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MDCT’s	
  role	
  in	
  pre-­‐cardiovascular	
  
procedure	
  planning	
  

Stephen	
  CW	
  Cheung	
  

Radiology,	
  Queen	
  Mary	
  Hospital,	
  
Hong	
  Kong	
  
Use	
  of	
  MDCT	
  before	
  procedures
•  MDCT	
  has	
  expanding	
  and	
  increasing	
  
important	
  role	
  in	
  the	
  planning	
  of	
  various	
  
endovascular	
  procedures.	
  	
  	
  
–  PCI,	
  especially	
  complicated	
  lesions	
  and	
  CTO	
  
–  TAVI	
  
–  LAA	
  closure	
  
–  Cardiac	
  re-­‐synchronisaLon	
  
Other	
  procedures
•  Re-­‐do	
  cardiac	
  surgery	
  
•  Closure	
  of	
  para-­‐prostheLc	
  heart	
  valve	
  leakage	
  
•  Mitral	
  valve	
  indirect	
  annuloplasty.	
  	
  
Re-­‐do	
  procedures
Re-­‐do	
  cardiovascular	
  procedures:	
  
CABG-­‐Valve
•  ReoperaLon	
  for	
  cardiac	
  condiLons	
  are	
  geQng	
  
more	
  prevalent	
  	
  
–  >10%	
  of	
  all	
  MVR	
  in	
  US	
  
–  CABG	
  seems	
  to	
  be	
  declining	
  (6%	
  in	
  2000,	
  3.4%	
  in	
  
2009)	
  
–  associated	
  with	
  increased	
  morbidity	
  and	
  
mortality.	
  	
  	
  
•  progression	
  of	
  disease	
  condiLons	
  
•  advanced	
  paLent	
  age	
  
•  risks	
  introduced	
  by	
  previous	
  surgery	
  which	
  can	
  
potenLally	
  be	
  well	
  evaluated	
  by	
  preoperaLve	
  imaging	
  
using	
  MDCT.
Risk	
  of	
  redo	
  MVR
•  Mortality	
  quoted:	
  6-­‐18%	
  
•  Injury	
  to	
  cardiac	
  structure:	
  5-­‐10%
High	
  risk	
  findings	
  on	
  MDCT	
  include:
•  Bypass	
  grac	
  crossing	
  the	
  midline	
  <1cm	
  from	
  
posterior	
  surface	
  of	
  sternum	
  or	
  fixed	
  to	
  
sternum	
  
•  Close	
  proximity	
  of	
  the	
  RV	
  or	
  adjacent	
  
pericardium	
  to	
  the	
  chest	
  wall,	
  <1cm.	
  
•  Ascending	
  aorta	
  <1cm	
  to	
  the	
  inner	
  edge	
  of	
  
chest	
  wall	
  or	
  sternum.	
  
•  Excessive	
  length	
  of	
  the	
  LIMA	
  grac	
  or	
  one	
  not	
  
adequately	
  mobilised.	
  
RV	
  dilataLon,	
  VSD,RCA	
  close	
  to	
  sternum
LIMA	
  relaLon	
  to	
  sternum/chest	
  wall
AddiLonal	
  factors	
  to	
  consider:
•  1. 	
  SVG	
  disease	
  where	
  manipulaLon	
  can	
  cause	
  
distal	
  embolisaLon.	
  
•  2. 	
  Incidental	
  lung	
  or	
  mediasLnal	
  mass,	
  
incidence	
  ~10%	
  in	
  this	
  paLent	
  group.	
  
•  3.	
  	
  	
  Evidence	
  of	
  previous	
  mediasLniLs	
  or	
  
dense	
  adhesions.	
  
ImplicaLon	
  on	
  operaLon
•  A	
  retrospecLve	
  study	
  conducted	
  by	
  Kamdar	
  et	
  al	
  in	
  2008	
  
shows	
  one	
  or	
  more	
  of	
  these	
  features	
  are	
  observed	
  in	
  49%	
  
of	
  paLents,	
  cohort	
  size=	
  167.	
  	
