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OSCE KKCTH



  OSCE – JAN 2007
Question No : 1

1)    4 causes for diastolic dysfunction and 4 causes for systolic

      dysfunction.

2)    Principles of Management of congestive cardiac failure.

     What are the specific drugs used in the

     management of congestive cardiac failure?



                        Answer for Question No : 1

     1) a)    MS / TS

      b)     Constrictive Pericarditis

      c)     Dilated cardio myopathy

      d)     Myocardial ischemia

      e)     Acute volume overload (AR & MR)

       f)    Restrictive cardiomyopathy

      Anemia

      RHP

      SVT

      UAO

      Cong. HD complicated by anemia, fever endocarditis




2)    a) Reducing cardiac work
b) Augmenting myocardial contractility

     c) Improving cardiac performance by reducing the heart size

     d) Correcting the underlying cause

     Reduce fever, anemia, and infection sedating the Patient

     Vasodialators

     Captopril         after load reducing agents

     Enalapril

     Digoxin

Question No : 2




                         .
1)   Identify the Organism

2)   Which immunodeficiency is associated with chronic

     symptomatic infection with this organism?

3)   Which 3 malabsorbtion can occur in this infection?

4)   What is the appropriate antimicrobial therapy for treating this

     infection?
Answer for Question No : 2

  1)    Giardia Lamblia -Trophozoite

  2)    Hypo or agammaglobilinemia

  3)    a) Carbohydrate b) Fats c) fat soluble vitamins

  4)    Antiprotozoal agent          Pediatric dose

Albendazole (albenza)         400mg once a day for 5 days PO

Furazolidone (Furoxone)       6 mg/kg/24 hr divided qid PO for 10 days

                              (maximum : 400mg/24 hr)

Metronidazole (Flagyl)        15mg/kg/24hr divided tid PO for 5 days

                              (maximum : 750mg/24 hr)

Paromomycin                    Not recommended

Quinacrine (Atabrine)         6mg/kg/24 hr divided tid PO for 5 days

                               (maximum : 300mg/24 hr)

Tinidazole                     50mg/kg once(maximum :2g) Not

                               available in the United States
Question No. 3

       1. Identify the organ

       2. Name 2 GI complications due to this organism

       3. Drug of Choice for the GI Complications and dose

       4. Name one Pulmonary Complication

       5. What is the life span of this organism?



                      Answer for Question No : 3

       1.   Ascaris

            Ova

       2. a) Intestinal Obstruction

            b) Biliary Obstruction

       3. a) Piperazine citrate 150 mg / kg stat

            Follwed by 6 doses of 65mg / kg Bd

       4. Loeffler’s Syndrome

       5.   10 to 24 Months
Question No. 4



A child weighing 12Kg is admitted with 25% burns

  1.   What is the total volume of fluid and what fluid is required for

       resuscitation?

  2.   What is the duration for replacement ?

  3.   How is it spaced?

  4.   Is colloid indicated in this child?

  5.   When is colloid indicated?



                   Answer for the Question No. 4

  1.   1180 ml of Ringer Lactate

  2.   24 hrs

  3.   50% in the first 8 hrs (590ml)

       50% in the next 16 hrs (590ml)

  4.   No

  5.   Burns more than 85 %
Question no. 5

                             Match the following :

1.        Phyrostygmine             :    Mushroom

2.        Pyridoxine                :    Diazepam

3.        Diphenhydramine           :    Clonidine

4.        Dimercaptosuccinic acid   :    Dystonia

5.        Flumazenie                :    Ethylene Glycol

6.        Naloxone                  :    Methanol

7.        Fomepizole                     :      Betablocker

8.        EDTA                           :      Arsenic

9.        Ethanol                        :      Anticholinergic Agent

10.       Glucogen                  :    Lead



                          Answer for Question no. 5

     1.     9

     2.     1

     3.     4

     4.     8

     5.     2

     6.     3

     7.     5 or 6

     8.     10
9.    6 or 5

10.   7



                           Question No. 6


1.    A Mother is being counseled for Prevention of Allergy. She

      wants to know which of the following could be

      (A) Food intolerance (B) Food Hypersensitivity

      i)        Lactose intolerance

      ii)       Migraine

      iii)      Urticana

      iv)       HEINER Syndrome

      v)        CELIAC disease

      vi)       Irritable Bowel Syndrome



2.    Match the Following :-


      a) Cow’s Milk              -         Paralbumin

      b) Egg                          -         Vicilin

      c) Peanut                       -         Ovomucoid

      d) Fish                    -         Casein
3.   What is the ideal age for introducing the following foods:-


     a)       Cow’s Milk

     b)       Egg

     c)       Peanut & Seafood



                     Answer for Question No. 6



1.   i) A

     ii) A

     iii) B

     iv) B

     v) B

     vi) A



2.   a) 4

     b) 3

     c) 2

     d) 1

3.   a) 1 year

     b) 1 ½ to 2 years

     c)              3 years
Question No. 7

1.   A child with Rickets has following Laboratory findings:-

     Sr. Ca                                 -      9 mg/dl

     Sr. Phosphare                          -      1.5 mg/dl

     ALP (Alkaline Phosphatase) -     2000 units



          a)    What is the diagnosis?

          b)    What is the mode of inheritance?

          c)    What is the first clinical manifestation?




2.   Another child with Rickets has the following findings:-

     Sr. Ca                                 -      7 mg/dl

     Sr. Phosphare                    -     1.7 mg/dl

     ALP (Alkaline Phosphatase) -     5000 units

     This child has got Alopecia



          a)    What is the diagnosis?

          b)    What is the type of inheritance?

          c)    What is the Rx of choice & the dose?
Answer for Question No. 7



     2.   a) Familial Hypophosphotemia

                             or

              Vit – D Resistant Rickets

          b) x – linked Dominant

          c) Bowing of lower extremities



     3.   a) Vit – D dependent Rickets

                       or

               Hypocalcemic Rickets Type II

          b) Autosomal recessive

          c) 1,25 Hydroxy Vit D3

              15 –30 micro gm / 24 hrs



                            Question No. 8

1.   What is the dose of Methotrexate in JRA?

2.   Name two important side effects?

3.   Which Micronutrient supplementation is necessary while giving

     Methotrexate on a long-term basis?

4.   Name one skin condition where Methotrexate is used?

5.   What is the mode of Action?
Answer for Question No. 8

        1.    5 to 15 mg / m2 / week

        2.    a) Hepetotoxicity

              b) Megaloblastic anemia

        3.    Folic Acid

        4.    Psoriasis

        5.    Antimetabolite

                      &

             Inhibits DNA & Purine Synthesis



                            Question No. 9

10 yrs old girl presented with history of recurrent spells of dizziness,

fatigue, syncopal attacks, her HR was 52/min

        1)    What are the ECG findings?

        2)    What are the probable causes for this bradyarrhythmia?

              (Atleast 3)

        3)    What is the treatment of choice?



                      Answer for Question No. 9

1)   Rate       -     Bradycardia

     Rhythm           -     Idioventricular

     Complete Heart Block
2)        Autoimmune disorder, complex CHD, Myocarditis, long OT

          Syndrome

3)          Pacing



                                Question No. 10

A 1½ yrs old child presents with failure to thrive Muscle weakness,

Constipation, Polyuria.

     ABG:



     Ph     7.55

     Co2       37

     Po2       99

     Sao2 98

     Hco3 37

          1. What is your interpretation of the ABG

          2. List 2 clinical conditions in which this ABG finding can be seen

          3. What electrolyte abnormality is associated

            with this condition?

                          Answer for Question No : 10

1. Metabolic alkalosis uncompensated

 Probable bartter syndrome

2. Laxative or diuretic use, persistent Vomiting, diabetic insipidus.
3. Hypokalemia



                               Question No : 11

  1) Identify the rhythm.

  2) What would be the management of a child with this rhythm and

  palpable pulses?

  3) Name three possible treatable causes for this arrhythmia.

  4) Name three drugs used to treat this.




                         Answer for Question No : 11
  1. Ventricular tachycardia
  2. Support ABC / Synchronized cardioversion
  3. Hypoxia / Hypovolemia / Hypocalcemia
      Hypokalemia / Toxin / Tension pneumothorax Thromboemboli /
      Tamponede / Pain
 4.      Lignocaine
           Procainamide

           Amiodorone
Question No : 12

  1) Identify the abnormality in the ECG.

  2) What electrolyte abnormality can cause this?

  3) Why is it important to identify this rhythm disturbance?




                        Answer for Question No : 12
        1. Prolonged QT interval.
        2. Hypocalcemia.
        3. As it can degenerate into dangerous rhythm – V Tac/VF and cardiac
           arrest.




                               Question No : 13

  A one year old child has a

                     - Weight of 6.4 kg

                     - Length of 70 cm

                     - There is no oedema

1) What is the nutritional status of the child as per?
a) IAP Classification

     b) WELLCOME Classification

     c) GOMEZ Classification

     d) WATERLOW Classification

2) Write details of Gomez and Waterlow classification.




