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Harvard-MIT Biomedical Engineering Center




The Center,
               “Construint una xarxa interdisciplinar de
What is
unique
                      treball i coneixement”
about it?                                  Mercè Balcells-Camps, PhD
- Education
- Research                                MIT Research Scientist
- Industry                Harvard-MIT Division of Health Sciences and Technology
- International
                                             merche@mit.edu




77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                   1
Harvard-MIT Biomedical Engineering Center




      AGENDA

      – Introduce the Harvard-MIT Biomedical Engineering Center (BMEC)
The Center,
What is     ∗Education, research,                          innovation, industry, international
unique
about Share an opportunity to
   – it?                                                   become affiliated with BMEC through
- Education
        IAccess
- Research                program
- Industry
- International
                   ∗international talent exchange
                   ∗targeted seminars, hands-on trainings and expert advice




77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                                 2
Harvard-MIT Biomedical Engineering Center




The Center,
What is
unique about                 • Advance human health through academic excellence
it?                            in education and research that integrates science,
EDUCATION
RESEARCH                       engineering and medicine.
INNOVATION
INDUSTRY
INTERNATIONAL                • Educate outstanding minds, cultivate leaders, create
                               knowledge, and generate cost-effective preventative,
                               diagnostic, and therapeutic innovations.



77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                      3
Harvard-MIT Biomedical Engineering Center



                                                                       EDUCATION
                                                                   MD, PhD Programs
                           Harvard
                                                            Train students to carry their
                                                            engineering and scientific
                                                            expertise from the laboratory
   US                              Harvard-MIT
                                                            bench to the patient's bedside
Academia                               BMEC                 and to bring clinical insights from
                                                            the patient's bedside to the
                     US                     MIT             laboratory bench.
                   Hospitals
                                                            40MD, 15PhD, 5MD/PhD, 5MBA
                                                           “teaches you how medical doctors
                                                           think and how they talk”
                                                           Kay Furman, HST PhD candidate
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                           4
Harvard-MIT Biomedical Engineering Center


                                                                        RESEARCH
                                                            Investigators have special access
                                                            to both universities' world-class
                           Harvard                          resources and to Harvard Medical
                                                            School's teaching hospitals.
                                                            This partnership facilitates
   US                              Harvard-MIT
                                                            collaborations across disciplines
Academia                               BMEC                 and leverages the strengths of
                                                            multiple institutions.
                     US                     MIT
                   Hospitals                                As a result, our researchers
                                                            accomplish more than they could
                                                            independently:
                                                           =>Top publications, awards, IP, $$$,…

77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                             5
Harvard-MIT Biomedical Engineering Center



                                                                      ACHIEVEMENTS
                                                                         Smart hardware
                           Harvard                                        EKG, monitors
                                                                   Intensive care unit medicine
                                                                         Space Medicine
   US                              Harvard-MIT
                                                                           Software
Academia                               BMEC                           Hospital and clinical
                     US                     MIT                Integrated functional biology
                   Hospitals
                                                                          Devices
                                                                           Drugs
                                                                       Gene Therapy
                                                                Tissue and cell engineering

77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                          6
TISSUE ENGINEERED EC
Allogeneic EC




1 x 4 x 0.3cm3




                                             CELL NUMBER/105
    Matrix                                                     10

                                                               8

                                                               6        Viability Assay
                                                               4

                                                               2

 In Vivo                         Vascugel®                     0    0        7            14
                                                                            TIME (days)
                                                                        AcLDL Uptake




           Paracrine regulation of
               Arterial Repair                                          7
AV ACCESS
  Sponge                 Nugent, et al. J Vasc Res (2002)
                                  Vein


                             I
              Graft
     Vein
    Sponge




                      Control 56 d       Vein     I           Artery   MEEC 56 d
Sponge                   Artery
             Artery                           I
                                                       I                     Vein

                                          I
 Sponge
      Vein
                                                              I          I
                                                      Lumen
                                                                             Lumen
                         I
Harvard-MIT Biomedical Engineering Center


                                       “MIT INNOVATION ECOSYSTEM”
                                                                   SEBC
                                                                          Enterprise        MIT Sloan
                                                  I-Teams                   Forum

                                                                  VCPE                                     100K
 $700 million                                                                                           competition
                                                                               Enterpreneurship
research/year                      Deshpande                                        Center
                                     Center

