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“Digital Changes Everything”
Why , How and Some Examples
Digital
Agenda
Sustainability
Agenda
Data is the New Natural Resource
Trend
The issues of
sustainability , C02 emissions and climate change resilience
are to significant extent
information issues:
Peter Williams
CTO: IBM Big Green Innovations
For
CO2 & Climate Change:
• What damage are we causing?
• What might happen if we continue
that damage?
• How can we mitigate the damage ?
• Is our mitigation working?
For
Climate Change Resilience :
• What might happen?
• What will break?
• How can we mitigate the risk?
• Are we on track with our plans?
• What just broke?
• Who/what needs help first?
Looking at Global CO2
Bad News Good News
2% 98%
Use of IT accounts for
2% of C02 emissions
Use of IT can significantly
control and reduce the other 98%
emissions caused by other sources
What is driving the change?
It is estimate …
1 billion transistors per human
Each costing
1/10 millionth of a cent.
http://research.ibm.com/cognitive-computing/neurosynaptic-
chips.shtml#fbid=TlDdajeaAJZ
IBM: SyNAPSE Chip: 5 Billion Transistor
Inspired by the brain, very low power consumption
An opportunity to think and
act in new ways :
economically, socially and
environmentally.
+ + =
A Smarter Planet
Something profound is happening….
Instrumented
Interconnected
Intelligent
As a New Natural Resource
Data is changing quickly
VolumeofData
PercentageofUncertaindata
9
Big Data
This is then amplified by a network effect,
combining technologies in new ways
Source: Bill Chamberlin
Cloud
Virtualization
Social Business
Mobile
Data Visualization
Green IT
Analytics
Consumerization
BYOD
Digital Marketing
Cognitive Computing
IoT
Gamification
Security
10
Look for the triangles
for new interesting innovations …
Source: Bill Chamberlin
Mobile
Data Visualization
Analytics
IoT
What makes a system smarter?
3 Patterns that enable
C02 reduction AND increased performance
Operational Efficiency Incident/Event Management
Planned
Maintenance Asset Failure Extreme
Weather
GOAL:- Situational awareness to keep on track GOAL:- information & processes to better respond
Incidents
GOAL:- connecting BOTH people AND systems
to drive collaboration
Intelligent
Operations
Better Collaboration and Response
• Situational awareness
• Analytics
• Smarter response
Foresight examples:
• Cave Man
• Agricultural Revolution
• Industrial Revolution
• Digital Revolution
• Environmental Revolution
What is it that drives the ability to change the system?
Foresight
Some Examples
of the
Digital Agenda enabling
improvements
in CO2 reduction
Using Biomimicry
Self Assembly Molecular Chemistry to Increase
Energy Efficiency of Computer Chips
By more precise insulation layers
IBM POWER Processor“Air Gap” Chip Technology
Designing like snowflakes and sea shells
IBM & Airlight Energy
Solar Concentrator:
IBM Zurich:
IBM & Airlight Energy
Poly-generation: Electricity, Heat, Cooling
Solar Concentrator = Sun x 2000
• Simple Materials: concrete structure, Plastic foil film mirrors
• High efficiency solar cells
• Supercomputer Cooling
Output = 50% overall system
efficiency
12 kwatts of electrical power
20 kwatts of heat (on a sunny day)
Hot Water at over 85 DegC
http://www.ted.com/watch/ted-institute/ted-ibm/gianluca-ambrosetti-solving-the-energy-
crisis-one-sunflower-at-a-time
Visualising Sustainability
Data Visualisation
Insight and change happen here
with people in the system
Collaboration
1. Moving from guessing to knowing
2. Connecting a network of people, systems and data to
create collective insight
3. Making sense of large amounts of data – in space and time
4. Evidence based decisions at pace
5. Ability to apply the right tools:
• Automate the simple
• Make sense of the complicated through analytics
• Make sense of the complex & unpredictable through visualisation
5 Smarter City Essentials
for making cities more efficient :
City in motion:
monitoring using existing data to design better solutions
Istanbul:
Movement Analysis using
Vodafone network data
• 2.4 million phones w. 156 million events/week
• Origin Destination analysis
• Accurate detection of meaningful locations
• Used for new metro line planning
Dubuque, USA:
Bus Route Optimization
Optimized routes will:
• Reduce OPEX and CO2 by 40%
• Generated 37% more demand
• Reduce average commuter travel time by 60%
Seeing the Whole System: Dublin Bus Network
Public Transport Awareness Tool
used by citizens and planners
‘Open Data’ + ‘Big Data’
http://www.smartplanet.com/blog/business-brains/predictive-analytics-at-work-predicting-traffic-jams-before-they-occur/10543
Smarter transport:
Singapore, San Francisco and Lyon
One hour ahead, 85% accuracy
Peterborough BedfordManchester
Out of city 90 000
Tonnes
BedfordManchester
In to city