                      Answer for Question No : 13

1)   A) Grade II PEM

     B) Under nutrition

     C) Grade II malnutrition

     D) Normal



2)   Gomez                             Weight for age

     Normal                            >90 %

     I degree malnutrition 75 – 90 %

     II degree malnutrition     60 – 75 %

     III degree malnutrition    < 60 %



     Waterlow classification

     Height for age

     Normal                            > 95 %
I degree stunting            90 – 95 %

  II degree stunting           85 – 90 %

  III degree stunting          < 85 %



  Weight for height

  Normal                               > 90 % of expected

  I degree wasting             80 – 90 %

  II degree wasting            70 – 80 %

  III degree wasting           < 70 %



                          Question No : 14

1) What is the radiological finding?

2) Name three common aetiological agents.

3) Name six complications of this condition.




                      Answer for Question No : 14

1) Consolidation right upper lobe

2) Pneumococcus

  H. Influenza

  Staphylococcus aureus

3) Pleural effusion
Empyema

     Pericarditis

     Meningitis

     Septic arthritis

     Osteomyelitis




                            Question No : 15

A 14 yrs old girl is seen at the OPD with short stature, sexual

infantilism, broad chest and cubitus valgue deformity.

1) What would be the clinical diagnosis?

2) What investigations would you ask for to confirm your diagnosis?

3) What cardiovascular anomaly is most commonly associated with

this condition?

4)     Name three skeletal deformities. You would look for in this

       child.




                        Answer for Question No : 15

1) Turner’s syndrome

2) Chromosomal analysis / Karyotyping
3) Bicuspid aortic valve is the commonest cardiovascular anomaly

seen in 1/3 to ½ of patients with turners.

4)

a) Short 4th metatarsal and metacarpal

b) Epiphyseal dysgenesis of knees and elbows

c) Scoliosis

d) Decreased mineralisation of bones.




                          Question No : 16

                       CHICKENPOX VACCINE

1) What is the dose?

2) Above what age are 2 doses recommended and at what intervals?

3) For postexposure prophylaxis within what period after exposure,

should the vaccine be administered?

4) How long can the vaccine be used after reconstitution?

5)   What is the indication for giving Varicella zostel

     Immunoglobulin in newborn?

6)   What is the route of administration?



                    Answer for Question No : 16

1) 0.5 ml
2)     13 yrs

       4 – 8 weeks

3) 72 hrs

4) 30 minutes

5) If mother develops Varicella 5 days before to 2 days after

delivery

6) Subcutaneous




                          Question No : 17

Fill up the contents of the following IV fluids

1) 5 % GDW                               ----- / caloric / L

2) Dextrose 10 %                         ----- / caloric / L

3) Blood Na                              ----- / meq / L

4) Ringer Lactate K                      ----- / meq / L

                          Na                   ----- / meq / L

                          HCo3           ----- / meq / L

5) 3 % saline        Na                  ----- / meq / L

6) Calcium Gluconate 10 %      Ca                 mg / ml

7) Magnesium Sulphate 50 %          Mg     meq / ml
8) Resomol solution         K                     meq / L

                                  Glucose               gm / L

                                  Na                     gm / L

                      Answer for Question No: 17

1) 200 caloric / L

2) 400 caloric / L

3) 135 – 145 meq / L

4) 4 meq / L

   130 meq / L

   28 meq / L

5) 513 meq / L

6) 9 mg / ml

7) 4 meq / ml

8) 40 mg / L

   125 gm / L

  45 gm / L

                             Question No : 18
1) What is the cut off age limit for diagnosis of primary Amenorrhoea?
2) Which is the commonest CNS tumour may be responsible for

primary Amenorrhoea?

3) If FSH and LH levels are elevated, what is the aetiology for

primary Amenorrhoea?
4) At which SMR, majority of girls reach Menarche?

5) A girl with primary Amenorrhoea presents with recurrent

abdominal pain. What is the commonest cause?

6) Name one psychological disorder that can cause primary

Amenorrhoea?



                   Answer for Question No: 18

1) 16 yrs

2) Craniopharyngioma

3) Primary Gonedal failure

4) SMR 4

5) Imperforete hymen / Hematocolpus

6) Anorexia nervose




                         Question No : 19

                 HIV INFECTION IN NEW BORN

1) Mother has HIV infection and if baby is PCR positive within 48 hrs

  What does it imply?

  PCR negative at 48 hrs but PCR positive within 7 – 90 days
What does it imply?

2) How early can P24 antigen test be done?

3) When do you label a newborn as HIV infected?

4) After what age is HIV ELISA considered the best test for

diagnosis and what is its sensitivity and specificity.

                        Answer for Question No. 19

1)

a) It implies inatero infection and rapidly progressive disease

b) It implies postnatal transmission and slowly progressive disease

2) After 1 month of age (as false possibility rates are higher if done

before)

3) If two positive virologic tests (PCR / culture P24 antegen) are

obtained from different blood samples.

4) > 18 months of age – it is 100 % specificity sensitive.



                              Question No : 20
A 4 month old baby is brought with respiratory distress. On examination baby is
floppy with absent. DTR has clubfoot and fasiculations in the tongue.
1) What is the most likely diagnosis?
2) Name two definitive diagnostic tests for this condition.
3) What is the mode of inheritance in this condition?
4) How will you counsel the mother?
Answer for Question No : 20

1) Spinal muscular atrophy type - I

2) a) Genetic analysis for SMN gene (surviour motorneurogene)

   b) Muscle biopsy

3) Autosomal recessive

4) Introduce myself to the mother and form a rapport with her

- appraise her regarding the genetic and progressive nature of the

illness her baby had the possibility of recurrences in the next

pregnancy has to be discussed

explain the various prenatal diagnostic options available and if

possible tell her where the tests are available

Discuss the treatment options for her present child has the disease

progresses.

Thanks the mother.




                          Question No : 21

Answer the questions regarding Turner’s syndrome

1) What is the characteristic neonatal manifestation?

2) Name 3 cardiac anomalies in Turner’s syndrome.

3) Name 2 endocrine problems in turner’s
4) Which GI problems can occur?

5) Name 3 hormones used in Turner’s.

6) What are the most common skeletal abnormalities?




                     Answer for Question No : 21



1) Oedema



2) a) Bicuspid aortic valve

b) Coarctation of Aorta

c) Aortic stenosis

d) Mitral valve prolapse

e) Anomalous pulmonary venous drainage



3) a) Autoimmune thyroid disease

b) Type 2 diabetes mellitus



4)

a) IBD

b) GI Bleed
C) Delayed Gastric Empyema



5)

a) GH

b) Estrogen

c) Progesterone

d) Thyroxine



6)

a) Shortening of 4th metatarsal and metacarpal bone

b) Epiphyseal dysgenesis in the joints of knees and elbows

c) Madeling deformity

d) Scoliosis
e)   Osseous mineralisation
                              Question No : 22



Obtain history from a mother who has brought her

6 yrs old child with history of unprovoked seizures.



Checklist:



1)   Introduces and establishes rapport.
2) Asks her to act out or re-create a seizure

3) Asks for Aura and automatism

4) Asks about headache and vomiting

5) Elicits h/o failure to thrive

6) Asks for details of medications used that may

      precipitate seizure

7)    Asks for details of anticonvulsant therapy

7)      Asks for compliance

8)      Asks for family history

9)      Asks for developmental history

10)     Asks for birth and neonatal problem

11)     Asks for the time of occurrence of seizures

12)     Asks for frequency

13)     Asks for precipitating factor like from fever.

14)     Asks for personality change / school problem / Intellectual

        deterioration.



                              Question No : 23

When the mother is HIV positive

1) What is the percentage of transmission of HIV through breast

milk?
2) What should be mother be appraised of, if she chooses to breast

feed her baby?

3) What are the methods by which breast milk can be processed to

reduce chances of transmission?

4) What criteria should be taken into account if mother wants to

feed the baby with formula milk?




                    Answer for Question No : 23

1) a) 14 % if mother acquired infection before pregnancy

  b) 29 % increased risk if mother acquired infection during

pregnancy



2) a) Benefits of breast feeding

   b) Risk of transmission while breastfeeding (e.g. through cracked

nipple)

   c) To avoid mixed feeding and to stop breastfeeds abruptly after

4th month.

  d) Mother should be on ART while feeding



3) a) Pasturised breast milk

   b) Boiled human milk
c) Frozen human milk

  d) Expressed breast milk allowed to stand and remove the lipid

layer



4) a) Acceptability

   b) Affordability

   c) Sustainability

   d) Safety and feasibility




                           Question No : 24

1) Define:

        a) Drowning

        b) Near drowning

2) List 3 predisposing aetiological factor for drowning.

3) List 2 electrolytic disturbances and 1 hematological complications

of near drowning

4) What is the commonest radiological finding?




                       Answer for Question No : 24
1. a) Death within 24 hours of an immersion event

  b) Any survival from an immersion event

2. a) Seizures

  b) Long QT syndrome

  c) Poisoning with drugs

3. 1. a) Hypernatremia

     b) Hyperkalemia

     c) Hypercalcemia

     d) Hypermagnesemia

   2. Hemolysis

4. Pulmonary edema

                            Question No : 25

  A 13 yr old girl is diagnosed to have graves disease.

  1) What are the earliest signs in children with graves disease?

  2) What cardiovascular complications would you anticipate in this

  child?

