1. Level I Pathways
Drug Cost is Only the Ground Floor
Oncology care is evolving faster than ever. Emerging drugs and technologies are driving new treatment
options for oncologists and their patients. Some are promising yet some are not. Knowing which ones offer
true clinical benefit is critical to optimizing outcomes and managing costs. The focus on drug reimbursement
is one important and necessary way of addressing costs. But this approach does not prevent “jumping to the
next drug” and does little to address the vast treatment variation seen in oncology. The real clinical and cost
opportunity is in using the right treatments in the first place.
Level I Pathways: The Next Step
Level I Pathways from Innovent Oncology are the next step in managing quality and cost. Moving beyond broad label
listings and public domain guidelines, Level I Pathways narrow the options to those with proven clinical effectiveness
and the least possible toxicity. When Level I evidence* points to a superior drug that is the one that is used. If there is
no clear evidence of clinical superiority, then drug toxicity and cost are factored into the pathway.
Community Oncologists Agree: Consensus Means Adoption
Clinical oncology is increasingly complex. Level I Pathways are developed and updated by a National Policy Board
from a network of more than 1,000 practicing community oncologists. Their work is an ongoing, exhaustive review
of documented clinical evidence from an array of sources including medical journals, outcomes data and
network experience.
The result of this process is a national treatment standard rooted in evidence and supported by more than 18 industry
accepted outcomes measures. The result for payers is local application by community oncologists working to limit the
treatment variation that drives substandard quality and unnecessary costs.
Technology Options: Compliance Drives Value
Innovent Oncology provides options that enable payers and oncologists to use Level I Pathways for oncology drug
selection within the oncologist’s practice. These technologies allow access to decision support tools for treatment
selection and data sharing essential to compliance documentation.
• Direct Electronic Medical Records (EMR) access
• EMR connectivity
• Oncology 837: Interactive Web Portal
• Adherence report engine
* Level I evidence is obtained from meta-analysis of multiple,
well-designed, controlled studies or from randomized trials with
low false-positive and low false-negative errors (high power).
Integrated Cancer Solutions

2. Level I Pathways
Features Benefits Expected Results
• Physician-led, expert driven • Refined guidelines limit variance • Value-based therapy choices
development
• Oncologist-derived consensus • Reduced diagnostic testing utilization
• Broad, deep and ongoing evidence promotes physician adoption and costs
review
• Clear, credible clinical standards • Reduced overall treatment costs
• Narrowed subset of label listings and inform utilization policy
public guidelines • Reduced drug testing utilization
• Documented treatment comparisons and costs
• Defines line of therapy based on identify physician compliance
cancer stage, current patient status
• Effectiveness and toxicity first,
cost second
Evidence-based Oncology: A New Level of Refinement
Convenient, easy-to-use web portal captures additional diagnosis and treatment information at the point of care.
"We’ve worked with oncologists and payers nationwide to develop this program,”
says Marcus A. Neubauer, MD, Chairman of US Oncology’s Level I Pathways
committee and medical oncologist with Kansas City Cancer Centers. “The
physicians affiliated with US Oncology developed evidence-based treatment
pathways several years ago to reduce the high variability of drug utilization
during treatment, but this program goes well beyond drug utilization in its quest
for improved quality and reduced costs."
Marcus A. Neubauer, MD
For more information about the
Integrated Cancer Solutions available from Innovent Oncology:
Call: (866) 214-2194
Email: innovent@usoncology.com • www.innoventoncology.com
Integrated Cancer Solutions

3. Advance Care Planning
Informing Transitions: The Direct Path
The cancer path is paved with many frightening twists and turns. Do I understand the possible course of
events? As each unfolds, do I know the choices I will make? Am I ready to face my personal circumstances?
Advance Care Planning helps patients explore these questions within the context of their specific disease,
understand their options and document their preferences for end-of-life care. Along with their caregivers and
family members, patients specify the treatments they do and do not desire and select a healthcare agent to
speak on their behalf when necessary.
Beyond Costs, Peace of Mind for Everyone
Only one-third of terminally ill cancer patients in a recent, federally funded study said their doctors had discussed
end-of-life care.* Trained to help patients fight their disease, oncologists are routinely confronted by the end-of-life
issues of patients and their loved ones. Some oncologists do it with ease. Others can’t do it at all. It’s one of the most
difficult things for everyone involved. Yet, doing so has clear benefits that go far beyond the associated costs of
eliminating futile treatment during the last months of life.
Innovent Oncology Advance Care Planning is designed to facilitate timely, sensitive discussions with patients and loved
ones as they confront transition from active/curative treatment to palliative care. The very same care team that guides
patients through their fight to overcome their cancer introduces end-of-life concepts to patients. They review treatment
options, discuss Advance Directives, and prepare for palliative care and hospice. These discussions empower patients,
increase their satisfaction with care and give everyone peace of mind.
Practical Guidance for End-of-Life Care
In the same recent end-of-life study, early findings show the promise of open, objective communication and
documentation of patient preferences for care. Those patients who had end-of-life talks were three times less likely to
spend their final week in intensive care, four times less likely to be on breathing machines and six times less likely to
be resuscitated.
Innovent Oncology Advance Care Planning is designed to equip oncologists with the tools to guide patients and their
loved ones along a path of discovery near the end-of-life.
* Alexi A. Wright, MD et al
Integrated Cancer Solutions