Tonnes
Peterborough
Flow of Regulated Commercial Waste
Waste flowing out of Peterborough
Waste flowing into Peterborough
Hydro Electric: Situational Awareness, Analytics & Smarter Response
Creating alternatives to coal fired power generation
Understanding the impact on the river flow
Putting the data in context: 3D landscape
Analytics to optimise the use of Water and Power:
• Environmental needs
• Power generation,
• Flood control,
• Energy storage
Using open data about public building
Jump to Google Earth
Jump to Live system
Understanding city energy metabolism in 30 seconds
Visualising City Scale Energy Load:
Jump to short video
IoT: Internet of Things
Why the IoT will be important:
http://jackuldrich.com/blog/internet-information-tech/10-unexpected-ways-the-internet-of-things-will-open-up-a-future-of-opportunity/
Thanks to Jack Uldrich
Fine Scale Environmental Sensing
High density data to create new insights (3D)
Fine Scale Thermal Management:
IBM Data Centre Sites :
All of our Strategic Data Centres use this (4M sq ft)
Saving 300 MkWhours per year through data (10% Reduction)
• Tecomms Cell Towers
• Hospitals
• Public Building
https://www.youtube.com/watch?v=VxtHHaMuVMg Jump to 3 minute video
IoT is Cool
What is needed in the
future?
Data by itself doesn’t do anything
without some creativity…
this is where you come in.
Principles in Information Science will be of use:
1. Whole system design (not sub)
2. Caching (clever use of read ahead)
3. Pipelining (fine scale priority management)
4. Real-time awareness (always monitoring and optimising)
5. Distributed inputs (creating systemic resilience)
6. The importance of storage in the system
7. Keeping things pure / Design for disassembly
A B CFrom Linear To Network
We need to find the ‘Moore’s Law’ for CO2
relentless performance improvement ‘doing more with different’
A
E
B
D
C
Cognitive Computing:
People Compute
power
AutomationPeople
Compute
power
Programming
• Natural Language
• Unstructured data
• Confidence levels
• Feedback by design
Computing is Changing:
How could this be used to reduce CO2?
Programming:
Imagine:
Doing 10,000 weeks of reading
in 15 seconds
and understanding all the relationships !
Ingest
Learn
Test
Experience
Jump to One Example:
• Watson Debater
• Watson Analytics
• Watson Discovery
• Watson Engagement Advisor
• Watson Healthcare
• Watson API
Replace Energy, Resources and CO2
With Information and Design
The grand challenge is to…
In summary:
“Digital Changes Everything”
that’s when
44
Thank-you
Ian Abbott-Donnelly
Augmenting Products with Data
Products
Data
Codifying a distinctive service capability
(Products become services)
+
industry Bindustry A
New insight
& value
= Combining data within and across industries
New insight
& value
trading Data Trading
DataAssets
Digitising assets
Data replaces the use of product or service:
• Less energy
• Less Resources
• Less cost (human intervention)
Data
Products
Composable components
(Products, assets, services)
Finer scale products & services enabled by data:
• Accuracy
• Control
• Feedback
• Complexity
Data
DataData
Homework: Using data to enable a new low carbon economy
1
2
3
4
7
6
5
8
Foresight creating a network of benefits
Where projects in one domain create multiple benefits in other domains
Energy
Management
Pipe Failure
Prediction
Distributed incident
management
Leakage
management
Customer
Portal
Situational
Awareness
Meter data
analytics
External Data
Weather
Impact and
recovery
Understanding
the system dynamics
using data
Example from Water Utility
Watson is the culmination of
several cognitive technologies
© 2014 International Business
Machines Corporation
47
Visualizes with Supporting Evidence
Learns Through Expert Training
Understands Scientific Entities & Relationships
Integrates All Types of Big Data
Ingest
Learn
Test
Experience
Watson enables insights by connecting and analyzing hundreds of internal
and external data sources in minutes rather than weeks
© 2014 International Business
Machines Corporation
48
Learn
Test
Experience
Ingest
16M+ patents from
US, Europe, WIPO
23M+ abstracts
100+ journals
50+ books
11,000+ drug labels
20,000+ genes
12M+ chemical
structuresWatson Corpus
Over 1TB of data
Over 40m
documents
Over 100m entities
and relationships
Internal Data
In vitro tests
In vivo studies
Compounds
Toxicology reports
Clinical trial data
Lab notes
Other
Available External Data
Chemical database
Public genomics
Medical textbooks
Medline
Other journals
FDA drugs/labels
Patents
Not just a search engine, Watson understands and interprets the
language of science
© 2014 International Business
Machines Corporation
49
Learn
Test
Experience
Ingest
Diagram
Formula
Names
(149)
Chemical ID
Valium, Dizapam Alboral,
Aliseum,AlupramAmiprol, Asiolin,
Ansiolisina Apaurin, Apoepam, etc.