  3) Name 2 drugs used in the treatment of graves disease and

  mention three severe reactions they can cause.
Answer for Question No : 25
1) Emotional disturbances with motor hyperactivity / irritability / emotional
lability
2) Cardiomegaly and failure atrial fibrillation mitral regurgitation due to
papillary muscle dysfunction.
3) Propylthiocracil
   Methimazole


Severe reactions


Agranulocytosis
Hepatic failure
Glomerulonephritis and Vasculitis




                                Question No : 26



A 6 yr old girl child is brought to ER with wheezing. She was diagnosed
outside as an asthmatic few months earlier. What relevant history would you
like to ask the mother?
Answer for Question No : 26

Present history

1) When did the present attack start and if the child is getting

better / worse / no improvement?

2) Does the child have rapid breathing / difficulty in talking or

feeding?

3) Any factors that triggered the present attack?

4) What medications has she been administered for the present

attack at what dose and frequency?

5) If associated with fever

Past history

1) How long has she been a wheezer / has frequent and for how many

days the episode last / seasonal / how often symptomatic at night /

how often absent from school?

2) If child is on long term medications – if she has been complaint

and if using MDI, if she follows the right technique?

3) How often she has to use reliever MDI / get nebulised.

4) H/o previous hospitalization and if she needed

  Parenteral or oral steroids / IV medications?

5) Frequency of visits to ER
6) Any admission to ICU and if so if mother has been told about

warning signs

7) H/o exposure to passive smoking / pets and other triggers

8) If wheeze is exercise induced?

9) History regarding comorbid conditions like sinusitis / GER / other

allergies

Family History

H/o asthma or atopy in family.




                            Question No : 27

                                 X - ray

1) Describe 2 essential findings.

2) What is the diagnosis?

3) What is the pathogenesis?

4) What is the treatment?
Answer for Question No : 27

1) (i) Emphysema of left upper lobe

  (ii) Herniation of left upper lobe to the right

  (iii) Mediastinal shift to right

2) Congenital Lobar Emphysema

3) (i) Congenital deficiency of bronchial cartilage

   (ii) External compression by aberrant vessels

   (iii) Bronchial stenosis

   (iv) Redundant mucosal flaps

   (v) Kinking of bronchus due to herniation into mediastinum

4) Lobectomy



                              Question No : 28

An infant is being evaluated for IEM.

The infant’s reports are as follows:

Plasma NH3 is 500

ABG – pH       7.38

        pCo2    42

1) What is the most likely defect leading to IEM?

2) Give 4 example of disorders in this group.

3) List 5 drugs used in treatment.

4) Which of these disorders affect males more severely?
5) Which is the most common form of these disorders?

                     Answer for Question No : 28

1) Urea cycle defect

2) (i) Carbamyl phosphate synthetase (CPS)

   (ii) Ornithine Transcarbamylase (OTC)

   (iii) Argininosuccinate Synthetase (AS)

   (iv) Argininosuccinate Lyase (AL)

   (v) Arginase

   (vi) N – Acetylglutamate Synthetase

3) (i) Sodium Benzoate

   (ii) Phenylacetate

   (iii) Arginine

   (iv) Lactulose

   (v) Neomycin

   (vi) Citruline

   (vii) Carnitine

4) OTC Deficiency

5) OTC Defects
Question No : 29

4 months old child brought to hospital with generalized hypotonia /

feeding difficulty since birth and h/o poor perception of fetal

movements by mother and polyhydramios antenatally.



1) What would be the probable diagnosis?

2) Name 3 specific types of this disease.

3) What is the basic pathology causing this condition?

4) What would be the line of management for this child?




                    Answer for Question No : 29

1) Congenital myopathy

2) Myotubular myopathy

     Nemaline rod myopathy

     Central core disease

3)

(a) Maturational arrest of fetal muscle during myotubular stage of

development

4)
(a) Confirm the disease

(b) Physiotherapy

(c) NG feeds

(d) Genetic counseling




                                Question No : 30


1. Picture A




 Picture A




Outline the treatment for this condition.
List 4 complications of this condition.
Any medications you would advise for his 5 yr old elder sister and his mother
who is 2 months pregnant?


2. Picture B
Picture B




What is the diagnosis?
List 3 clinical features of this condition




                         Answer for Question No. 30

I. Varicella

a) Symptomatic treatment with antipyeretics / antihistamines /

hygiene etc is adviced if child is healthy and is uncomplicated

varicella.

   A cyclovir is started within 72 hrs if child is immunosuppressed /

on steroids or salicylater.         Child has chronic cardiac / pulmonary

disorder or is complicated varicella.

b) Secondary bacterial skin infections

    Encephalitis / cerebellar ataxia

    Pneumonia

    Purpura / HUS
Nephritic syndrome

  Arthritis

  Myocarditis / pericarditis

  Pancreatitis

  c) Varicella vaccine can be given for 5 yrs old sister within 3 to 5

days after exposure if she has not been infected or vaccinated

earlier. If mother has not been infected or vaccinated earlier.

V21G can be given to the mother to prevent her from getting chicken

pox but she has to be told that it may not prevent the fetus from

being infected or prevent development of total embryopathy.

II. a) congenital varicella syndrome

    b) Shortened / malformed extremities

        Zigzag scarring of skin – cicatrix

        Neurological defects including dysfunction of anal + urethral

sphineters developmental defect of eye including hormone syndrome

and cataracts.



                          Question No : 31

                    Regarding Mantoux skin test



1) What is the composition of tuberculin used?
2) After what duration does it become reactive following TB

     infection?

     3) Mention 4 host related factors, which can depress the skin test in

     a child infected with M.T.B.

     4) When can a tuberculin reaction of > 5 mm be taken as positive?

     (Mention 2 conditions)




                            Answer for Question No : 31




1) 0.1 ml contains 1 TU of PPD stabilized with tween 80
2) 3 weeks to 3 months (most often between 4 – 8 weeks)
3)
(i) Malnutrition
(ii) Immune suppression by measles, mumps, varicella, influenza
(iii) Vaccination with live virus vaccine
(iv) Immunosuppression by drugs
(V) Disseminated TB / military TB


4) Children with immunosuppressive conditions – HIV / organ transplantation or on
corticosteriods > 15 mg / 24 hrs for > 1 month.
Question No : 32
A baby born to HBSAG positive mother receives HBIG and HBV soon after
delivery at 1 and 6 months.
1) (i) When would you recommend post vaccination testing for HBSAG and anti
HBS?
  (ii) How would you interpret the results?
2) What is the strength of the HBV vaccine used at different ages and for the
immune suppressed?
3) What would be the vaccination schedule for a 2-year-old child who has received
only two doses of HBV vaccine at 1 ½ and 2 ½ months of age?
4) A 15 months old child due for MMR has missed HBV vaccine is infancy what
would be your advice?




                              Answer for Question No : 32


1) (i) 9 – 15 months of age
  (ii) If positive for anti HBS – immune to HBV
       If negative for HBSAG and anti HBS a second complete
     HBV series of vaccination followed by retesting.
     If positive for HBS the parent should be counselled.


2) 0 – 10 yrs            5 microgram or 10 microgram
  >10 yrs          10 microgram or 20 microgram
  Immune
 suppressed        40 microgram or 40 microgram
3) Give only one dose of HBV to complete the schedule.
4) To start HBV vaccination and administer the I dose simultaneously with MMR
at a different site.




                                Question No : 33


A 1 ½ years old child is admitted and treated for HAV infection. Child has not
received any immunization so far as he comes from a tribal area. What will be the
immunizations you would advice for this child and at what schedule?




                          Answer for Question No. 33


As many vaccines as possible can be administered to this child simultaneously
following the IAP schedule and administering optional vaccines as per the mothers
request. No need for HAV vaccine.
Question No : 34


An 8 months old child is diagnosed to have HIB meningitis


1) What are the factors, which would influence the child’s prognosis? (Mention 3)


2) Mention five major neurological sequelae this child can have.


3) What would be your advice to the child’s parents regarding prevention of spread
of this disease to other members in the household?




                           Answer for Question No. 34


1) Prognosis depends on
(a) Age at presentation
(b) duration of illness before appropriate antimicrobial therapy
(c) CSF polysaccharide concentration and the rapidity with which it is cleaned from
blood, CSF and urine


2) Major Neuro Sequelae
Behavioural problems
Language disorder
Impaired vision
Mentalretardation
Motor abnormalities
Ataxia
Seizures
Hydrocephalus
Hearing loss




                      Question No : 35
1)Comment on this smear




 2)Mention atleast 3 DD of this smear




 3)How do you confirm the diagnosis?




                            Answer for Question No. 35


1) Hypochromic microcytic anemia with few target cells and tear drop cells. WBC
and platelets appear normal.
2)
a) Iron deficiency anemia
b) Thalassemia
c) Sideroblastic anemia


3) Serum Iron / TIBC
     Hemoglobin electrophoresis
     Bone marrow study.
Question No : 36


Write your dietary advice for a child with CRF.