                                                        MIT TLO

                                                                     MIT VMS



   Academic                                                                                   Commercial
   Research                                                                                    Enterprise
                                              COMMERCIALIZATION
 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                                                9
Harvard-MIT Biomedical Engineering Center


    Deshpande Center (2002)
     • Gift of $17.5MM from Desh and
       Jaishree Deshpande
     • Have raised additional $4MM since
       from donors, corporations
     • Grants: - 500 proposals
                                    - 72 projects
                                    - $11+MM grants


     • Results:                     -     200+ faculty/students
                                    -     100+ volunteers (catalyst program)
                                    -     22 start-ups + 1 license
                                    -     Capital >$180 MM
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                               10
Harvard-MIT Biomedical Engineering Center

           Spinouts
                Active Spectrum                            Test Equipment
                Beam Power                                 Amplifiers for Wireless
                Brontes(3M)                                Dental Imaging
                ERC                                        Titanium production
                Entra                                      Drug delivery
                Hepregen                                   Drug Discovery
                Molecular Stamping                         Nano Production
                Myomo                                      Stroke Rehabilitation
                Pervasis                                   Tissue Repair
                Pufco                                      Secure Processors
                QD vision                                  Displays
                Sentina                                    Auto Sensors
                Taris Biomedical                           Drug Delivery
                1366                                       Solar Cells
                Vertica                                    Database Software

77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                     11
Harvard-MIT Biomedical Engineering Center



                                                                                 ACHIEVEMENTS
                                                                                   Smart hardware
                                  Harvard                     Regulatory            EKG, monitors
              Preclinical                                     Agency         Intensive care unit medicine
International?CBSET                                           FDA                         International?
                                                                                   Space Medicine
                                           Harvard-MIT
                                               BMEC                                   Software
                                                                                 Hospital and clinical
                     US                            MIT                       Integrated functional biology
                   Hospitals                                         US
                                                                                        Devices
                                                                  Industry
 International?                            International?                                Drugs
                                                                                     Gene Therapy
                                                                              Tissue and cell engineering

   77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                                     12
Harvard-MIT Biomedical Engineering Center




                                                            MIT-
                                                            MIT-SPAIN




77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                        13
Harvard-MIT Biomedical Engineering Center


                                       MIT-Spain en números
 3.5 Anys d’operació
1 de 5 Estudiants de MIT que busquen oportunitats a l’estranger
       escull MIT-Spain
 170 Incorporacions de talent de MIT en empreses, centres i
       universitats arreu l’Estat; 321 solicituds
 40% A Catalunya
 95% Index de satisfacció entre hosts i estudiants
  18   Visites de professors del MIT (seminaris, congressos,
       assessoria, ...)
  11   Actes organitzats a Barcelona o al MIT
  54   Projectes punters de col.laboració descuberts; 14 finançats
       MIT-Spain/La Cambra Seed Fund for collaborative research


77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                     14
Harvard-MIT Biomedical Engineering Center

                                          A GLOBAL OPPORTUNITY:
                     International Access Program (IACCESS)
                                                                           a cutting edge model based
                                                                           on the successful academia-
                                                                           industry relationship at BMEC
                                             Regulatory
                      Preclinical            Agency
                      CBSET                  FDA, EMA
                                  Harvard-MIT
                                                                             Biocluster de BCN
                                                 BMEC
                                                                              Sant Pau        Grifols
                                                                              Biopol’H        Almirall
                                                                              H. Clínic       Ferrer
                                                                              Vall d’Hebron   Esteve
                                                                              Parc UB         CH Werfen
                                                           International      Parc UAB        IHT
                    Hospitals                                                 IQS…            Lipotec…
                                                              Industry
                   World wide

                                                                           La Cambra de Barcelona
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                                          15
Harvard-MIT Biomedical Engineering Center

                                            Collaborative Research              Education

              ACTIVITIES                      Sponsored               IAccess                IAccess
                                               Research              Seminars                Visitor
      PARTNER                                   Project                                     Program
      Founding
      Patron

      Industrial
      Collaborator

      Educational
      Partner

                                                                                Included      Optional
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                                         16
Harvard-MIT Biomedical Engineering Center

                                    IAccess Visitor Program:
                                Structured rotation that enables
                             engineers learn medicine and vive versa

