Model of Multiple Sclerosis

•

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Michael Changaris

A model of MS that is rooted in systemic regulation of tissue.

Gesundheit & Medizin

Adverse

Childhood

Experiences

(ACEs)

Autonomic

Dysregula1on

Allosta1c

Load

Telomerase

Telemeres

ROS,
CASP9,

CREB,
Bcl2
etc.

Apoptosis

Regulators

Cell
Markers
of

Cell
Health

and
Self

Removal
of

Healthy
Cells

Neuroplas1c

Immunofunc1ons

Neuroplas1c
Changes

Remove
Brake

On
Plas1city

Increase
Rate

of
Brain
Tissue

Change

Glial
Func1oning

• 

Glutamate
Reuptake

• 

Immune
Barrior

• 

Synap1c
Plas1city

• 

Apop1c
Signal

Rapid
Tissue

Loss

Cell
Repair
Cycles

•  Neurogenesis

•  LTP

•  Cell
Repair

Lesion

Regrowth

Metabolic

Changes

(e.g.
Sugar/Insulin,

Mitochondria
fxn)

Model
of

Mul1ple

Sclerosis

Balance

Decrease
Cell

Replacement

And
Reduced

Cell
Health

Gene1c

&
Other

Factors

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