                            Answer for Question No. 36
Diet in CRF
1) Calories – at least the daily requirement of 100 kcal / kg / day
               should be given.
                 For stunted children. RDA for height age is given.
                 20 % extra calories can be recommended.
2) Protein -                      Protein (g / kg)
                                  0 – 1 yr             1 – 5 yrs               5 – 10 yrs
mild GFR (20 – 40)                 1.8           1.4                     1
Mod GFR (5 – 20)            4.1              1                     0.8
Severe GFR (< 5)            1                    0.8                     0.6
3) Salt – no added salt of edema / hypertension is severe (or)
           Restrict to 0.5 gm / day in infants and 1 gm / day is older child.
4) water – Insensible water loss and previous days output
5)If Hyperkalemic – avoid K containing food restriction of po4 if severe Po4 is
high.
Vitamins – water soluble – routinely supplemented.
               (AEK) Fat soluble vitamins – not needed
               W & D supplementation – based on PTH / ca / phosphorous levels
(maintain ca x p level < 55).
Question No : 37


A 3 years old child is seen at OPD with short limbs, long narrow trunk and large
head. The limb shortening is greatest in the proximal segments.


1) What would be your diagnosis?


2) Mention 5 skeletal radiological changes associated with this condition.


3) What two neurological complication would you anticipate in this child?




                               Answer for Question No. 37


1) Achondioplasia
2)
(a) Short vertebral pedicles
(b) Progressive decrease in interpedicular distance from L1 to L5 spine
© Short and round iliac bones with flat acetabular roof
(d) Irregular and flared metaphysis and short tubular bones
(e) Disproportionately long fibula compared to tibia
(f) Large calavarial bone with small cranial and skull bones.


3)
(a) Hydrocephalus
(b) Lumbar canal stenosis
Question No : 38


16 months old child with Thalassemia major, had urtricarial rashes following egg
ingestion brought for MMR vaccine.


1) What history would you ask before vaccination & why?


2) What precaution would you take to store, reconstitute and administer MMR
vaccine?


3) If the mother want to administer varicella vaccine also what would be your
advice.




                            Answer for Question No. 38


1) When the child last received blood transfusion.
Whether the child had anaphylaxis to egg ingestion – though it is not a
contraindication for MMR the child has to be observed for 90 minutes after
vaccination if there is history of anaphylaxis.


2) MMR has to be stored in the first shelf of the refrigerator and given within 4 hrs
after reconstitution it is given subcutaneously.


3) Both can be given simultaneously at two different sites or at 4 – 8 weeks
interval.
Question No : 39


1) Write your comments on the x - ray


2) Give 3 differential diagnosis which can led to this condition.




                            Answer for Question No : 39


1) Normal lungs and heart
  Bilateral adrenal calcification


2)a) TB of the adrenals
 b) Recovery after waterhouse fridrichsen
 c) Woolmans disease


(Calcification is almost always unilateral in adrenal tumour)
Question No : 40


1) What is pulseoximetry?


2) What is the principle behind it?


3) What are its limitations?


4) How does it co-relate with Po2?




                               Answer for Question No. 40


1) Pulse oximetry is a non-invasive method of measuring the oxygen saturation of
hemoglobin in arterial blood.


2) Red and infra red light of different wavelengths when transmitted through the
capillary have differential absorption by oxy hemoglobin and reduced hemoglobin.
This ratio is the detected by a transducer and displayed as oxygen saturation.


3) False values occurred in
a) Poor perfusion
b) Ambient light
c) Presence of carboxy hemoglobin / methhemoglobin


4) As per the oxyhemoglobin dissociation curve




                                  Question No : 41


1) What are the 3 classes of histiocytosis syndrome in children?


2) Name 2 of each in class I histiocytosis.


      1) Dermal manifestations.
      2) Endocrine problems
      3) X – ray skeletal findings.


3) What are the serological abnormalities seen in class II histiocytosis?




                            Answer for Question No. 41
I
1) Langerhans cell histocytosis
2) a)Familial erythrophagocytic lymphohistiocytosis
b) Infection associated hemo phagocytic syndrome
3) a) malignant histiocytosis
b) Acute monocytic leukemia


2) a) seborrheic dermatitis / petechia
b) Hypothalamic involvement / pituitary dysfunction – diabetis insipidus / primary
hypothyroidism.
c) Osteolytic lesion in born with no evidence of reactive newborn formation /
fractures / vertebral collapse / floating teeth.


3) Hyperlipidemia, hypofibrinogenimia, elevated lever enzymes, extremely
elevated circulating interlukin 2 receptors




                                    Question No. 42


1) What would be the clinical presentation? Describe atleast 5 clinical features.


2) Describe the CT Scan findings.


3) What is the pathologic defects in this condition?
Answer for Question No. 42


1)
a) Prominent occiput
b) Cerebellar ataxia
c) Macrocephaly
d) Sunset Sign
e) Spasticity of lower limbs


2) Dilated IV ventricle / III & lateral ventricles / Dandy walker malformation.
3) Failure of development of roof of IV ventricles.




                                    Question No. 43


Storage of Vaccines
1. Picture of a Refrigerator
Vaccines are stored in this refrigerator in your clinic. Mention the correct place of
storage of the following.


a) BCG
b) OPV
c) MEASLES
d) DPT / DT / TT
e) Varicella
f) Hepatitis – B
g) Hepatitis – A
h) Typhoid
i) Diluent
j) Ice Cubes
k) Ice Packs
l) Dial Thermometer
m) Water Bottles
                         Answer for Question No. 43


1) Top shelf
2) Freezer
3) Top Shelf / freezer
4) Middle Shelf
5) Lower Shelf
6) Middle Shelf
7) Middle Shelf
8) Middle Shelf
9) Crispator
10) Freezer
11) Freezer
12) Top Shelf
13) Side door
Question No. 44


1) If 2 or more soft neurologic signs are persistent it correlates with 4 conditions.
What are they?


2) ELICIT SOFT NEUROLOGICAL SIGNS
                          (Observer: Dr. Ganesh)
                       a) TANDEM WALKING
                       b) DISDIADOKOKINESIS
                       c) SYNKINESIS (MIRROR IMAGE MOVEMENT)
                       d) HAND PATS
                       e) REPETITIVE AND SUCCESSIVE FINGER
                           MOVEMENT
                       f) ARM PRONATION – SUPINATION MOVEMENT
                       g) FOOT TAPS
                       h) HOPPING
                       i) ELICITS CHOREOATHETOSIS BY EXTENSION OF
                           ARMS.


                            Answer for Question No. 44


1)
a) Neurologic dysfunction
b) ADHD
c) LD
d) CP
Question No. 45


Match the following


Hb electrophoresis                   Hemoglobinopathy


1) FA                                B – Thalassemia
2) FAS                                       Alpha Thalassemia
3) FS                                Sickle cell trait
4) F                                         Normal
5) FA Bart’s                         Sickle cell anemia




                      Answer for Question No. 45


Hb electrophoresis                   Hemoglobinopathy


1) FA                                Normal
2) FAS                                       Sickle Cell Trait
3) FS                                Sickle cell anemia
4) F                                         B – Thalassemia
5) FA Bart’s                         alpha thalassemia
Question No. 46


You are investigating some children with reference to
Hepatitis B. Interpret the reports and give your diagnosis.


I. Child A     - HbSAg +ve


                       - Anti HbCAg Igm +ve
                       - Anti HbSAg –ve
                       - HbeAg +ve


II. Child B        - HbSAg +ve
                          - Anti HbcAg -ve


III. Child C       - HbSAg –ve
                          - Igm Anti Hbc +ve


IV. Child D        - HbSAg +ve
                       - Hbe +ve
                       - Anti Hbc IgG +ve


V. Child E         - HbSAg –ve
                       - Anti Hbc IgG –ve
                       - Anti HbSAg +ve
                       - Anti Hbe +ve
VI. Child F        - HbSAg –ve
                         - Anti Hbs +ve
                         - Anti Hbc IgG –ve
                         - Anti Hbe –ve




Answer for Question No. 46


I. Acute Hepatitis B highly infective


II. Carrier


III. Acute Hepatitis B


IV. Chronic Hepatitis B high infectivity


V. Recovery from Hepatitis B


VI. Immunised child / Remote hepatitis B infection
Question No. 47




1) Name the factors deficiency of which will be corrected by transfusion of FFP.
(At least 4)
2) What is the dose?
3) List 1 renal condition and 1 thrombolic condition in which FFP may be useful?
4) What are the components of cryoprecipitate?




                                Answer for Question No. 47


1)
     a) Factor II
     b) Factor V
     c) Factor X
     d) Factor XI
     e) Functional deficiency of factors II, VII, IX, X in emergencies (rapid reversal
         of warfarin effects)


2) 15 ml / hr


3) - TTP
     - Antithrombic C, Pr C, Pr S deficiency
4)
     a) Fibrinogen
     b) Factor VIII
     c) Factor XIII




                                 Question No. 48




Write the correct symbols for the following used in pedigree chart.




1) Sex unspecified
2) Divorced
3) Monozygotic twinn
4) Proband
5) Deceased individual
6) Miscarriage
7) Adopted into family
8) Stillbirth
9) No offspring
10) Affected
Question No. 49


I. Child ‘A’ walks up and down stairs one leg at a time, climbs on
 furniture and jumps.


a) What would be your assessment of the age of this child?


b) Name 2 adaptive milestones specific for this age.




II. Child B   - copies cross and square
                    - Imitates construction of “gate” of 5 cubes


   a) What would be the child’s probable age?


   b) Mention 2 specific motor milestones for this age.