                            Harvard-MIT                        Mass General Hospital
                        Biomedical Engineering                  St. Elizabeth’s Medical
                               Center                                    Center
                                                           Brigham and Women’s Hospital




                              IACCESS                       Concord Biomedical Sciences
                           Member Institution                and Emerging Technologies




77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                                          17
Harvard-MIT Biomedical Engineering Center



* The Harvard-MIT Biomedical Engineering Center as an example of
how at MIT we:
       - integrate science, engineering and medicine
       - educate outstanding minds, and cultivate leaders
       - leverage the strengths of multiple institutions

* IAccess is a cutting edge model based on the successful academia-
industry relationship at BMEC:
        - international talent exchange
        - targeted seminars, hands-on trainings and expert advice

* Initial (seed) grant from La Cambra to move operation concept
forward in Barcelona

* Opportunity for a second founding patron in the short term
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                      18
Harvard-MIT Biomedical Engineering Center




                                                  Acknowledgements

                          Harvard-MIT Biomedical Engineering Center
                              La Cambra de Comerç de Barcelona
                                   Institut Químic de Sarrià




77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
                                                                      19

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Construint una xarxa interdisciplinar de treball i coneixement

  • 1. Harvard-MIT Biomedical Engineering Center The Center, “Construint una xarxa interdisciplinar de What is unique treball i coneixement” about it? Mercè Balcells-Camps, PhD - Education - Research MIT Research Scientist - Industry Harvard-MIT Division of Health Sciences and Technology - International merche@mit.edu 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 1
  • 2. Harvard-MIT Biomedical Engineering Center AGENDA – Introduce the Harvard-MIT Biomedical Engineering Center (BMEC) The Center, What is ∗Education, research, innovation, industry, international unique about Share an opportunity to – it? become affiliated with BMEC through - Education IAccess - Research program - Industry - International ∗international talent exchange ∗targeted seminars, hands-on trainings and expert advice 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 2
  • 3. Harvard-MIT Biomedical Engineering Center The Center, What is unique about • Advance human health through academic excellence it? in education and research that integrates science, EDUCATION RESEARCH engineering and medicine. INNOVATION INDUSTRY INTERNATIONAL • Educate outstanding minds, cultivate leaders, create knowledge, and generate cost-effective preventative, diagnostic, and therapeutic innovations. 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 3
  • 4. Harvard-MIT Biomedical Engineering Center EDUCATION MD, PhD Programs Harvard Train students to carry their engineering and scientific expertise from the laboratory US Harvard-MIT bench to the patient's bedside Academia BMEC and to bring clinical insights from the patient's bedside to the US MIT laboratory bench. Hospitals 40MD, 15PhD, 5MD/PhD, 5MBA “teaches you how medical doctors think and how they talk” Kay Furman, HST PhD candidate 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 4
  • 5. Harvard-MIT Biomedical Engineering Center RESEARCH Investigators have special access to both universities' world-class Harvard resources and to Harvard Medical School's teaching hospitals. This partnership facilitates US Harvard-MIT collaborations across disciplines Academia BMEC and leverages the strengths of multiple institutions. US MIT Hospitals As a result, our researchers accomplish more than they could independently: =>Top publications, awards, IP, $$$,… 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 5
  • 6. Harvard-MIT Biomedical Engineering Center ACHIEVEMENTS Smart hardware Harvard EKG, monitors Intensive care unit medicine Space Medicine US Harvard-MIT Software Academia BMEC Hospital and clinical US MIT Integrated functional biology Hospitals Devices Drugs Gene Therapy Tissue and cell engineering 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 6
  • 7. TISSUE ENGINEERED EC Allogeneic EC 1 x 4 x 0.3cm3 CELL NUMBER/105 Matrix 10 8 6 Viability Assay 4 2 In Vivo Vascugel® 0 0 7 14 TIME (days) AcLDL Uptake Paracrine regulation of Arterial Repair 7
