This document summarizes a presentation on designing Mycoplasma vaccines using synthetic biology tools. The research aims to develop an effective vaccine for contagious bovine pleuropneumonia (CBPP), a widespread and economically important livestock disease in Africa. The project will employ genome transplantation to delete genes involved in the Mycoplasma capsule, which could allow for a more effective glycoconjugated vaccine. Initial results showed the successful deletion of three capsule biosynthesis genes and backtransplantation of altered genomes. The vaccine has the potential to significantly improve food security, nutrition, health, and poverty reduction in Africa by controlling CBPP.