Allergy and Hypersensitivity

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MedicineAndHealth

Health & Medicine

Immunology and immunotherapy in allergic disease Jing Shen , M. D. Matthew Ryan, M. D.

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Hypersensitivity (animated) for MBBS Students Hypersensitivity refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system. Hypersensitivity reactions require a pre-sensitized state of the host. Four types of hypersensitivity Type I – anaphylactic Type II – cytotoxic Type III – immune complex mediated Type IV – contact, tuberculin and granulomatous Anaphylaxis is defined as a life-threatening allergic reaction set in action by a wide range of antigens and involving multiple organ systems. The true incidence is difficult to estimate, but in 1973 the Boston Collaborative Drug Surveillance Program reported six anaphylactic reactions and 0.87 deaths from anaphylaxis per 10,000 patients. Reactions to insect stings alone are responsible for at least 50 deaths in the United States each year. These figures reveal the importance of continued research into the biology of anaphylaxis along with developing new (and improving existing) therapies.

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Prevalence of Allergy and Autoimmune Diseases are high in developed countries, but not in developing countries. Helminth infection were associated with lower level of allergy but the mechanism is not yet clear. In hygiene countries like UK, Japan and Korea, Fecal Microbiota Transplantation (FMT) has gained interest as novel therapy and prevention and reach to medicine industrial manufactures. This study will support it by associate Hygiene Hypothesis (HyHy) and the high prevalence of Allergy and Autoimmune Disease. Systematic review and Bayesian network analysis in EBSCO host search engine were used. Result from dynaMed Evidence Based, Point-of-care Reference e Journals: Dentistry, Medical and Nursing has describe 9 literatures support the association of Hy-hy/parasite infection with Allergy and/ or Autoimmune Diseases: 2 publications of meta-analysis are chosen and supported by 5 cross sectional, longitudinal, cause-effect design, and 2 clinical and animal trial. Conclusions: Low-middle-high income countries has a life style of Hyhy pattern support FMT industrial medicine and travelling to developing countries with broad diversity bacteria and worm in therapeutic and prevention potential, supported by sub-saharan and tropical rainforest developing countries.

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Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity. There is no cure for hypersensitivity vasculitis itself. The main goal of treatment will be to relieve your symptoms. this chart is all about hypersensitivity , i made this for my academic purpose . please comment thank u

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Normally, immune responses eradicate infectious pathogens without serious injury to host tissues. However, these responses are sometimes inadequately controlled inappropriately targeted to host tissues triggered by commensal microorganisms or environmental antigens that are usually harmless. In these situations, the normally beneficial immune response is the cause of disease. Disorders caused by immune responses are called hypersensitivity diseases. This term , hypersensitivity , arose from the clinical definition of immunity as sensitivity, which is based on the observation that an individual who has been exposed to an antigen exhibits a detectable reaction, or is sensitive, to subsequent encounters with that antigen. Today, we will describe the pathogenesis of different types of hypersensitivity reactions, with an emphasis on the effector mechanisms that cause tissue injury. A variety of human diseases are caused by immune responses to non-microbial environmental antigens, and involve the type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13 produced by Th2 cells and innate lymphoid cells (ILCs), immunoglobulin E (IgE), mast cells, and eosinophils. The antigens that elicit immediate hypersensitivity are called allergens. Most of them are common environmental proteins, animal products, and chemicals that can modify self proteins. In the effector phase of these responses, mast cells and eosinophils are activated to rapidly release mediators that cause increased vascular permeability Vasodilation bronchial and visceral smooth muscle contraction This vascular reaction is called immediate hypersensitivity because it begins rapidly, within minutes of antigen challenge in a previously sensitized individual (immediate), and has major pathologic consequences (hypersensitivity). Following the immediate response, there is a more slowly developing inflammatory component called the late-phase reaction characterized by the accumulation of neutrophils, eosinophils, and macrophages.

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Infection control and prevention is the practice of implementing measures to prevent or reduce the transmission of infectious diseases in healthcare settings and the general community. It involves a wide range of strategies, including hand hygiene, personal protective equipment (PPE), environmental cleaning, and the appropriate use of antibiotics. Infection control and prevention is crucial to ensuring the safety of patients, healthcare workers, and the general public. It helps to minimize the risk of healthcare-associated infections (HAIs) and the spread of infectious diseases in the community. Effective infection control and prevention requires a multi-faceted approach, involving education, training, and adherence to guidelines and best practices. This includes proper hand hygiene techniques, appropriate use of PPE, and the implementation of environmental cleaning and disinfection protocols. In addition, infection control and prevention also involves the appropriate use of antibiotics to minimize the development of antibiotic resistance. This includes the judicious use of antibiotics, as well as the development of alternative treatment options. Overall, infection control and prevention is an essential component of public health, and plays a critical role in reducing the spread of infectious diseases and protecting the health and well-being of individuals and communities.

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