CAS# 439-14-5
C16H13CIN2ORich dictionaries
enable Watson
to link all entity
representations
H C3
O
CI N
N
More than mere text mining, Watson can identify relationships
© 2014 International Business
Machines Corporation
50
Learn
Test
Experience
Ingest
Symptoms
Arthritis
pain
Chronic
pain
Fever Headache
Drug class
Antiplatelet
NSAID
Analgesic
Adverse
Effects
GI pain
Gastritis
GI bleeding
Nausea
Indications Reduce MI
Reduce
stroke
Reduce
fever
Reduce
pain
Anti-
Inflammatory
Aspirin
Illustrative Example
Ontologies: The relationship between any entity and other scientific domains
Annotators allow Watson to read and extract appropriate
information
© 2014 International Business
Machines Corporation
51
Learn
Test
Experience
Ingest
…doxorubicin results in extracellular signal-regulated kinase (ERK)2 activation, which in
turn phosphorylates p53 on a previously uncharacterized site, Thr55…
Extracts Preposition
 Recognizes preposition location on Thr55
Extracts Entities
 ERK2 = Protein, P53 = Protein, Thr55 = Amino Acid
Extracts Verb
 Maps to domain of Post Translational Modification
 Recognizes subject / object relationships
Extracts Entities
 ERK2 = Protein, P53 = Protein, Thr55 = Amino Acid
Extracts Entities
 ERK2 = Protein, P53 = Protein, Thr55 = Amino Acid
ERK2
phosphorylates
p53
on
Thr55
Machine learning enables Watson to teach itself over time
© 2014 International Business
Machines Corporation
52
Learn
Test
Experience
Ingest
Aspirin
GI Pain
Valium
Depression
Annotator
Logic
Watson Applies
Annotators to Text
Watson Creates
Knowledge Graph
• Aspirin is an antiplatelet indicated to
reduce the risk of myocardial
infarction
• Known side effects include
Gastrointestinal (GI) pain, GI upset,
ulcers, GI bleeding, and nausea
• Valium or Diazepam is a
benzodiazepine derivative, indicated
for the treatment of anxiety, muscle
spasms
• Valium may cause depression,
suicidal ideation, hyperactivity,
agitation, aggression, hostility…
• Drug = entity
• Side effect = entity
association cause
• Cause = relating verb
• Rule = 1 drug to 1
side effect
Machine learning also enables Watson to learn from experts
© 2014 International Business
Machines Corporation
53
Learn
Test
Experience
Ingest
Aspirin
GI Pain
Valium
Depression
Watson Creates
Knowledge Graph
Drugs can
have
more than
one side
effect
Expert
Interventio
n
Watson Applies Annotators &
Refines Knowledge Graph
Aspirin
GI Pain
GI Upset
Nausea
Ulcers
GI Bleed
Depression
Valium
Agitation
Aggression
Hostility
Hyperactivity
Beyond mere algorithms, Watson evaluates supporting evidence
© 2014 International Business
Machines Corporation
54
Learn
Test
Experience
Ingest • Quantity
• Proximity
• Relationship
• Domain Truths/
Business Rules
What genes
contribute to
developing
colon cancer?
