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NANOTECHNOLOGY,NANOPHARMACOLOGY,[object Object],National O.O. Bogomolets Medical University,[object Object],E.O.Paton  Electric  Welding  Institute,[object Object],Kyiv, Ukraine,[object Object]
2,[object Object],NANOTECHNOLOGY,[object Object],	Nanotechnology is a complex of scientific knowledge, methods and means,[object Object],aimed at controllable assembly (synthesis) of various substances, materials and items,[object Object],with the linear size of structural elements of up to 100 nm (1 nm – 10-9 m; 1 nm =,[object Object],10 Ǻ) from individual atoms and molecules.,[object Object]
3,[object Object],NANOTECHNOLOGY: PRODUCING OF NANOPARTICLES,[object Object],Mechanical disintegration.,[object Object],Chemical synthesis.,[object Object],Photochemical synthesis.,[object Object],Vacuumevaporation methods.,[object Object],Microbiological synthesis.,[object Object]
4,[object Object],ELECTRON BEAM TECHNOLOGY,[object Object],Electron beam evaporation of materials in vacuum differs from other methodsof vacuum evaporation – thermal and ion-plasma, ,[object Object],primarily, by its versatility,technological flexibility, efficiency and cost-effectiveness. ,[object Object],	The electron beam is one of the most effective heat sources. At collision of the flying electron with the solid surface the main fraction of kinetic energy of the electrons is converted into thermal energy in a thin surface layer 1 – 2 μm thick. Therefore, at heating by the electron beam the heat source is in the solid itself and ensures the maximum complete conversion of electric energy into thermal energy.,[object Object]
5,[object Object],ELECTRON BEAM TECHNOLOGY,[object Object],Modernelectronbeamgunsof 50 – 100 kWpowerallowevaporationofmetallicandnon-metallicsubstancesatsufficientlyhighrates, approximatelyupto10-2g · cm-2 · s-1. Evaporatorsconsistingofacopperwater-cooledcrucible (cylinder),intowhichtheevaporationmaterialisplacedintheformofingot (castorcompacted)of 25 to 70 mmdiameter, havebecomethemostwidelyappliedinpractice.,[object Object]
6,[object Object],SCHEMATIC OF ELECTRON BEAM EVAPORATION,[object Object]
7,[object Object],NANOPARTICLESFe3O4,[object Object]
8,[object Object],ELECTRON BEAM TECHNOLOGY,[object Object],The International Center for Electron Beam Technologies of the E.O. Paton,[object Object],Electric Welding Institute designed and organized manufacturing of laboratory, pilotproductionand production electron beam equipment for realization of the consideredvariants of the technology.,[object Object]
9,[object Object],ELECTRON BEAM TECHNOLOGY,[object Object],More than 10 units have already been manufactured for universities, scientific centersand industrial enterprises of the USA, China, Canada and India.,[object Object]
10,[object Object],ELECTRON BEAM TECHNOLOGY,[object Object],Modern electron beam nanotechnology ofproducing advanced nanomaterialsand aircraft engine construction, has a real potential of furtherscientific and economic advances in medicine, pharmacology and pharmacy, inparticular in development and manufacturing of :,[object Object],1. Heterogeneous inorganic and some variants of organic materials and,[object Object],coatings, in the solid and liquid states, in a broad range of shapes, nano- and,[object Object],microsizes of their structural elements.,[object Object],2. Magnetic nanofluids.,[object Object],3. Consolidated or discrete nanostructures of carbon and its compounds.,[object Object],4. Filters.,[object Object],5. Sorbents.,[object Object],6. Graded biological coatings.,[object Object],7. Catalyst carriers, catalysts and catalysis devices.,[object Object],8. Components of medical instruments and equipment,[object Object]
11,[object Object],SILICA NANOPOWDER,[object Object],Scientists from the O.O. Chuiko Institute of Surface Chemistry (The National Academy of Sciences of Ukraine) and Vinnitsa National Pirogov Memorial Medical University developed a drug “Silics” - new sorbent of polydirected action, based on highly disperse amorphous silicaamorphous silica nanopowder, obtained by chemical synthesis.,[object Object]
12,[object Object],SILICA NANOPOWDER,[object Object],	At the Department of Pharmacology and Clinical Pharmacology (National O.O. Bogomolets Medical University) drugs, created using nanotechnology, including those based on silica nanopowder, are studied. ,[object Object],	Unlike other sorbents silica nanopowder - a powder of aporose structure consisting of nanoparticles with size 5-20 nm,[object Object]
13,[object Object],FINE SILICA SUSPENSION: DECREASING TOXICITY OF ANTITUBERCULOUS DRUGS,[object Object],Ethambutol  ,[object Object],Isoniazid,[object Object],Pyrazinamide,[object Object]
14,[object Object],FINE SILICA SUSPENSION: DECREASING TOXICITY OF ANTITUBERCULOUS DRUGS,[object Object]
15,[object Object],FINE SILICA SUSPENSION: DECREASING HEPATOTOXICITY OF ETHYL ALCOHOL,[object Object]
16,[object Object],AG NANOPARTICLES FROM DRIED WATER SOLUTION,[object Object]
17,[object Object],EFFECTIVE CONCENTRATIONS OF AG-NANOIN COMPARISON WITH З AGNO3,[object Object],Ag-nano,[object Object]
18,[object Object],NANOCOMPOSITES OF SILVER AND COPPER,[object Object],Using electron-beam technologies were received composite nanoparticles of silver and copper. ,[object Object],It was established that this composite by antimicrobial activity much more potent than silver nanoparticles and copper nanoparticles.,[object Object]
19,[object Object],PROSPECTS OF INVESTIGATIONS,[object Object],1. Development of new technologies of nanoparticles manufacturing, especially composites of organic and inorganic origin. ,[object Object],	2. Design of new dosage forms for external and internal application and inhalation. ,[object Object],	3. Study the therapeutic mechanisms of action of new nanodrugs. ,[object Object],	4. Investigations of nanomaterials toxicity.,[object Object]
20,[object Object],CONTACTS,[object Object]
21,[object Object],CONTACTS,[object Object]

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