7. Chronic Urticaria and Angioedema by the Urticaria and Angioedema Committee © AAAAI 2006

9. Chronic Urticaria/Angioedema (Mast cell driven) Urticaria & Angioedema Urticaria Angioedema 40% 50% 10 %

11. Drug Induced Urticaria / Angioedema Bradykinin responsible for swelling in angioedema in patients with HAE Kaplan A et al J Allergy Clin Immunol 2002;109:195-209 Angiotensin converting enzyme (ACE) inhibitors interfere with metabolism of bradykinin via interference with kininase Ii Gavras I Kidney Int 1992; 42:1020-29 Patients on angiotensin converting enzyme blockers (ARBs) may not be at risk for angioedema Gavras I Arch Int Med 2003; 163: 240-1

17. (Ecalantide)

27. Cholinergic Urticaria

31. Delayed Pressure Urticaria

33. Vibratory angioedema Lawlor F et al Br J Dermatol 1989; 120: 93-99 Vortex to induce angioedema in a patient with swelling of hands while driving car

35. B Cell Lymphoma Associated with Symptomatic Dermatographism Patient’s dermatographism resistant to fexofenadine and cetirizine sent a clue that something else may be causing her itching and hives.

37. Antibodies associated with urticaria IgG auto ab to IgE receptor 35-40% Antithyroglobulin Ab 8% Antimicrosomal Ab 5%