III. Match the following


a) Palmar grasp gone                               - 8 months
b) Transfers object from hand-to-hand        - 4 months
c) Turn pages of book                              - 5.5 months
d) Thumb finger grasp                              - 12 months
Answer for Question No. 49


I.
       a) 30 months
       b) – Makes tower of 7 cubes
          - Circular scribbling
          - Imitates vertical stroke
          - Dumps pellets from bottle
II.
       a) 48 months
       b) – Hops on one foot
          - Throws ball menhead
          - Uses scissors to cut out pictures
          - Climbs well


III.
       a) 4 months
       b) 5.5 months
       c) 12 months
       d) 8 months
Question No. 50


E.T. Tube
1) Identify the instrument.
2) Name its parts.
3) What size would you use in a 6 yrs old child?
4) Mention 5 physiological changes, which occur when it is used in children.


                              Answer for Question No. 50
1) Endotracheal tube uncuffed
2)
     a) Adaptor
     b) Markings on tube for nasal / oral fixing
     c) Vocal cord guide
     d) Murphy’s eye
     e) Radiological marker


3) 5.5 cm uncuffed (tubes 0.5 cm less and greater in size to be kept ready)


4)
     a)   ICP
     b)   Laryngospasm
     c)   Hypoxia
     d)   Tachycardia and hypertension in older children
     e)   Bradycardia and Hypotension in infants
http://oscepediatrics.blogspot.in/


  http://dnbpediatricstheory.blogspot.in/




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OSCE KKCTH Diastolic and Systolic Dysfunction

