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Follow-up: Evidence and optimalisation Klaas Havenga University Medical Center Groningen The Netherlands
This talk: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale to FU     Approaches      Trials    Framing    CEAwatch    Summary
Results of hepatic resection for colorectal cancer Source: Uptodate Rationale to FU     Approaches      Trials    Framing    CEAwatch    Summary Author and year Number of patients 5 yr OS, percent Hughes, KS; 1986 607 33 Scheele, J; 1995 434 33 Nordlinger, B; 1996 1568 28 Jamison, RL; 1997 280 27 Fong, Y; 1999 1001 37 Iwatsuki, S; 1999 305 32 Choti, M; 2002 133 58 Abdalla, E; 2004 190 58 Fernandez, FG; 2004 100 58 Wei, AC; 2006 423 47 Rees, M; 2008 929 36 De Jong, M; 2009 1669 47 Morris, EJ; 2010 3116 44
Developments in treatment of metastatic disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale to FU     Approaches      Trials    Framing    CEAwatch    Summary
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Office Visits ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
. Chau I et al. JCO 2004;22:1420-1429 ©2004 by American Society of Clinical Oncology Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Office Visits ,[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Guidelines    CEAwatch    Summary
Office Visits ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Endoscopy: colonoscopy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Endoscopy: sigmoidoscopy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Carcino Embryonic Antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Guidelines    CEAwatch    Summary
Carcino Embryonic Antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Grossmann et al. CEA measurement during follow-up for rectal carcinoma is useful even if normal levels exist before surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
. Chau I et al. JCO 2004;22:1420-1429 ©2004 by American Society of Clinical Oncology Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Carcino Embryonic Antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Carcino Embryonic Antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
. Chau I et al. JCO 2004;22:1420-1429 ©2004 by American Society of Clinical Oncology Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Not supported ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale     Approaches to FU     Trials    Framing    CEAwatch    Summary
Figueredo - BioMed Central 2003 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU     Trials     Framing    CEAwatch    Summary
Jeffery 2007 (Cochrane) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU     Trials     Framing    CEAwatch    Summary
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU     Trials     Guidelines    CEAwatch    Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Wattchow 2006 (Australia) General practice vs surgical-based follow-up for patients with colon cancer: randomised controlled trial. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU     Trials     Guidelines    CEAwatch    Summary
Discussing Wattchow trial ,[object Object],[object Object],Rationale    Approaches to FU     Trials     Guidelines    CEAwatch    Summary
Rodriguez (2006, Barcelona) . ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU     Trials     Framing    CEAwatch    Summary
Rodriguez (2006, Barcelona) . ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU     Trials     Framing    CEAwatch    Summary
Evidence for CT? Confused? ,[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU     Trials     Framing    CEAwatch    Summary
General considerations ,[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU      Trials     Framing     CEAwatch    Summary
General considerations ,[object Object],Rationale    Approaches to FU      Trials     Framing     CEAwatch    Summary
General considerations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU      Trials     Framing     CEAwatch    Summary
CEAwatch ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU      Trials    Framing     CEAwatch     Summary
APR 02-07-2010 female pt 10-06-1960 T3N0 Rationale    Approaches to FU      Trials    Framing     CEAwatch     Summary
CEAwatch - study ,[object Object],[object Object],[object Object],Rationale    Approaches to FU      Trials    Framing     CEAwatch     Summary
CEAwatch - study ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale    Approaches to FU      Trials    Framing     CEAwatch     Summary
Stepped wedge design Patients in control group Time  Patients in intervention group 1st  Hospital randomization Rationale    Approaches to FU      Trials    Framing     CEAwatch     Summary
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale to FU    Approaches      Trials    Guidelines    CEAwatch     Summary
 

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MCC 2011 - Slide 22

  • 1. Follow-up: Evidence and optimalisation Klaas Havenga University Medical Center Groningen The Netherlands
  • 2.
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  • 4. Results of hepatic resection for colorectal cancer Source: Uptodate Rationale to FU  Approaches  Trials  Framing  CEAwatch  Summary Author and year Number of patients 5 yr OS, percent Hughes, KS; 1986 607 33 Scheele, J; 1995 434 33 Nordlinger, B; 1996 1568 28 Jamison, RL; 1997 280 27 Fong, Y; 1999 1001 37 Iwatsuki, S; 1999 305 32 Choti, M; 2002 133 58 Abdalla, E; 2004 190 58 Fernandez, FG; 2004 100 58 Wei, AC; 2006 423 47 Rees, M; 2008 929 36 De Jong, M; 2009 1669 47 Morris, EJ; 2010 3116 44
  • 5.
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  • 7.
  • 8. . Chau I et al. JCO 2004;22:1420-1429 ©2004 by American Society of Clinical Oncology Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary
  • 9.
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  • 16. . Chau I et al. JCO 2004;22:1420-1429 ©2004 by American Society of Clinical Oncology Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary
  • 17.
  • 18.
  • 19.
  • 20.
  • 21. . Chau I et al. JCO 2004;22:1420-1429 ©2004 by American Society of Clinical Oncology Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary
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  • 35. APR 02-07-2010 female pt 10-06-1960 T3N0 Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary
  • 36.
  • 37.
  • 38. Stepped wedge design Patients in control group Time Patients in intervention group 1st Hospital randomization Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary
  • 39.
  • 40.