1.
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Electrical and Magnetic Neurostimulation: Applications, Technologies, and
Market Potential
February 1, 2010
Stimulation of muscles and nerves by the use of electrical stimulation, notably TENS
and EMS, has long been part of pain management. But recent developments, such as
implanted technologies and the small size/low cost systems, have created a pathway for
increased usage and revenue growth. The growing approval of these applications by
government regulators and insurance carriers have helped boost demand.
Since Kalorama Information's last look at this market six years ago, several implanted
electrode therapeutic systems have recently emerged in the market and the potential of
this market has clearly caught the eye of pharmaceutical and microelectronics
companies, which are actively expanding their stake in electrode therapeutics through
research, collaborations, and acquisitions. These actions will push more applications
into the marketplace, and medical insurance will likely recognize a long-term savings for
electronic treatment of chronic and debilitating conditions.
Kalorama's Electrical and Magnetic Neurostimulation: Applications, Technologies, and
Market Potential, looks at the market for these devices and provides current market and
forecast for the following segments:
External Electrical and Neurological Stimulation Devices, including:
• Bone Growth Stimulators
• TENS
• EMS
• Ultrasound-accelerated Fracture Healing
• Other (ECT/TMS)
Implanted Electrical and Neurological Stimulation Devices, including:
• Implantable Bone Growth
• Cardiac Rhythm Management
• Deep Brain (DBS)

2. • Gastric Electrical (GES)
• Sacral Nerve (SNS)
• Spinal Cord (SCS)
• Vagus Nerve (VNS)
As part of its comprehensive coverage of electrical and magnetic neurostimulation, the
report looks at several trends that will have positive and negative effects on the
marketplace. These include:
• Neurostim and Obesity
• Implantable Therapy for Resistant Hypertension
• New Developments and Alternative Technologies
• Transcranial Magnetic Stimulation (TMS)
• Magnetic Stimulation and Depression Treatment
• Magnetic Stimulation and Neurological Trauma Therapy
• Magnetic Stimulation and Auditory Hallucinations
• Magnetic Stimulation and the Effects on Cerebral Blood Flow
• TMS Potential
• TMS/rTMS Instrument Parameters
• Neuroprosthetics
• Functional Electrical Stimulation (FES)
• Bidirectional Neuroprotheses
• Retinal Implants
• Neurostimulation for Depression
• The Neuron-Silicon Interface
• Physiology of EMS Applications
• Endurance Training by Increased Oxygen Supply
• Muscle Recovery via Increased Blood Flow
• Muscle Diagnostics with Electromyography
• Uncertainties in Electrostimulation Business Development Management
• New Technology Challenges
As Kalorama Information's report details, this could be very god timing for these
devices. Combined with new telemedicine strategies, implanted sensors, and drug
delivery systems, electrical and magnetic neurostimulation can usher in a new wave of
care for the chronically ill.
This Kalorama Information report is based primarily on interviews with technology
suppliers, other market participants, and analysts in the industry and on comprehensive
searches of current research, product literature, company reports, market data, and
other sources.
Table of Contents

3. CHAPTER ONE: EXECUTIVE SUMMARY
• Electrostimulation and Neuroprosthetic Technology Introduction
•
• Scope of This Report
• A Strong Market Foundation
• Future Directions
• Market Size and Projections
CHAPTER TWO: INTRODUCTION
• Stimulation Therapeutics for Muscles and Nerves
• Medical Applications of External Electrode Modalities
o Electrical Stimulation
o Measurement and Diagnosis
o Stimulation by Magnetic Field Pulses
o Ultrasonic and Short Wavelength Diathermy
• Medical Applications of Implanted Electrode Modalities
o Bladder Stimulators
o Carotid Sinus Nerve Stimulation
o Cochlear Implant
o Deep Brain Stimulation
o Electrical Continence
o Electrical Nerve Stimulation
o Pelvic Floor Stimulation
o Phrenic Nerve Stimulation
o Sacral Nerve Stimulation
o Spinal Cord Stimulation
o Vagus Nerve Stimulation
• Characteristics of the Electrostimulation Market
o Market Segmentation of Neurostimulation Modalities
• Trends and Assumptions
• Competitive Landscape and Issues
o Applicable Industrial and Regulatory Codes
o Companies in the Electrostimulation Market
• End-User Segments
CHAPTER THREE: EXTERNAL ELECTRICAL STIMULATION DEVICES
• Introduction
• External Electrostimulation Technologies
• EMS, NMS, TENS
o Transcutaneous Electrical Nerve Stimulation (TENS)
o Early Observations of Pain Relief
o Physiological Model Theories
o Interferential Current