  • 1. OSCE KKCTH OSCE – JAN 2007
  • 2. Question No : 1 1) 4 causes for diastolic dysfunction and 4 causes for systolic dysfunction. 2) Principles of Management of congestive cardiac failure. What are the specific drugs used in the management of congestive cardiac failure? Answer for Question No : 1 1) a) MS / TS b) Constrictive Pericarditis c) Dilated cardio myopathy d) Myocardial ischemia e) Acute volume overload (AR & MR) f) Restrictive cardiomyopathy Anemia RHP SVT UAO Cong. HD complicated by anemia, fever endocarditis 2) a) Reducing cardiac work
  • 3. b) Augmenting myocardial contractility c) Improving cardiac performance by reducing the heart size d) Correcting the underlying cause Reduce fever, anemia, and infection sedating the Patient Vasodialators Captopril after load reducing agents Enalapril Digoxin Question No : 2 . 1) Identify the Organism 2) Which immunodeficiency is associated with chronic symptomatic infection with this organism? 3) Which 3 malabsorbtion can occur in this infection? 4) What is the appropriate antimicrobial therapy for treating this infection?
  • 4. Answer for Question No : 2 1) Giardia Lamblia -Trophozoite 2) Hypo or agammaglobilinemia 3) a) Carbohydrate b) Fats c) fat soluble vitamins 4) Antiprotozoal agent Pediatric dose Albendazole (albenza) 400mg once a day for 5 days PO Furazolidone (Furoxone) 6 mg/kg/24 hr divided qid PO for 10 days (maximum : 400mg/24 hr) Metronidazole (Flagyl) 15mg/kg/24hr divided tid PO for 5 days (maximum : 750mg/24 hr) Paromomycin Not recommended Quinacrine (Atabrine) 6mg/kg/24 hr divided tid PO for 5 days (maximum : 300mg/24 hr) Tinidazole 50mg/kg once(maximum :2g) Not available in the United States
  • 5. Question No. 3 1. Identify the organ 2. Name 2 GI complications due to this organism 3. Drug of Choice for the GI Complications and dose 4. Name one Pulmonary Complication 5. What is the life span of this organism? Answer for Question No : 3 1. Ascaris Ova 2. a) Intestinal Obstruction b) Biliary Obstruction 3. a) Piperazine citrate 150 mg / kg stat Follwed by 6 doses of 65mg / kg Bd 4. Loeffler’s Syndrome 5. 10 to 24 Months
  • 6. Question No. 4 A child weighing 12Kg is admitted with 25% burns 1. What is the total volume of fluid and what fluid is required for resuscitation? 2. What is the duration for replacement ? 3. How is it spaced? 4. Is colloid indicated in this child? 5. When is colloid indicated? Answer for the Question No. 4 1. 1180 ml of Ringer Lactate 2. 24 hrs 3. 50% in the first 8 hrs (590ml) 50% in the next 16 hrs (590ml) 4. No 5. Burns more than 85 %
  • 7. Question no. 5 Match the following : 1. Phyrostygmine : Mushroom 2. Pyridoxine : Diazepam 3. Diphenhydramine : Clonidine 4. Dimercaptosuccinic acid : Dystonia 5. Flumazenie : Ethylene Glycol 6. Naloxone : Methanol 7. Fomepizole : Betablocker 8. EDTA : Arsenic 9. Ethanol : Anticholinergic Agent 10. Glucogen : Lead Answer for Question no. 5 1. 9 2. 1 3. 4 4. 8 5. 2 6. 3 7. 5 or 6 8. 10
  • 8. 9. 6 or 5 10. 7 Question No. 6 1. A Mother is being counseled for Prevention of Allergy. She wants to know which of the following could be (A) Food intolerance (B) Food Hypersensitivity i) Lactose intolerance ii) Migraine iii) Urticana iv) HEINER Syndrome v) CELIAC disease vi) Irritable Bowel Syndrome 2. Match the Following :- a) Cow’s Milk - Paralbumin b) Egg - Vicilin c) Peanut - Ovomucoid d) Fish - Casein
  • 9. 3. What is the ideal age for introducing the following foods:- a) Cow’s Milk b) Egg c) Peanut & Seafood Answer for Question No. 6 1. i) A ii) A iii) B iv) B v) B vi) A 2. a) 4 b) 3 c) 2 d) 1 3. a) 1 year b) 1 ½ to 2 years c) 3 years
  • 10. Question No. 7 1. A child with Rickets has following Laboratory findings:- Sr. Ca - 9 mg/dl Sr. Phosphare - 1.5 mg/dl ALP (Alkaline Phosphatase) - 2000 units a) What is the diagnosis? b) What is the mode of inheritance? c) What is the first clinical manifestation? 2. Another child with Rickets has the following findings:- Sr. Ca - 7 mg/dl Sr. Phosphare - 1.7 mg/dl ALP (Alkaline Phosphatase) - 5000 units This child has got Alopecia a) What is the diagnosis? b) What is the type of inheritance? c) What is the Rx of choice & the dose?
  • 11. Answer for Question No. 7 2. a) Familial Hypophosphotemia or Vit – D Resistant Rickets b) x – linked Dominant c) Bowing of lower extremities 3. a) Vit – D dependent Rickets or Hypocalcemic Rickets Type II b) Autosomal recessive c) 1,25 Hydroxy Vit D3 15 –30 micro gm / 24 hrs Question No. 8 1. What is the dose of Methotrexate in JRA? 2. Name two important side effects? 3. Which Micronutrient supplementation is necessary while giving Methotrexate on a long-term basis? 4. Name one skin condition where Methotrexate is used? 5. What is the mode of Action?
  • 12. Answer for Question No. 8 1. 5 to 15 mg / m2 / week 2. a) Hepetotoxicity b) Megaloblastic anemia 3. Folic Acid 4. Psoriasis 5. Antimetabolite & Inhibits DNA & Purine Synthesis Question No. 9 10 yrs old girl presented with history of recurrent spells of dizziness, fatigue, syncopal attacks, her HR was 52/min 1) What are the ECG findings? 2) What are the probable causes for this bradyarrhythmia? (Atleast 3) 3) What is the treatment of choice? Answer for Question No. 9 1) Rate - Bradycardia Rhythm - Idioventricular Complete Heart Block
  • 13. 2) Autoimmune disorder, complex CHD, Myocarditis, long OT Syndrome 3) Pacing Question No. 10 A 1½ yrs old child presents with failure to thrive Muscle weakness, Constipation, Polyuria. ABG: Ph 7.55 Co2 37 Po2 99 Sao2 98 Hco3 37 1. What is your interpretation of the ABG 2. List 2 clinical conditions in which this ABG finding can be seen 3. What electrolyte abnormality is associated with this condition? Answer for Question No : 10 1. Metabolic alkalosis uncompensated Probable bartter syndrome 2. Laxative or diuretic use, persistent Vomiting, diabetic insipidus.
  • 14. 3. Hypokalemia Question No : 11 1) Identify the rhythm. 2) What would be the management of a child with this rhythm and palpable pulses? 3) Name three possible treatable causes for this arrhythmia. 4) Name three drugs used to treat this. Answer for Question No : 11 1. Ventricular tachycardia 2. Support ABC / Synchronized cardioversion 3. Hypoxia / Hypovolemia / Hypocalcemia Hypokalemia / Toxin / Tension pneumothorax Thromboemboli / Tamponede / Pain 4. Lignocaine Procainamide Amiodorone
  • 15. Question No : 12 1) Identify the abnormality in the ECG. 2) What electrolyte abnormality can cause this? 3) Why is it important to identify this rhythm disturbance? Answer for Question No : 12 1. Prolonged QT interval. 2. Hypocalcemia. 3. As it can degenerate into dangerous rhythm – V Tac/VF and cardiac arrest. Question No : 13 A one year old child has a - Weight of 6.4 kg - Length of 70 cm - There is no oedema 1) What is the nutritional status of the child as per?
  • 16. a) IAP Classification b) WELLCOME Classification c) GOMEZ Classification d) WATERLOW Classification 2) Write details of Gomez and Waterlow classification. Answer for Question No : 13 1) A) Grade II PEM B) Under nutrition C) Grade II malnutrition D) Normal 2) Gomez Weight for age Normal >90 % I degree malnutrition 75 – 90 % II degree malnutrition 60 – 75 % III degree malnutrition < 60 % Waterlow classification Height for age Normal > 95 %
  • 17. I degree stunting 90 – 95 % II degree stunting 85 – 90 % III degree stunting < 85 % Weight for height Normal > 90 % of expected I degree wasting 80 – 90 % II degree wasting 70 – 80 % III degree wasting < 70 % Question No : 14 1) What is the radiological finding? 2) Name three common aetiological agents. 3) Name six complications of this condition. Answer for Question No : 14 1) Consolidation right upper lobe 2) Pneumococcus H. Influenza Staphylococcus aureus 3) Pleural effusion
  • 18. Empyema Pericarditis Meningitis Septic arthritis Osteomyelitis Question No : 15 A 14 yrs old girl is seen at the OPD with short stature, sexual infantilism, broad chest and cubitus valgue deformity. 1) What would be the clinical diagnosis? 2) What investigations would you ask for to confirm your diagnosis? 3) What cardiovascular anomaly is most commonly associated with this condition? 4) Name three skeletal deformities. You would look for in this child. Answer for Question No : 15 1) Turner’s syndrome 2) Chromosomal analysis / Karyotyping
  • 19. 3) Bicuspid aortic valve is the commonest cardiovascular anomaly seen in 1/3 to ½ of patients with turners. 4) a) Short 4th metatarsal and metacarpal b) Epiphyseal dysgenesis of knees and elbows c) Scoliosis d) Decreased mineralisation of bones. Question No : 16 CHICKENPOX VACCINE 1) What is the dose? 2) Above what age are 2 doses recommended and at what intervals? 3) For postexposure prophylaxis within what period after exposure, should the vaccine be administered? 4) How long can the vaccine be used after reconstitution? 5) What is the indication for giving Varicella zostel Immunoglobulin in newborn? 6) What is the route of administration? Answer for Question No : 16 1) 0.5 ml
  • 20. 2) 13 yrs 4 – 8 weeks 3) 72 hrs 4) 30 minutes 5) If mother develops Varicella 5 days before to 2 days after delivery 6) Subcutaneous Question No : 17 Fill up the contents of the following IV fluids 1) 5 % GDW ----- / caloric / L 2) Dextrose 10 % ----- / caloric / L 3) Blood Na ----- / meq / L 4) Ringer Lactate K ----- / meq / L Na ----- / meq / L HCo3 ----- / meq / L 5) 3 % saline Na ----- / meq / L 6) Calcium Gluconate 10 % Ca mg / ml 7) Magnesium Sulphate 50 % Mg meq / ml
  • 21. 8) Resomol solution K meq / L Glucose gm / L Na gm / L Answer for Question No: 17 1) 200 caloric / L 2) 400 caloric / L 3) 135 – 145 meq / L 4) 4 meq / L 130 meq / L 28 meq / L 5) 513 meq / L 6) 9 mg / ml 7) 4 meq / ml 8) 40 mg / L 125 gm / L 45 gm / L Question No : 18 1) What is the cut off age limit for diagnosis of primary Amenorrhoea? 2) Which is the commonest CNS tumour may be responsible for primary Amenorrhoea? 3) If FSH and LH levels are elevated, what is the aetiology for primary Amenorrhoea?
  • 22. 4) At which SMR, majority of girls reach Menarche? 5) A girl with primary Amenorrhoea presents with recurrent abdominal pain. What is the commonest cause? 6) Name one psychological disorder that can cause primary Amenorrhoea? Answer for Question No: 18 1) 16 yrs 2) Craniopharyngioma 3) Primary Gonedal failure 4) SMR 4 5) Imperforete hymen / Hematocolpus 6) Anorexia nervose Question No : 19 HIV INFECTION IN NEW BORN 1) Mother has HIV infection and if baby is PCR positive within 48 hrs What does it imply? PCR negative at 48 hrs but PCR positive within 7 – 90 days
  • 23. What does it imply? 2) How early can P24 antigen test be done? 3) When do you label a newborn as HIV infected? 4) After what age is HIV ELISA considered the best test for diagnosis and what is its sensitivity and specificity. Answer for Question No. 19 1) a) It implies inatero infection and rapidly progressive disease b) It implies postnatal transmission and slowly progressive disease 2) After 1 month of age (as false possibility rates are higher if done before) 3) If two positive virologic tests (PCR / culture P24 antegen) are obtained from different blood samples. 4) > 18 months of age – it is 100 % specificity sensitive. Question No : 20 A 4 month old baby is brought with respiratory distress. On examination baby is floppy with absent. DTR has clubfoot and fasiculations in the tongue. 1) What is the most likely diagnosis? 2) Name two definitive diagnostic tests for this condition. 3) What is the mode of inheritance in this condition? 4) How will you counsel the mother?
