1. Guideline Summary Updated US Public Health Service Guidelines for the Management of Occupational Exposures to HIV and Recommendations for Postexposure Prophylaxis

2. Guidelines for the Management of Occupational Exposures to HIV and Recommendations for Postexposure Prophylaxis Developed by the Public Health Service Interagency Working Group, convened by National Center for Infectious Diseases, CDC

9. PEP after Occupational Exposure http://www.hivguidelines.org/GuideLine.aspx?pageID=78&guideLineID=3

27. NY AIDS inst recommended PEP www.hivguidelines.org

44. PEP for Percutaneous Injuries Exposure Type Infection Status of Source Recommend expanded ≥ 3-drug PEP Recommend expanded 3-drug PEP More severe Recommend expanded ≥ 3-drug PEP Recommend basic 2-drug PEP Less severe HIV+, class 2 HIV+, class 1

45. PEP for Percutaneous Injuries (2) Exposure Type Infection Status of Source *If PEP is given and source is later determined to be HIV negative, PEP should be discontinued. As above Generally, no PEP warranted; consider basic 2-drug PEP if exposure to HIV-infected persons is likely Unknown source As above More severe Generally, no PEP warranted; consider basic 2-drug PEP if source has HIV risk factors Less severe Unknown HIV status*

46. PEP for Percutaneous Injuries (3) Exposure Type Infection Status of Source No PEP More severe No PEP Less severe HIV negative

47. PEP for Mucous Membrane and Nonintact Skin Exposures Exposure Type Infection Status of Source Recommend expanded ≥ 3-drug PEP Recommend basic 2-drug PEP More severe Recommend basic 2-drug PEP Consider basic 2-drug PEP Less severe HIV+, class 2 HIV+, class 1

48. PEP for Mucous Membrane and Nonintact Skin Exposures (2) Exposure Type Infection Status of Source *If source is determined to be HIV negative after PEP is initiated, discontinue PEP. Generally, no PEP warranted; consider basic 2-drug PEP if exposure to HIV-infected persons is likely Generally, no PEP warranted Unknown source Generally, no PEP warranted; consider basic 2-drug PEP if source has HIV risk factors More severe Generally, no PEP warranted Less severe Unknown HIV status*

49. PEP for Mucous Membrane and Nonintact Skin Exposures (3) Exposure Type Infection Status of Source No PEP More severe No PEP Less severe HIV negative

61. About This Presentation These slides were developed using the September 2005 guidelines on postexposure prophylaxis (PEP) following occupational exposure to HIV. The intended audience is clinicians involved in the care of health care personnel (HCP) with occupational exposure to HIV. Users are cautioned that, because of the rapidly changing field of HIV care, this information could become out of date quickly. Finally, it is intended that these slides be used as prepared, without changes in either content or attribution. Users are asked to honor this intent. – AETC NRC http://www.aidsetc.org