4CH3
.
OH I
H2N NH2 Cl O
H2N NH2
Cl Cl
2 HOCH2CH2SO3
) !
# - #
6 5"
/
- 2 ) #
H3C
CH3
CH3 C
S N CH3
H3C N O
CH3 ."
)
4

5. " . .
-
."
S
$
O N CH3 #
-
CH3
! 2 ) #
7
-
. , 34
CH3
S 3 4#
5 !
O N CH3 )
CH3
5 8 *5
5 " '
8 5 5
8 ( '
# ) -
5

6. H3C
CH3
CH3 C
N CH3
."
; 9 6
%
- !
9 :
9
( ! &) #
& - &) 9 <
-
H3C
CH3 CH3
CH3 C
N N CH3
-
-
61 7 61
.
; .
; µ( .
; .
;
+, ,$+ ,,$ $ ,, =
,
> ,"$ ,,? ,? ,, >
,
#: ,,+ ,, >
, . ,, $
, ,, "
,
4 . ? @@ . "@
6

7. .
2
'
OCH3 O OCH3 &# .
8 > 9: >: .
6 " # "
;
=
" 8: O
H3CO O =:
0
;
6:
<
Cl H3C H
/
OH OH OH
O O
H3CO C HO C OH
OH OH
.
#
) #:
) #: #:
( !
#: & #
! 4*
/ ;*
!
4'
7

8. . , 34
!
) 5 $ 8@ 5 ? 83 ?
5 8" A B 8
?
OCH3 O OCH3
9:
O
H3CO <
O O
Cl H3C H O
?
8 / # 34
-
OCH3 O OCH3
O
H3CO O
Cl H3C H
OCH3
HO
Cl
>. 2 OCH3
COOH
O
O
- 3 OH
OH Cl
OH
8

9. .. .
(
Cl Cl
O2 N
N
H
'
*
9

10. . $ (, ,
6,
6
NH2 #
F
N
O N !
H / #
6, C
+.
2!
D
6, . ( $ /
:
O
H F
NH 2 O N
F H F
N N O O N
* HO P OCH2
O N # O N OH O
H # H
HO OH
6, 6,
O O
H
N
F H
N
F $
O O O N O O N
HO P O P OCH2 HO P OCH2
O O
OH OH OH
HO HO
# 6, ,9:
6, ,# #
! 6,
%* 4*
10

11. $ /
: $ / % $ /
. / &
08, # 5
- #! #
#
HO HO
) !
:! #
- #
! ) !
#
- #
# '
@ HO
. $
! 3+ >, / (
E
9
? + > @ 9
#
) 4 9
# ' 7
% % & '
( (5 F
11

12. . $
) #:
B , '*
) ) G )4 ) 9
*! *!
#:
-
#
4)
) *
- ) #
' $$8?@*5 $
λ HI $,,
; $>8+$*5 $ &
?>8@@*5 3 &
$+8+=*5 &
λ HI $?,
)
&
λ HI $=,
" ?>8@$*5", &
12

13. .
$$8?@*5 $ !; "> ) ( *!
5 4!
. $
. $.
OH O
. "
H OH 00 09 OH NH2
O
H A HO OH
8 < O
OH H
06
9 0= O O CH3
0
O O 9=
0+
H3C 96 99 91
/
.
?>8@@*5 3 !; $= ) ( *!
5 4!
/ . $.
OH
OH
H3C O OH
0 > 6 < 00 06
>< 01 0>
HO >= O OH OH OH O
0= O
OH
CH3
>6 .
>9 >1 9+ 9= 98 99 91 OH
H3C >8
$
0A
O O CH3
.
HO OH
NH2
.
"
13

14. . "
?>8@$*5", !; $= ) ( *!
5 4!
OH
OH
H3C >< O 0 00 OH
> 6 + A
0> 06
HO >= O OH OH OH OH O 0= O
CH3
>6 H
>9 >1 9+ 9= 98 99 91
0A OH
H3C >8
O O CH3
9
HO OH
NH2
#
* -
JJ -
1
.
" ! )B #
% ' 3
01 & 3
! . . )
2 ! .
14

15. /
E E
E # 0C 8,
9C *.
D ! ) ) )
. . #
6 ."
1 >,
)
#
# :
?α. F ?+,
'
/
34
) %&
D
15

16. $ /
N )
N Cl ! ' :
N N
R
Cl O
4K 8 *.
4K 3>3 / : 2
2: Cl
.
N Cl
Cl
N
N N
/ - Cl O
O O Cl
E
( Cl
#
O
O N N
Cl
7
3@3 L 3>3 L '#
%6 ( (
*
. /
N F
Cl !
N N
N
N
N C
OH F
O O Cl
N
O N
N N
O N N N
N
3=>
% ) /
3=> /. , ,
. , C
& H
6
* - ?α.
& -E
( =+9
F ?+,
'
& 7
/ -
9 -
-
,M
, 9 )1
16

17. H
14
CH3 CH2 OH CHO
HO
08, # 5
- #! #
#
17

18. . # # # ,
# E 861
RH + O2 + NADPH/H+
CYP450
ROH + H2O + NADP+
3 # 9 # ) # #
% &
RH
e
Fe 3+ Fe 3+ RH Fe 2+ RH
RH
ROH oxene O2
transfer
H+
e Fe 3+ RH
Fe 4+ RH Fe3+ RH
OH -
O- O2- O -2
2
18

19. # #
! E 861
. !
N
# 7
8"5D
!
!!
,
, K +A 5
K
7 ;
D
.
3 # E 861
% # - # !F - &
1. Binding dello steroide (es. Desossicorticosterone)
Cys-S
N
N
Fe
N
N
OH
O
O- O
H
O
19

20. 2. Binding di inibitore competitivo
Cys-S
N
N
Fe
N
N
X
Inhibitor
# # - # !# - 3 -
% !&
,> *.?
! % &
# :
5"
; - #
4#
) ,0
; ?.α.
. ?
20

21. β .
HO 08
8
α
% .? . ? O αP C
8$ . ? - O αP
-
-
#: #!
)
- ! &7
7
" , / 4*
2
/ /
*
% +. .
# 4 *
# +. +. ." .
#
Q ! ?.α.
F ?+,
' ?.
! -
21

22. . // .
$ ) * , - .
! %
& '
() +
"#
( 0 1 +
! ( 1 +
! ( 1
& %" / 1
" (( () 1
1 1 2 ) 1
) 2 ( 1
( 1
22