  The	
  most	
  common	
  finding	
  is	
  
finding	
  1,	
  noted	
  in	
  38%	
  of	
  paLents.	
  	
  	
  
•  These	
  CT	
  findings	
  have	
  impact	
  on	
  surgical	
  approach,	
  with	
  7	
  
paLents	
  had	
  the	
  surgery	
  cancelled.	
  	
  	
  
•  In	
  88	
  paLents	
  (55%	
  of	
  the	
  remaining	
  160	
  paLents)	
  the	
  
surgeons	
  adopted	
  some	
  form	
  of	
  prevenLve	
  measures	
  	
  
– 
– 
– 
– 



non-­‐midline	
  incision	
  eg.	
  R	
  thoracotomy	
  (n=14)	
  	
  
deep	
  hypothermic	
  circulatory	
  arrest	
  (n=7)	
  	
  
peripheral	
  cardiopulmonary	
  bypass	
  before	
  incision	
  (n=18)	
  	
  
peripheral	
  arterial	
  and	
  venous	
  dissecLon	
  before	
  incision	
  (n=	
  83).	
  	
  
ImplicaLon	
  on	
  operaLon
•  Another	
  study	
  looking	
  for	
  similar	
  CT	
  features	
  
find	
  that	
  MDCT	
  before	
  the	
  operaLon	
  is	
  
associated	
  with	
  	
  
–  shorter	
  perfusion	
  and	
  cross	
  clamp	
  Lme	
  	
  
–  shorter	
  ICU	
  stay	
  	
  	
  
–  less	
  frequent	
  perioperaLve	
  MI	
  	
  	
  
•  (Maluenda	
  et	
  al	
  2010)
USG	
  to	
  measure	
  CFA/CFV
•  Ensure	
  the	
  vessels	
  are	
  of	
  adequate	
  size	
  for	
  
cannulaLon	
  in	
  peripheral	
  cardiopulmonary	
  
bypass	
  
Ann	
  Thorac	
  Surg	
  2013;96:1358-­‐66
Re-­‐do	
  MVR	
  has	
  low	
  mortality,	
  morbidity	
  and	
  intraopera7ve	
  injury	
  with	
  careful	
  planning

Ann	
  Thorac	
  Surg	
  2013;96:1358-­‐66	
  
Para-­‐prostheLc	
  Heart	
  Valve	
  Leak
Assessment	
  of	
  para-­‐prostheLc	
  valvular	
  
leak	
  

•  Paravalvular	
  leak	
  is	
  esLmated	
  to	
  occur	
  
in	
  3-­‐12.5%	
  of	
  prosthesis	
  within	
  a	
  few	
  
years	
  of	
  operaLon.	
  	
  	
  
•  With	
  the	
  large	
  number	
  of	
  procedures	
  
done	
  every	
  year,	
  the	
  number	
  of	
  leaks	
  
requiring	
  treatment	
  is	
  increasing.	
  	
  	
  
•  With	
  the	
  advent	
  of	
  percutaneous	
  
closure	
  instead	
  of	
  re-­‐operaLon,	
  high	
  
quality	
  imaging	
  is	
  needed.	
  	
  	
  
•  2D/3D	
  TEE	
  is	
  usually	
  the	
  main	
  state	
  of	
  
imaging	
  while	
  CT	
  is	
  also	
  gaining	
  greater	
  
importance-­‐	
  crescent	
  shaped
CT	
  of	
  para-­‐prostheLc	
  valvular	
  leak	
  
•  In	
  a	
  small	
  study	
  consisted	
  of	
  20	
  paLents,	
  MDCT	
  
has	
  been	
  used	
  to	
  evaluate	
  para-­‐prostheLc	
  aorLc	
  
valve	
  leak	
  and	
  regurgitaLon.	
  	