4. o Galvanic Stimulation
o Electrodes
o Market Analysis
• Bone Growth Stimulation
o Market Analysis
• Ultrasound-Accelerated Fracture Healing
• Market Analysis
• Other Treatments
• ECT
• TMS and rTMS
• Market Forecasts for Electrostimulation With External Electrodes
CHAPTER FOUR: IMPLANTED ELECTRICAL AND NEUROLOGICAL STIMULATION
DEVICES
• Introduction
• Types of Implanted Electrode Systems
• Implanted Bone Growth Stimulators
• Market Analysis
• Cardiac Rhythm Management
o Cardiac Resynchronization Therapy
o Implantable Cardiac Pacemakers
o Implantable Cardioverter-Defibrillators
o Market Analysis
• Spinal Cord Stimulation (SCS)
o Basic Implementation
o SCS vs TENS in Pain Relief
o Cost-Benefit Analysis of SCS
o Market Analysis
• Sacral Nerve Stimulation (SNS)
o Control of Urinary Incontinence
o Control of Fecal Incontinence
o Market Analysis
• Vagus Nerve Stimulation (VNS)
o Seizure Control in Epilepsy
o Treatment of Depression
o Market Analysis
• Deep Brain Stimulation (DBS)
o Treatment of Neurological Movement Disorders
o Market Analysis
• Gastric Electrical Stimulation (GES)
o Market Analysis
• Market Analysis for Implanted Electrical and Neurological Stimulation Devices
CHAPTER FIVE: TRENDS AND ISSUES

5. • New Innovations
• Neurostim and Obesity
• Implantable Therapy for Resistant Hypertension
• New Developments and Alternative Technologies
• Magnetic Stimulation
• Transcranial Magnetic Stimulation (TMS)
• Magnetic Stimulation and Depression Treatment
• Magnetic Stimulation and Neurological Trauma Therapy
• Magnetic Stimulation and Auditory Hallucinations
• Magnetic Stimulation and the Effects on Cerebral Blood Flow
• TMS Potential
• TMS/rTMS Instrument Parameters
• Neuroprosthetics
• Functional Electrical Stimulation (FES)
• Bidirectional Neuroprotheses
• Cochlear Implants
• Retinal Implants
• Neurostimulation for Depression
• The Neuron-Silicon Interface
• Physiology of EMS Applications
• Endurance Training by Increased Oxygen Supply
• Muscle Recovery via Increased Blood Flow
• Muscle Diagnostics with Electromyography
• Uncertainties in Electrostimulation Business Development Management
• Future Advancements
• New Technology Challenges
CHAPTER SIX: MARKET SUMMARY
• Total Market Overview
• Geographical Market Analysis
CHAPTER SEVEN: COMPANY PROFILES
• Amrex Electrotherapy Equipment (Division of Amrex-Zetron)
• Biomet, Inc.
• Bioness, Inc.
• Boston Scientific, Inc
• Cyberonics, INC
• Delsys, INC
• DJO International
• Dynatronics Corporation
• Electromedical Products International (EPI)
• Magstim Company, Ltd.
• MedFaxx, INC
• Medtronic, INC

6. • Multi radiance Medical, Inc
• Neuronetics, Inc
• Noraxon USA, Inc
• Orthofix International NV
• Prizm Medical, Inc.
• Rich-Mar Corporation
• RS Medical
• Smith & Nephew
• Somatics, LLC
• ST Jude Medical, Inc.
• Thought Technology Ltd.
APPENDIX
COMPANY DIRECTORY
LIST OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY
• Table 1-1: Electrical and Neurostimulation Equipment/Device Market by
Application Method, 2006-2013
• Figure 1-1: Electrical and Neurostimulation Equipment/Device Market by
Application Method, 2006-2013
CHAPTER TWO: INTRODUCTION
• Table 2-1: Energy/Radiation Stimulation Medical Electronics Products
• Table 2-2: Implanted Electrode Stimulation Technologies
• Table 2-3: Market Drivers Impacting Electrostimulation Equipment Sales
• Table 2-4: Market Restraints Limiting Electrostimulation Equipment Sales
• Table 2-5: Standard Industrial Codes (SIC) for Electrical/Magnetic
Stimulation Equipment
• Table 2-6: North American Industry Classification System (NAICS) Codes
for Electrical/Magnetic Stimulation Equipment
• Table 2-7: Major Electrostimulation Equipment Companies 2009
• Table 2-8: Major Players by Segment, 2009 Table 2-9: Healthcare
Practitioners by Occupation Title, 2008
CHAPTER THREE: EXTERNAL ELECTRICAL STIMULATION DEVICES
• Table 3-1: Electrode Stimulation Modalities with External Electrodes Type
and Description
• Table 3-2: TENS and EMS Stimulation Modes
• Table 3-3: The World Market for TENS and EMS Devices 2006-2013
• Figure 3-1: The World Market for TENS and EMS Devices 2006-2013