  • 8. AV ACCESS Sponge Nugent, et al. J Vasc Res (2002) Vein I Graft Vein Sponge Control 56 d Vein I Artery MEEC 56 d Sponge Artery Artery I I Vein I Sponge Vein I I Lumen Lumen I
  • 9. Harvard-MIT Biomedical Engineering Center “MIT INNOVATION ECOSYSTEM” SEBC Enterprise MIT Sloan I-Teams Forum VCPE 100K $700 million competition Enterpreneurship research/year Deshpande Center Center MIT TLO MIT VMS Academic Commercial Research Enterprise COMMERCIALIZATION 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 9
  • 10. Harvard-MIT Biomedical Engineering Center Deshpande Center (2002) • Gift of $17.5MM from Desh and Jaishree Deshpande • Have raised additional $4MM since from donors, corporations • Grants: - 500 proposals - 72 projects - $11+MM grants • Results: - 200+ faculty/students - 100+ volunteers (catalyst program) - 22 start-ups + 1 license - Capital >$180 MM 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 10
  • 11. Harvard-MIT Biomedical Engineering Center Spinouts Active Spectrum Test Equipment Beam Power Amplifiers for Wireless Brontes(3M) Dental Imaging ERC Titanium production Entra Drug delivery Hepregen Drug Discovery Molecular Stamping Nano Production Myomo Stroke Rehabilitation Pervasis Tissue Repair Pufco Secure Processors QD vision Displays Sentina Auto Sensors Taris Biomedical Drug Delivery 1366 Solar Cells Vertica Database Software 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 11
  • 12. Harvard-MIT Biomedical Engineering Center ACHIEVEMENTS Smart hardware Harvard Regulatory EKG, monitors Preclinical Agency Intensive care unit medicine International?CBSET FDA International? Space Medicine Harvard-MIT BMEC Software Hospital and clinical US MIT Integrated functional biology Hospitals US Devices Industry International? International? Drugs Gene Therapy Tissue and cell engineering 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 12
  • 13. Harvard-MIT Biomedical Engineering Center MIT- MIT-SPAIN 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 13
  • 14. Harvard-MIT Biomedical Engineering Center MIT-Spain en números 3.5 Anys d’operació 1 de 5 Estudiants de MIT que busquen oportunitats a l’estranger escull MIT-Spain 170 Incorporacions de talent de MIT en empreses, centres i universitats arreu l’Estat; 321 solicituds 40% A Catalunya 95% Index de satisfacció entre hosts i estudiants 18 Visites de professors del MIT (seminaris, congressos, assessoria, ...) 11 Actes organitzats a Barcelona o al MIT 54 Projectes punters de col.laboració descuberts; 14 finançats MIT-Spain/La Cambra Seed Fund for collaborative research 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 14
  • 15. Harvard-MIT Biomedical Engineering Center A GLOBAL OPPORTUNITY: International Access Program (IACCESS) a cutting edge model based on the successful academia- industry relationship at BMEC Regulatory Preclinical Agency CBSET FDA, EMA Harvard-MIT Biocluster de BCN BMEC Sant Pau Grifols Biopol’H Almirall H. Clínic Ferrer Vall d’Hebron Esteve Parc UB CH Werfen International Parc UAB IHT Hospitals IQS… Lipotec… Industry World wide La Cambra de Barcelona 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 15
  • 16. Harvard-MIT Biomedical Engineering Center Collaborative Research Education ACTIVITIES Sponsored IAccess IAccess Research Seminars Visitor PARTNER Project Program Founding Patron Industrial Collaborator Educational Partner Included Optional 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 16
  • 17. Harvard-MIT Biomedical Engineering Center IAccess Visitor Program: Structured rotation that enables engineers learn medicine and vive versa Harvard-MIT Mass General Hospital Biomedical Engineering St. Elizabeth’s Medical Center Center Brigham and Women’s Hospital IACCESS Concord Biomedical Sciences Member Institution and Emerging Technologies 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 17
  • 18. Harvard-MIT Biomedical Engineering Center * The Harvard-MIT Biomedical Engineering Center as an example of how at MIT we: - integrate science, engineering and medicine - educate outstanding minds, and cultivate leaders - leverage the strengths of multiple institutions * IAccess is a cutting edge model based on the successful academia- industry relationship at BMEC: - international talent exchange - targeted seminars, hands-on trainings and expert advice * Initial (seed) grant from La Cambra to move operation concept forward in Barcelona * Opportunity for a second founding patron in the short term 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 18
  • 19. Harvard-MIT Biomedical Engineering Center Acknowledgements Harvard-MIT Biomedical Engineering Center La Cambra de Comerç de Barcelona Institut Químic de Sarrià 77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA 19