Patenting is crucial for biomedical startups to protect their innovations and attract investors. However, the patenting process is expensive and complex. This document outlines key patenting challenges for startups and provides recommendations to reduce costs, such as thorough prior art searches, provisional patent filings, limiting patent claims and countries, and working closely with experienced patent counsel. Strong patents are important startup assets, so preparation and oversight of the patenting process is necessary to maximize value while managing expenses.