7. • Table 3-4: The World Market for External Bone Growth Stimulation Devices
2006-2013
• Figure 3-2 The World Market for External Bone Growth Stimulation Devices
2006-2013
• Table 3-5: The World Market for Ultrasound-Accelerated Fracture Healing
Systems 2006-2013
• Figure 3-3 The World Market for Ultrasound-Accelerated Fracture Healing
Systems 2006-2013
• Table 3-6: The World Market for Other External Electrostimulation Devices
2006-2013
• Figure 3-3: The World Market for Other External Electrostimulation Devices
2006-2013
• Table 3-7: External Electrostimulation Device Market by Product Type
(Bone Growth Stimulators, Ultrasound-Accelerated Fracture Healing, Other
(ECT/TMS)) 2006-2013
• Figure 3-4: External Electrostimulation Device Market by Product Type
(Bone Growth Stimulators, Ultrasound-Accelerated Fracture Healing, Other
(ECT/TMS)) 2006-2013
• Figure 3-5: External Electrostimulation Device Market by Product Type 2009
and 2013
CHAPTER FOUR: IMPLANTED ELECTRICAL AND NEUROLOGICAL STIMULATION
DEVICES
• Table 4-1: The World Market for Implantable Bone Growth Stimulation
Devices 2006-2013 Compound Annual Growth Rate
• Figure 4-1: The World Market for Implantable Bone Growth Stimulation
Devices 2006-2013
• Table 4-2: The World Market for Implantable Cardiac Rhythm Management
Devices 2006-2013 Compound Annual Growth Rate
• Figure 4-2: The World Market for Implantable Cardiac Rhythm Management
Devices 2006-2013
• Table 4-3: The World Market for Spinal Cord Stimulation Devices 2006-2013
Compound Annual Growth Rate
• Figure 4-3: The World Market for Spinal Cord Stimulation Devices 2006-
2013
• Table 4-4: The World Market for Sacral Nerve Stimulation Devices 2006-
2013 Compound Annual Growth Rate
• Figure 4-4: The World Market for Sacral Nerve Stimulation Devices 2006-
2013
• Table 4-5: The World Market for Vagus Nerve Stimulation Devices 2006-
2013 Compound Annual Growth Rate
• Figure 4-5: The World Market for Vagus Nerve Stimulation Devices 2006-
2013
• Table 4-6: The World Market for Deep Brain Stimulation Devices 2006-2013
Compound Annual Growth Rate

8. • Figure 4-6: The World Market for Deep Brain Stimulation Devices 2006-2013
• Table 4-7: The World Market for GastricElectrical Stimulation Devices 2006-
2013
• Figure 4-7: The World Market for Gastric Electrical Stimulation Devices
2006-2013
• Table 4-8: Implantable Electrical and Neurological Stimulation Market by
Product Segment (Bone Growth, Cardiac Rhythm Management, Deep Brain,
Gastric Electrical, Sacral Nerve(SCS), Spinal Nerve (SNS), Vagus Nerve
(VNS)) 2006-2013
• Figure 4-8: Implantable Electrical and Neurological Stimulation Market by
Product Segment 2006-2013
• Figure 4-9: Implantable Electrical and Neurological Stimulation Market by
Product Segment 2009 and 2013
Market Summary
• Table 4-9: Electrical and Neurostimulation Equipment/Device Market by
Application Method, 2006-2013 Compound Annual Growth Rate
• Figure 4-10: Electrical and Neurostimulation Equipment/Device Market by
Application Method, 2006-2013
• Figure 4-11: Electrical and Neurostimulation Equipment/Device Market by
Application Method, 2009 and 2013
• Table 4-10: Electrical and Neurostimulation Equipment/Device Market
Estimated Sales by Geographic Region 2006-2013 Compound Annual
Growth Rate
• Figure 4-12: Electrical and Neurostimulation Equipment/Device Market
Estimated Sales by Geographic Region 2006-2013
• Figure 4-13: Electrical and Neurostimulation Equipment/Device Market
Estimated Sales by Geographic Region 2009 and 2013
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