4. Advance Care Planning
Features Benefits Expected Results
• Introduce end of life (EOL) • Introduce and review Advance • Reduced overall costs associated
concepts early Directives with EOL care
• Introduce and review Advance • Reinforce best standards of care • Increased hospice utilization
Directives
• Prepare patient, family and care • Increased use of Advance Directives
• Involve physician and qualified team for advanced disease state
non-physician professionals • Increased patient and family comfort,
• Open option of clinical trials peace of mind and satisfaction
• Hold specific EOL discussions with care
• Ease patient EOL distress
• Implement Palliative Care Plan and • Avoidance of costly, futile care
hospice care as appropriate • Ensure appropriate services delivery
• Empower patients and increase
satisfaction with care
Team-based, Compassionate Care.
Patients and their care team have tools to facilitate preparation for advanced disease state.
“We recognize we will not be able to cure all of our cancer patients. We can,
however, provide care that helps them live life as well as they can,” says Russell
Hoverman, MD, Medical Director of Managed Care with US Oncology and
medical oncologist with Texas Oncology. “The tools provided by Innovent
Oncology enhance our ability to help our patients by supporting a team-based
approach to the delivery of our goal of compassionate care.”
Russell Hoverman, MD
For more information about the
Integrated Cancer Solutions available from Innovent Oncology:
Call: (866) 214-2194
Email: innovent@usoncology.com • www.innoventoncology.com
Integrated Cancer Solutions

5. Patient Support Services
Touch the Patient, Heal the System
During their treatment, cancer patients are often confronted with more than they can handle. Managing
the physical impacts of the disease, its impact on their lives and those around them, and their treatment
plan—potentially including potent, home-administered oral chemotherapy—is daunting.
What will happen next? Can I really handle chemotherapy? How will I know what side effects to watch for
and how to manage them? What if something goes wrong?
The inability to manage through these issues can result in unnecessary patient and family distress,
unplanned, frightening trips to the emergency room, or worse, a hospitalization. These events are hard on
patients and costly to our healthcare system. Proactive management to limit patient fear and anxiety while
ensuring efficient resource utilization is the purpose of Innovent Oncology Patient Support Services.
Physician-Directed Disease Management
The full promise of disease management is realized when informed by the oncologist’s plan of care. Patients need
clear information that reinforces what they have already heard from their trusted oncologist. Innovent Oncology
Patient Support Services are integrated with and initiated by the oncology care team. Focused education specific to
the patient’s disease is delivered by oncology certified registered nurses using evidence-based, standardized education
materials. Patients receive regular outreach and support tailored to their disease, their specific drug regimen and
potential side effects.
Technology Enabled: Practice-Integrated and Call Center Supported
Innovent Oncology provides technologies to better connect the oncology care team with their patients. The resulting
interactive decision support and data sharing drives proactive patient monitoring, care team interventions, and patient
compliance documentation.
• Direct Electronic Medical Records (EMR) views by registered nurse care manager
• CRM connectivity, alerts and patient status views
• Call center support
• Print and web patient education content
Integrated Cancer Solutions

6. Patient Support Services
Features Benefits Expected Results
• Physician directed and integrated • Extend proactive engagement to • Increased adherence and
with care plan members between office visits compliance to treatment plan
• Focused education and intervention • Increased member confidence in • Improved health status
by cancer specialist at-home management
• Reduced unplanned office visits
• Practice-based and/or call • Ensure most appropriate services
center-supported utilization • Reduced ER visits, hospitalizations
and hospital days
• Patient-specific disease and • Consolidate excessive care
treatment counseling management contacts • Increased patient and physician
satisfaction
• Evidence-based, standardized • Broader program participation
education materials
• Drug specific information
• Side effect profile and plan
• Nutrition education
Improving Care. Managing Costs.
Patients receive standardized education materials that increase their confidence in at-home management of their disease.
“We all want the same thing—the most effective, compassionate care
possible for cancer patients and their families as they go through what can
be a very frightening experience,” says Michael A. Kolodziej, MD, Medical
Director for US Oncology and medical oncologist with New York Oncology
Hematology. “This comprehensive approach helps providers and payers
work together to focus on patient services in a way that will improve patient
care and manage costs at the same time.”
Michael A. Kolodziej, MD
For more information about the
Integrated Cancer Solutions available from Innovent Oncology:
Call: (866) 214-2194
Email: innovent@usoncology.com • www.innoventoncology.com
Integrated Cancer Solutions