This document outlines 10 secrets to success for intrauterine insemination (IUI). It discusses factors such as choosing the right patients based on their infertility diagnosis and prognosis, understanding the patient's ovarian and endometrial response based on age and biomarkers, using an individualized ovarian stimulation protocol, modifying treatment based on endometrial thickness, proper follicle monitoring and HCG trigger timing, optimizing IUI timing and semen preparation, ensuring proper IUI technique, providing luteal phase support with vaginal progesterone, knowing when to stop IUI treatment, and maintaining a cohesive team with thorough documentation and analysis of results. The overall message is that success in IUI lies in attention to many details of patient selection, treatment planning