  Excellent	
  
correlaLon	
  was	
  found	
  between	
  MDCT	
  
determined	
  regurgitaLon	
  orifice	
  area	
  and	
  
echocardiogram/surgical	
  findings.	
  
•  However	
  beam	
  hardening	
  artefacts	
  are	
  
significant	
  and	
  depend	
  on	
  type	
  of	
  prosthesis,	
  
rendering	
  12	
  of	
  these	
  subjects	
  non-­‐evaluable.	
  
–  SJM	
  standard	
  	
  √	
  
–  SJM	
  HP,	
  SJM	
  Regent	
  	
  ×
CT	
  of	
  para-­‐prostheLc	
  
valvular	
  leak	
  
•  MDCT	
  detecLon	
  of	
  
paravalvular	
  leak	
  	
  
–  Clock-­‐face	
  view	
  
–  Surgical	
  

•  used	
  as	
  a	
  guidance	
  
during	
  fluoroscopy	
  for	
  
passing	
  guidewire	
  and	
  
deployment	
  of	
  vascular	
  
plugs
Paravalvular	
  leak

MV

AV
Recent	
  Case
Paravalvular	
  Leak
Paravalvular	
  leak	
  locaLon
Paravalvular	
  Leak	
  locaLon
Carlos	
  Ruiz,	
  JACC	
  2011	
  (21)
Para-­‐valvular	
  pseudoaneurysm	
  
Just	
  caudal	
  to	
  AV	
  annulus
Percutaneous	
  MV	
  Repair
Development	
  of	
  veins
Greater	
  and	
  Lesser	
  cardiac	
  venous	
  systems
•  Lesser	
  CVS	
  

–  Thebesian	
  veins,	
  common	
  at	
  ventricular	
  apex	
  and	
  base	
  of	
  
papillary	
  muscles	
  
–  Drain	
  most	
  of	
  RV,	
  LA,	
  RA	
  
–  Can	
  be	
  dilated	
  acer	
  MI	
  
–  Not	
  septal	
  defects
•  Greater	
  CVS	
  	
  
–  CS	
  and	
  non-­‐CS	
  tributaries	
  
–  Drain	
  LV,	
  part	
  of	
  RV	
  
Veins	
  of	
  LA	
  Wall
•  Septal	
  veins	
  of	
  LA	
  drain	
  into	
  
RA	
  through	
  the	
  septum	
  
•  Most	
  common	
  is	
  antero-­‐
superior	
  septum	
  
•  They	
  are	
  not	
  septal	
  defects	
  
or	
  fistulas

Posteroinferior	
  veins

Anterosuperior	
  veins

PFO
Veins	
  of	
  LA	
  Wall	
  

Interatrial	
  muscle	
  connecLon
CS	
  System

AIV=	
  anterior	
  interventricular	
  vein	
  
MCV=IIV	
  (inferior	
  interventricular	
  vein)	
  
Between	
  AIV	
  and	
  IIV:	
  several	
  lateral	
  and	
  posterior	
  branches
GCV

Usually	
  pass	
  over	
  the	
  LAD	
  and	
  	
  LCX	
  but	
  can	
  be	
  under
Assessment	
  for	
  percutaneous	
  mitral	
  valve	
  repair	
  
Indirect	
  Annuloplasty
•  Percutaneous	
  repair	
  of	
  MV	
  can	
  be	
  performed	
  
by	
  placing	
  device	
  inside	
  the	
  great	
  cardiac	
  vein	
  
and	
  coronary	
  sinus	
  aiming	
  at	
  providing	
  inward	
  
pressure	
  on	
  the	
  mitral	
  annulus	
  to	
  achieve	
  
beser	
  leaflet	
  apposiLon.	
  
–  Reduce	
  septal	
  lateral	
  dimension	
  
Monarc	
  
system
Viacor

CARILLON

• Coronary	
  artery	
  compression	
  
• 30%	
  
• MI
Assessment	
  for	
  percutaneous	
  mitral	
  valve	
  repair
•  The	
  course	
  of	
  the	
  lec	
  circumflex	
  artery	
  and	
  
OM	
  branches	
  are	
  of	
  potenLal	
  importance	
  
since	
  excessive	
  pressure	
  on	
  these	
  arteries	
  can	
  
result	
  in	
  ischemia.	
  	
