3. Effects of RT on breast cancer mortality and all cause mortality after breast conserving / mastectomy and axillary clearance EBCTCG. Lancet 2005.

17. PMRT 1-3 L N+ with 8 or more nodes dissected- DBCG 82 b and 82 c trial Overgaard et al. Radioth Oncol 2007. RT No RT p value LRR 4% 27% <0.001 Overall survival 57% 48% 0.03

19. . Pierce L J JCO 2005 . British Columbia Trial - OS

31. Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival. An overview of the randomised trials Lancet 2005;366:2087-2106

32. Trials of post-mastectomy RT Effect on LR and breast cancer mortality in N- pts Mastect + AC Mastect + AC Mastect + AC + RT Mastect + AC + RT

33. Trials of post-mastectomy RT Effect on LR and breast cancer mortality in N+ pts Mastect + AC + RT Mastect + AC Mastect + AC + RT Mastect + AC

35. Incidence of 2nd cancers and mortality from causes other than breast cancer

36. Breast cancer and overall mortality after RM/RT Mastect + AC Mastect + AC + RT Mastect + AC Mastect + AC + RT

37. Main findings II RT can increase mortality for heart disease and lung cancer and incidence of contr a lateral breast cance r which reduce its net beneficial effect on 15-y breast cancer mortality. Nevertheless, RT produced reductions not only in 15-y breast cancer mortality but also in 15-y overall mortality.

43. 4D CT: sorting process Full respiratory cycle End-inspiration CT Image Sorting Program End-expiration 4 sec

44. Opto-electronic system IR flash IR flash Processing unit Motion analyzer Bunker Control room

45. Breath adapted radiotherapy D eep inspiration breath hold Free breathing Irradiated heart volume 8% Irradiated heart volume 1% AN Pedersen, Copenhagen