Search
Corpus
Extract
Evidence
Score &
Weigh
Question
• Side Effects
• Lab Notes
• Genes
• Publications
• Drugs
• Animal Models
• Clinical Trial
Data
The Result: Watson enables breakthrough insights after analyzing thousands
of articles and other corpus data in minutes
© 2014 International Business
Machines Corporation
55
Learn
Test
Experience
Ingest
Gene Network
csnk1d
ros1 pdlim7
prkcg
aurka
nrgn
cdc20
ugcg
hist1h1c
ca2
dach1
prb3
ccnb11
ppm1d
tp53inp1
mms
tpt1
csnk2a1
mapk1
plk1
csnk1g2
ppp2r4
cdk7
gfm1
mapk14
mdm2hipk4
arl2
mapkapk2
cdk1
dyrk2
mapk8
chek1
tceal1
h2afx
brca1
jun
card16
atm
atr
stat3
cdk5
plk3
cdk9
mapk10
chek2
ep300
mapk9
nuak1
mgst1
pdik1lptch1
tgm2
cdc25c
ccne1
dnm1l
krt20
kat2b
bbc3
stk11
nr1h2
cdk2
chmp1a
aldh1l1
slco6a1
e2f1
prrt2 csnk1a1
tmprss11d
ephb2
bard1
ptk2b
agt
cdkn2a
ccn2a
ptgs2
hdac6
vhl
tbp
pin1
sgsm3
dyrk1aprkdc
des
dusp26
tp53
csnk1d
ros1 pdlim7
prkcg
aurka
nrgn
cdc20
ugcg
hist1h1c
ca2
dach1
prb3
ccnb11
ppm1d
tp53inp1
mms
tpt1
csnk2a1
mapk1
plk1
csnk1g2
ppp2r4
cdk7
gfm1
mapk14
mdm2hipk4
arl2
mapkapk2
cdk1
dyrk2
mapk8
chek1
tceal1
h2afx
brca1
jun
card16
atm
atr
stat3
cdk5
plk3
cdk9
mapk10
chek2
ep300
mapk9
nuak1
mgst1
pdik1lptch1
tgm2
cdc25c
ccne1
dnm1l
krt20
kat2b
bbc3
stk11
nr1h2
cdk2
chmp1a
aldh1l1
slco6a1
e2f1
prrt2 csnk1a1
tmprss11d
ephb2
bard1
ptk2b
agt
cdkn2a
ccn2a
ptgs2
hdac6
vhl
tbp
pin1
sgsm3
dyrk1aprkdc
des
dusp26
tp53
60534927591476718347480Proto-Oncogene Proteins
141062882603331334542169757Phosphorylation
19045070423056756308401Cell Cycle
75224756202167488821588076Cell Line
4106135439013003642528911125571728Humans
8943133032023216123305620060Apoptosis
137131016023957713092515820178Mice
27206382254401022216311004235507Animals
439241028910736465036465Tumor Suppressor Protein p53
2230471239721062969612327Aged
3942162138117609900130313252Mutation
268225416411321262984714728Middle Aged
623391893366485163922215559Signal Transduction
750
0
0
0
chek1
1745
255
0
198
cdk2MeSH Name Total pik3ca p53 braf chek2 epha2
Adult 12112 763 10291 928 144 47
Phosphatidylinositol 3-Kinases 11066 10726 0 271 0 0
Immunohistochemistry 10127 710 8930 309 38 57
Protein-Serine-Threonine Kinases 7413 2076 2600 162 1287 0
60534927591476718347480Proto-Oncogene Proteins
141062882603331334542169757Phosphorylation
19045070423056756308401Cell Cycle
75224756202167488821588076Cell Line
4106135439013003642528911125571728Humans
8943133032023216123305620060Apoptosis
137131016023957713092515820178Mice
27206382254401022216311004235507Animals
439241028910736465036465Tumor Suppressor Protein p53
2230471239721062969612327Aged
3942162138117609900130313252Mutation
268225416411321262984714728Middle Aged
623391893366485163922215559Signal Transduction
750
0
0
0
chek1
1745
255
0
198
cdk2MeSH Name Total pik3ca p53 braf chek2 epha2
Adult 12112 763 10291 928 144 47
Phosphatidylinositol 3-Kinases 11066 10726 0 271 0 0
Immunohistochemistry 10127 710 8930 309 38 57
Protein-Serine-Threonine Kinases 7413 2076 2600 162 1287 0
High
Affinity
Moderate
Affinity
Some
Affinity
no
Affinity
• Select entities from two different ontologies (i.e.