  	
  
–  GCV	
  and	
  OM	
  

•  There	
  is	
  significant	
  anatomical	
  variaLon	
  in	
  the	
  
cardiac	
  venous	
  anatomy	
  and	
  relaLon	
  of	
  the	
  
coronary	
  sinus	
  to	
  the	
  mitral	
  annulus.	
  
–  PTOLEMY	
  Trial:	
  9/29	
  subjects	
  excluded	
  
Heart	
  2011:97
Assessment	
  for	
  percutaneous	
  mitral	
  valve	
  repair

Annulus	
  calcificaLon	
  
Annulus	
  size	
  
CondiLons	
  of	
  the	
  leaflets
Cardiac	
  ResynchronizaLon	
  Therapy
Semitransparent	
  volume	
  
Include	
  bony	
  landmarks	
  
Angle	
  similar	
  to	
  that	
  used	
  in	
  
fluoroscopy

RAO	
  view

AP	
  view

PACE	
  2009;32:323-­‐329

LAO	
  view
Detailed	
  mapping	
  with	
  CT
Avoid	
  placement	
  in	
  infarct	
  zone

Absence	
  of	
  a	
  vein	
  can	
  be	
  due	
  to	
  infarct	
  in	
  the	
  same	
  region
Measurements	
  

Angle	
  of	
  entrance	
  to	
  CS	
  and	
  size	
  of	
  osLum
Vein	
  of	
  Marshall	
  
(Oblique	
  vein	
  of	
  LA)

• 
• 
• 
• 

Persistent	
  LSVC	
  
Define	
  the	
  boundary	
  of	
  GCV	
  and	
  CS	
  
Seen	
  in	
  35-­‐40%	
  of	
  CT	
  
Increased	
  risk	
  of	
  perforaLon	
  if	
  
entered	
  during	
  CRT
Venous	
  valves
•  Can	
  hinder	
  advancement	
  of	
  guidewires/leads	
  
•  May	
  not	
  be	
  well	
  seen	
  on	
  CTA	
  
•  Seen	
  as	
  a	
  depression	
  on	
  the	
  outer	
  surface	
  
–  Thebesian	
  valve	
  at	
  CS	
  origin	
  
–  Valve	
  of	
  Vieussens	
  at	
  CS/GCV	
  juncLon
Thank	
  you

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Thorax cardio pre procedure ct s cheung

