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Roman Paskulin Presentation 2009 Sayulita

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Sheldon Pelletier
Sheldon Pelletier
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Ibogaine and cellular metabolism
Traditional use of Iboga ,[object Object],[object Object],[object Object],[object Object],[object Object]
Use of Iboga/ibogaine in the West ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ibogaine in medicine ,[object Object],[object Object],[object Object]
Pharmacodynamics of ibogaine ,[object Object],[object Object]
Pharmacodynamics of ibogaine ,[object Object],[object Object],[object Object]
Composition of cell ,[object Object],[object Object],[object Object],[object Object],[object Object]
Proteins ,[object Object],[object Object]
Structural proteins- cytoskeleton
Functional proteins- receptor
Functional proteins- enzyme
Protein separation by 2-D electrophoresis
Computer scan of gel
Computer scan of gel
“ In silico” analysis of results
Spots of interest
Peptide mapping by mass spectrometry
Identification of proteins by matching with data bases
Induction of energy metabolism related enzymes in rat brain 10 70 58314/7.19 2.94 1.38 Pyruvate kinase 9 60 39783/8.05 2.45 1.23 Aldolase 9 54 36117/8.79 3.64 1.42 Malate dehydrogenase 9 62 36090/8.14 3.21 1.13 Glyceraldehyde-3-phosphate dehydrogenase Peptide matching Score Mr(Da)/pI Fold 72 h Fold 24 h Enzyme
Induction of energy metabolism related enzymes
Nonspecific activation of metabolism
Interpretation of results ,[object Object],[object Object]
Aura and ibogaine ,[object Object],+3 h +54 h
Aura and ibogaine
Aura and ibogaine – thantanosis
Aura and ibogaine
Aura and ibogaine
Aura and ibogaine Maybe illumination and revelation are proper words to describe what is at this moment difficult to explain
Pharmacodynamics of Entheogen Drugs - Influence on Gene Expression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],OMI, Institut e of Anthropological Medicine www.omi.si

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