disease/gene)
• Visualize co-occurrence
• Use statistics to spot the intersections
• Drill down to see the evidence
• Select two or more genes of interest
• See network of relationships
• Show strength, nature & proximity of the relationship
• Colored vectors indicate the nature of the interaction
• Hover over connections to see the evidence
Co-occurrence Table

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Edinburgh 2020 digital changes everything v10

  • 1. “Digital Changes Everything” Why , How and Some Examples
  • 3. The issues of sustainability , C02 emissions and climate change resilience are to significant extent information issues: Peter Williams CTO: IBM Big Green Innovations For CO2 & Climate Change: • What damage are we causing? • What might happen if we continue that damage? • How can we mitigate the damage ? • Is our mitigation working? For Climate Change Resilience : • What might happen? • What will break? • How can we mitigate the risk? • Are we on track with our plans? • What just broke? • Who/what needs help first?
  • 4. Looking at Global CO2 Bad News Good News 2% 98% Use of IT accounts for 2% of C02 emissions Use of IT can significantly control and reduce the other 98% emissions caused by other sources
  • 5. What is driving the change? It is estimate … 1 billion transistors per human Each costing 1/10 millionth of a cent.
  • 6. http://research.ibm.com/cognitive-computing/neurosynaptic- chips.shtml#fbid=TlDdajeaAJZ IBM: SyNAPSE Chip: 5 Billion Transistor Inspired by the brain, very low power consumption
  • 7. An opportunity to think and act in new ways : economically, socially and environmentally. + + = A Smarter Planet Something profound is happening…. Instrumented Interconnected Intelligent
  • 8. As a New Natural Resource Data is changing quickly VolumeofData PercentageofUncertaindata
  • 9. 9 Big Data This is then amplified by a network effect, combining technologies in new ways Source: Bill Chamberlin Cloud Virtualization Social Business Mobile Data Visualization Green IT Analytics Consumerization BYOD Digital Marketing Cognitive Computing IoT Gamification Security
  • 10. 10 Look for the triangles for new interesting innovations … Source: Bill Chamberlin Mobile Data Visualization Analytics IoT
  • 11. What makes a system smarter?
  • 12. 3 Patterns that enable C02 reduction AND increased performance Operational Efficiency Incident/Event Management Planned Maintenance Asset Failure Extreme Weather GOAL:- Situational awareness to keep on track GOAL:- information & processes to better respond Incidents GOAL:- connecting BOTH people AND systems to drive collaboration Intelligent Operations Better Collaboration and Response
  • 13. • Situational awareness • Analytics • Smarter response Foresight examples: • Cave Man • Agricultural Revolution • Industrial Revolution • Digital Revolution • Environmental Revolution What is it that drives the ability to change the system? Foresight
  • 14. Some Examples of the Digital Agenda enabling improvements in CO2 reduction
  • 15. Using Biomimicry Self Assembly Molecular Chemistry to Increase Energy Efficiency of Computer Chips By more precise insulation layers IBM POWER Processor“Air Gap” Chip Technology Designing like snowflakes and sea shells
  • 16. IBM & Airlight Energy Solar Concentrator: IBM Zurich:
  • 17. IBM & Airlight Energy Poly-generation: Electricity, Heat, Cooling
  • 18. Solar Concentrator = Sun x 2000 • Simple Materials: concrete structure, Plastic foil film mirrors • High efficiency solar cells • Supercomputer Cooling Output = 50% overall system efficiency 12 kwatts of electrical power 20 kwatts of heat (on a sunny day) Hot Water at over 85 DegC http://www.ted.com/watch/ted-institute/ted-ibm/gianluca-ambrosetti-solving-the-energy- crisis-one-sunflower-at-a-time
  • 19. Visualising Sustainability Data Visualisation Insight and change happen here with people in the system Collaboration
