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S. mutans was originally isolated from carious human teeth by Clarke in 1924. Little attention was paid to this species until the 1960s when it was demonstrated that caries could be experimentally-induced and transmitted in animals artificially-infected with strains resembling S. mutans. Besides functioning as a resistant structural matrix, insoluble extracellular polysaccharides can act as a diffusion barrier. The transport of metabolites and salivary buffers into the plaque and the diffusion of acid out of the plaque may be affected by glucan. Fructans, on the other hand, unlike the mutan homopolymer of glucan, are generally soluble and can be degraded by plaque bacteria, thus serving as a reservoir of fermentable sugars for oral bacteria. A group of fructans produced by bacteria or created by breaking down other kinds of plant fructans are called levan . Levans are both more soluble and more readily catabolized than glucans. Since levan hydrolysis is rapid, it may function as a short-term reservoir for the sustenance of bacterial anaerobic glycolysis in times of relative unavailability of dietary carbohydrate. Lipoteichoic acid is another extracellular polymer that is found in cultures of S. mutans. These highly negatively charged compounds might contribute to the adhesiveness of bacteria. In addition to this, S. mutans strains have an ability to store intracellular glycogen amylopectin type polysaccharide, which provides a reservoir of substrate and enables prolonged periods of increased metabolic activity. Intracellular glycogen and extracellular polysaccharides serve as substrate reservoirs, which the organism may utilize for energy production, as the exogenous supplies of readily metabolized carbohydrate are depleted. In this fashion, both types of polysaccharides may play a role in the survival of organisms and in their potential to prolong acid production via glycolysis well beyond meal time. It is known that sucrose-adapted S. mutans strains possess significant levels of invertase activity, and this enzyme isknown to hydrolyze sucrose intracellularly to free glucose and fructose. Invertase is activated by inorganic phosphate and since phosphate accumulation is coupled with acid production, it is probable that one of the several mechanisms by which sucrose degradation is regulated in S. mutans is the activation of invertase by inorganic phosphate. Cariogenic features of mutans streptococci - Binding to and colonization of teeth Accumulation on tooth surfaces & participation in the formation of dental plaque. Production of acid at a high rate. Tolerance of high concentration of sugar, high ionic strength & highly acidic conditions Association with dental caries in humans Causation of dental caries in animals Transmissible in animals & apparently in man Reduction or elimination of mutans results in reduction or elimination of dental caries
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💥 You’re lucky! We’ve found two different (lead) developers that are willing to share their valuable lessons learned about using UiPath Document Understanding! Based on recent implementations in appealing use cases at Partou and SPIE. Don’t expect fancy videos or slide decks, but real and practical experiences that will help you with your own implementations. 📕 Topics that will be addressed: • Training the ML-model by humans: do or don't? • Rule-based versus AI extractors • Tips for finding use cases • How to start 👨🏫👨💻 Speakers: o Dion Morskieft, RPA Product Owner @Partou o Jack Klein-Schiphorst, Automation Developer @Tacstone Technology
DEV meet-up UiPath Document Understanding May 7 2024 Amsterdam
DEV meet-up UiPath Document Understanding May 7 2024 Amsterdam
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In this talk, we are going to cover the use-case of food image generation at Delivery Hero, its impact and the challenges. In particular, we will present our image scoring solution for filtering out inappropriate images and elaborate on the models we are using.
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apidays
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Corporate and higher education. Two industries that, in the past, have had a clear divide with very little crossover. The difference in goals, learning styles and objectives paved the way for differing learning technologies platforms to evolve. Now, those stark lines are blurring as both sides are discovering they have content that’s relevant to the other. Join Tammy Rutherford as she walks through the pros and cons of corporate and higher ed collaborating. And the challenges of these different technology platforms working together for a brighter future.
Corporate and higher education May webinar.pptx
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Streptococcus mutans cell
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Streptococcus mutans: tooth
decay, caries, plaque By:Goua Vang
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