Overview of Hormones and Epilepsy

Overview of Hormones and Epilepsy Joyce Liporace, M.D. Women’s and Men’s Conference May 1, 2010

Topics ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hormones ,[object Object],[object Object],[object Object],[object Object]

Estrogen ,[object Object],[object Object],[object Object]

Estrogen ,[object Object],[object Object]

Progesterone ,[object Object],[object Object],[object Object]

Progesterone ,[object Object],[object Object]

Anatomic Changes with Estrogen-Dendritic spines Neurons from a rat embryo Left: Estrogen supplement Right: Control

Seizures and Hormones ,[object Object],[object Object],[object Object]

Seizures and Hormones ,[object Object],[object Object]

Menstrual cycle: Three phases ,[object Object],[object Object],[object Object]

Normal cycles 21-35 days, bleeding 2-6 days Day 1 = First day of bleeding

Hormones and seizures ,[object Object],[object Object]

Menstrual cycle ,[object Object],[object Object],[object Object]

Three Patterns-Catamenial Seizures ,[object Object],[object Object],[object Object]

Determine if your seizures are linked to menstrual cycle ,[object Object],[object Object],[object Object]

Treatment options ,[object Object],[object Object],[object Object]

Progesterone Supplements ,[object Object],[object Object],[object Object]

Natural Progesterone Options ,[object Object],[object Object],[object Object]

Birth Control ,[object Object],[object Object],[object Object]

Medications that reduce the effectiveness of the pill ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Medications that do not affect the pill ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Depo-provera ,[object Object],[object Object],[object Object]

IUDs ,[object Object],[object Object],[object Object]

Ortho Evra ,[object Object],[object Object],[object Object],[object Object]

Morning after pill ,[object Object],[object Object],[object Object]

Birth Control may affect blood levels of seizure meds ,[object Object],[object Object],[object Object]

Attention Women with Epilepsy! Despite the importance of birth control to women of reproductive age, there has been little formal investigation of the safety and effectiveness of birth control methods in women with epilepsy. To remedy this, doctors from Harvard and Columbia University Medical Schools have developed a website that offers a survey to help us gain more knowledge and some educational material that will be updated regularly to provide the latest information. The ultimate goal is to develop guidelines for the selection of safe and effective birth control methods and to make sure that the best forms of birth control become available to women with epilepsy in all communities of our society. Go to www.epilepsybirthcontrolregistry.com , take our survey and then catch up on the latest information about birth control for women with epilepsy. LEARN MORE ABOUT YOUR BIRTH CONTROL OPTIONS!

Premenstrual Syndrome ,[object Object],[object Object],[object Object],[object Object]

Premenstrual Syndrome ,[object Object],[object Object],[object Object]

PMS and Epilepsy ,[object Object],[object Object],[object Object]

PMS-Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PMS-Diet ,[object Object],[object Object],[object Object],[object Object]

PMS-Medication ,[object Object],[object Object],[object Object]

Polycystic Ovarian Syndrome ,[object Object],[object Object],[object Object],[object Object],.

PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object]

Vicious Cycle Insulin Resistance Increased Androgen Production Weight Gain Anovulation

PCOS and PCO: General Population and Epilepsy Prevalence (%) PCOS PCO Genton P, et al. Epilepsia . 2001;42:295-304. Dunaif A, et al. Annu Rev Med . 2001;52:401-419. Herzog AG, et al. Epilepsia . 2001;42:311-315. 12% 23% 25% 38% All premenopausal women Women with epilepsy

Epilepsy and PCOS Baseline Epilepsy PCOS Treatment of Epilepsy ?

PCOS ,[object Object],[object Object],[object Object]

Overview of Hormones and Epilepsy

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