  • 20. 1. Moving from guessing to knowing 2. Connecting a network of people, systems and data to create collective insight 3. Making sense of large amounts of data – in space and time 4. Evidence based decisions at pace 5. Ability to apply the right tools: • Automate the simple • Make sense of the complicated through analytics • Make sense of the complex & unpredictable through visualisation 5 Smarter City Essentials for making cities more efficient :
  • 21. City in motion: monitoring using existing data to design better solutions Istanbul: Movement Analysis using Vodafone network data • 2.4 million phones w. 156 million events/week • Origin Destination analysis • Accurate detection of meaningful locations • Used for new metro line planning Dubuque, USA: Bus Route Optimization Optimized routes will: • Reduce OPEX and CO2 by 40% • Generated 37% more demand • Reduce average commuter travel time by 60%
  • 22. Seeing the Whole System: Dublin Bus Network Public Transport Awareness Tool used by citizens and planners ‘Open Data’ + ‘Big Data’
  • 24. Peterborough BedfordManchester Out of city 90 000 Tonnes BedfordManchester In to city Tonnes Peterborough Flow of Regulated Commercial Waste
  • 25. Waste flowing out of Peterborough
  • 26. Waste flowing into Peterborough
  • 27. Hydro Electric: Situational Awareness, Analytics & Smarter Response Creating alternatives to coal fired power generation
  • 28. Understanding the impact on the river flow
  • 29. Putting the data in context: 3D landscape
  • 30. Analytics to optimise the use of Water and Power: • Environmental needs • Power generation, • Flood control, • Energy storage
  • 31. Using open data about public building Jump to Google Earth
  • 32. Jump to Live system
  • 33. Understanding city energy metabolism in 30 seconds Visualising City Scale Energy Load: Jump to short video
  • 35. Why the IoT will be important: http://jackuldrich.com/blog/internet-information-tech/10-unexpected-ways-the-internet-of-things-will-open-up-a-future-of-opportunity/ Thanks to Jack Uldrich
  • 36. Fine Scale Environmental Sensing High density data to create new insights (3D)
  • 37. Fine Scale Thermal Management: IBM Data Centre Sites : All of our Strategic Data Centres use this (4M sq ft) Saving 300 MkWhours per year through data (10% Reduction) • Tecomms Cell Towers • Hospitals • Public Building
  • 39. What is needed in the future? Data by itself doesn’t do anything without some creativity… this is where you come in.
  • 40. Principles in Information Science will be of use: 1. Whole system design (not sub) 2. Caching (clever use of read ahead) 3. Pipelining (fine scale priority management) 4. Real-time awareness (always monitoring and optimising) 5. Distributed inputs (creating systemic resilience) 6. The importance of storage in the system 7. Keeping things pure / Design for disassembly A B CFrom Linear To Network We need to find the ‘Moore’s Law’ for CO2 relentless performance improvement ‘doing more with different’ A E B D C
  • 41. Cognitive Computing: People Compute power AutomationPeople Compute power Programming • Natural Language • Unstructured data • Confidence levels • Feedback by design Computing is Changing: How could this be used to reduce CO2? Programming: Imagine: Doing 10,000 weeks of reading in 15 seconds and understanding all the relationships ! Ingest Learn Test Experience
  • 42. Jump to One Example: • Watson Debater • Watson Analytics • Watson Discovery • Watson Engagement Advisor • Watson Healthcare • Watson API
  • 43. Replace Energy, Resources and CO2 With Information and Design The grand challenge is to… In summary: “Digital Changes Everything” that’s when
  • 45. Augmenting Products with Data Products Data Codifying a distinctive service capability (Products become services) + industry Bindustry A New insight & value = Combining data within and across industries New insight & value trading Data Trading DataAssets Digitising assets Data replaces the use of product or service: • Less energy • Less Resources • Less cost (human intervention) Data Products Composable components (Products, assets, services) Finer scale products & services enabled by data: • Accuracy • Control • Feedback • Complexity Data DataData Homework: Using data to enable a new low carbon economy 1 2 3 4 7 6 5 8