  • 24. Answer for Question No : 20 1) Spinal muscular atrophy type - I 2) a) Genetic analysis for SMN gene (surviour motorneurogene) b) Muscle biopsy 3) Autosomal recessive 4) Introduce myself to the mother and form a rapport with her - appraise her regarding the genetic and progressive nature of the illness her baby had the possibility of recurrences in the next pregnancy has to be discussed explain the various prenatal diagnostic options available and if possible tell her where the tests are available Discuss the treatment options for her present child has the disease progresses. Thanks the mother. Question No : 21 Answer the questions regarding Turner’s syndrome 1) What is the characteristic neonatal manifestation? 2) Name 3 cardiac anomalies in Turner’s syndrome. 3) Name 2 endocrine problems in turner’s
  • 25. 4) Which GI problems can occur? 5) Name 3 hormones used in Turner’s. 6) What are the most common skeletal abnormalities? Answer for Question No : 21 1) Oedema 2) a) Bicuspid aortic valve b) Coarctation of Aorta c) Aortic stenosis d) Mitral valve prolapse e) Anomalous pulmonary venous drainage 3) a) Autoimmune thyroid disease b) Type 2 diabetes mellitus 4) a) IBD b) GI Bleed
  • 26. C) Delayed Gastric Empyema 5) a) GH b) Estrogen c) Progesterone d) Thyroxine 6) a) Shortening of 4th metatarsal and metacarpal bone b) Epiphyseal dysgenesis in the joints of knees and elbows c) Madeling deformity d) Scoliosis e) Osseous mineralisation Question No : 22 Obtain history from a mother who has brought her 6 yrs old child with history of unprovoked seizures. Checklist: 1) Introduces and establishes rapport.
  • 27. 2) Asks her to act out or re-create a seizure 3) Asks for Aura and automatism 4) Asks about headache and vomiting 5) Elicits h/o failure to thrive 6) Asks for details of medications used that may precipitate seizure 7) Asks for details of anticonvulsant therapy 7) Asks for compliance 8) Asks for family history 9) Asks for developmental history 10) Asks for birth and neonatal problem 11) Asks for the time of occurrence of seizures 12) Asks for frequency 13) Asks for precipitating factor like from fever. 14) Asks for personality change / school problem / Intellectual deterioration. Question No : 23 When the mother is HIV positive 1) What is the percentage of transmission of HIV through breast milk?
  • 28. 2) What should be mother be appraised of, if she chooses to breast feed her baby? 3) What are the methods by which breast milk can be processed to reduce chances of transmission? 4) What criteria should be taken into account if mother wants to feed the baby with formula milk? Answer for Question No : 23 1) a) 14 % if mother acquired infection before pregnancy b) 29 % increased risk if mother acquired infection during pregnancy 2) a) Benefits of breast feeding b) Risk of transmission while breastfeeding (e.g. through cracked nipple) c) To avoid mixed feeding and to stop breastfeeds abruptly after 4th month. d) Mother should be on ART while feeding 3) a) Pasturised breast milk b) Boiled human milk
  • 29. c) Frozen human milk d) Expressed breast milk allowed to stand and remove the lipid layer 4) a) Acceptability b) Affordability c) Sustainability d) Safety and feasibility Question No : 24 1) Define: a) Drowning b) Near drowning 2) List 3 predisposing aetiological factor for drowning. 3) List 2 electrolytic disturbances and 1 hematological complications of near drowning 4) What is the commonest radiological finding? Answer for Question No : 24
  • 30. 1. a) Death within 24 hours of an immersion event b) Any survival from an immersion event 2. a) Seizures b) Long QT syndrome c) Poisoning with drugs 3. 1. a) Hypernatremia b) Hyperkalemia c) Hypercalcemia d) Hypermagnesemia 2. Hemolysis 4. Pulmonary edema Question No : 25 A 13 yr old girl is diagnosed to have graves disease. 1) What are the earliest signs in children with graves disease? 2) What cardiovascular complications would you anticipate in this child? 3) Name 2 drugs used in the treatment of graves disease and mention three severe reactions they can cause.
  • 31. Answer for Question No : 25 1) Emotional disturbances with motor hyperactivity / irritability / emotional lability 2) Cardiomegaly and failure atrial fibrillation mitral regurgitation due to papillary muscle dysfunction. 3) Propylthiocracil Methimazole Severe reactions Agranulocytosis Hepatic failure Glomerulonephritis and Vasculitis Question No : 26 A 6 yr old girl child is brought to ER with wheezing. She was diagnosed outside as an asthmatic few months earlier. What relevant history would you like to ask the mother?
  • 32. Answer for Question No : 26 Present history 1) When did the present attack start and if the child is getting better / worse / no improvement? 2) Does the child have rapid breathing / difficulty in talking or feeding? 3) Any factors that triggered the present attack? 4) What medications has she been administered for the present attack at what dose and frequency? 5) If associated with fever Past history 1) How long has she been a wheezer / has frequent and for how many days the episode last / seasonal / how often symptomatic at night / how often absent from school? 2) If child is on long term medications – if she has been complaint and if using MDI, if she follows the right technique? 3) How often she has to use reliever MDI / get nebulised. 4) H/o previous hospitalization and if she needed Parenteral or oral steroids / IV medications? 5) Frequency of visits to ER
  • 33. 6) Any admission to ICU and if so if mother has been told about warning signs 7) H/o exposure to passive smoking / pets and other triggers 8) If wheeze is exercise induced? 9) History regarding comorbid conditions like sinusitis / GER / other allergies Family History H/o asthma or atopy in family. Question No : 27 X - ray 1) Describe 2 essential findings. 2) What is the diagnosis? 3) What is the pathogenesis? 4) What is the treatment?
  • 34. Answer for Question No : 27 1) (i) Emphysema of left upper lobe (ii) Herniation of left upper lobe to the right (iii) Mediastinal shift to right 2) Congenital Lobar Emphysema 3) (i) Congenital deficiency of bronchial cartilage (ii) External compression by aberrant vessels (iii) Bronchial stenosis (iv) Redundant mucosal flaps (v) Kinking of bronchus due to herniation into mediastinum 4) Lobectomy Question No : 28 An infant is being evaluated for IEM. The infant’s reports are as follows: Plasma NH3 is 500 ABG – pH 7.38 pCo2 42 1) What is the most likely defect leading to IEM? 2) Give 4 example of disorders in this group. 3) List 5 drugs used in treatment. 4) Which of these disorders affect males more severely?
  • 35. 5) Which is the most common form of these disorders? Answer for Question No : 28 1) Urea cycle defect 2) (i) Carbamyl phosphate synthetase (CPS) (ii) Ornithine Transcarbamylase (OTC) (iii) Argininosuccinate Synthetase (AS) (iv) Argininosuccinate Lyase (AL) (v) Arginase (vi) N – Acetylglutamate Synthetase 3) (i) Sodium Benzoate (ii) Phenylacetate (iii) Arginine (iv) Lactulose (v) Neomycin (vi) Citruline (vii) Carnitine 4) OTC Deficiency 5) OTC Defects
  • 36. Question No : 29 4 months old child brought to hospital with generalized hypotonia / feeding difficulty since birth and h/o poor perception of fetal movements by mother and polyhydramios antenatally. 1) What would be the probable diagnosis? 2) Name 3 specific types of this disease. 3) What is the basic pathology causing this condition? 4) What would be the line of management for this child? Answer for Question No : 29 1) Congenital myopathy 2) Myotubular myopathy Nemaline rod myopathy Central core disease 3) (a) Maturational arrest of fetal muscle during myotubular stage of development 4)
  • 37. (a) Confirm the disease (b) Physiotherapy (c) NG feeds (d) Genetic counseling Question No : 30 1. Picture A Picture A Outline the treatment for this condition. List 4 complications of this condition. Any medications you would advise for his 5 yr old elder sister and his mother who is 2 months pregnant? 2. Picture B
  • 38. Picture B What is the diagnosis? List 3 clinical features of this condition Answer for Question No. 30 I. Varicella a) Symptomatic treatment with antipyeretics / antihistamines / hygiene etc is adviced if child is healthy and is uncomplicated varicella. A cyclovir is started within 72 hrs if child is immunosuppressed / on steroids or salicylater. Child has chronic cardiac / pulmonary disorder or is complicated varicella. b) Secondary bacterial skin infections Encephalitis / cerebellar ataxia Pneumonia Purpura / HUS
  • 39. Nephritic syndrome Arthritis Myocarditis / pericarditis Pancreatitis c) Varicella vaccine can be given for 5 yrs old sister within 3 to 5 days after exposure if she has not been infected or vaccinated earlier. If mother has not been infected or vaccinated earlier. V21G can be given to the mother to prevent her from getting chicken pox but she has to be told that it may not prevent the fetus from being infected or prevent development of total embryopathy. II. a) congenital varicella syndrome b) Shortened / malformed extremities Zigzag scarring of skin – cicatrix Neurological defects including dysfunction of anal + urethral sphineters developmental defect of eye including hormone syndrome and cataracts. Question No : 31 Regarding Mantoux skin test 1) What is the composition of tuberculin used?
  • 40. 2) After what duration does it become reactive following TB infection? 3) Mention 4 host related factors, which can depress the skin test in a child infected with M.T.B. 4) When can a tuberculin reaction of > 5 mm be taken as positive? (Mention 2 conditions) Answer for Question No : 31 1) 0.1 ml contains 1 TU of PPD stabilized with tween 80 2) 3 weeks to 3 months (most often between 4 – 8 weeks) 3) (i) Malnutrition (ii) Immune suppression by measles, mumps, varicella, influenza (iii) Vaccination with live virus vaccine (iv) Immunosuppression by drugs (V) Disseminated TB / military TB 4) Children with immunosuppressive conditions – HIV / organ transplantation or on corticosteriods > 15 mg / 24 hrs for > 1 month.
  • 41. Question No : 32 A baby born to HBSAG positive mother receives HBIG and HBV soon after delivery at 1 and 6 months. 1) (i) When would you recommend post vaccination testing for HBSAG and anti HBS? (ii) How would you interpret the results? 2) What is the strength of the HBV vaccine used at different ages and for the immune suppressed? 3) What would be the vaccination schedule for a 2-year-old child who has received only two doses of HBV vaccine at 1 ½ and 2 ½ months of age? 4) A 15 months old child due for MMR has missed HBV vaccine is infancy what would be your advice? Answer for Question No : 32 1) (i) 9 – 15 months of age (ii) If positive for anti HBS – immune to HBV If negative for HBSAG and anti HBS a second complete HBV series of vaccination followed by retesting. If positive for HBS the parent should be counselled. 2) 0 – 10 yrs 5 microgram or 10 microgram >10 yrs 10 microgram or 20 microgram Immune suppressed 40 microgram or 40 microgram