  • 1.   MDCT’s  role  in  pre-­‐cardiovascular   procedure  planning   Stephen  CW  Cheung   Radiology,  Queen  Mary  Hospital,   Hong  Kong  
  • 2. Use  of  MDCT  before  procedures •  MDCT  has  expanding  and  increasing   important  role  in  the  planning  of  various   endovascular  procedures.       –  PCI,  especially  complicated  lesions  and  CTO   –  TAVI   –  LAA  closure   –  Cardiac  re-­‐synchronisaLon  
  • 3. Other  procedures •  Re-­‐do  cardiac  surgery   •  Closure  of  para-­‐prostheLc  heart  valve  leakage   •  Mitral  valve  indirect  annuloplasty.    
  • 5. Re-­‐do  cardiovascular  procedures:   CABG-­‐Valve •  ReoperaLon  for  cardiac  condiLons  are  geQng   more  prevalent     –  >10%  of  all  MVR  in  US   –  CABG  seems  to  be  declining  (6%  in  2000,  3.4%  in   2009)   –  associated  with  increased  morbidity  and   mortality.       •  progression  of  disease  condiLons   •  advanced  paLent  age   •  risks  introduced  by  previous  surgery  which  can   potenLally  be  well  evaluated  by  preoperaLve  imaging   using  MDCT.
  • 6. Risk  of  redo  MVR •  Mortality  quoted:  6-­‐18%   •  Injury  to  cardiac  structure:  5-­‐10%
  • 7. High  risk  findings  on  MDCT  include: •  Bypass  grac  crossing  the  midline  <1cm  from   posterior  surface  of  sternum  or  fixed  to   sternum   •  Close  proximity  of  the  RV  or  adjacent   pericardium  to  the  chest  wall,  <1cm.   •  Ascending  aorta  <1cm  to  the  inner  edge  of   chest  wall  or  sternum.   •  Excessive  length  of  the  LIMA  grac  or  one  not   adequately  mobilised.  
  • 8. RV  dilataLon,  VSD,RCA  close  to  sternum
  • 9. LIMA  relaLon  to  sternum/chest  wall
  • 10. AddiLonal  factors  to  consider: •  1.  SVG  disease  where  manipulaLon  can  cause   distal  embolisaLon.   •  2.  Incidental  lung  or  mediasLnal  mass,   incidence  ~10%  in  this  paLent  group.   •  3.      Evidence  of  previous  mediasLniLs  or   dense  adhesions.  
  • 11. ImplicaLon  on  operaLon •  A  retrospecLve  study  conducted  by  Kamdar  et  al  in  2008   shows  one  or  more  of  these  features  are  observed  in  49%   of  paLents,  cohort  size=  167.    The  most  common  finding  is   finding  1,  noted  in  38%  of  paLents.       •  These  CT  findings  have  impact  on  surgical  approach,  with  7   paLents  had  the  surgery  cancelled.       •  In  88  paLents  (55%  of  the  remaining  160  paLents)  the   surgeons  adopted  some  form  of  prevenLve  measures     –  –  –  –  non-­‐midline  incision  eg.  R  thoracotomy  (n=14)     deep  hypothermic  circulatory  arrest  (n=7)     peripheral  cardiopulmonary  bypass  before  incision  (n=18)     peripheral  arterial  and  venous  dissecLon  before  incision  (n=  83).    
  • 12. ImplicaLon  on  operaLon •  Another  study  looking  for  similar  CT  features   find  that  MDCT  before  the  operaLon  is   associated  with     –  shorter  perfusion  and  cross  clamp  Lme     –  shorter  ICU  stay       –  less  frequent  perioperaLve  MI       •  (Maluenda  et  al  2010)
  • 13. USG  to  measure  CFA/CFV •  Ensure  the  vessels  are  of  adequate  size  for   cannulaLon  in  peripheral  cardiopulmonary   bypass  
  • 14. Ann  Thorac  Surg  2013;96:1358-­‐66
  • 15. Re-­‐do  MVR  has  low  mortality,  morbidity  and  intraopera7ve  injury  with  careful  planning Ann  Thorac  Surg  2013;96:1358-­‐66  
  • 17. Assessment  of  para-­‐prostheLc  valvular   leak   •  Paravalvular  leak  is  esLmated  to  occur   in  3-­‐12.5%  of  prosthesis  within  a  few   years  of  operaLon.       •  With  the  large  number  of  procedures   done  every  year,  the  number  of  leaks   requiring  treatment  is  increasing.       •  With  the  advent  of  percutaneous   closure  instead  of  re-­‐operaLon,  high   quality  imaging  is  needed.       •  2D/3D  TEE  is  usually  the  main  state  of   imaging  while  CT  is  also  gaining  greater   importance-­‐  crescent  shaped