  • 46. Foresight creating a network of benefits Where projects in one domain create multiple benefits in other domains Energy Management Pipe Failure Prediction Distributed incident management Leakage management Customer Portal Situational Awareness Meter data analytics External Data Weather Impact and recovery Understanding the system dynamics using data Example from Water Utility
  • 47. Watson is the culmination of several cognitive technologies © 2014 International Business Machines Corporation 47 Visualizes with Supporting Evidence Learns Through Expert Training Understands Scientific Entities & Relationships Integrates All Types of Big Data Ingest Learn Test Experience
  • 48. Watson enables insights by connecting and analyzing hundreds of internal and external data sources in minutes rather than weeks © 2014 International Business Machines Corporation 48 Learn Test Experience Ingest 16M+ patents from US, Europe, WIPO 23M+ abstracts 100+ journals 50+ books 11,000+ drug labels 20,000+ genes 12M+ chemical structuresWatson Corpus Over 1TB of data Over 40m documents Over 100m entities and relationships Internal Data In vitro tests In vivo studies Compounds Toxicology reports Clinical trial data Lab notes Other Available External Data Chemical database Public genomics Medical textbooks Medline Other journals FDA drugs/labels Patents
  • 49. Not just a search engine, Watson understands and interprets the language of science © 2014 International Business Machines Corporation 49 Learn Test Experience Ingest Diagram Formula Names (149) Chemical ID Valium, Dizapam Alboral, Aliseum,AlupramAmiprol, Asiolin, Ansiolisina Apaurin, Apoepam, etc. CAS# 439-14-5 C16H13CIN2ORich dictionaries enable Watson to link all entity representations H C3 O CI N N
  • 50. More than mere text mining, Watson can identify relationships © 2014 International Business Machines Corporation 50 Learn Test Experience Ingest Symptoms Arthritis pain Chronic pain Fever Headache Drug class Antiplatelet NSAID Analgesic Adverse Effects GI pain Gastritis GI bleeding Nausea Indications Reduce MI Reduce stroke Reduce fever Reduce pain Anti- Inflammatory Aspirin Illustrative Example Ontologies: The relationship between any entity and other scientific domains
  • 51. Annotators allow Watson to read and extract appropriate information © 2014 International Business Machines Corporation 51 Learn Test Experience Ingest …doxorubicin results in extracellular signal-regulated kinase (ERK)2 activation, which in turn phosphorylates p53 on a previously uncharacterized site, Thr55… Extracts Preposition  Recognizes preposition location on Thr55 Extracts Entities  ERK2 = Protein, P53 = Protein, Thr55 = Amino Acid Extracts Verb  Maps to domain of Post Translational Modification  Recognizes subject / object relationships Extracts Entities  ERK2 = Protein, P53 = Protein, Thr55 = Amino Acid Extracts Entities  ERK2 = Protein, P53 = Protein, Thr55 = Amino Acid ERK2 phosphorylates p53 on Thr55
  • 52. Machine learning enables Watson to teach itself over time © 2014 International Business Machines Corporation 52 Learn Test Experience Ingest Aspirin GI Pain Valium Depression Annotator Logic Watson Applies Annotators to Text Watson Creates Knowledge Graph • Aspirin is an antiplatelet indicated to reduce the risk of myocardial infarction • Known side effects include Gastrointestinal (GI) pain, GI upset, ulcers, GI bleeding, and nausea • Valium or Diazepam is a benzodiazepine derivative, indicated for the treatment of anxiety, muscle spasms • Valium may cause depression, suicidal ideation, hyperactivity, agitation, aggression, hostility… • Drug = entity • Side effect = entity association cause • Cause = relating verb • Rule = 1 drug to 1 side effect
