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Management of the Treatment Naïve Patient Jason M. Leider, MD, PhD NBHN Adult HIV Director Associate Professor of Internal Medicine @ AECOM August 5, 2009
ST, a 56-year-old white man, presents to your clinic for initial management of HIV infection. He was diagnosed 4 months ago at the local health department where he underwent testing after learning of exposure from a previous sexual partner. He has no signs or symptoms of an opportunistic infection. His past medical history includes a myocardial infarction, hypertension, and dyslipidemia. His CD4 count is 420 cells/µL and his viral load is 83,000 copies/mL. Prior to his appointment, you review the lab results and determine that it may be prudent to recommend initiation of antiretroviral therapy (ART).
This recommendation is based on which of the following factors that mirrors the recommendations of the US Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents, issued November 3, 2008?  ,[object Object],[object Object],[object Object],[object Object]
Which of these laboratory values or conditions  would not  influence the choice of an initial regimen for ST?   ,[object Object],[object Object],[object Object],[object Object]
After assessing his readiness to take medication and addressing factors that might limit adherence, you negotiate a treatment plan. He commits to beginning an antiretroviral regimen.  Given his current medical problems and treatment-naive HIV status, is there any class of drugs that should be avoided as initial therapy?   ,[object Object],[object Object],[object Object],[object Object],[object Object]
A 35-year-old black woman who was screened in your office tests positive for HIV on rapid testing. A Western blot test confirms the initial positive screening result. Her only risk factor is 3 male sexual partners in the past 6 years. She reports that she is not currently sexually active. She has no current medical problems and takes no prescription medications. Her initial CD4 count is 387 cells/µL and her initial HIV-1 RNA serum level is 46,000 copies/mL. She is very nervous about having an infection in her body and wants to start treatment as soon as possible.
Which of the following would  not  be an indication to start ART in this patient at this time?  ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
RW, a 57-year-old Hispanic man, presents to your clinic for initial management of HIV infection. He was diagnosed 4 months ago at the local health department where he underwent testing after learning of exposure from a previous sexual partner. He has no signs or symptoms of an opportunistic infection. His past medical history includes a previous myocardial infarction, hypertension, and dyslipidemia. His CD4 count is 410 cells/µL and his viral load is 78,000 copies/mL. Prior to his appointment, you review the lab results and determine that it may be prudent to recommend initiation of antiretroviral therapy (ART).
This recommendation is based on which of the following factors that mirrors the recommendations of the US Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents, issued November 3, 2008?  ,[object Object],[object Object],[object Object],[object Object]
This recommendation is based on which of the following factors that mirrors the recommendations of the US Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents, issued November 3, 2008?  ,[object Object],[object Object]
Which of these laboratory values or conditions  would not  influence the choice of an initial regimen for RW? ,[object Object],[object Object],[object Object],[object Object]
Which of these laboratory values or conditions  would not  influence the choice of an initial regimen for RW? ,[object Object],[object Object]
After assessing his readiness to take medication and addressing factors that might limit adherence, you negotiate a treatment plan. He commits to beginning an antiretroviral regimen. Given his current medical problems and treatment-naive HIV status, is there any class of drugs that should be avoided as initial therapy?  ,[object Object],[object Object],[object Object],[object Object]
After assessing his readiness to take medication and addressing factors that might limit adherence, you negotiate a treatment plan. He commits to beginning an antiretroviral regimen. Given his current medical problems and treatment-naive HIV status, is there any class of drugs that should be avoided as initial therapy?  ,[object Object]
A 27-year-old black woman who was screened in your office tests positive for HIV on rapid testing. A Western blot test confirms the initial positive screening result. Her only risk factor is 4 male sexual partners in the past 5 years. She reports that she is not currently sexually active. She has smoked a pack of cigarettes per day since age 14 but otherwise has no current medical problems and takes no prescription medications. Her initial CD4 count is 378 cells/µL and her initial HIV-1 RNA serum level is 34,000 copies/mL. She wants to start treatment as soon as possible.
Which of the following  would not  be an indication to start ART in this patient at this time?   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Which of the following  would not  be an indication to start ART in this patient at this time?   ,[object Object],[object Object]

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Aug 2009 H I V Int Med Noon Lecture

  • 1. Management of the Treatment Naïve Patient Jason M. Leider, MD, PhD NBHN Adult HIV Director Associate Professor of Internal Medicine @ AECOM August 5, 2009
  • 2. ST, a 56-year-old white man, presents to your clinic for initial management of HIV infection. He was diagnosed 4 months ago at the local health department where he underwent testing after learning of exposure from a previous sexual partner. He has no signs or symptoms of an opportunistic infection. His past medical history includes a myocardial infarction, hypertension, and dyslipidemia. His CD4 count is 420 cells/µL and his viral load is 83,000 copies/mL. Prior to his appointment, you review the lab results and determine that it may be prudent to recommend initiation of antiretroviral therapy (ART).
  • 3.
  • 4.
  • 5.
  • 6. A 35-year-old black woman who was screened in your office tests positive for HIV on rapid testing. A Western blot test confirms the initial positive screening result. Her only risk factor is 3 male sexual partners in the past 6 years. She reports that she is not currently sexually active. She has no current medical problems and takes no prescription medications. Her initial CD4 count is 387 cells/µL and her initial HIV-1 RNA serum level is 46,000 copies/mL. She is very nervous about having an infection in her body and wants to start treatment as soon as possible.
  • 7.
  • 8.  
  • 9.  
  • 10.  
  • 11.  
  • 12.  
  • 13.  
  • 14.  
  • 15.  
  • 16.  
  • 17.  
  • 18.  
  • 19.  
  • 20.  
  • 21.  
  • 22.  
  • 23.  
  • 24.  
  • 25.  
  • 26. RW, a 57-year-old Hispanic man, presents to your clinic for initial management of HIV infection. He was diagnosed 4 months ago at the local health department where he underwent testing after learning of exposure from a previous sexual partner. He has no signs or symptoms of an opportunistic infection. His past medical history includes a previous myocardial infarction, hypertension, and dyslipidemia. His CD4 count is 410 cells/µL and his viral load is 78,000 copies/mL. Prior to his appointment, you review the lab results and determine that it may be prudent to recommend initiation of antiretroviral therapy (ART).
  • 27.
  • 28.
  • 29.
  • 30.
  • 31.
  • 32.
  • 33. A 27-year-old black woman who was screened in your office tests positive for HIV on rapid testing. A Western blot test confirms the initial positive screening result. Her only risk factor is 4 male sexual partners in the past 5 years. She reports that she is not currently sexually active. She has smoked a pack of cigarettes per day since age 14 but otherwise has no current medical problems and takes no prescription medications. Her initial CD4 count is 378 cells/µL and her initial HIV-1 RNA serum level is 34,000 copies/mL. She wants to start treatment as soon as possible.
  • 34.
  • 35.