  • 42. 3) Give only one dose of HBV to complete the schedule. 4) To start HBV vaccination and administer the I dose simultaneously with MMR at a different site. Question No : 33 A 1 ½ years old child is admitted and treated for HAV infection. Child has not received any immunization so far as he comes from a tribal area. What will be the immunizations you would advice for this child and at what schedule? Answer for Question No. 33 As many vaccines as possible can be administered to this child simultaneously following the IAP schedule and administering optional vaccines as per the mothers request. No need for HAV vaccine.
  • 43. Question No : 34 An 8 months old child is diagnosed to have HIB meningitis 1) What are the factors, which would influence the child’s prognosis? (Mention 3) 2) Mention five major neurological sequelae this child can have. 3) What would be your advice to the child’s parents regarding prevention of spread of this disease to other members in the household? Answer for Question No. 34 1) Prognosis depends on (a) Age at presentation (b) duration of illness before appropriate antimicrobial therapy (c) CSF polysaccharide concentration and the rapidity with which it is cleaned from blood, CSF and urine 2) Major Neuro Sequelae Behavioural problems Language disorder
  • 45. 1)Comment on this smear 2)Mention atleast 3 DD of this smear 3)How do you confirm the diagnosis? Answer for Question No. 35 1) Hypochromic microcytic anemia with few target cells and tear drop cells. WBC and platelets appear normal. 2) a) Iron deficiency anemia b) Thalassemia c) Sideroblastic anemia 3) Serum Iron / TIBC Hemoglobin electrophoresis Bone marrow study.
  • 46. Question No : 36 Write your dietary advice for a child with CRF. Answer for Question No. 36 Diet in CRF 1) Calories – at least the daily requirement of 100 kcal / kg / day should be given. For stunted children. RDA for height age is given. 20 % extra calories can be recommended. 2) Protein - Protein (g / kg) 0 – 1 yr 1 – 5 yrs 5 – 10 yrs mild GFR (20 – 40) 1.8 1.4 1 Mod GFR (5 – 20) 4.1 1 0.8 Severe GFR (< 5) 1 0.8 0.6 3) Salt – no added salt of edema / hypertension is severe (or) Restrict to 0.5 gm / day in infants and 1 gm / day is older child. 4) water – Insensible water loss and previous days output 5)If Hyperkalemic – avoid K containing food restriction of po4 if severe Po4 is high. Vitamins – water soluble – routinely supplemented. (AEK) Fat soluble vitamins – not needed W & D supplementation – based on PTH / ca / phosphorous levels (maintain ca x p level < 55).
  • 47. Question No : 37 A 3 years old child is seen at OPD with short limbs, long narrow trunk and large head. The limb shortening is greatest in the proximal segments. 1) What would be your diagnosis? 2) Mention 5 skeletal radiological changes associated with this condition. 3) What two neurological complication would you anticipate in this child? Answer for Question No. 37 1) Achondioplasia 2) (a) Short vertebral pedicles (b) Progressive decrease in interpedicular distance from L1 to L5 spine © Short and round iliac bones with flat acetabular roof (d) Irregular and flared metaphysis and short tubular bones (e) Disproportionately long fibula compared to tibia (f) Large calavarial bone with small cranial and skull bones. 3) (a) Hydrocephalus (b) Lumbar canal stenosis
  • 48. Question No : 38 16 months old child with Thalassemia major, had urtricarial rashes following egg ingestion brought for MMR vaccine. 1) What history would you ask before vaccination & why? 2) What precaution would you take to store, reconstitute and administer MMR vaccine? 3) If the mother want to administer varicella vaccine also what would be your advice. Answer for Question No. 38 1) When the child last received blood transfusion. Whether the child had anaphylaxis to egg ingestion – though it is not a contraindication for MMR the child has to be observed for 90 minutes after vaccination if there is history of anaphylaxis. 2) MMR has to be stored in the first shelf of the refrigerator and given within 4 hrs after reconstitution it is given subcutaneously. 3) Both can be given simultaneously at two different sites or at 4 – 8 weeks interval.
  • 49. Question No : 39 1) Write your comments on the x - ray 2) Give 3 differential diagnosis which can led to this condition. Answer for Question No : 39 1) Normal lungs and heart Bilateral adrenal calcification 2)a) TB of the adrenals b) Recovery after waterhouse fridrichsen c) Woolmans disease (Calcification is almost always unilateral in adrenal tumour)
  • 50. Question No : 40 1) What is pulseoximetry? 2) What is the principle behind it? 3) What are its limitations? 4) How does it co-relate with Po2? Answer for Question No. 40 1) Pulse oximetry is a non-invasive method of measuring the oxygen saturation of hemoglobin in arterial blood. 2) Red and infra red light of different wavelengths when transmitted through the capillary have differential absorption by oxy hemoglobin and reduced hemoglobin. This ratio is the detected by a transducer and displayed as oxygen saturation. 3) False values occurred in a) Poor perfusion b) Ambient light
  • 51. c) Presence of carboxy hemoglobin / methhemoglobin 4) As per the oxyhemoglobin dissociation curve Question No : 41 1) What are the 3 classes of histiocytosis syndrome in children? 2) Name 2 of each in class I histiocytosis. 1) Dermal manifestations. 2) Endocrine problems 3) X – ray skeletal findings. 3) What are the serological abnormalities seen in class II histiocytosis? Answer for Question No. 41 I 1) Langerhans cell histocytosis 2) a)Familial erythrophagocytic lymphohistiocytosis b) Infection associated hemo phagocytic syndrome 3) a) malignant histiocytosis
  • 52. b) Acute monocytic leukemia 2) a) seborrheic dermatitis / petechia b) Hypothalamic involvement / pituitary dysfunction – diabetis insipidus / primary hypothyroidism. c) Osteolytic lesion in born with no evidence of reactive newborn formation / fractures / vertebral collapse / floating teeth. 3) Hyperlipidemia, hypofibrinogenimia, elevated lever enzymes, extremely elevated circulating interlukin 2 receptors Question No. 42 1) What would be the clinical presentation? Describe atleast 5 clinical features. 2) Describe the CT Scan findings. 3) What is the pathologic defects in this condition?
  • 53. Answer for Question No. 42 1) a) Prominent occiput b) Cerebellar ataxia c) Macrocephaly d) Sunset Sign e) Spasticity of lower limbs 2) Dilated IV ventricle / III & lateral ventricles / Dandy walker malformation. 3) Failure of development of roof of IV ventricles. Question No. 43 Storage of Vaccines 1. Picture of a Refrigerator Vaccines are stored in this refrigerator in your clinic. Mention the correct place of storage of the following. a) BCG b) OPV c) MEASLES d) DPT / DT / TT e) Varicella
  • 54. f) Hepatitis – B g) Hepatitis – A h) Typhoid i) Diluent j) Ice Cubes k) Ice Packs l) Dial Thermometer m) Water Bottles Answer for Question No. 43 1) Top shelf 2) Freezer 3) Top Shelf / freezer 4) Middle Shelf 5) Lower Shelf 6) Middle Shelf 7) Middle Shelf 8) Middle Shelf 9) Crispator 10) Freezer 11) Freezer 12) Top Shelf 13) Side door
  • 55. Question No. 44 1) If 2 or more soft neurologic signs are persistent it correlates with 4 conditions. What are they? 2) ELICIT SOFT NEUROLOGICAL SIGNS (Observer: Dr. Ganesh) a) TANDEM WALKING b) DISDIADOKOKINESIS c) SYNKINESIS (MIRROR IMAGE MOVEMENT) d) HAND PATS e) REPETITIVE AND SUCCESSIVE FINGER MOVEMENT f) ARM PRONATION – SUPINATION MOVEMENT g) FOOT TAPS h) HOPPING i) ELICITS CHOREOATHETOSIS BY EXTENSION OF ARMS. Answer for Question No. 44 1) a) Neurologic dysfunction b) ADHD c) LD d) CP
  • 56. Question No. 45 Match the following Hb electrophoresis Hemoglobinopathy 1) FA B – Thalassemia 2) FAS Alpha Thalassemia 3) FS Sickle cell trait 4) F Normal 5) FA Bart’s Sickle cell anemia Answer for Question No. 45 Hb electrophoresis Hemoglobinopathy 1) FA Normal 2) FAS Sickle Cell Trait 3) FS Sickle cell anemia 4) F B – Thalassemia 5) FA Bart’s alpha thalassemia
  • 57. Question No. 46 You are investigating some children with reference to Hepatitis B. Interpret the reports and give your diagnosis. I. Child A - HbSAg +ve - Anti HbCAg Igm +ve - Anti HbSAg –ve - HbeAg +ve II. Child B - HbSAg +ve - Anti HbcAg -ve III. Child C - HbSAg –ve - Igm Anti Hbc +ve IV. Child D - HbSAg +ve - Hbe +ve - Anti Hbc IgG +ve V. Child E - HbSAg –ve - Anti Hbc IgG –ve - Anti HbSAg +ve - Anti Hbe +ve
  • 58. VI. Child F - HbSAg –ve - Anti Hbs +ve - Anti Hbc IgG –ve - Anti Hbe –ve Answer for Question No. 46 I. Acute Hepatitis B highly infective II. Carrier III. Acute Hepatitis B IV. Chronic Hepatitis B high infectivity V. Recovery from Hepatitis B VI. Immunised child / Remote hepatitis B infection
  • 59. Question No. 47 1) Name the factors deficiency of which will be corrected by transfusion of FFP. (At least 4) 2) What is the dose? 3) List 1 renal condition and 1 thrombolic condition in which FFP may be useful? 4) What are the components of cryoprecipitate? Answer for Question No. 47 1) a) Factor II b) Factor V c) Factor X d) Factor XI e) Functional deficiency of factors II, VII, IX, X in emergencies (rapid reversal of warfarin effects) 2) 15 ml / hr 3) - TTP - Antithrombic C, Pr C, Pr S deficiency
  • 60. 4) a) Fibrinogen b) Factor VIII c) Factor XIII Question No. 48 Write the correct symbols for the following used in pedigree chart. 1) Sex unspecified 2) Divorced 3) Monozygotic twinn 4) Proband 5) Deceased individual 6) Miscarriage 7) Adopted into family 8) Stillbirth 9) No offspring 10) Affected
  • 61. Question No. 49 I. Child ‘A’ walks up and down stairs one leg at a time, climbs on furniture and jumps. a) What would be your assessment of the age of this child? b) Name 2 adaptive milestones specific for this age. II. Child B - copies cross and square - Imitates construction of “gate” of 5 cubes a) What would be the child’s probable age? b) Mention 2 specific motor milestones for this age. III. Match the following a) Palmar grasp gone - 8 months b) Transfers object from hand-to-hand - 4 months c) Turn pages of book - 5.5 months d) Thumb finger grasp - 12 months
  • 62. Answer for Question No. 49 I. a) 30 months b) – Makes tower of 7 cubes - Circular scribbling - Imitates vertical stroke - Dumps pellets from bottle II. a) 48 months b) – Hops on one foot - Throws ball menhead - Uses scissors to cut out pictures - Climbs well III. a) 4 months b) 5.5 months c) 12 months d) 8 months
  • 63. Question No. 50 E.T. Tube 1) Identify the instrument. 2) Name its parts. 3) What size would you use in a 6 yrs old child? 4) Mention 5 physiological changes, which occur when it is used in children. Answer for Question No. 50 1) Endotracheal tube uncuffed 2) a) Adaptor b) Markings on tube for nasal / oral fixing c) Vocal cord guide d) Murphy’s eye e) Radiological marker 3) 5.5 cm uncuffed (tubes 0.5 cm less and greater in size to be kept ready) 4) a) ICP b) Laryngospasm c) Hypoxia d) Tachycardia and hypertension in older children e) Bradycardia and Hypotension in infants