  • 53. Machine learning also enables Watson to learn from experts © 2014 International Business Machines Corporation 53 Learn Test Experience Ingest Aspirin GI Pain Valium Depression Watson Creates Knowledge Graph Drugs can have more than one side effect Expert Interventio n Watson Applies Annotators & Refines Knowledge Graph Aspirin GI Pain GI Upset Nausea Ulcers GI Bleed Depression Valium Agitation Aggression Hostility Hyperactivity
  • 54. Beyond mere algorithms, Watson evaluates supporting evidence © 2014 International Business Machines Corporation 54 Learn Test Experience Ingest • Quantity • Proximity • Relationship • Domain Truths/ Business Rules What genes contribute to developing colon cancer? Search Corpus Extract Evidence Score & Weigh Question • Side Effects • Lab Notes • Genes • Publications • Drugs • Animal Models • Clinical Trial Data
  • 55. The Result: Watson enables breakthrough insights after analyzing thousands of articles and other corpus data in minutes © 2014 International Business Machines Corporation 55 Learn Test Experience Ingest Gene Network csnk1d ros1 pdlim7 prkcg aurka nrgn cdc20 ugcg hist1h1c ca2 dach1 prb3 ccnb11 ppm1d tp53inp1 mms tpt1 csnk2a1 mapk1 plk1 csnk1g2 ppp2r4 cdk7 gfm1 mapk14 mdm2hipk4 arl2 mapkapk2 cdk1 dyrk2 mapk8 chek1 tceal1 h2afx brca1 jun card16 atm atr stat3 cdk5 plk3 cdk9 mapk10 chek2 ep300 mapk9 nuak1 mgst1 pdik1lptch1 tgm2 cdc25c ccne1 dnm1l krt20 kat2b bbc3 stk11 nr1h2 cdk2 chmp1a aldh1l1 slco6a1 e2f1 prrt2 csnk1a1 tmprss11d ephb2 bard1 ptk2b agt cdkn2a ccn2a ptgs2 hdac6 vhl tbp pin1 sgsm3 dyrk1aprkdc des dusp26 tp53 csnk1d ros1 pdlim7 prkcg aurka nrgn cdc20 ugcg hist1h1c ca2 dach1 prb3 ccnb11 ppm1d tp53inp1 mms tpt1 csnk2a1 mapk1 plk1 csnk1g2 ppp2r4 cdk7 gfm1 mapk14 mdm2hipk4 arl2 mapkapk2 cdk1 dyrk2 mapk8 chek1 tceal1 h2afx brca1 jun card16 atm atr stat3 cdk5 plk3 cdk9 mapk10 chek2 ep300 mapk9 nuak1 mgst1 pdik1lptch1 tgm2 cdc25c ccne1 dnm1l krt20 kat2b bbc3 stk11 nr1h2 cdk2 chmp1a aldh1l1 slco6a1 e2f1 prrt2 csnk1a1 tmprss11d ephb2 bard1 ptk2b agt cdkn2a ccn2a ptgs2 hdac6 vhl tbp pin1 sgsm3 dyrk1aprkdc des dusp26 tp53 60534927591476718347480Proto-Oncogene Proteins 141062882603331334542169757Phosphorylation 19045070423056756308401Cell Cycle 75224756202167488821588076Cell Line 4106135439013003642528911125571728Humans 8943133032023216123305620060Apoptosis 137131016023957713092515820178Mice 27206382254401022216311004235507Animals 439241028910736465036465Tumor Suppressor Protein p53 2230471239721062969612327Aged 3942162138117609900130313252Mutation 268225416411321262984714728Middle Aged 623391893366485163922215559Signal Transduction 750 0 0 0 chek1 1745 255 0 198 cdk2MeSH Name Total pik3ca p53 braf chek2 epha2 Adult 12112 763 10291 928 144 47 Phosphatidylinositol 3-Kinases 11066 10726 0 271 0 0 Immunohistochemistry 10127 710 8930 309 38 57 Protein-Serine-Threonine Kinases 7413 2076 2600 162 1287 0 60534927591476718347480Proto-Oncogene Proteins 141062882603331334542169757Phosphorylation 19045070423056756308401Cell Cycle 75224756202167488821588076Cell Line 4106135439013003642528911125571728Humans 8943133032023216123305620060Apoptosis 137131016023957713092515820178Mice 27206382254401022216311004235507Animals 439241028910736465036465Tumor Suppressor Protein p53 2230471239721062969612327Aged 3942162138117609900130313252Mutation 268225416411321262984714728Middle Aged 623391893366485163922215559Signal Transduction 750 0 0 0 chek1 1745 255 0 198 cdk2MeSH Name Total pik3ca p53 braf chek2 epha2 Adult 12112 763 10291 928 144 47 Phosphatidylinositol 3-Kinases 11066 10726 0 271 0 0 Immunohistochemistry 10127 710 8930 309 38 57 Protein-Serine-Threonine Kinases 7413 2076 2600 162 1287 0 High Affinity Moderate Affinity Some Affinity no Affinity • Select entities from two different ontologies (i.e. disease/gene) • Visualize co-occurrence • Use statistics to spot the intersections • Drill down to see the evidence • Select two or more genes of interest • See network of relationships • Show strength, nature & proximity of the relationship • Colored vectors indicate the nature of the interaction • Hover over connections to see the evidence Co-occurrence Table