  • 18. CT  of  para-­‐prostheLc  valvular  leak   •  In  a  small  study  consisted  of  20  paLents,  MDCT   has  been  used  to  evaluate  para-­‐prostheLc  aorLc   valve  leak  and  regurgitaLon.    Excellent   correlaLon  was  found  between  MDCT   determined  regurgitaLon  orifice  area  and   echocardiogram/surgical  findings.   •  However  beam  hardening  artefacts  are   significant  and  depend  on  type  of  prosthesis,   rendering  12  of  these  subjects  non-­‐evaluable.   –  SJM  standard    √   –  SJM  HP,  SJM  Regent    ×
  • 19.
  • 20. CT  of  para-­‐prostheLc   valvular  leak   •  MDCT  detecLon  of   paravalvular  leak     –  Clock-­‐face  view   –  Surgical   •  used  as  a  guidance   during  fluoroscopy  for   passing  guidewire  and   deployment  of  vascular   plugs
  • 21.
  • 27. Carlos  Ruiz,  JACC  2011  (21)
  • 28. Para-­‐valvular  pseudoaneurysm   Just  caudal  to  AV  annulus
  • 31. Greater  and  Lesser  cardiac  venous  systems •  Lesser  CVS   –  Thebesian  veins,  common  at  ventricular  apex  and  base  of   papillary  muscles   –  Drain  most  of  RV,  LA,  RA   –  Can  be  dilated  acer  MI   –  Not  septal  defects
  • 32. •  Greater  CVS     –  CS  and  non-­‐CS  tributaries   –  Drain  LV,  part  of  RV  
  • 33. Veins  of  LA  Wall •  Septal  veins  of  LA  drain  into   RA  through  the  septum   •  Most  common  is  antero-­‐ superior  septum   •  They  are  not  septal  defects   or  fistulas Posteroinferior  veins Anterosuperior  veins PFO
  • 34. Veins  of  LA  Wall   Interatrial  muscle  connecLon
  • 35. CS  System AIV=  anterior  interventricular  vein   MCV=IIV  (inferior  interventricular  vein)   Between  AIV  and  IIV:  several  lateral  and  posterior  branches
  • 36. GCV Usually  pass  over  the  LAD  and    LCX  but  can  be  under
  • 37. Assessment  for  percutaneous  mitral  valve  repair   Indirect  Annuloplasty •  Percutaneous  repair  of  MV  can  be  performed   by  placing  device  inside  the  great  cardiac  vein   and  coronary  sinus  aiming  at  providing  inward   pressure  on  the  mitral  annulus  to  achieve   beser  leaflet  apposiLon.   –  Reduce  septal  lateral  dimension  
  • 38. Monarc   system Viacor CARILLON • Coronary  artery  compression   • 30%   • MI
  • 39. Assessment  for  percutaneous  mitral  valve  repair •  The  course  of  the  lec  circumflex  artery  and   OM  branches  are  of  potenLal  importance   since  excessive  pressure  on  these  arteries  can   result  in  ischemia.       –  GCV  and  OM   •  There  is  significant  anatomical  variaLon  in  the   cardiac  venous  anatomy  and  relaLon  of  the   coronary  sinus  to  the  mitral  annulus.   –  PTOLEMY  Trial:  9/29  subjects  excluded  
  • 41. Assessment  for  percutaneous  mitral  valve  repair Annulus  calcificaLon   Annulus  size   CondiLons  of  the  leaflets
  • 43. Semitransparent  volume   Include  bony  landmarks   Angle  similar  to  that  used  in   fluoroscopy RAO  view AP  view PACE  2009;32:323-­‐329 LAO  view
  • 45. Avoid  placement  in  infarct  zone Absence  of  a  vein  can  be  due  to  infarct  in  the  same  region
  • 46. Measurements   Angle  of  entrance  to  CS  and  size  of  osLum
  • 47. Vein  of  Marshall   (Oblique  vein  of  LA) •  •  •  •  Persistent  LSVC   Define  the  boundary  of  GCV  and  CS   Seen  in  35-­‐40%  of  CT   Increased  risk  of  perforaLon  if   entered  during  CRT
  • 48. Venous  valves •  Can  hinder  advancement  of  guidewires/leads   •  May  not  be  well  seen  on  CTA   •  Seen  as  a  depression  on  the  outer  surface   –  Thebesian  valve  at  CS  origin   –  Valve  of  Vieussens  at  CS/GCV  juncLon