Waldenstrom macroglobulinemia

1. Waldenstrom Macroglobulinemia (WM)

2. Introduction of Waldenstrom Macroglobulinemia (WM)
Waldenstrom macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of
non-Hodgkin lymphoma. It is very uncommon, slow-growing cancer that begins in the immune
system. Abnormal white blood cells (lymphocytes) in the bone marrow make an abnormal protein
called monoclonalimmunoglobulin M (IgM) that thickens the blood plasma. This causes the
symptoms of Waldenstrom macroglobulinemia.
Waldenstrom macroglobulinemia cells develop mainly in the bone marrow, where they can crowd
out the normal cells that make the different types of blood cells. This can cause
low levels of red blood cells, effects of which may make people tired and weak. It can also cause
low numbers of white blood cells, which makes it difficult for the body to fight infection.

3. Symptoms of Waldenstrom Macroglobulinemia (WM)
The most common signs and symptoms of Waldenstrom macroglobulinemia include:
•Weakness
•Loss of appetite
•Fever, sweats, weight loss
•Painful pins and needles sensation in the feet and legs
•Enlarged lymph nodes
•Swollen abdomen
•Nervous system symptoms such as headache, confusion, and dizziness
•Abnormal bleeding
•Vision problems
•Kidney problems
•Heart problems such as heart palpitations, shortness of breath
•Infections
•Digestive symptoms such as diarrhea, poor absorption of vitamins, orgastrointestinal bleeding

4. Diagnoses of Waldenstrom Macroglobulinemia (WM)
Diagnoses of Waldenstrom macroglobulinemia include a series of examinations and tests:
•Your doctor will perform a physical exam to determine any health changes you may have, such as
enlarged lymph nodes.
•Lab tests show changes in your blood cells, blood chemistry and your urine. These tests also tell your
doctor if you have the IgM protein, a sign of Waldenstrom macroglobulinemia.
•A bone marrow biopsy can tell your doctor about changes in the lymphocyte cells in your bone
marrow.
•X-rays can show your doctor any changes in your bones.
•A CT scan combines a series of X-ray views to produce images of the bones and soft tissues inside
your body so that your doctor can look for changes.

5. Treatments of Waldenstrom Macroglobulinemia (WM)
Once you have been diagnosed with Waldenstrom macroglobulinemia, it’s time for the doctor to
discuss your treatment options with you. These may include:
Chemotherapy: In chemotherapy, medicines are used that attack abnormal cells to reduce their
effect on healthy bone marrow and lower the level of abnormal protein. It can be taken
intravenously or in the form of a pill.
Plasma exchange: If thickening of the blood causes problems, plasma exchange can be used to
wash the IgM protein out of your bloodstream and replace it with healthy plasma. It is very
effective procedure which requires only one or two treatments to lower blood protein levels.
Biotherapy: Biotherapy may be used alone or in coordination with chemotherapy. Biological
therapy, as it is often known, boosts your immune system's ability to fight cancer and help decrease
side effects from certain types of cancer treatments.
Radiation therapy: It uses high-energy rays to kill cancer cells. However, this type of treatment is
not used often to treat Waldenstrom macroglobulinemia.
Current forms of treatment for Waldenstrom macroglobulinemia are not likely to result in a cure.
Patients are treated for some time, followed by a break, and then treated again when the disease
comes back.

6. Treatments of Waldenstrom Macroglobulinemia (WM)
Once you have been diagnosed with Waldenstrom macroglobulinemia, it’s time for the doctor to
discuss your treatment options with you. These may include:
Chemotherapy: In chemotherapy, medicines are used that attack abnormal cells to reduce their
effect on healthy bone marrow and lower the level of abnormal protein. It can be taken
intravenously or in the form of a pill.
Plasma exchange: If thickening of the blood causes problems, plasma exchange can be used to
wash the IgM protein out of your bloodstream and replace it with healthy plasma. It is very
effective procedure which requires only one or two treatments to lower blood protein levels.
Biotherapy: Biotherapy may be used alone or in coordination with chemotherapy. Biological
therapy, as it is often known, boosts your immune system's ability to fight cancer and help decrease
side effects from certain types of cancer treatments.
Radiation therapy: It uses high-energy rays to kill cancer cells. However, this type of treatment is
not used often to treat Waldenstrom macroglobulinemia.
Current forms of treatment for Waldenstrom macroglobulinemia are not likely to result in a cure.
Patients are treated for some time, followed by a break, and then treated again when the disease
comes back.